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Using Medication Dispensation Data to Identify Clusters with Similar Prescribing Patterns in Older Adults Living with Dementia
Using Medication Dispensation Data to Identify Clusters with Similar Prescribing Patterns in Older Adults Living with Dementia
Older adults living with dementia are a heterogeneous group, which can make studying optimal medication management challen...
Hypoglycaemia in Older Adults with Diabetes: Pathophysiology, Prevention, and Personalized Care in an Aging Population
Hypoglycaemia in Older Adults with Diabetes: Pathophysiology, Prevention, and Personalized Care in an Aging Population
Managing diabetes in older adults requires balancing long-term glycaemic control with the prevention of hypoglycaemia, to ...
Reduced-Dose Edoxaban in Patients Aged ≥ 80 Years: A Single-Center Real-World Analysis
Reduced-Dose Edoxaban in Patients Aged ≥ 80 Years: A Single-Center Real-World Analysis
Optimal anticoagulation strategies in octogenarians remain controversial owing to age-related risks of thromboembolism and...
Characteristics of Late-Onset Systemic Lupus Erythematosus: Clinical Manifestations and Diagnostic and Treatment Challenges
Characteristics of Late-Onset Systemic Lupus Erythematosus: Clinical Manifestations and Diagnostic and Treatment Challenges
Systemic lupus erythematosus (SLE) is widely recognized as a systemic autoimmune disease predominantly affecting young wom...
Anesthesia Considerations in Older Adults Undergoing Emergency Mechanical Thrombectomy for Acute Ischaemic Stroke
Anesthesia Considerations in Older Adults Undergoing Emergency Mechanical Thrombectomy for Acute Ischaemic Stroke
Acute ischemic stroke (AIS) is a significant cause of morbidity and mortality among older adults, with its incidence, seve...
Association of Antipsychotic Dose with Surrogate Efficacy and Safety Outcomes in Hospitalized Older Adults: A Retrospective Cohort Study
Association of Antipsychotic Dose with Surrogate Efficacy and Safety Outcomes in Hospitalized Older Adults: A Retrospective Cohort Study
Antipsychotics are frequently used in hospitalized older adults to manage agitation and delirium, despite limited supporti...
Sarcopenia and Cachexia in Older Patients with Cancer: Pathophysiology, Diagnosis, Impact on Outcomes, and Management Strategies
Sarcopenia and Cachexia in Older Patients with Cancer: Pathophysiology, Diagnosis, Impact on Outcomes, and Management Strategies
Sarcopenia and cachexia are two common and overlapping but distinct muscle wasting syndromes that predict adverse outcomes...
Frailty-Informed Pain Management: A Clinical Imperative Beyond Chronological Age
Frailty-Informed Pain Management: A Clinical Imperative Beyond Chronological Age
Chronic pain is a prevalent and disabling condition whose management becomes increasingly complex with aging and frailty. ...
Anti-hypertensive Drug Classes and Risk of New-Onset Atrial Fibrillation in Healthy Older Adults: A Post Hoc Analysis of ASPREE Trial
Anti-hypertensive Drug Classes and Risk of New-Onset Atrial Fibrillation in Healthy Older Adults: A Post Hoc Analysis of ASPREE Trial
Prior studies have suggested potential benefits of antihypertensive medication (AHM) in preventing atrial fibrillation. It...
Patterns and Characteristics of Gabapentin Use Among Medicare Beneficiaries
Patterns and Characteristics of Gabapentin Use Among Medicare Beneficiaries
Gabapentin is increasingly prescribed to older adults, yet prescribing patterns and characteristics of gabapentin initiato...
Effectiveness of Patient-Directed Education to Sustain Deprescribing: A Pragmatic Trial
Effectiveness of Patient-Directed Education to Sustain Deprescribing: A Pragmatic Trial
More than one in three older adults use potentially inappropriate medications (PIMs), and those with chronic conditions ar...
Trends and Guideline Adherence in Gabapentinoid Use among Geriatric Outpatients: A Retrospective Cross-Sectional Study at a Falls Clinic
Trends and Guideline Adherence in Gabapentinoid Use among Geriatric Outpatients: A Retrospective Cross-Sectional Study at a Falls Clinic
With pain treatment shifting away from opioids, alternative analgesics—such as gabapentinoids—are increasingly...
Inclusion of Older Adults in Early-Phase Cancer Clinical Trials: Safety, Efficacy and a Way Forward
Inclusion of Older Adults in Early-Phase Cancer Clinical Trials: Safety, Efficacy and a Way Forward
Early-phase clinical trials (EPCTs) are critical for evaluating the safety, tolerability, efficacy and pharmacokinetics of...
Initial Real-World Evidence for Lecanemab in the United States
Initial Real-World Evidence for Lecanemab in the United States
Lecanemab is the first anti-amyloid monoclonal antibody with full approval in the US for the treatment of early Alzheimer&...
Pharmacologic Management of Heart Failure with Preserved Ejection Fraction (HFpEF) in Older Adults
Pharmacologic Management of Heart Failure with Preserved Ejection Fraction (HFpEF) in Older Adults
There are several pharmacologic agents that have been touted as guideline-directed medical therapy for heart failure with ...
How Should Clinicians Discuss Deprescribing with Caregivers of Older Adults Living with Dementia? A Qualitative Study
How Should Clinicians Discuss Deprescribing with Caregivers of Older Adults Living with Dementia? A Qualitative Study
Preventive medications are potential targets for deprescribing in older adults with dementia as goals of care change from ...
An Educational Intervention to Promote Central Nervous System-Active Deprescribing in Dementia: A Pilot Study
An Educational Intervention to Promote Central Nervous System-Active Deprescribing in Dementia: A Pilot Study
Central nervous system (CNS)-active polypharmacy (defined as concurrent exposure to three or more antidepressant, antipsyc...
Psychotropic Polypharmacy in Dementia: A Retrospective Analysis for People with Neuropsychiatric Symptoms Referred to an Australian Dementia Support Service
Psychotropic Polypharmacy in Dementia: A Retrospective Analysis for People with Neuropsychiatric Symptoms Referred to an Australian Dementia Support Service
Despite their limited benefits and serious adverse effects, psychotropics remain frequently prescribed for neuropsychiatri...
Regular Use of Oral Nonsteroidal Anti-inflammatory Drugs in a Population of Polish Seniors: Findings from the PolSenior2 Cross-Sectional Survey
Regular Use of Oral Nonsteroidal Anti-inflammatory Drugs in a Population of Polish Seniors: Findings from the PolSenior2 Cross-Sectional Survey
Older adults represent a growing proportion of the general population. Nonsteroidal anti-inflammatory drugs (NSAIDs) const...
Perioperative Anticholinergic Medication Use and Incident Dementia among Older Surgical Patients: a Retrospective Cohort Study using Real-World Data
Perioperative Anticholinergic Medication Use and Incident Dementia among Older Surgical Patients: a Retrospective Cohort Study using Real-World Data
Inpatient anticholinergic medications have been associated with a higher likelihood of postoperative delirium in older adu...
Safety Study of Anticoagulants for Preventing Deep Venous Thrombosis after Intracerebral Hemorrhage: Data from the Chinese Stroke Center Alliance
Safety Study of Anticoagulants for Preventing Deep Venous Thrombosis after Intracerebral Hemorrhage: Data from the Chinese Stroke Center Alliance
The use of anticoagulants to prevent deep vein thrombosis (DVT) after intracerebral hemorrhage (ICH) remains controversial...
Unveiling Cognitive Impairment in Older Adults with Cancer on Systemic Anticancer Therapy: A Comprehensive Review
Unveiling Cognitive Impairment in Older Adults with Cancer on Systemic Anticancer Therapy: A Comprehensive Review
Cancer-related cognitive impairment significantly affects cancer management and decision-making. While the exact mechanism...
Antidepressants to Manage Osteoarthritic Pain: The Value of Pain Phenotyping
Antidepressants to Manage Osteoarthritic Pain: The Value of Pain Phenotyping
Osteoarthritis (OA) is a chronic condition in which pain significantly affects quality of life, often leading to reduced p...
Factors Influencing General Practitioners’ Deprescribing Decisions for Older Adults, with Insights into Frailty: a Qualitative Study in Greek Primary Care
Factors Influencing General Practitioners’ Deprescribing Decisions for Older Adults, with Insights into Frailty: a Qualitative Study in Greek Primary Care
Polypharmacy is increasing among older individuals worldwide. Deprescribing has been suggested as a strategy to reduce pol...
Safety and Efficacy of Sodium-Glucose Cotransporter 2 Inhibitors in Older Adults with Variable Disease States: A Meta-analysis of Large Placebo-Controlled Trials
Safety and Efficacy of Sodium-Glucose Cotransporter 2 Inhibitors in Older Adults with Variable Disease States: A Meta-analysis of Large Placebo-Controlled Trials
Recent guidelines recommend the use of sodium-glucose cotransporter 2 (SGLT-2) inhibitors (SGLT2i) in patients suffering f...
Dementia Medications and Their Association with Pain Medication Use in Medicare Beneficiaries with Alzheimer’s Disease/Alzheimer’s Disease-Related Dementias and Chronic Pain
Dementia Medications and Their Association with Pain Medication Use in Medicare Beneficiaries with Alzheimer’s Disease/Alzheimer’s Disease-Related Dementias and Chronic Pain
Chronic pain is prevalent among older adults with Alzheimer’s disease (AD) and Alzheimer’s disease-related dem...
Trazodone and Risk of Orthostatic Hypotension, Syncope and Falls in Geriatric Outpatients with Hypertension
Trazodone and Risk of Orthostatic Hypotension, Syncope and Falls in Geriatric Outpatients with Hypertension
In older adults, trazodone is frequently prescribed for anxiety and insomnia owing to its perceived greater tolerability i...
Medicine Optimisation and Deprescribing Intervention Outcomes for Older People with Dementia or Mild Cognitive Impairment: A Systematic Review
Medicine Optimisation and Deprescribing Intervention Outcomes for Older People with Dementia or Mild Cognitive Impairment: A Systematic Review
Polypharmacy is common amongst older people with dementia or mild cognitive impairment (MCI), increasing the risk of medic...
Impact of Disease-Modifying Antirheumatic Drugs on Cognitive Function in Older Adults with Rheumatoid Arthritis
Impact of Disease-Modifying Antirheumatic Drugs on Cognitive Function in Older Adults with Rheumatoid Arthritis
Cognitive impairment poses significant challenges for aging populations. Systemic inflammation, a hallmark of rheumatoid a...
A Post Hoc Analysis of Older Patients with Metastatic Colorectal Cancer Receiving Oxaliplatin-Based Chemotherapy Plus Bevacizumab: The Randomized Obelics Study
A Post Hoc Analysis of Older Patients with Metastatic Colorectal Cancer Receiving Oxaliplatin-Based Chemotherapy Plus Bevacizumab: The Randomized Obelics Study
Phase II trials and subgroup analyses of clinical studies suggest that bevacizumab plus an oxaliplatin-based chemotherapy ...
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