Davis, F. F. & Allen, F. W. Ribonucleic acids from yeast which contain a fifth nucleotide. J. Biol. Chem. 227, 907–915 (1957).
Article CAS PubMed Google Scholar
Boccaletto, P. et al. MODOMICS: a database of RNA modification pathways. 2021 update. Nucleic Acids Res. 50, D231–D235 (2022).
Article CAS PubMed Google Scholar
Pan, T. Modifications and functional genomics of human transfer RNA. Cell Res. 28, 395–404 (2018).
Article CAS PubMed PubMed Central Google Scholar
Topisirovic, I., Svitkin, Y. V., Sonenberg, N. & Shatkin, A. J. Cap and cap-binding proteins in the control of gene expression. Wiley Interdiscip. Rev. RNA 2, 277–298 (2011).
Article CAS PubMed Google Scholar
Cheng, Y. et al. Targeting epigenetic regulators for cancer therapy: mechanisms and advances in clinical trials. Signal Transduct. Target. Ther. 4, 62 (2019).
Article PubMed PubMed Central Google Scholar
Zhong, S. et al. MTA is an Arabidopsis messenger RNA adenosine methylase and interacts with a homolog of a sex-specific splicing factor. Plant Cell 20, 1278–1288 (2008).
Article CAS PubMed PubMed Central Google Scholar
Dominissini, D. et al. Topology of the human and mouse m6A RNA methylomes revealed by m6A-seq. Nature 485, 201–206 (2012).
Article CAS PubMed Google Scholar
Jia, G. et al. N6-Methyladenosine in nuclear RNA is a major substrate of the obesity-associated FTO. Nat. Chem. Biol. 7, 885–887 (2011).
Article CAS PubMed PubMed Central Google Scholar
He, C. Grand challenge commentary: RNA epigenetics? Nat. Chem. Biol. 6, 863–865 (2010). Together with Jia et al. (2011), this paper pinpoints the biological significance of reversible m6A modification.
Article CAS PubMed Google Scholar
Zhang, Y., Lu, L. & Li, X. Detection technologies for RNA modifications. Exp. Mol. Med. 54, 1601–1616 (2022).
Article CAS PubMed PubMed Central Google Scholar
Meyer, K. D. et al. Comprehensive analysis of mRNA methylation reveals enrichment in 3′ UTRs and near stop codons. Cell 149, 1635–1646 (2012).
Article CAS PubMed PubMed Central Google Scholar
Geula, S. et al. m6A mRNA methylation facilitates resolution of naïve pluripotency toward differentiation. Science 347, 1002–1006 (2015).
Article CAS PubMed Google Scholar
Mendel, M. et al. Methylation of structured RNA by the m6A writer METTL16 is essential for mouse embryonic development. Mol. Cell 71, 986–1000.e11 (2018).
Article CAS PubMed PubMed Central Google Scholar
Li, M. et al. Ythdf2-mediated m6A mRNA clearance modulates neural development in mice. Genome Biol. 19, 69 (2018).
Article PubMed PubMed Central Google Scholar
Lin, Z. et al. Mettl3-/Mettl14-mediated mRNA N6-methyladenosine modulates murine spermatogenesis. Cell Res. 27, 1216–1230 (2017).
Article CAS PubMed PubMed Central Google Scholar
Fustin, J. M. et al. Two Ck1δ transcripts regulated by m6A methylation code for two antagonistic kinases in the control of the circadian clock. Proc. Natl Acad. Sci. USA 115, 5980–5985 (2018).
Article PubMed PubMed Central Google Scholar
Liu, N. et al. N6-methyladenosine alters RNA structure to regulate binding of a low-complexity protein. Nucleic Acids Res. 45, 6051–6063 (2017).
Article CAS PubMed PubMed Central Google Scholar
Roundtree, I. A. et al. YTHDC1 mediates nuclear export of N6-methyladenosine methylated mRNAs. eLife 6, e31311 (2017).
Article PubMed PubMed Central Google Scholar
Erales, J. et al. Evidence for rRNA 2′-O-methylation plasticity: control of intrinsic translational capabilities of human ribosomes. Proc. Natl Acad. Sci. USA 114, 12934–12939 (2017).
Article CAS PubMed PubMed Central Google Scholar
Liu, F. et al. ALKBH1-mediated tRNA demethylation regulates translation. Cell 167, 816–828.e16 (2016).
Article CAS PubMed PubMed Central Google Scholar
Shi, H. et al. YTHDF3 facilitates translation and decay of N6-methyladenosine-modified RNA. Cell Res. 27, 315–328 (2017).
Article CAS PubMed PubMed Central Google Scholar
Pandolfini, L. et al. METTL1 promotes let-7 MicroRNA processing via m7G methylation. Mol. Cell 74, 1278–1290.e9 (2019).
Article CAS PubMed PubMed Central Google Scholar
Abakir, A. et al. N6-methyladenosine regulates the stability of RNA:DNA hybrids in human cells. Nat. Genet. 52, 48–55 (2020).
Article CAS PubMed Google Scholar
Wei, J. & He, C. Chromatin and transcriptional regulation by reversible RNA methylation. Curr. Opin. Cell Biol. 70, 109–115 (2021).
Article CAS PubMed PubMed Central Google Scholar
Zhang, C. et al. Reduced m6A modification predicts malignant phenotypes and augmented Wnt/PI3K-Akt signaling in gastric cancer. Cancer Med. 8, 4766–4781 (2019).
Article CAS PubMed PubMed Central Google Scholar
Liu, J. et al. m6A mRNA methylation regulates AKT activity to promote the proliferation and tumorigenicity of endometrial cancer. Nat. Cell Biol. 20, 1074–1083 (2018).
Article CAS PubMed PubMed Central Google Scholar
Xia, P. et al. MYC-targeted WDR4 promotes proliferation, metastasis, and sorafenib resistance by inducing CCNB1 translation in hepatocellular carcinoma. Cell Death Dis. 12, 691 (2021).
Article CAS PubMed PubMed Central Google Scholar
Nagy, Z. et al. An ALYREF-MYCN coactivator complex drives neuroblastoma tumorigenesis through effects on USP3 and MYCN stability. Nat. Commun. 12, 1881 (2021).
Article CAS PubMed PubMed Central Google Scholar
Raj, N. et al. The Mettl3 epitranscriptomic writer amplifies p53 stress responses. Mol. Cell 82, 2370–2384.e10 (2022).
Article CAS PubMed PubMed Central Google Scholar
Yankova, E. et al. Small-molecule inhibition of METTL3 as a strategy against myeloid leukaemia. Nature 593, 597–601 (2021).
Comments (0)