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Sinapic acid alleviates glutamate-induced excitotoxicity by inhibiting neuroinflammation and endoplasmic reticulum stress pathway in C6 glioma cells
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Tannic acid modulates SARS-CoV-2 pathogenesis by curbing key host receptors and oxidative stress
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Conditioned medium of human umbilical cord-mesenchymal stem cells cultivated with human cord blood serum enhances stem cell stemness and secretome profiles
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Cyclosporin A toxicity on endothelial cells differentiated from induced pluripotent stem cells: Assembling an adverse outcome pathway
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Mictlan-D3: A novel medium sized RGD-Disintegrin obtained from Crotalus mictlantecuhtli venom, in vitro tested against human breast Cancer and endothelial cells
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β-Arbutin and cisplatin: A combined approach to modulating apoptosis, cell viability, and migration in bladder cancer cells
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Porcupine inhibitors LGK-974 and ETC-159 inhibit Wnt/β-catenin signaling and result in inhibition of the fibrosis
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Effects of 2,4-dichlorophenoxyacetic acid (2,4-D), isolated and in a formulated product, on the functional parameters of isolated rat liver mitochondria
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Essential oil from Ocimum carnosum induces ROS mediated mitochondrial dysfunction and intrinsic apoptosis in HL-60 cells
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The protective impact of myricetin against PM2.5-induced cellular apoptosis by inhibiting endoplasmic reticulum stress
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Oxidative Stress, Lysosomal Permeability, and Mitochondrial-Derived Vesicles Induced in NL-20 Human Bronchial Cells Exposed to Benzo[ghi]Perylene
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Washing with buffered vitamin C after corrosive chemical (sodium hypochlorite) exposure reduces ocular depth of injury
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Toxicological investigation of bisphenol A and its derivates on human breast epithelial (MCF-10A) cells
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Protective effects of methylnissolin and methylnissolin-3-O-β-d-glucopyranoside on TNF-α-induced inflammation in human dermal fibroblasts
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Airway organoids: 3D toxicology evaluation models in vitro of heated tobacco products for health risk
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Development of a human FaFg prediction system for polyphenols using human induced pluripotent stem cell-derived small intestinal epithelial cells
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TPD-seq: A high throughput RNA-seq method to derive transcriptomic points of departure from cell lines
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Cellular and chromosomal interaction of bio-synthesized copper oxide nanoparticles - Induced nano-cytotoxicity and genotoxicity
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Exploring the potential of reconstructed human epithelial tissue models for safety assessment of intraoral medical devices
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Neutrophil extracellular traps formation and autophagy in bongkrekic acid exposed human neutrophils
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Chemotherapeutic effect of baicalein/epirubicin combination against liver cell carcinoma in-vitro: Inducing apoptosis and autophagy
Chemotherapeutic effect of baicalein/epirubicin combination against liver cell carcinoma in-vitro: Inducing apoptosis and autophagy
Hepatocellular carcinoma (HCC) is considered a major problem worldwide. It is the fifth most common cancer and the second ...
Electromagnetic field (50 Hz) enhance metabolic potential and induce adaptive/reprogramming response mediated by the increase of N6-methyladenosine RNA methylation in adipose-derived mesenchymal stem cells in vitro
Electromagnetic field (50 Hz) enhance metabolic potential and induce adaptive/reprogramming response mediated by the increase of N6-methyladenosine RNA methylation in adipose-derived mesenchymal stem cells in vitro
Mesenchymal stem cells (MSCs) are multipotent cells that play an important role in tissue homeostasis and regeneration by ...
Inhibitory effects of the main metabolites of Apatinib on CYP450 isozymes in human and rat liver microsomes
Inhibitory effects of the main metabolites of Apatinib on CYP450 isozymes in human and rat liver microsomes
PurposeThe inhibitory effect of Apatinib on cytochrome P450 (CYP450) enzymes has been studied. However, it is unknown whet...
A multiparametric and orthogonal approach indicates low toxicity for zein nanoparticles in a repellent formulation
A multiparametric and orthogonal approach indicates low toxicity for zein nanoparticles in a repellent formulation
Arthropods can transmit pathogens and infect other organisms, contributing to endemics worldwide (Benelli, 2015; Benelli a...
Pyruvate dehydrogenase is a potential mitochondrial off-target for gentamicin based on in silico predictions and in vitro inhibition studies
Pyruvate dehydrogenase is a potential mitochondrial off-target for gentamicin based on in silico predictions and in vitro inhibition studies
KeywordsIn silico predictionsDrug-induced kidney injuryPyruvate dehydrogenaseMitochondriaOff-targetData availabilityThe ra...
Phototoxic action of meloxicam contributes to dysregulation of redox homeostasis in normal human skin cells – Molecular and biochemical analysis of antioxidant enzymes in melanocytes and fibroblasts
Phototoxic action of meloxicam contributes to dysregulation of redox homeostasis in normal human skin cells – Molecular and biochemical analysis of antioxidant enzymes in melanocytes and fibroblasts
The World Health Organization defines an adverse drug reaction (ADR) as “a response to a drug that is harmful and unintend...
Evaluation of the acute toxicity of ellagic acid and gallic acid incorporated in Poloxamer407® gel, in Zophobas morio larvae
Evaluation of the acute toxicity of ellagic acid and gallic acid incorporated in Poloxamer407® gel, in Zophobas morio larvae
Gallic acid (GA) and ellagic acid (EA) are natural compounds known for their antioxidant properties and potential health b...
DEHP and DINP accelerate aging effects in male and female of Drosophila melanogaster depend on AKT/FOXO pathway
DEHP and DINP accelerate aging effects in male and female of Drosophila melanogaster depend on AKT/FOXO pathway
Phthalates are commonly used as plasticizers to improve the durability, resistance, and flexibility of polyvinyl chloride ...
Newly synthesized derivatives with a thiosemicarbazide group reduce the viability of cancer cell lines. Acute toxicity assessment in Zebrafish (Danio rerio) early life stages
Newly synthesized derivatives with a thiosemicarbazide group reduce the viability of cancer cell lines. Acute toxicity assessment in Zebrafish (Danio rerio) early life stages
Cancers are the most common cause of death worldwide, and the number is still increasing in developing countries (Wild et ...
Cytotoxic and genotoxic effects of triphenyl phosphate on root tip cells of Allium cepa L.
Cytotoxic and genotoxic effects of triphenyl phosphate on root tip cells of Allium cepa L.
Currently, different polymer types are used for producing various consumer products ranging from electric and electronic d...
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