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Advancing Vaccination Strategies for Older Adults: Insights of the Adult Immunization Board Meeting
Advancing Vaccination Strategies for Older Adults: Insights of the Adult Immunization Board Meeting
As Europe’s population ages, optimizing vaccination strategies for older adults is an increasing public health prior...
Association Between Anticholinergic Burden and Dry Mouth Severity in Acutely Ill Older Adults
Association Between Anticholinergic Burden and Dry Mouth Severity in Acutely Ill Older Adults
Dry mouth is a common and burdensome condition in older adults and its severity may increase with use of anticholinergic m...
Efficacy and Safety of DOACs in Patients with Atrial Fibrillation and History of Falls or Risk of Falls: The Liverpool AF-Falls Project. A Systematic Review and Bayesian Network Meta-analysis
Efficacy and Safety of DOACs in Patients with Atrial Fibrillation and History of Falls or Risk of Falls: The Liverpool AF-Falls Project. A Systematic Review and Bayesian Network Meta-analysis
Non-vitamin K antagonist oral anticoagulants (DOACs) are the preferred treatment over vitamin K antagonists (VKAs) for pat...
Investigating Potential Prescribing Cascades Resulting in Prochlorperazine Prescription: An Exploratory Analysis of Antihypertensives and NSAIDs
Investigating Potential Prescribing Cascades Resulting in Prochlorperazine Prescription: An Exploratory Analysis of Antihypertensives and NSAIDs
A prescribing cascade occurs when medication is used to treat or prevent an adverse drug reaction (ADR) to another medicat...
Managing Acute Severe Ulcerative Colitis in the Older Patient: A Growing Concern
Managing Acute Severe Ulcerative Colitis in the Older Patient: A Growing Concern
Since the prevalence of older patients with ulcerative colitis is increasing, hospitalizations for severe disease in this ...
Prescribing Cascades: An Umbrella Review and Updated Systematic Review
Prescribing Cascades: An Umbrella Review and Updated Systematic Review
Prescribing cascades (PCs) often remain underrecognized, contributing to inappropriate prescribing and increased healthcar...
Propofol Use and Delirium in Patients Aged 80 Years and Over: A Retrospective Cohort Study of 9850 ICU Admissions
Propofol Use and Delirium in Patients Aged 80 Years and Over: A Retrospective Cohort Study of 9850 ICU Admissions
There is inconsistent evidence regarding the relationship between propofol and delirium, and this evidence is predominantl...
Hospitalisation as an Opportunity to Optimise Quality Use of Medicines in Older Adults: A Systematic Review
Hospitalisation as an Opportunity to Optimise Quality Use of Medicines in Older Adults: A Systematic Review
Hospitalisation represents an opportunity to optimise medication therapy in patients at high risk of medication-related ha...
Cardiovascular-Related Polypharmacy and Its Association with Liver and Kidney Function: A Cross-Sectional Study Using Primary Care Data
Cardiovascular-Related Polypharmacy and Its Association with Liver and Kidney Function: A Cross-Sectional Study Using Primary Care Data
Individuals at high risk of cardiovascular disease (CVD) often require multiple concurrent medications, resulting in polyp...
Longitudinal Non-interventional Changes of the FORTA Score are Associated with Changes of Cognitive and Physical Function Tests in Community-Dwelling Older People
Longitudinal Non-interventional Changes of the FORTA Score are Associated with Changes of Cognitive and Physical Function Tests in Community-Dwelling Older People
Listing tools were found to ameliorate drug treatment in older people; the FORTA (Fit-fOR-The-Aged) list is a clinically v...
Efficacy and Safety of Mirabegron in Frail Older Adults with Overactive Bladder
Efficacy and Safety of Mirabegron in Frail Older Adults with Overactive Bladder
Overactive bladder (OAB) is a commonly occurring condition in older adults that has significant consequences on health and...
Guideline-Directed Heart Failure Pharmacotherapy in Adults Aged ≥75 Years: Evidence Gaps, Tolerability, and Implications for Clinical Practice
Guideline-Directed Heart Failure Pharmacotherapy in Adults Aged ≥75 Years: Evidence Gaps, Tolerability, and Implications for Clinical Practice
Heart failure predominantly affects older adults, yet the evidence supporting guideline-directed medical therapy is largel...
Exploring the Link Between Pharmacological Management of Orthostatic Hypotension and Cognitive Performance: A Scoping Review
Exploring the Link Between Pharmacological Management of Orthostatic Hypotension and Cognitive Performance: A Scoping Review
Orthostatic hypotension is recognized as a potential contributor to cognitive impairment in older adults. It is still unkn...
Trends in Multi-dose Drug Dispensing Amongst Older Adults in Sweden: A Nationwide Repeated Cross-Sectional Register Study, 2014–2023
Trends in Multi-dose Drug Dispensing Amongst Older Adults in Sweden: A Nationwide Repeated Cross-Sectional Register Study, 2014–2023
Multi-dose dispensing (MDD) is a medication management system in Sweden that pre-packages regularly used prescription medi...
Using Medication Dispensation Data to Identify Clusters with Similar Prescribing Patterns in Older Adults Living with Dementia
Using Medication Dispensation Data to Identify Clusters with Similar Prescribing Patterns in Older Adults Living with Dementia
Older adults living with dementia are a heterogeneous group, which can make studying optimal medication management challen...
Hypoglycaemia in Older Adults with Diabetes: Pathophysiology, Prevention, and Personalized Care in an Aging Population
Hypoglycaemia in Older Adults with Diabetes: Pathophysiology, Prevention, and Personalized Care in an Aging Population
Managing diabetes in older adults requires balancing long-term glycaemic control with the prevention of hypoglycaemia, to ...
Reduced-Dose Edoxaban in Patients Aged ≥ 80 Years: A Single-Center Real-World Analysis
Reduced-Dose Edoxaban in Patients Aged ≥ 80 Years: A Single-Center Real-World Analysis
Optimal anticoagulation strategies in octogenarians remain controversial owing to age-related risks of thromboembolism and...
Characteristics of Late-Onset Systemic Lupus Erythematosus: Clinical Manifestations and Diagnostic and Treatment Challenges
Characteristics of Late-Onset Systemic Lupus Erythematosus: Clinical Manifestations and Diagnostic and Treatment Challenges
Systemic lupus erythematosus (SLE) is widely recognized as a systemic autoimmune disease predominantly affecting young wom...
Anesthesia Considerations in Older Adults Undergoing Emergency Mechanical Thrombectomy for Acute Ischaemic Stroke
Anesthesia Considerations in Older Adults Undergoing Emergency Mechanical Thrombectomy for Acute Ischaemic Stroke
Acute ischemic stroke (AIS) is a significant cause of morbidity and mortality among older adults, with its incidence, seve...
Association of Antipsychotic Dose with Surrogate Efficacy and Safety Outcomes in Hospitalized Older Adults: A Retrospective Cohort Study
Association of Antipsychotic Dose with Surrogate Efficacy and Safety Outcomes in Hospitalized Older Adults: A Retrospective Cohort Study
Antipsychotics are frequently used in hospitalized older adults to manage agitation and delirium, despite limited supporti...
Sarcopenia and Cachexia in Older Patients with Cancer: Pathophysiology, Diagnosis, Impact on Outcomes, and Management Strategies
Sarcopenia and Cachexia in Older Patients with Cancer: Pathophysiology, Diagnosis, Impact on Outcomes, and Management Strategies
Sarcopenia and cachexia are two common and overlapping but distinct muscle wasting syndromes that predict adverse outcomes...
Frailty-Informed Pain Management: A Clinical Imperative Beyond Chronological Age
Frailty-Informed Pain Management: A Clinical Imperative Beyond Chronological Age
Chronic pain is a prevalent and disabling condition whose management becomes increasingly complex with aging and frailty. ...
Anti-hypertensive Drug Classes and Risk of New-Onset Atrial Fibrillation in Healthy Older Adults: A Post Hoc Analysis of ASPREE Trial
Anti-hypertensive Drug Classes and Risk of New-Onset Atrial Fibrillation in Healthy Older Adults: A Post Hoc Analysis of ASPREE Trial
Prior studies have suggested potential benefits of antihypertensive medication (AHM) in preventing atrial fibrillation. It...
Patterns and Characteristics of Gabapentin Use Among Medicare Beneficiaries
Patterns and Characteristics of Gabapentin Use Among Medicare Beneficiaries
Gabapentin is increasingly prescribed to older adults, yet prescribing patterns and characteristics of gabapentin initiato...
Effectiveness of Patient-Directed Education to Sustain Deprescribing: A Pragmatic Trial
Effectiveness of Patient-Directed Education to Sustain Deprescribing: A Pragmatic Trial
More than one in three older adults use potentially inappropriate medications (PIMs), and those with chronic conditions ar...
Trends and Guideline Adherence in Gabapentinoid Use among Geriatric Outpatients: A Retrospective Cross-Sectional Study at a Falls Clinic
Trends and Guideline Adherence in Gabapentinoid Use among Geriatric Outpatients: A Retrospective Cross-Sectional Study at a Falls Clinic
With pain treatment shifting away from opioids, alternative analgesics—such as gabapentinoids—are increasingly...
Inclusion of Older Adults in Early-Phase Cancer Clinical Trials: Safety, Efficacy and a Way Forward
Inclusion of Older Adults in Early-Phase Cancer Clinical Trials: Safety, Efficacy and a Way Forward
Early-phase clinical trials (EPCTs) are critical for evaluating the safety, tolerability, efficacy and pharmacokinetics of...
Initial Real-World Evidence for Lecanemab in the United States
Initial Real-World Evidence for Lecanemab in the United States
Lecanemab is the first anti-amyloid monoclonal antibody with full approval in the US for the treatment of early Alzheimer&...
Pharmacologic Management of Heart Failure with Preserved Ejection Fraction (HFpEF) in Older Adults
Pharmacologic Management of Heart Failure with Preserved Ejection Fraction (HFpEF) in Older Adults
There are several pharmacologic agents that have been touted as guideline-directed medical therapy for heart failure with ...
How Should Clinicians Discuss Deprescribing with Caregivers of Older Adults Living with Dementia? A Qualitative Study
How Should Clinicians Discuss Deprescribing with Caregivers of Older Adults Living with Dementia? A Qualitative Study
Preventive medications are potential targets for deprescribing in older adults with dementia as goals of care change from ...
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