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Correction: Xantholipin B produced by the stnR inactivation mutant Streptomyces flocculus CGMCC 4.1223 WJN-1
Author notesThese authors contributed equally: Sifan Wu, Tingting Huang, Dan Xie.Authors and AffiliationsState Key Laborat...
Multiplexed activity metabolomics for isolation of filipin macrolides from a hypogean actinomycete
Multiplexed activity metabolomics for isolation of filipin macrolides from a hypogean actinomycete
Chemical and biological stimulus screening in a hypogean actinomycete was used to elicit secondary metabolism. Op...
Inhibitors of acetohydroxyacid synthase as promising agents against non-tuberculous mycobacterial diseases
Inhibitors of acetohydroxyacid synthase as promising agents against non-tuberculous mycobacterial diseases
Acetohydroxyacid synthase (AHAS), exclusively present in microorganisms and plants, is a promising target for several herb...
Structure-function analysis of 2-sulfamoylacetic acid synthase in altemicidin biosynthesis
Structure-function analysis of 2-sulfamoylacetic acid synthase in altemicidin biosynthesis
Altemicidin and its analogs are valuable sulfonamide antibiotics with valuable antitumor and antibacterial activities. Str...
Differential gene expression analysis shows that cephalosporin resistance is intrinsic to Clostridioides difficile strain 630
Differential gene expression analysis shows that cephalosporin resistance is intrinsic to Clostridioides difficile strain 630
Clostridioides difficile infection (CDI) is the most common nosocomial infection in the US. CDI has become a growing conce...
Novobiocin primarily targets ParE in Neisseria gonorrhoeae
Novobiocin primarily targets ParE in Neisseria gonorrhoeae
Multidrug-resistant Neisseria gonorrhoeae is a pathogenic bacterium that poses a public health concern. In this study, we ...
Therapeutic potential of isoallolithocholic acid in methicillin-resistant Staphylococcus Aureus peritoneal infection
Therapeutic potential of isoallolithocholic acid in methicillin-resistant Staphylococcus Aureus peritoneal infection
A significant increase in multidrug-resistant Methicillin-resistant Staphylococcus aureus (MRSA) infections has made it cr...
Activity of cefiderocol in combination with tetracycline analogues against carbapenem-resistant Acinetobacter baumannii
Activity of cefiderocol in combination with tetracycline analogues against carbapenem-resistant Acinetobacter baumannii
Therapeutic options for carbapenem-resistant Acinetobacter baumannii (CA-AB) are quite limited. Cefiderocol, a novel sider...
Anti-microbial efficacy of l-glutaminase (EC 3.5.1.2) against multidrug-resistant Pseudomonas aeruginosa infection
Anti-microbial efficacy of l-glutaminase (EC 3.5.1.2) against multidrug-resistant Pseudomonas aeruginosa infection
The aims of this study were isolation-purification and characterization of l-glutaminase from L. gasseri BRLHM clinical is...
Antimicrobial resistance rates of urogenital Mycoplasma hominis and Ureaplasma species before and during the COVID-19 pandemic: results from a Greek survey, 2014 to 2022
Antimicrobial resistance rates of urogenital Mycoplasma hominis and Ureaplasma species before and during the COVID-19 pandemic: results from a Greek survey, 2014 to 2022
The prevalence of antibiotic-resistant urogenital mycoplasmas and ureaplasmas has been gradually increasing over the years...
Remembering Dr. Shinichi Kondo (15 June 1928–8 October 2022)
Remembering Dr. Shinichi Kondo (15 June 1928–8 October 2022)
Dr. Shinichi Kondo, an Emeritus Member of the Journal of Antibiotics, died on October 8, 2022 at his ...
Chromatin-modifying protein 4C (CHMP4C) affects breast cancer cell growth and doxorubicin resistance as a potential breast cancer therapeutic target
Chromatin-modifying protein 4C (CHMP4C) affects breast cancer cell growth and doxorubicin resistance as a potential breast cancer therapeutic target
Breast cancer (BCa) is one of the common malignancies among women. Doxorubicin (Dox), a type of anthracycline anti-tumor d...
Retraction Note: Molecular docking simulation, drug-likeness assessment, and pharmacokinetic study of some cephalosporin analogues against a penicillin-binding protein of Salmonella typhimurium
Retraction to: The Journal of AntibioticsThe Editor-in-chief has retracted this article because after the publication of t...
Two new adenopeptins B and C inhibit sphere formation of pancreatic cancer cells
Two new adenopeptins B and C inhibit sphere formation of pancreatic cancer cells
Cancer remains one of the leading causes of death worldwide, particularly pancreatic cancer being lethal because of its ag...
Evaluation of A-ring hydroxymethylene-amino- triterpenoids as inhibitors of SARS-CoV-2 spike pseudovirus and influenza H1N1
Evaluation of A-ring hydroxymethylene-amino- triterpenoids as inhibitors of SARS-CoV-2 spike pseudovirus and influenza H1N1
A set of triterpene A-ring hydroxymethylene-amino-derivatives was synthesized and their antiviral activity was studied. Th...
Catenulopyrizomicins, new anti-Hepatitis B virus compounds, from the rare actinomycete Catenuloplanes sp. MM782L-181F7
Catenulopyrizomicins, new anti-Hepatitis B virus compounds, from the rare actinomycete Catenuloplanes sp. MM782L-181F7
Hepatitis B virus (HBV) causes chronic hepatitis in humans, and current antiviral therapies rarely treat viral infections....
Amoxetamide A, a new anoikis inducer, produced by combined-culture of Amycolatopsis sp. and Tsukamurella pulmonis
Amoxetamide A, a new anoikis inducer, produced by combined-culture of Amycolatopsis sp. and Tsukamurella pulmonis
Cancer cells including colorectal cancer cells are resistant to anoikis, an anchorage-independent programmed death, which ...
Correction: Antibiotics in the clinical pipeline as of December 2022
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which...
Antiviral potency of lupane and oleanane alkynyl-derivatives against human cytomegalovirus and papillomavirus
Antiviral potency of lupane and oleanane alkynyl-derivatives against human cytomegalovirus and papillomavirus
A library of 18 structurally diverse semisynthetic lupane, oleanane, and ursane types triterpenoids, including C19- or C28...
Notch activator cyclopiazonic acid induces apoptosis in HL-60 cells through calcineurin activation
Notch activator cyclopiazonic acid induces apoptosis in HL-60 cells through calcineurin activation
We screened a library of microbial extracts and compounds library using our constructed assay cells and found pulicatins F...
Identification of siderophores blocking infection of Pseudomonas aeruginosa from Kitasatospora sp. LS1784
Identification of siderophores blocking infection of Pseudomonas aeruginosa from Kitasatospora sp. LS1784
Siderophores are low-molecular-mass, high-affinity chelators of Fe3+ ions that are critical for the survival of bacteria i...
Bioactive ambuic acid congeners from endophytic fungus Pestalotiopsis trachicarpicola SC-J551
Bioactive ambuic acid congeners from endophytic fungus Pestalotiopsis trachicarpicola SC-J551
New ambuic acid derivatives, pestallic acids R–V (1−5), together with ambuic acid (6), were isolated from the ...
A new steroid with potent antimicrobial activities and two new polyketides from Penicillium variabile EN-394, a fungus obtained from the marine red alga Rhodomela confervoides
A new steroid with potent antimicrobial activities and two new polyketides from Penicillium variabile EN-394, a fungus obtained from the marine red alga Rhodomela confervoides
Three new compounds, including one steroid named penivariod A (1) and two polyketides penivarides A and B (2 and 3), as we...
Potent Rifampicin derivatives can clear MRSA infections at single low doses when concomitantly dosed with Vancomycin
Potent Rifampicin derivatives can clear MRSA infections at single low doses when concomitantly dosed with Vancomycin
For a number of years, antimicrobial resistance (AMR) has been a critical issue for humanity. Drug discovery efforts have ...
Eleuthemarins A and B, two new isocoumarin derivatives from the Arctic fungus Eleutheromyces sp. CPCC 401592
Eleuthemarins A and B, two new isocoumarin derivatives from the Arctic fungus Eleutheromyces sp. CPCC 401592
Two new isocoumarin derivatives, eleuthemarins A (1) and B (2), were isolated from the Arctic fungus Eleutheromyces sp. CP...
Formanilides from the culture broth of Perenniporia fraxinea
Formanilides from the culture broth of Perenniporia fraxinea
A new formanilide dimer, fraxinin (1), and three known formanilides (2‒4) were isolated from the culture broth of Pe...
Antimicrobial polyketides from Magellan Seamount-derived fungus Talaromyces scorteus AS-242
Antimicrobial polyketides from Magellan Seamount-derived fungus Talaromyces scorteus AS-242
Two new nonadride derivatives, namely, talarodrides G and H (1 and 2), and one new depsidone derivative, botryorhodine K (...
Unveiling synergism of polymyxin B with chloramphenicol derivatives against multidrug-resistant (MDR) Klebsiella pneumoniae
Unveiling synergism of polymyxin B with chloramphenicol derivatives against multidrug-resistant (MDR) Klebsiella pneumoniae
Polymyxins are last-line antibiotics against multidrug-resistant Klebsiella pneumoniae but using polymyxins alone may not ...
Rv1255c, a dormancy-related transcriptional regulator of TetR family in Mycobacterium tuberculosis, enhances isoniazid tolerance in Mycobacterium smegmatis
Rv1255c, a dormancy-related transcriptional regulator of TetR family in Mycobacterium tuberculosis, enhances isoniazid tolerance in Mycobacterium smegmatis
Mycobacterium tuberculosis is exposed to diverse stresses inside the host during dormancy. Meanwhile, many metabolic and t...
Two new diketopiperazines from the Cordyceps fungus Samsoniella sp. XY4
Two new diketopiperazines from the Cordyceps fungus Samsoniella sp. XY4
Two new diketopiperazines, namely samsoniellain A (1) and samsoniellain B (2), together with two known compounds (3, 4) we...
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