SCI Abstract

search
+
Melatonin's paradox: From therapeutic benefits to toxicity warnings
Update your browser to view ScienceDirect correctly. Your technical details and browser version: Request ID: 94c36...
Zn2+ regulates mitochondrial DNA efflux to inhibit AIM2-mediated ZBP1-PANoptosome pathway and alleviate septic myocardial injury
Update your browser to view ScienceDirect correctly. Your technical details and browser version: Request ID: 94c36...
Paris saponin VII restrains PD-L1 mediated immune evasion through the AKT1 and STAT3 signaling pathways
Update your browser to view ScienceDirect correctly. Your technical details and browser version: Request ID: 94c36...
PP2A attenuates α-amanitin-induced liver injury by promoting autophagy and inhibiting apoptosis in mouse models
Update your browser to view ScienceDirect correctly. Your technical details and browser version: Request ID: 94c36...
Stereoisomeric mitomycins interstrand crosslinks differently impact gene expression in MCF-7 and K562 cancer cells
Update your browser to view ScienceDirect correctly. Your technical details and browser version: Request ID: 94c36...
Exposure of human neuroblastoma SH-SY5Y cells to amphetamine-type stimulants leads to oxidative-antioxidative imbalance associated with DNA damage and acetylcholine antagonism
Update your browser to view ScienceDirect correctly. Your technical details and browser version: Request ID: 94c36...
Cholinesterase activity modulators: Evaluation of dodecylaminoquinuclidines as inhibitors of human AChE and BChE
Update your browser to view ScienceDirect correctly. Your technical details and browser version: Request ID: 94c36...
Tamoxifen regulates ferroptosis of hepatocytes by targeting SLC1A5 to activate hepatic stellate cells and liver fibrosis
Update your browser to view ScienceDirect correctly. Your technical details and browser version: Request ID: 94c36...
Synergistic anti-hypernociceptive interaction between morphine and JM-20 in neuropathic rats. Mechanistic insights into metabolism, transport, and safety
Update your browser to view ScienceDirect correctly. Your technical details and browser version: Request ID: 94c36...
Inhibition of JMJD3 attenuates acute liver injury by suppressing inflammation and oxidative stress in LPS/D-Gal-induced mice
Update your browser to view ScienceDirect correctly. Your technical details and browser version: Request ID: 94c36...
Semaglutide attenuates lipotoxicity-induced cardiac injury by inhibiting Slc27a2 expression
Update your browser to view ScienceDirect correctly. Your technical details and browser version: Request ID: 94c36...
Platycodin D reverses tumor necrosis factor-α-induced endothelial dysfunction by increasing nitric oxide through G protein-coupled estrogen receptor-mediated eNOS activity
Update your browser to view ScienceDirect correctly. Your technical details and browser version: Request ID: 94c36...
D-limonene complexed with hydroxypropyl-β-cyclodextrin prevents impaired cardiac excitation-contraction coupling by reducing oxidative stress and cardiac apoptosis in an animal model of cardiotoxicity induced by doxorubicin
Update your browser to view ScienceDirect correctly. Your technical details and browser version: Request ID: 94c36...
Liquiritigenin regulates MAPK (p38/JNK) signaling through inhibition of IRAK4, attenuates inflammatory response, fibrosis and kidney dysfunction in a high-salt diet induced chronic kidney disease
Update your browser to view ScienceDirect correctly. Your technical details and browser version: Request ID: 94c36...
Demethoxycurcumin induces metabolic crisis and ATF4/ATF3/CHOP-dependent cell death in hepatocellular carcinoma
Update your browser to view ScienceDirect correctly. Your technical details and browser version: Request ID: 94c36...
Sulforaphane treatment of HL-60 cells protects against clozapine toxicity and protein covalent binding: implications for clozapine-induced agranulocytosis
Update your browser to view ScienceDirect correctly. Your technical details and browser version: Request ID: 94c36...
Effects of zearalenone on endoplasmic reticulum stress-induced apoptosis via global and gene-specific histone modifications and miRNA-mediated p53-signaling pathway in HEK-293 cells
Update your browser to view ScienceDirect correctly. Your technical details and browser version: Request ID: 94c36...
Incorporating alkylthio groups provides potent in vitro anticancer activity to water-soluble and aqueous-stable diiron(I) bis-cyclopentadienyl complexes
Update your browser to view ScienceDirect correctly. Your technical details and browser version: Request ID: 94c36...
Uremic toxin indoxyl sulfate induces the imbalance of cellular iron metabolism and oxidative stress to interfere with myogenesis in myoblasts
Update your browser to view ScienceDirect correctly. Your technical details and browser version: Request ID: 94c36...
RS194B oxime mediated AChE-reactivation and protection in lethal sarin and insecticide organophosphate exposed macaques is accompanied by oxime-independent BChE increases; likely a result of liver damage
Update your browser to view ScienceDirect correctly. Your technical details and browser version: Request ID: 94c36...
Aldo-keto reductases 7A subfamily: A mini review
Aldo-keto reductases 7A subfamily: A mini review
Aldo-keto reductases (AKRs) are a superfamily of NAD(P)(H)-dependent oxidoreductases, catalyzing the reduction of carbonyl...
Pholiotic acid promotes apoptosis in human metastatic melanoma cells
Pholiotic acid promotes apoptosis in human metastatic melanoma cells
The plant kingdom is an unlimited source of biologically active substances with therapeutic potential [[1], [2], [3], [4],...
The comprehensive prediction of carcinogenic potency and tumorigenic dose (TD50) for two problematic N-nitrosamines in food: NMAMPA and NMAMBA using toxicology in silico methods
The comprehensive prediction of carcinogenic potency and tumorigenic dose (TD50) for two problematic N-nitrosamines in food: NMAMPA and NMAMBA using toxicology in silico methods
N-nitrosamines (N–NAs) are a group of organic compounds that are known to be potentially carcinogenic [1]. They are formed...
Cannabinoids improve mitochondrial function in skeletal muscle of exhaustive exercise training rats by inhibiting mitophagy through the PINK1/PARKIN and BNIP3 pathways
Cannabinoids improve mitochondrial function in skeletal muscle of exhaustive exercise training rats by inhibiting mitophagy through the PINK1/PARKIN and BNIP3 pathways
As one of the largest organ systems, skeletal muscle accounts for approximately 40 % of the mammalian body mass [1], and i...
GW4064 inhibits migration and invasion through cathepsin B and MMP2 downregulation in human bladder cancer
GW4064 inhibits migration and invasion through cathepsin B and MMP2 downregulation in human bladder cancer
Urothelial carcinoma is an important health issue worldwide. Previous studies have clearly shown that cigarette smoking is...
β-Lapachone induces ferroptosis of colorectal cancer cells via NCOA4-mediated ferritinophagy by activating JNK pathway
β-Lapachone induces ferroptosis of colorectal cancer cells via NCOA4-mediated ferritinophagy by activating JNK pathway
As an important source of new drug discovery, natural products play a vital role in drug development [1,2]. According to s...
Vitamin D inhibits tamoxifen-induced non-alcoholic fatty liver disease through a nonclassical estrogen receptor/liver X receptor pathway
Vitamin D inhibits tamoxifen-induced non-alcoholic fatty liver disease through a nonclassical estrogen receptor/liver X receptor pathway
Non-Alcoholic Fatty Liver Disease (NAFLD) is a multifactorial disease, mainly characterized by diffuse bubble-like fatty d...
Aldose reductase is a potential therapeutic target for neurodegeneration
Aldose reductase is a potential therapeutic target for neurodegeneration
Aldose reductase (AR) is the rate-limiting step in the polyol pathway, where it converts glucose into sorbitol [1]. The ac...
HNF4A as a potential target of PFOA and PFOS leading to hepatic steatosis: Integrated molecular docking, molecular dynamic and transcriptomic analyses
HNF4A as a potential target of PFOA and PFOS leading to hepatic steatosis: Integrated molecular docking, molecular dynamic and transcriptomic analyses
PFASs refer to a group of emerging pollutants that have garnered remarkable attention. Since PFASs were synthesized in the...
Inhibition of sphingosine kinase 1 attenuates LPS-induced acute lung injury by suppressing endothelial cell pyroptosis
Inhibition of sphingosine kinase 1 attenuates LPS-induced acute lung injury by suppressing endothelial cell pyroptosis
Acute lung injury (ALI) is a frequent complication of sepsis, with pyroptosis playing a pivotal role. Analysis of Gene Exp...
Load More
format_indent_increase