Lipsky, P. E. et al. Infliximab and methotrexate in the treatment of rheumatoid arthritis. N. Engl. J. Med. 343, 1594–1602 (2000).

Article  PubMed  Google Scholar 

Zintzaras, E., Dahabreh, I. J., Giannouli, S., Voulgarelis, M. & Moutsopoulos, H. M. Infliximab and methotrexate in the treatment of rheumatoid arthritis: a systematic review and meta-analysis of dosage regimens. Clin. Ther. 30, 1939–1955 (2008).

Article  PubMed  Google Scholar 

Rosenberg, S. A. Entering the mainstream of cancer treatment. Nat. Rev. Clin. Oncol. 11, 630–632 (2014).

Article  PubMed  PubMed Central  Google Scholar 

Disis, M. L. Mechanism of action of immunotherapy. Semin. Oncol. 41, S3–S13 (2014).

Article  PubMed  Google Scholar 

van Der Zanden, S. Y., Luimstra, J. J., Neefjes, J., Borst, J. & Ovaa, H. Opportunities for small molecules in cancer immunotherapy. Trends Immunol. 41, 493–511 (2020).

Article  PubMed  Google Scholar 

Wu, Y., Yang, Z., Cheng, K., Bi, H. & Chen, J. Small molecule-based immunomodulators for cancer therapy. Acta Pharm. Sin. B 12, 4287–4308 (2022).

Article  PubMed  PubMed Central  Google Scholar 

Ho, L.-J. & Lai, J.-H. Small-molecule inhibitors for autoimmune arthritis: success, failure and the future. Eur. J. Pharmacol. 747, 200–205 (2015).

Article  PubMed  Google Scholar 

Rosenberg, S. A. IL-2: the first effective immunotherapy for human cancer. J. Immunol. 192, 5451–5458 (2014).

Article  PubMed  Google Scholar 

Kantoff, P. W. et al. Sipuleucel-T immunotherapy for castration-resistant prostate cancer. N. Engl. J. Med. 363, 411–422 (2010).

Article  PubMed  Google Scholar 

O’Leary, M. C. et al. FDA approval summary: tisagenlecleucel for treatment of patients with relapsed or refractory B-cell precursor acute lymphoblastic leukemia. Clin. Cancer Res. 25, 1142–1146 (2019).

Article  PubMed  Google Scholar 

Riley, R. S., June, C. H., Langer, R. & Mitchell, M. J. Delivery technologies for cancer immunotherapy. Nat. Rev. Drug Discov. 18, 175–196 (2019).

Article  PubMed  PubMed Central  Google Scholar 

Jung, S. M. & Kim, W.-U. Targeted immunotherapy for autoimmune disease. Immune Netw. 22, e9 (2022).

Article  PubMed  PubMed Central  Google Scholar 

Scott, L. J. Tocilizumab: a review in rheumatoid arthritis. Drugs 77, 1865–1879 (2017).

Article  PubMed  PubMed Central  Google Scholar 

Frieder, J., Kivelevitch, D. & Menter, A. Secukinumab: a review of the anti-IL-17A biologic for the treatment of psoriasis. Ther. Adv. Chronic Dis. 9, 5–21 (2018).

Article  PubMed  Google Scholar 

Honap, S. et al. Effectiveness and safety of ustekinumab in inflammatory bowel disease: a systematic review and meta-analysis. Dig. Dis. Sci. 67, 1018–1035 (2022).

Article  PubMed  Google Scholar 

Peters, S., Reck, M., Smit, E. F., Mok, T. & Hellmann, M. D. How to make the best use of immunotherapy as first-line treatment of advanced/metastatic non-small-cell lung cancer. Ann. Oncol. 30, 884–896 (2019).

Article  PubMed  Google Scholar 

Ellebrecht, C. T. et al. Reengineering chimeric antigen receptor T cells for targeted therapy of autoimmune disease. Science 353, 179–184 (2016).

Article  PubMed  PubMed Central  Google Scholar 

Mackensen, A. et al. Anti-CD19 CAR T cell therapy for refractory systemic lupus erythematosus. Nat. Med. 28, 2124–2132 (2022).

Article  PubMed  Google Scholar 

Islam, T., Hasan, M., Rahman, M. S. & Islam, M. R. Comparative evaluation of authorized drugs for treating Covid-19 patients. Health Sci. Rep. 5, e671 (2022).

Article  PubMed  PubMed Central  Google Scholar 

Upadhaya, S., Hubbard-Lucey, V. M. & Yu, J. X. Immuno-oncology drug development forges on despite COVID-19. Nat. Rev. Drug Discov. 19, 751–752 (2020).

Article  PubMed  Google Scholar 

Sinton, D. & Kelley, S. O. AbCellera’s success is unprecedented: what have we learned? Lab Chip 21, 2330–2332 (2021).

Article  PubMed  Google Scholar 

Paterson, K., Zanivan, S., Glasspool, R., Coffelt, S. B. & Zagnoni, M. Microfluidic technologies for immunotherapy studies on solid tumours. Lab Chip 21, 2306–2329 (2021).

Article  PubMed  PubMed Central  Google Scholar 

Ngan Ngo, T. K., Kuo, C.-H. & Tu, T.-Y. Recent advances in microfluidic-based cancer immunotherapy-on-a-chip strategies. Biomicrofluidics 17, 011501 (2023).

Article  PubMed  PubMed Central  Google Scholar 

Kim, H., Kim, S., Lim, H. & Chung, A. J. Expanding CAR-T cell immunotherapy horizons through microfluidics. Lab Chip 24, 1088–1120 (2024).

Article  PubMed  Google Scholar 

Pechnikova, N. A. et al. Implantable biomaterials for Cancer Immunotherapies. AdvaFunct. Mater. 35, 2416813 (2025).

Google Scholar 

Wang, Z. & Kelley, S. Microfluidic technologies for enhancing the potency, predictability and affordability of adoptive cell therapies. Nat. Biomed. Eng. 9, 803–821 (2025).

Article  PubMed  Google Scholar 

Chen, K. & Wang, Z. Micro-magnetofluidic system for rare cell analysis: from principle to translation. Chemosensors 11, 335 (2023).

Article  Google Scholar 

Leach, D. G., Young, S. & Hartgerink, J. D. Advances in immunotherapy delivery from implantable and injectable biomaterials. Acta Biomater. 88, 15–31 (2019).

Article  PubMed  PubMed Central  Google Scholar 

Chen, K., Wang, W. & Wang, Z. Designing next-generation immune cell therapies with nanomaterials. BMEMat 3, e70003 (2025).

Article  Google Scholar 

Mitchell, M. J. et al. Engineering precision nanoparticles for drug delivery. Nat. Rev. Drug Discov. 20, 101–124 (2021).

Article  PubMed  Google Scholar 

Mijatovic, D., Eijkel, J. C. T. & van den Berg, A. Technologies for nanofluidic systems: top-down vs. bottom-up—a review. Lab Chip 5, 492–500 (2005).

Article  PubMed  Google Scholar 

Park, S.‐M. et al. Directed assembly of lamellae‐ forming block copolymers by using chemically and topographically patterned substrates. Adv. Mater. 19, 607–611 (2007).

Article  Google Scholar 

Suh, H. S. et al. Sub-10-nm patterning via directed self-assembly of block copolymer films with a vapour-phase deposited topcoat. Nat. Nanotechnol. 12, 575–581 (2017).

Article  PubMed  Google Scholar 

Persano, L., Camposeo, A. & Pisignano, D. Integrated bottom-up and top-down soft lithographies and microfabrication approaches to multifunctional polymers. J. Mater. Chem. C 1, 7663–7680 (2013).

Article  Google Scholar 

Whitesides, G. M. & Grzybowski, B. Self-assembly at all scales. Science 295, 2418–2421 (2002).

Article  PubMed  Google Scholar 

Lee, S. W., Chang, W.-J., Bashir, R. & Koo, Y.-M. “Bottom-up” approach for implementing nano/microstructure using biological and chemical interactions. Biotechnol. Bioprocess Eng. 12, 185–199 (2007).

Article  Google Scholar 

Sun, Z. et al. Using block copolymer architecture to achieve sub-10 nm periods. Polymer 121, 297–303 (2017).

Article  Google Scholar 

Li, W. & Müller, M. Defects in the self-assembly of block copolymers and their relevance for directed self-assembly. Annu. Rev. Chem. Biomol. Eng. 6, 187–216 (2015).

Article