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Benchmarking pharmaceutical quality and manufacturing costs of 3D printing against conventional compounding methods for personalization of medicine
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The thermodynamic pharma challenge: A cross-cutting perspective
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Public perspectives on 3D printed medications: Insight for formulation design and regulatory development
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Improving solubility by crystallographic disorder: Enabling Peposertib first-in-human trials
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Artificial intelligence-driven discovery of novel scaffolds for selective TLR7 antagonists and their application in enhancing mRNA translation efficiency
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LPAR4-targeted dual-loaded liposome for synergistic lung cancer therapy
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Particulate contamination in parenteral fluid from glass ampoules: compliance assessment and comparative analysis of needle types and ampoule-breaking strategies
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Combining chromatographic and spectroscopic fingerprinting with chemometrics and data fusion to characterize the phytochemical composition of anthocyanin-rich fruit extracts
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Advancing continuous encapsulation and purification of mRNA vaccines and therapeutics
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Thermal shear rheology of silicone O/W emulsions used in surface coating of parenteral containers
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FiBar: A tool for analyzing fiber diameters in complex drug delivery systems from scanning electron microscopy images
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Development of a novel physiologically based biopharmaceutics modeling (PBBM) framework using the open systems pharmacology suite, part 1: in vitro modeling of vericiguat
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Development of a novel physiologically based biopharmaceutics modeling (PBBM) framework using the open systems pharmacology suite, part 2: in vivo pharmacokinetic modeling of vericiguat
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Archaeosomal nanocarriers improve pharmacokinetics and bioavailability of vancomycin after oral administration
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The impact of lipid compositions on siRNA and mRNA lipid nanoparticle performance for pulmonary delivery
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Rheological and physicochemical optimization of hydrogels as potential vitreous body substitutes for in vitro release testing
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Visualization and quantification of citalopram hydrobromide within highly porous drug products by near-infrared chemical imaging
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Explainable artificial neural network as a soft sensor to predict the moisture content in a continuous granulation line
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Advancing Direct Tablet Compression with AI: A multi-task framework for quality control, batch acceptance, and causal analysis
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Unveiling the transformative power of near-infrared spectroscopy in biomedical and pharmaceutical analysis: Trends, advancements, and applications
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Application of nanofiber-based drug delivery systems in improving anxiolytic effect of new 1,2,3-triazolo-1,4-benzodiazepine derivatives
Application of nanofiber-based drug delivery systems in improving anxiolytic effect of new 1,2,3-triazolo-1,4-benzodiazepine derivatives
Anxiety disorders are highly prevalent worldwide and can affect people of all ages, genders and backgrounds. Much efforts ...
Small molecules modified mesoporous silica nanoparticles orally deliver indomethacin with synergistic effect
Small molecules modified mesoporous silica nanoparticles orally deliver indomethacin with synergistic effect
Molecularly functional drug delivery systems possessed huge potentials to realize novel drug administration. To explore sm...
Methotrexate-loaded hyaluronan-modified liposomes integrated into dissolving microneedles for the treatment of psoriasis
Methotrexate-loaded hyaluronan-modified liposomes integrated into dissolving microneedles for the treatment of psoriasis
Volume 195, 1 April 2024, 106711Author links open overlay panel, , , , , , , , AbstractMethotrexate (MTX) is a first-line ...
Predicting the intrinsic membrane permeability of Caco-2/MDCK cells by the solubility-diffusion model
Predicting the intrinsic membrane permeability of Caco-2/MDCK cells by the solubility-diffusion model
Membrane permeability is one of the main determinants for the absorption, distribution, metabolism and excretion of compou...
Evaluation of omadacycline dosing regimens in Chinese using population pharmacokinetic-pharmacodynamic analysis
Evaluation of omadacycline dosing regimens in Chinese using population pharmacokinetic-pharmacodynamic analysis
PurposeOmadacycline (PTK-0796) is a first-in-class aminomethylcycline for adult patients with community-acquired bacterial...
The role of partial area under the curve and maximum concentrations in assessing the bioequivalence of long-acting injectable formulation of exenatide_A sensitivity analysis
The role of partial area under the curve and maximum concentrations in assessing the bioequivalence of long-acting injectable formulation of exenatide_A sensitivity analysis
To ensure therapeutic equivalence between the long-acting injectable (LAI) products, additional PK metrics other than Cmax...
A remodeled ivermectin polycaprolactone-based nanoparticles for inhalation as a promising treatment of pulmonary inflammatory diseases
A remodeled ivermectin polycaprolactone-based nanoparticles for inhalation as a promising treatment of pulmonary inflammatory diseases
In recent years, ivermectin (IVM), an antiparasitic drug of low water solubility and poor oral bioavailability, has shown ...
Effects of H2S-donor ascorbic acid derivative and ischemia/reperfusion-induced injury in isolated rat hearts
Effects of H2S-donor ascorbic acid derivative and ischemia/reperfusion-induced injury in isolated rat hearts
Hydrogen sulfide (H2S), a gasotransmitter, plays a crucial role in vasorelaxation, anti-inflammatory processes and mitigat...
Investigating distributions of inhaled aerosols in the lungs of post-COVID-19 clusters through a unified imaging and modeling approach
Investigating distributions of inhaled aerosols in the lungs of post-COVID-19 clusters through a unified imaging and modeling approach
BackgroundRecent studies, based on clinical data, have identified sex and age as significant factors associated with an in...
Safety, tolerability, pharmacokinetics and neutrophil elastase inhibitory effects of Sivelestat: A randomized, double-blind, placebo-controlled single- and multiple-dose escalation study in Chinese healthy subjects
Safety, tolerability, pharmacokinetics and neutrophil elastase inhibitory effects of Sivelestat: A randomized, double-blind, placebo-controlled single- and multiple-dose escalation study in Chinese healthy subjects
Volume 195, 1 April 2024, 106723Author links open overlay panel, , , , , , , , , , , , , , , Highlights•Sivelestat was saf...
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