SCI Abstract

search
+
Targeted Treatments for Myasthenia Gravis in Children and Adolescents
Targeted Treatments for Myasthenia Gravis in Children and Adolescents
Myasthenia gravis (MG) is an antibody-mediated disorder of the neuromuscular junction affecting children and adults. MG is...
Recent Developments in the Treatment of Pediatric Distal Renal Tubular Acidosis
Recent Developments in the Treatment of Pediatric Distal Renal Tubular Acidosis
Distal renal tubular acidosis (dRTA) is characterized by a primary defect in proton secretion by α-intercalated cells...
Adverse Event Profile of First-line Drugs for Treating Patent Ductus Arteriosus in Neonates: A Disproportionality Analysis Study of USFDA Adverse Event Reporting System
Adverse Event Profile of First-line Drugs for Treating Patent Ductus Arteriosus in Neonates: A Disproportionality Analysis Study of USFDA Adverse Event Reporting System
Acetaminophen, ibuprofen, and indomethacin are widely used as first-line drugs for patent ductus arteriosus (PDA) closure ...
The Effect of Levetiracetam and Valproic Acid Treatment on Anger and Attention Deficit Hyperactivity Disorder Clinical Features in Children and Adolescents with Epilepsy: A Prospective Study
The Effect of Levetiracetam and Valproic Acid Treatment on Anger and Attention Deficit Hyperactivity Disorder Clinical Features in Children and Adolescents with Epilepsy: A Prospective Study
Antiseizure medications (ASMs) can potentially trigger psychobehavioral adverse events associated with the onset or exacer...
Apremilast: First Pediatric Approval
Apremilast: First Pediatric Approval
Apremilast (Otezla®) is an inhibitor of phosphodiesterase-4 (PDE-4) being developed by Amgen. It is approved in multi...
Dexmedetomidine for Less Invasive Surfactant Administration: A Pilot Study
Dexmedetomidine for Less Invasive Surfactant Administration: A Pilot Study
Less invasive surfactant administration (LISA) involves delivering surfactant to a spontaneously breathing infant by passi...
High-Fidelity Clinical Simulation to Improve a Pediatric Clinical Trial Design: Lessons Learned and Conceptualization of the Return on Investment (ROI) and Return on Engagement (ROE) Analysis
High-Fidelity Clinical Simulation to Improve a Pediatric Clinical Trial Design: Lessons Learned and Conceptualization of the Return on Investment (ROI) and Return on Engagement (ROE) Analysis
Clinical trials entail complex processes that are more challenging when they are addressed to pediatric patients and inclu...
Population Pharmacokinetics and Dose Optimization of Piperacillin in Infants and Children with Pneumonia
Population Pharmacokinetics and Dose Optimization of Piperacillin in Infants and Children with Pneumonia
We aimed to determine the piperacillin disposition and optimize the dosing regimens for infants and children with pneumoni...
How Consistent are Anti-Infective Drug Dosing Recommendations Across Three European Paediatric Formularies?
How Consistent are Anti-Infective Drug Dosing Recommendations Across Three European Paediatric Formularies?
Drug dosing recommendations in paediatrics are mainly based on the age and bodyweight of the child. Because of the limited...
A New Perspective on Drugs for Duchenne Muscular Dystrophy: Proposals for Better Respiratory Outcomes and Improved Regulatory Pathways
A New Perspective on Drugs for Duchenne Muscular Dystrophy: Proposals for Better Respiratory Outcomes and Improved Regulatory Pathways
New drugs for Duchenne muscular dystrophy (DMD) are emerging rapidly. However, we and others believe these drugs are achie...
Optimizing Drug Selection in Children with Multiple Sclerosis: What Do We Know and What Remains Unanswered?
Optimizing Drug Selection in Children with Multiple Sclerosis: What Do We Know and What Remains Unanswered?
Pediatric-onset multiple sclerosis (POMS) refers to multiple sclerosis with onset before 18 years of age. It is characteri...
Bosutinib: Pediatric First Approval
Bosutinib: Pediatric First Approval
Bosutinib (BOSULIF®), an orally administered BCR–ABL tyrosine kinase inhibitor (TKI) developed by Pfizer Inc., ...
Approaches to the Prevention and Treatment of Respiratory Syncytial Virus Infection in Children: Rationale and Progress to Date
Approaches to the Prevention and Treatment of Respiratory Syncytial Virus Infection in Children: Rationale and Progress to Date
Respiratory syncytial virus (RSV) is the most common cause of lower respiratory tract infection (LRTI) in children, and is...
Cantharidin Topical Solution 0.7%: First Approval
Cantharidin Topical Solution 0.7%: First Approval
Cantharidin (YCANTH™) is a proprietary drug-device combination product containing a formulation of cantharidin 0.7% ...
Prophylactic Intravenous Acetaminophen in Extremely Premature Infants: Minimum Effective Dose Research by Bayesian Approach
Prophylactic Intravenous Acetaminophen in Extremely Premature Infants: Minimum Effective Dose Research by Bayesian Approach
Patent ductus arteriosus (PDA) in preterm infants is associated with increased morbidities and mortality. Prophylactic tre...
Practical Questions About Rescue Medications for Acute Treatment of Seizure Clusters in Children and Adolescents with Epilepsy in the USA: Expanding Treatment Options to Address Unmet Needs
Practical Questions About Rescue Medications for Acute Treatment of Seizure Clusters in Children and Adolescents with Epilepsy in the USA: Expanding Treatment Options to Address Unmet Needs
Epilepsy is a common pediatric neurological condition, affecting approximately 470,000 children in the USA and having a pr...
Emerging Treatments for Childhood Interstitial Lung Disease
Emerging Treatments for Childhood Interstitial Lung Disease
Childhood interstitial lung disease (chILD) is a large and heterogeneous group of disorders characterized by diffuse lung ...
Correction to: Viloxazine: Pediatric First Approval
Correction to: Viloxazine: Pediatric First Approval
Open Access This article is licensed under a Creative Commons Attribution-NonCommercial 4.0 International ...
Topical Management of Pediatric Psoriasis: A Review of New Developments and Existing Therapies
Topical Management of Pediatric Psoriasis: A Review of New Developments and Existing Therapies
Psoriasis is a chronic immune-mediated disorder that commonly affects adults and children. In recent years, pediatric psor...
Pediatric Drugs, Accelerated Approval, and Prospects for Reform
Pediatric Drugs, Accelerated Approval, and Prospects for Reform
U.S. Food and Drug Administration. Accelerated approval. 2023. https://www.fda.gov/patients/fast-track-breakthrough-therap...
Respiratory Syncytial Virus Prefusion F Subunit Vaccine: First Approval of a Maternal Vaccine to Protect Infants
Respiratory Syncytial Virus Prefusion F Subunit Vaccine: First Approval of a Maternal Vaccine to Protect Infants
Pfizer is developing a bivalent respiratory syncytial virus (RSV) prefusion F subunit vaccine (RSVpreF; ABRYSVO™) fo...
Diagnosis and Management of the Systemic Juvenile Idiopathic Arthritis Patient with Emerging Lung Disease
Diagnosis and Management of the Systemic Juvenile Idiopathic Arthritis Patient with Emerging Lung Disease
Chronic lung disease in children with systemic juvenile idiopathic arthritis (SJIA-LD) is an emerging and potentially life...
Scope of JAK Inhibitors in Children: Recent Evidence and Way Forward
Scope of JAK Inhibitors in Children: Recent Evidence and Way Forward
Over the last decade, there has been an increase in the use of targeted therapy using small molecules such as Janus kinase...
Hidradenitis Suppurativa in Children and Adolescents: An Update on Pharmacologic Treatment Options
Hidradenitis Suppurativa in Children and Adolescents: An Update on Pharmacologic Treatment Options
Hidradenitis suppurativa (HS) is a chronic, recurrent, inflammatory skin condition that manifests as painful, deep-seated,...
Diagnosis and Management of Non-Infectious Uveitis in Pediatric Patients
Diagnosis and Management of Non-Infectious Uveitis in Pediatric Patients
Uveitis in children accounts for 5–10% of all cases. The causes vary considerably. Classically, uveitis is distingui...
Low-Dose Remifentanil in Preterm Cesarean Section with General Anesthesia: A Randomized Controlled Trial
Low-Dose Remifentanil in Preterm Cesarean Section with General Anesthesia: A Randomized Controlled Trial
The conventional technique of general anesthesia induction during a Cesarean section involves the use of opioids only afte...
Azacitidine (Vidaza®) in Pediatric Patients with Relapsed Advanced MDS and JMML: Results of a Phase I/II Study by the ITCC Consortium and the EWOG-MDS Group (Study ITCC-015)
Azacitidine (Vidaza®) in Pediatric Patients with Relapsed Advanced MDS and JMML: Results of a Phase I/II Study by the ITCC Consortium and the EWOG-MDS Group (Study ITCC-015)
Advanced myelodysplastic syndrome (MDS) and juvenile myelomonocytic leukemia (JMML) are rare hematological malignancies in...
Developments in the Management of Severe Asthma in Children and Adolescents: Focus on Dupilumab and Tezepelumab
Developments in the Management of Severe Asthma in Children and Adolescents: Focus on Dupilumab and Tezepelumab
Severe asthma in children and adolescents exerts a substantial health, financial, and societal burden. Severe asthma is a ...
Pharmacotherapy for Cancer Treatment-Related Cardiac Dysfunction and Heart Failure in Childhood Cancer Survivors
Pharmacotherapy for Cancer Treatment-Related Cardiac Dysfunction and Heart Failure in Childhood Cancer Survivors
The number of childhood cancer survivors is increasing rapidly. According to American Association for Cancer Research, the...
The Future of Advanced Therapies for Pediatric Crohn’s Disease
The Future of Advanced Therapies for Pediatric Crohn’s Disease
Pediatric Crohn’s disease commonly presents with moderate-to-severe intestinal inflammation with a greater risk of c...
Load More
format_indent_increase