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Tapinarof Cream 1%: Pediatric First Approval
Tapinarof Cream 1%: Pediatric First Approval
The aryl hydrocarbon receptor (AhR) has an integral role in maintaining skin homeostasis. Tapinarof cream 1% (VTAMA®)...
Risk Factors for Nephrotoxicity Among Neonates Receiving Vancomycin: A Systematic Review and Meta-analysis
Risk Factors for Nephrotoxicity Among Neonates Receiving Vancomycin: A Systematic Review and Meta-analysis
Nephrotoxicity may increase the risk of neonatal mortality. Early identification of risk factors for nephrotoxicity is ess...
Prescription Trends for Primary Headache in Children and Adolescents in China During 2019–2023: A Retrospective Study
Prescription Trends for Primary Headache in Children and Adolescents in China During 2019–2023: A Retrospective Study
Globally, primary headache disorders, including migraine, tension type headache and cluster headache, are a leading cause ...
Current and Emerging Therapies for Prevention and Treatment of Bronchopulmonary Dysplasia in Preterm Infants
Current and Emerging Therapies for Prevention and Treatment of Bronchopulmonary Dysplasia in Preterm Infants
Although advances in the care of extremely preterm born infants have yielded improvements in survival and reductions in im...
Efficacy and Safety of Wound Catheter Infusion with Ropivacaine After Abdominal Surgery in Children Aged < 1 Year: A Randomized Controlled Trial
Efficacy and Safety of Wound Catheter Infusion with Ropivacaine After Abdominal Surgery in Children Aged < 1 Year: A Randomized Controlled Trial
Wound catheter infusion (WCI) with local anesthetics provides effective postoperative analgesia in adults, without adverse...
Clinical Study to Evaluate the Possible Efficacy and Safety of -Arginine in Children with Sickle Cell Disease and Increased Tricuspid Regurgitant Jet Velocity: a Randomized Controlled Trial
Clinical Study to Evaluate the Possible Efficacy and Safety of -Arginine in Children with Sickle Cell Disease and Increased Tricuspid Regurgitant Jet Velocity: a Randomized Controlled Trial
Pulmonary hypertension (PH) is a common chronic complication of sickle cell disease (SCD), and patients at risk for PH can...
A Systematic Review of Anti-TNF and Anti-IL-6 Treatments for Pediatric Takayasu Arteritis: Addressing a Therapeutic Dilemma
A Systematic Review of Anti-TNF and Anti-IL-6 Treatments for Pediatric Takayasu Arteritis: Addressing a Therapeutic Dilemma
Takayasu arteritis (TAK) is a rare large-vessel vasculitis primarily affecting young female patients, with pediatric cases...
Association of Serum Levels of Ustekinumab, Vedolizumab, and Faecal Calprotectin in Paediatric Patients with Inflammatory Bowel Diseases: A Prospective Observational Study
Association of Serum Levels of Ustekinumab, Vedolizumab, and Faecal Calprotectin in Paediatric Patients with Inflammatory Bowel Diseases: A Prospective Observational Study
Ustekinumab (USTE) and vedolizumab (VEDO) are increasingly used in paediatric patients with inflammatory bowel diseases (p...
Physiologically Based Pharmacokinetic Modeling-Based Evaluation of Current Carbamazepine and Valproic Acid Dosing Guidelines for Pediatric Epilepsy Treatment
Physiologically Based Pharmacokinetic Modeling-Based Evaluation of Current Carbamazepine and Valproic Acid Dosing Guidelines for Pediatric Epilepsy Treatment
Carbamazepine and valproic acid (VPA) are long-standing treatments for epilepsy in children. Interestingly, they display u...
Effective Sirolimus Use in Prenatal and Postnatal Management of Symptomatic Extensive Congenital Capillary-Lymphatic-Venous Malformations (CLVMs): A Report of Two Cases
Effective Sirolimus Use in Prenatal and Postnatal Management of Symptomatic Extensive Congenital Capillary-Lymphatic-Venous Malformations (CLVMs): A Report of Two Cases
Congenital capillary-lymphatic-venous malformations (CLVMs) often result in life-threatening complications, which may begi...
Levetiracetam Versus Fosphenytoin Infusions as Second-Line Treatment for Pediatric Status Epilepticus: A Multicenter Study Examining Effectiveness, Tolerability, and Ease of Use
Levetiracetam Versus Fosphenytoin Infusions as Second-Line Treatment for Pediatric Status Epilepticus: A Multicenter Study Examining Effectiveness, Tolerability, and Ease of Use
Status epilepticus is a life-threatening neurological emergency that requires rapid and effective treatment to prevent lon...
Targeted Treatments for Myasthenia Gravis in Children and Adolescents
Targeted Treatments for Myasthenia Gravis in Children and Adolescents
Myasthenia gravis (MG) is an antibody-mediated disorder of the neuromuscular junction affecting children and adults. MG is...
Recent Developments in the Treatment of Pediatric Distal Renal Tubular Acidosis
Recent Developments in the Treatment of Pediatric Distal Renal Tubular Acidosis
Distal renal tubular acidosis (dRTA) is characterized by a primary defect in proton secretion by α-intercalated cells...
Adverse Event Profile of First-line Drugs for Treating Patent Ductus Arteriosus in Neonates: A Disproportionality Analysis Study of USFDA Adverse Event Reporting System
Adverse Event Profile of First-line Drugs for Treating Patent Ductus Arteriosus in Neonates: A Disproportionality Analysis Study of USFDA Adverse Event Reporting System
Acetaminophen, ibuprofen, and indomethacin are widely used as first-line drugs for patent ductus arteriosus (PDA) closure ...
The Effect of Levetiracetam and Valproic Acid Treatment on Anger and Attention Deficit Hyperactivity Disorder Clinical Features in Children and Adolescents with Epilepsy: A Prospective Study
The Effect of Levetiracetam and Valproic Acid Treatment on Anger and Attention Deficit Hyperactivity Disorder Clinical Features in Children and Adolescents with Epilepsy: A Prospective Study
Antiseizure medications (ASMs) can potentially trigger psychobehavioral adverse events associated with the onset or exacer...
Apremilast: First Pediatric Approval
Apremilast: First Pediatric Approval
Apremilast (Otezla®) is an inhibitor of phosphodiesterase-4 (PDE-4) being developed by Amgen. It is approved in multi...
Dexmedetomidine for Less Invasive Surfactant Administration: A Pilot Study
Dexmedetomidine for Less Invasive Surfactant Administration: A Pilot Study
Less invasive surfactant administration (LISA) involves delivering surfactant to a spontaneously breathing infant by passi...
High-Fidelity Clinical Simulation to Improve a Pediatric Clinical Trial Design: Lessons Learned and Conceptualization of the Return on Investment (ROI) and Return on Engagement (ROE) Analysis
High-Fidelity Clinical Simulation to Improve a Pediatric Clinical Trial Design: Lessons Learned and Conceptualization of the Return on Investment (ROI) and Return on Engagement (ROE) Analysis
Clinical trials entail complex processes that are more challenging when they are addressed to pediatric patients and inclu...
Population Pharmacokinetics and Dose Optimization of Piperacillin in Infants and Children with Pneumonia
Population Pharmacokinetics and Dose Optimization of Piperacillin in Infants and Children with Pneumonia
We aimed to determine the piperacillin disposition and optimize the dosing regimens for infants and children with pneumoni...
How Consistent are Anti-Infective Drug Dosing Recommendations Across Three European Paediatric Formularies?
How Consistent are Anti-Infective Drug Dosing Recommendations Across Three European Paediatric Formularies?
Drug dosing recommendations in paediatrics are mainly based on the age and bodyweight of the child. Because of the limited...
A New Perspective on Drugs for Duchenne Muscular Dystrophy: Proposals for Better Respiratory Outcomes and Improved Regulatory Pathways
A New Perspective on Drugs for Duchenne Muscular Dystrophy: Proposals for Better Respiratory Outcomes and Improved Regulatory Pathways
New drugs for Duchenne muscular dystrophy (DMD) are emerging rapidly. However, we and others believe these drugs are achie...
Optimizing Drug Selection in Children with Multiple Sclerosis: What Do We Know and What Remains Unanswered?
Optimizing Drug Selection in Children with Multiple Sclerosis: What Do We Know and What Remains Unanswered?
Pediatric-onset multiple sclerosis (POMS) refers to multiple sclerosis with onset before 18 years of age. It is characteri...
Bosutinib: Pediatric First Approval
Bosutinib: Pediatric First Approval
Bosutinib (BOSULIF®), an orally administered BCR–ABL tyrosine kinase inhibitor (TKI) developed by Pfizer Inc., ...
Approaches to the Prevention and Treatment of Respiratory Syncytial Virus Infection in Children: Rationale and Progress to Date
Approaches to the Prevention and Treatment of Respiratory Syncytial Virus Infection in Children: Rationale and Progress to Date
Respiratory syncytial virus (RSV) is the most common cause of lower respiratory tract infection (LRTI) in children, and is...
Cantharidin Topical Solution 0.7%: First Approval
Cantharidin Topical Solution 0.7%: First Approval
Cantharidin (YCANTH™) is a proprietary drug-device combination product containing a formulation of cantharidin 0.7% ...
Prophylactic Intravenous Acetaminophen in Extremely Premature Infants: Minimum Effective Dose Research by Bayesian Approach
Prophylactic Intravenous Acetaminophen in Extremely Premature Infants: Minimum Effective Dose Research by Bayesian Approach
Patent ductus arteriosus (PDA) in preterm infants is associated with increased morbidities and mortality. Prophylactic tre...
Practical Questions About Rescue Medications for Acute Treatment of Seizure Clusters in Children and Adolescents with Epilepsy in the USA: Expanding Treatment Options to Address Unmet Needs
Practical Questions About Rescue Medications for Acute Treatment of Seizure Clusters in Children and Adolescents with Epilepsy in the USA: Expanding Treatment Options to Address Unmet Needs
Epilepsy is a common pediatric neurological condition, affecting approximately 470,000 children in the USA and having a pr...
Emerging Treatments for Childhood Interstitial Lung Disease
Emerging Treatments for Childhood Interstitial Lung Disease
Childhood interstitial lung disease (chILD) is a large and heterogeneous group of disorders characterized by diffuse lung ...
Correction to: Viloxazine: Pediatric First Approval
Correction to: Viloxazine: Pediatric First Approval
Open Access This article is licensed under a Creative Commons Attribution-NonCommercial 4.0 International ...
Topical Management of Pediatric Psoriasis: A Review of New Developments and Existing Therapies
Topical Management of Pediatric Psoriasis: A Review of New Developments and Existing Therapies
Psoriasis is a chronic immune-mediated disorder that commonly affects adults and children. In recent years, pediatric psor...
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