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Cosibelimab: First Approval
Cosibelimab: First Approval
Cosibelimab (UNLOXCYT; cosibelimab-ipdl) is an anti-PD-L1 antibody developed by Checkpoint Therapeutics for the treatment ...
Iparomlimab and Tuvonralimab: First Approval
Iparomlimab and Tuvonralimab: First Approval
Iparomlimab and tuvonralimab (齐倍安®) is a bifunctional combination of anti-programmed death recep...
Efficiency and Safety of Noninvasive and Intravesical Therapy for Adult Neurogenic Lower Urinary Tract Dysfunction: A Systematic Review and Network Meta-analysis of Randomized Controlled Trials
Efficiency and Safety of Noninvasive and Intravesical Therapy for Adult Neurogenic Lower Urinary Tract Dysfunction: A Systematic Review and Network Meta-analysis of Randomized Controlled Trials
Neurogenic lower urinary tract dysfunction (NLUTD), a complex abnormality caused by multiple neurologic disorders, is a&am...
The Potential of RNA Therapeutics in Treating Cardiovascular Disease
The Potential of RNA Therapeutics in Treating Cardiovascular Disease
Despite significant advances in cardiology over the past few decades, cardiovascular diseases (CVDs) remain the leading ca...
Acoramidis: First Approval
Acoramidis: First Approval
Disassociation of transthyretin (TTR) has been identified as a key step in the pathology of TTR amyloid cardiomyopathy, wh...
PI3K Inhibitors as Potential Therapeutic Agents for the Treatment of COPD with Associated Atherosclerosis
PI3K Inhibitors as Potential Therapeutic Agents for the Treatment of COPD with Associated Atherosclerosis
Chronic obstructive pulmonary disease (COPD) and cardiovascular disease (CVD) share a complex and multifactorial relations...
Association of Glucagon-Like Peptide-1 Receptor Agonist with Progression to Liver Cirrhosis and Alcohol-Related Admissions in Patients with Alcohol Use Disorder and Diabetes: A Retrospective Cohort Study
Association of Glucagon-Like Peptide-1 Receptor Agonist with Progression to Liver Cirrhosis and Alcohol-Related Admissions in Patients with Alcohol Use Disorder and Diabetes: A Retrospective Cohort Study
In recent years, use of glucagon-like peptide-1 receptor agonists (GLP-1RA) has exponentially increased due to their benef...
Crinecerfont: First Approval
Crinecerfont: First Approval
Crinecerfont (CRENESSITY™) is a corticotropin releasing factor type 1 (CRF1) receptor antagonist developed by Neuroc...
Therapeutic Potential of Centhaquine Citrate, a Selective Alpha-2B Adrenoceptor Agonist, in the Management of Circulatory Shock
Therapeutic Potential of Centhaquine Citrate, a Selective Alpha-2B Adrenoceptor Agonist, in the Management of Circulatory Shock
Shock is a life-threatening condition marked by inadequate tissue perfusion and organ dysfunction with high morbidity and ...
Garadacimab: First Approval
Garadacimab: First Approval
Garadacimab (Andembry®) is a fully human IgG4/lambda recombinant monoclonal anti-activated Factor XII antibody being ...
Catumaxomab: First Approval
Catumaxomab: First Approval
Catumaxomab (Korjuny®) is a first-in-class bispecific trifunctional rat-mouse hybrid monoclonal antibody currently un...
Differentiating IL-23 Inhibitors in Crohn’s Disease
Differentiating IL-23 Inhibitors in Crohn’s Disease
Interleukin-23 (IL-23), a member of the IL-12 family of cytokines, plays a critical role in intestinal homeostasis and inf...
Datopotamab Deruxtecan: First Approval
Datopotamab Deruxtecan: First Approval
Datopotamab deruxtecan (DATROWAY®) is a trophoblast cell surface antigen 2 (TROP2)-directed antibody-drug co...
Lipid-Lowering Therapy and Cardiovascular Prevention in Elderly
Lipid-Lowering Therapy and Cardiovascular Prevention in Elderly
The global population aged 80 years and older will reach approximately half a billion in the coming years, and cardiovascu...
The Role of CPX-351 in the Acute Myeloid Leukemia Treatment Landscape: Mechanism of Action, Efficacy, and Safety
The Role of CPX-351 in the Acute Myeloid Leukemia Treatment Landscape: Mechanism of Action, Efficacy, and Safety
CPX-351 (also known as VYXEOS® or Vyxeos liposomal) is a dual-drug liposomal encapsulation of cytarabine and daunorub...
Navigating Psoriatic Arthritis: Treatment Pathways and Patient-Specific Strategies for Improved Outcomes
Navigating Psoriatic Arthritis: Treatment Pathways and Patient-Specific Strategies for Improved Outcomes
Psoriatic arthritis (PsA) is a multifaceted chronic immune-mediated disease characterized by joint, skin, nail and enthese...
Treatment of Advanced HIV in the Modern Era
Treatment of Advanced HIV in the Modern Era
Antiretroviral therapy has transformed human immunodeficiency virus (HIV) infection from a fatal illness into a manageable...
Gepirone Extended-Release: First Approval
Gepirone Extended-Release: First Approval
Gepirone HCL extended-release (gepirone ER; EXXUA™), an oral, selective serotonin (5HT)1A receptor agonist formulate...
New Therapies on the Horizon for Primary Biliary Cholangitis
New Therapies on the Horizon for Primary Biliary Cholangitis
Primary biliary cholangitis (PBC) is a chronic cholestatic liver disease that can progress to cirrhosis and hepatic failur...
Zilucoplan: First Approval
Zilucoplan: First Approval
Zilucoplan (Zilbrysq®) is a subcutaneously administered macrocyclic peptide inhibitor of complement component 5 (C5 i...
Vamorolone: First Approval
Vamorolone: First Approval
Vamorolone (AGAMREE®) is an oral, selective, dissociative corticosteroid developed by ReveraGen BioPharma and Santher...
Pharmacological Treatments of Temporomandibular Disorders: A Systematic Review Including a Network Meta-Analysis
Pharmacological Treatments of Temporomandibular Disorders: A Systematic Review Including a Network Meta-Analysis
Temporomandibular disorders (TMD) comprise a cluster of conditions with a wide range of etiological factors that causes pa...
Reply to the Comments on “Recent Human Papillomavirus Vaccination is Associated with a Lower Risk of COVID-19: A US Database Cohort Study”
Reply to the Comments on “Recent Human Papillomavirus Vaccination is Associated with a Lower Risk of COVID-19: A US Database Cohort Study”
Funding The original article was supported by funding from Chung Sh...
Comment on: “Recent Human Papillomavirus Vaccination is Associated with a Lower Risk of COVID-19: A US Database Cohort Study”
Comment on: “Recent Human Papillomavirus Vaccination is Associated with a Lower Risk of COVID-19: A US Database Cohort Study”
Conflict of interest TWC and C-HH declare that they have no competi...
Targeting KRAS-Mutated Gastrointestinal Malignancies with Small-Molecule Inhibitors: A New Generation of Breakthrough Therapies
Targeting KRAS-Mutated Gastrointestinal Malignancies with Small-Molecule Inhibitors: A New Generation of Breakthrough Therapies
Kirsten rat sarcoma virus (KRAS) is one of the most important and frequently mutated oncogenes in cancer and the mutationa...
Narlumosbart: First Approval
Narlumosbart: First Approval
Narlumosbart (津立生) is a recombinant, fully human, anti-receptor activator of nuclear factor kappa- ...
Spesolimab for the Treatment of Generalized Pustular Psoriasis
Spesolimab for the Treatment of Generalized Pustular Psoriasis
Generalized pustular psoriasis (GPP) is a rare but severe skin inflammatory disorder characterized by the eruption of wide...
Poly-Agonist Pharmacotherapies for Metabolic Diseases: Hopes and New Challenges
Poly-Agonist Pharmacotherapies for Metabolic Diseases: Hopes and New Challenges
The use of glucagon-like peptide-1 (GLP-1) receptor-based multi-agonists in the treatment of type 2 diabetes and obesity h...
Correction to: Motixafortide: First Approval
Correction to: Motixafortide: First Approval
In the published PDF version, Section 2.1 Pharmacodynamics, second paragraph, sixth s...
Efficacy and Safety of the Travoprost Intraocular Implant in Reducing Topical IOP-Lowering Medication Burden in Patients with Open-Angle Glaucoma or Ocular Hypertension
Efficacy and Safety of the Travoprost Intraocular Implant in Reducing Topical IOP-Lowering Medication Burden in Patients with Open-Angle Glaucoma or Ocular Hypertension
A randomized, double-masked, multicenter, phase 2 trial to evaluate the long-term safety and efficacy of travoprost intrao...
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