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An update of murine models and their methodologies in immune-mediated joint damage and pain research
An update of murine models and their methodologies in immune-mediated joint damage and pain research
The rheumatic and musculoskeletal diseases (RMD) shape a broad group of conditions in which joint diseases such as rheumat...
Adequate cumulative exposure to tacrolimus and low tacrolimus variability decrease the incidence of biliary complications after liver transplantation
Adequate cumulative exposure to tacrolimus and low tacrolimus variability decrease the incidence of biliary complications after liver transplantation
Biliary complications (BCs) are one of the most common complications after liver transplantation (LT). BCs mainly include ...
Schisandrin A enhances pathogens resistance by targeting a conserved p38 MAPK pathway
Schisandrin A enhances pathogens resistance by targeting a conserved p38 MAPK pathway
With the development of multi-drug-resistant bacteria, identification of a chemical or pharmacological drug that could inf...
Sivelestat ameliorates sepsis-induced myocardial dysfunction by activating the PI3K/AKT/mTOR signaling pathway
Sivelestat ameliorates sepsis-induced myocardial dysfunction by activating the PI3K/AKT/mTOR signaling pathway
Sepsis is defined as organ dysfunction caused by an abnormal host immune response to infection and is the most common caus...
Melatonin alleviates necrotizing enterocolitis by reducing bile acid levels through the SIRT1/FXR signalling axis
Melatonin alleviates necrotizing enterocolitis by reducing bile acid levels through the SIRT1/FXR signalling axis
KeywordsMelatoninNecrotizing enterocolitisBile acidsAbbreviationsASBTapical membrane sodium-dependent bile acid transporte...
6-Gingerol ameliorates alveolar hypercoagulation and fibrinolytic inhibition in LPS-provoked ARDS via RUNX1/NF-κB signaling pathway
6-Gingerol ameliorates alveolar hypercoagulation and fibrinolytic inhibition in LPS-provoked ARDS via RUNX1/NF-κB signaling pathway
Keywords6-GingerolAlveolar hypercoagulationFibrinolytic inhibitionAcute respiratory distress syndromeRunt-related transcri...
Coptisine inhibits aggressive and proliferative actions of fibroblast like synoviocytes and exerts a therapeutic potential for rheumatoid arthritis
Coptisine inhibits aggressive and proliferative actions of fibroblast like synoviocytes and exerts a therapeutic potential for rheumatoid arthritis
Rheumatoid arthritis (RA) is a systemic autoimmune disorder characterized by chronic and progressive inflammation and dest...
Blocking CXCR1/2 attenuates experimental periodontitis by suppressing neutrophils recruitment
Blocking CXCR1/2 attenuates experimental periodontitis by suppressing neutrophils recruitment
Periodontitis (PD) is a prevalent chronic inflammatory disorder that is associated with alveolar bone loss and systemic di...
Nitrated T cell epitope linked vaccine targeting CD47 elicits antitumor immune responses and acts synergistically with vaccine targeting PDL1
Nitrated T cell epitope linked vaccine targeting CD47 elicits antitumor immune responses and acts synergistically with vaccine targeting PDL1
The clinical breakthrough of immune checkpoint blockades (ICB) has yielded a new era of cancer immunotherapy. Several immu...
GDF-15 alleviates diabetic nephropathy via inhibiting NEDD4L-mediated IKK/NF-κB signalling pathways
GDF-15 alleviates diabetic nephropathy via inhibiting NEDD4L-mediated IKK/NF-κB signalling pathways
Podocyte inflammatory injury has been indicated to play a pivotal role in the occurrence and development of diabetic nephr...
Haemolysin Ahh1 secreted from Aeromonas dhakensis activates the NLRP3 inflammasome in macrophages and mediates severe soft tissue infection
Haemolysin Ahh1 secreted from Aeromonas dhakensis activates the NLRP3 inflammasome in macrophages and mediates severe soft tissue infection
Severe soft tissue infections (SSTIs), such as necrotizing fasciitis (NF), also called flesh-eating disease, are among the...
Periplogenin inhibits pathologic synovial proliferation and infiltration in rheumatsuoid arthritis by regulating the JAK2/3-STAT3 pathway
Periplogenin inhibits pathologic synovial proliferation and infiltration in rheumatsuoid arthritis by regulating the JAK2/3-STAT3 pathway
Rheumatoid arthritis (RA) is a chronic autoimmune disease that affects the joints, causing pain, swelling, and deformity [...
CFL1 restores the migratory capacity of bone marrow mesenchymal stem cells in primary Sjögren's syndrome by regulating CCR1 expression
CFL1 restores the migratory capacity of bone marrow mesenchymal stem cells in primary Sjögren's syndrome by regulating CCR1 expression
Primary Sjögren's syndrome (pSS) is a systemic chronic autoimmune disease characterized by lymphocytic infiltration of the...
Predictive indicators of immune therapy efficacy in hepatocellular carcinoma based on neutrophil-to-lymphocyte ratio
Predictive indicators of immune therapy efficacy in hepatocellular carcinoma based on neutrophil-to-lymphocyte ratio
Hepatocellular carcinoma (HCC) is the sixth most common cancer worldwide and the third leading cause of cancer-related dea...
TSP-1 increases autophagy level in cartilage by upregulating HSP27 which delays progression of osteoarthritis
TSP-1 increases autophagy level in cartilage by upregulating HSP27 which delays progression of osteoarthritis
This study aimed to determine whether Thrombospondin-1 (TSP-1) can be used as a biomarker to diagnose early osteoarthritis...
Characterization of chicken-derived antibody against Alpha-Enolase of Streptococcus pneumoniae
Characterization of chicken-derived antibody against Alpha-Enolase of Streptococcus pneumoniae
Streptococcus pneumoniae is an opportunistic pathogen that asymptomatically colonizes the upper respiratory tracts and fre...
Population pharmacokinetics of immunoglobulin G after intravenous, subcutaneous, or hyaluronidase-facilitated subcutaneous administration in immunoglobulin-naive patients with primary immunodeficiencies
Population pharmacokinetics of immunoglobulin G after intravenous, subcutaneous, or hyaluronidase-facilitated subcutaneous administration in immunoglobulin-naive patients with primary immunodeficiencies
Primary immunodeficiency diseases (PIDs), also referred to as inborn errors of immunity, reflect a group of more than 480 ...
Comparison of gut microbiota dysbiosis between pemphigus vulgaris and bullous pemphigoid
Comparison of gut microbiota dysbiosis between pemphigus vulgaris and bullous pemphigoid
Bullous diseases, including pemphigus and pemphigoid, are a set of autoimmune diseases that involve abnormal production of...
Inhibition of Sirt3 activates the cGAS-STING pathway to aggravate hepatocyte damage in hepatic ischemia–reperfusion injury mice
Inhibition of Sirt3 activates the cGAS-STING pathway to aggravate hepatocyte damage in hepatic ischemia–reperfusion injury mice
Hepatic ischemia–reperfusion injury (IRI) is a condition characterized by liver damage resulting from the interruption and...
Artificial intelligence-driven design of the assembled major cat allergen Fel d 1 to improve its spatial folding and IgE-reactivity
Artificial intelligence-driven design of the assembled major cat allergen Fel d 1 to improve its spatial folding and IgE-reactivity
Allergic diseases affect approximately 20 % of the population worldwide [1] and are recognized by the World Health Organiz...
Dapagliflozin alleviates arsenic trioxide-induced hepatic injury in rats via modulating PI3K/AkT/mTOR, STAT3/SOCS3/p53/MDM2 signaling pathways and miRNA-21, miRNA-122 expression
Dapagliflozin alleviates arsenic trioxide-induced hepatic injury in rats via modulating PI3K/AkT/mTOR, STAT3/SOCS3/p53/MDM2 signaling pathways and miRNA-21, miRNA-122 expression
Arsenic Trioxide (ATO, As2O3) has been employed as chemotherapy to treat the relapsed or refractory type of acute promyelo...
Saikosaponin-d alleviates depression by promoting NLRP3 ubiquitination and inhibiting inflammasome activation
Saikosaponin-d alleviates depression by promoting NLRP3 ubiquitination and inhibiting inflammasome activation
Major Depressive Disorder (MDD) is one of the most prevalent debilitating personal and public disorders worldwide. The hug...
The enteroprotective effect of nifuroxazide against methotrexate-induced intestinal injury involves co-activation of PPAR-γ, SIRT1, Nrf2, and suppression of NF-κB and JAK1/STAT3 signals
The enteroprotective effect of nifuroxazide against methotrexate-induced intestinal injury involves co-activation of PPAR-γ, SIRT1, Nrf2, and suppression of NF-κB and JAK1/STAT3 signals
Methotrexate (MTX) has been used effectively to treat several neoplastic and autoimmune disorders. As a structural analog ...
Predictive role of E2F6 in cancer prognosis and responses of immunotherapy
Predictive role of E2F6 in cancer prognosis and responses of immunotherapy
aGvHDacute graft-versus-host diseaseCAFscancer-associated fibroblastsCCLECancer Cell Line EncyclopediaComPPICompartmentali...
C5a enhances inflammation and chemotaxis of γδ T cells in malignant pleural effusion
C5a enhances inflammation and chemotaxis of γδ T cells in malignant pleural effusion
Pleural effusion, characterized by the accumulation of fluid in the pleural space, can be categorized as either benign or ...
Development of a nomogram prognostic model for early Grade ≥ 3 infection in newly diagnosed multiple myeloma based on immunoparesis
Development of a nomogram prognostic model for early Grade ≥ 3 infection in newly diagnosed multiple myeloma based on immunoparesis
BackgroundInfection, a significant cause of death in multiple myeloma (MM) patients, is a common complication and is close...
Comprehensive molecular analysis identifies RET alterations association with response of ICIs in multi-immunotherapy cohorts
Comprehensive molecular analysis identifies RET alterations association with response of ICIs in multi-immunotherapy cohorts
The use of immune checkpoint inhibitors (ICIs) has achieved remarkable success in the treatment of patients with advanced ...
Maternal immune activation mediated prenatal chronic stress induces Th17/Treg cell imbalance may relate to the PI3K/Akt/NF-κB signaling pathway in offspring rats
Maternal immune activation mediated prenatal chronic stress induces Th17/Treg cell imbalance may relate to the PI3K/Akt/NF-κB signaling pathway in offspring rats
Psychological stress is as an emotional state caused by unexpected changes in external surroundings. Women in pregnancy ne...
Safety, pharmacokinetics and pharmacodynamics of HWH486 capsules in healthy adults: A randomized, double-blind, placebo-controlled, phase I dose-escalation study
Safety, pharmacokinetics and pharmacodynamics of HWH486 capsules in healthy adults: A randomized, double-blind, placebo-controlled, phase I dose-escalation study
Autoimmune diseases, in which B and T lymphocytes drive responses to self-antigens [1], span about 100 clinical indication...
Enhanced expression of miR-204 attenuates LPS stimulated inflammatory injury through inhibiting the Wnt/β-catenin pathway via targeting CCND2
Enhanced expression of miR-204 attenuates LPS stimulated inflammatory injury through inhibiting the Wnt/β-catenin pathway via targeting CCND2
One of the most common bacterial diseases of the reproductive system in cattle industry is endometritis, that seriously af...
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