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Development and characterization of long-acting darifenacin intravaginal ring for managing overactive bladder in women: harnessing QbD approach
Development and characterization of long-acting darifenacin intravaginal ring for managing overactive bladder in women: harnessing QbD approach
The oral administration of darifenacin hydrobromide (DBr) is associated with low bioavailability of 15–19% due to po...
Antidiabetic effect of Prosopis farcta extract on human adipose-derived mesenchymal stem cells in 3D culture electrospun with PLA
Antidiabetic effect of Prosopis farcta extract on human adipose-derived mesenchymal stem cells in 3D culture electrospun with PLA
Diabetes mellitus is a disordered syndrome which has destructive effects on cells. The aim of this study is to reduce the ...
Green synthesis, spectroscopic characterization, and biological studies of some fluoroimine-based oxovanadium(V) complexes
Green synthesis, spectroscopic characterization, and biological studies of some fluoroimine-based oxovanadium(V) complexes
In the realm of inorganic synthesis, the adoption of green chemistry principles has led to the utilization of "Microw...
Preparation, characterization, and evaluation of bedaquiline fumarate: ascorbic acid co-crystals with enhanced pharmaceutical and physicochemical properties
Preparation, characterization, and evaluation of bedaquiline fumarate: ascorbic acid co-crystals with enhanced pharmaceutical and physicochemical properties
Bedaquiline fumarate (BDQ) is an anti-tubercular Biopharmaceutics Classification System (BCS class-II) drug & it h...
In vitro and in vivo evaluation of nanoliposomes loading quercetin and 3-bromopyruvate against glioma
In vitro and in vivo evaluation of nanoliposomes loading quercetin and 3-bromopyruvate against glioma
Diffuse astrocytoma (a type of glioma) and its prevalence are matters of concern worldwide. Patients with this type of tum...
A unique revolutionary eco-friendly spectrophotometric technique for solving the spectral overlap in the determination of carvedilol and ivabradine in their binary combination: stability study
A unique revolutionary eco-friendly spectrophotometric technique for solving the spectral overlap in the determination of carvedilol and ivabradine in their binary combination: stability study
Carivalan® dosage form containing carvedilol and ivabradine is widely indicated for patients with stable angina. Thre...
Assessment of potential drug–drug interaction knowledge, attitude, and practice among Egyptian hospital and community pharmacists: a cross-sectional multicenter study
Assessment of potential drug–drug interaction knowledge, attitude, and practice among Egyptian hospital and community pharmacists: a cross-sectional multicenter study
Pharmacists have an important role in preventing prescribing errors and providing appropriate information. They can detect...
Screening and characterization of bioactive compounds from two epiphytic microlichen and evaluation of their in vitro antioxidant activity
Screening and characterization of bioactive compounds from two epiphytic microlichen and evaluation of their in vitro antioxidant activity
Lichens in symbiosis produce a wide range of primary and secondary fine compounds in extreme environmental conditions that...
Chemical profiling of antifungal Dicerocaryum senecioides and Diospyros mespiliformis extracts using TLC-p-iodonitrotetrazolium violet assay and GC–MS/MS
Chemical profiling of antifungal Dicerocaryum senecioides and Diospyros mespiliformis extracts using TLC-p-iodonitrotetrazolium violet assay and GC–MS/MS
Despite the availability of conventional medication for fungal skin diseases, dermatophytic infections are now a major cri...
Inhibitory capacity of extracts and main constituents of hop flowers
Inhibitory capacity of extracts and main constituents of hop flowers
Hops (Humulus lupulus Linn.) produce flowers that are used on an industrial scale to impart sensory properties to beer and...
QbD-driven RP-HPLC method for novel chemo-herbal combination, in-silico, force degradation studies, and characterization of dual drug-loaded polymeric and lipidic nanocarriers
QbD-driven RP-HPLC method for novel chemo-herbal combination, in-silico, force degradation studies, and characterization of dual drug-loaded polymeric and lipidic nanocarriers
In cancer therapies, chemo-herbal combinations are receiving increased attention. A multiple tyrosine kinase inhibitor, le...
Development of novel gradient RP-HPLC method for separation of dapagliflozin and its process-related impurities: insight into stability profile and degradation pathway, identification of degradants using LCMS
Development of novel gradient RP-HPLC method for separation of dapagliflozin and its process-related impurities: insight into stability profile and degradation pathway, identification of degradants using LCMS
In the dapagliflozin (DPF) synthesis, 5-Bromo-2-chlorobenzoic acid (5-BC impurity) and 4-Bromo-1-chloro-2-(4-ethoxybenzyl)...
Peptide-modified PAMAM-based bone-targeting RNA delivery system
Peptide-modified PAMAM-based bone-targeting RNA delivery system
Osteoporosis, among other bone diseases, has become a prevalent cause of decreased quality of life in older and postmenopa...
A validated RP-UPLC method for estimation of Samidorphan and Olanzapine in mixed powder and combined tablets
A validated RP-UPLC method for estimation of Samidorphan and Olanzapine in mixed powder and combined tablets
The key objective of the research study is to develop a new stability-indicating RP-UPLC approach to determine the presenc...
A study of impurity profiling via method development and force degradation in hydrocortisone butyrate at low concentration
A study of impurity profiling via method development and force degradation in hydrocortisone butyrate at low concentration
Since long, triamcinolone and fluocinolone, fluorinated derivatives, have been used for treating various types of dermatit...
Development of stability-indicating HPLC method for quantification of pharmacopeia impurities of Zuclopenthixol and characterization of its stress degradation products by LCMS/MS
Development of stability-indicating HPLC method for quantification of pharmacopeia impurities of Zuclopenthixol and characterization of its stress degradation products by LCMS/MS
The present study focused to develop a simple and sensitive HPLC method for resolution and estimation process-related impu...
IVIVC assessment, pharmacokinetic evaluation, and X-ray radiography mapping of Novel Parteck® SRP 80 and hypromellose-loaded LTD4 receptor antagonist chronosystem
IVIVC assessment, pharmacokinetic evaluation, and X-ray radiography mapping of Novel Parteck® SRP 80 and hypromellose-loaded LTD4 receptor antagonist chronosystem
The current research aims to determine the pharmacokinetic parameters, mucoadhesive strength, and IVIVC correlation of the...
Biomimetic microneedles: exploring the recent advances on a microfabricated system for precision delivery of drugs, peptides, and proteins
Biomimetic microneedles: exploring the recent advances on a microfabricated system for precision delivery of drugs, peptides, and proteins
Despite its popularity, acceptability, and convenience, the oral route is not the classical route for the administration o...
Multi-wavelength fusion spectral extraction-assisted HPLC for simultaneous quantification of multiple secondary metabolites in herbal matrices
Multi-wavelength fusion spectral extraction-assisted HPLC for simultaneous quantification of multiple secondary metabolites in herbal matrices
The existing HPLC methods for the assaying of multiple markers in standardized herbal extracts use a single wavelength for...
Exploration of the aptitude to alleviate oxidative impairment and curb colorectal cancer manifestation by Nostoc calcicola in HT-29 adenocarcinoma cells
Exploration of the aptitude to alleviate oxidative impairment and curb colorectal cancer manifestation by Nostoc calcicola in HT-29 adenocarcinoma cells
Marine cyanobacteria have been known to contain several unique bioactive compounds which have different therapeutic potent...
Therapeutic benefits of gossypin as an emerging phytoconstituents of Hibiscus spp.: a critical review
Therapeutic benefits of gossypin as an emerging phytoconstituents of Hibiscus spp.: a critical review
Flavonoids are one of the crucial secondary metabolites as several functions are carried out by flavonoids, including regu...
Efficient in vitro oxaliplatin delivery with functionalized single-walled carbon nanotube for enhanced colon cancer treatment
Efficient in vitro oxaliplatin delivery with functionalized single-walled carbon nanotube for enhanced colon cancer treatment
Site-specific transport of medicinal products to malignant cells and tissues is an intriguing area since it has an ability...
Method operable design region for robust RP-HPLC analysis of pioglitazone hydrochloride and teneligliptin hydrobromide hydrate: incorporating hybrid principles of white analytical chemistry and design of experiments
Method operable design region for robust RP-HPLC analysis of pioglitazone hydrochloride and teneligliptin hydrobromide hydrate: incorporating hybrid principles of white analytical chemistry and design of experiments
A combination of pioglitazone hydrochloride with teneligliptin hydrobromide hydrate is used to treat type-2 diabe...
Effect of physicochemical parameters on the L-methioninase activity of Methylobacterium sp. and its in vitro anticancer activity in combination with tamoxifen citrate
Effect of physicochemical parameters on the L-methioninase activity of Methylobacterium sp. and its in vitro anticancer activity in combination with tamoxifen citrate
Methionine dependence is a metabolic abnormality observed exclusively in cancer cells. Methionine depletion using methioni...
Rapid and validated UHPLC method for simultaneous determination of sofosbuvir, ledipasvir and paracetamol as commonly repurposed drugs for COVID-19 treatment: application in spiked human plasma
Rapid and validated UHPLC method for simultaneous determination of sofosbuvir, ledipasvir and paracetamol as commonly repurposed drugs for COVID-19 treatment: application in spiked human plasma
Sofosbuvir/ledipasvir (SOF/LDV), a combination of antiviral drugs, has been recently repurposed for COVID-19 management, a...
Optimizing pulsatile release of febuxostat for managing gout flares: a chronotherapeutic approach
Optimizing pulsatile release of febuxostat for managing gout flares: a chronotherapeutic approach
Chronic conditions such as nocturnal asthma, cardiac disorder, diabetes mellitus, joint pain and inflammation, and hyperch...
Spectroscopic study of drug–drug interactions: influence of two over-the-counter drugs on the albumin binding affinities of carbamazepine and its major metabolite
Spectroscopic study of drug–drug interactions: influence of two over-the-counter drugs on the albumin binding affinities of carbamazepine and its major metabolite
Multidrug regimens can increase the risk of drug–drug interactions at the level of albumin binding especially for dr...
Nanoengineered approaches to improve the efficacy of targeted drug delivery for the treatment of malignancy: a comprehensive review
Nanoengineered approaches to improve the efficacy of targeted drug delivery for the treatment of malignancy: a comprehensive review
The second leading cause of mortality in the world, behind cardiovascular disorders, is cancer. The currently employed tre...
Antiproliferative and apoptotic activities of tomato bioactive metabolite on MDA-MB-435 cell line: in silico molecular modeling and molecular dynamics investigation
Antiproliferative and apoptotic activities of tomato bioactive metabolite on MDA-MB-435 cell line: in silico molecular modeling and molecular dynamics investigation
As an external organ, the skin protects the whole body against hazardous external influences. Ultraviolet (UV) radiation i...
Assessment of computational approaches in the prediction of spectrogram and chromatogram behaviours of analytes in pharmaceutical analysis: assessment review
Assessment of computational approaches in the prediction of spectrogram and chromatogram behaviours of analytes in pharmaceutical analysis: assessment review
Today, artificial intelligence-based computational approach is facilitating multitasking and interdisciplinary an...
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