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Extrapolating Guselkumab Efficacy to Juvenile Psoriatic Arthritis from Adult Psoriatic Arthritis and Adult and Pediatric Psoriasis Data
Extrapolating Guselkumab Efficacy to Juvenile Psoriatic Arthritis from Adult Psoriatic Arthritis and Adult and Pediatric Psoriasis Data
Psoriatic arthritis (PsA) and juvenile PsA (jPsA) are chronic inflammatory diseases with similar features that differ by a...
Dosing and Discontinuation of Methylphenidate Medication in Relation to Weight Status in Children and Adolescents
Dosing and Discontinuation of Methylphenidate Medication in Relation to Weight Status in Children and Adolescents
Evidence and clinical guidelines on methylphenidate dosing in different weight status groups are limited. This study aimed...
Advances in Pharmacotherapy for Congenital Hyperinsulinism
Advances in Pharmacotherapy for Congenital Hyperinsulinism
Congenital hyperinsulinism (CHI) is a rare disorder causing persistent hypoglycaemia in infants due to excessive insulin s...
Neurological Adverse Effects of Antipsychotic Medication in Children and Young People
Neurological Adverse Effects of Antipsychotic Medication in Children and Young People
Neurological adverse effects (NAEs) are commonly reported in individuals treated with antipsychotic medications. Children ...
Toward Optimal Treatment Outcomes in New-Onset Polyarticular-Course Juvenile Idiopathic Arthritis
Toward Optimal Treatment Outcomes in New-Onset Polyarticular-Course Juvenile Idiopathic Arthritis
Polyarticular-course juvenile idiopathic arthritis (polyJIA) is a chronic inflammatory arthritis involving > 4 dist...
Doxecitine and Doxribtimine: First Approval
Doxecitine and Doxribtimine: First Approval
Doxecitine and doxribtimine (KYGEVVI®) are pyrimidine nucleosides developed by UCB for the treatment of thymidine kin...
Impact of β-Blockers on the Risk of Low-Birth-Weight Infants in Women with Long QT Syndrome or Marfan Syndrome: A Single-Center Retrospective Study from 2008 to 2022 in a Tertiary Care Center
Impact of β-Blockers on the Risk of Low-Birth-Weight Infants in Women with Long QT Syndrome or Marfan Syndrome: A Single-Center Retrospective Study from 2008 to 2022 in a Tertiary Care Center
β-Blockers are an essential treatment for cardiovascular disease, the incidence of which is rising among women of chi...
Pediatric Myocarditis: Challenges in Diagnosis and Treatment
Pediatric Myocarditis: Challenges in Diagnosis and Treatment
Pediatric myocarditis is a clinically diverse and often under-recognized inflammatory condition of the myocardium, with pr...
Acute Phase Reaction After First Neridronate Infusion in Children with Osteogenesis Imperfecta: An Analysis Based on Questionnaire Data from 65 Patients
Acute Phase Reaction After First Neridronate Infusion in Children with Osteogenesis Imperfecta: An Analysis Based on Questionnaire Data from 65 Patients
Bisphosphonates represent the current standard of care for the pharmacological treatment of pediatric patients with osteog...
Guselkumab: Pediatric First Approval
Guselkumab: Pediatric First Approval
Guselkumab (TREMFYA®) is a fully human IgG1λ monoclonal antibody developed by Johnson & Johnson to selec...
Puzolcabtagene Autoleucel: Pediatric First Approval
Puzolcabtagene Autoleucel: Pediatric First Approval
Puzolcabtagene autoleucel [普利得凯®] is an autologous, humanized anti-CD19 chimeric antigen ...
Therapeutic Role of Neostigmine and Pyridostigmine in Pediatric Chronic Intestinal Pseudo-Obstruction: A Systematic Review
Therapeutic Role of Neostigmine and Pyridostigmine in Pediatric Chronic Intestinal Pseudo-Obstruction: A Systematic Review
Chronic intestinal pseudo-obstruction (CIPO) is a rare and severe disorder presenting with the clinical and radiological f...
Established and Emerging Therapies for High-Risk Neuroblastoma
Established and Emerging Therapies for High-Risk Neuroblastoma
High-risk neuroblastoma (HRNB) accounts for a disproportionately high percentage of cancer-related deaths among pediatric ...
Advances in Management of Eosinophilic Esophagitis in Pediatrics
Advances in Management of Eosinophilic Esophagitis in Pediatrics
Eosinophilic esophagitis is a chronic immune-mediated inflammatory disorder of the esophagus comprising symptoms of esopha...
Oral Lamivudine for Extended HIV Postnatal Prophylaxis
Oral Lamivudine for Extended HIV Postnatal Prophylaxis
Despite considerable progress in preventing mother-to-child transmission (PMTCT) of human immunodeficiency virus (HIV), el...
Effect of Lactoferrin in Obese Children and Adolescents with Metabolic Dysfunction-Associated Steatotic Disease: A Randomized Controlled Study
Effect of Lactoferrin in Obese Children and Adolescents with Metabolic Dysfunction-Associated Steatotic Disease: A Randomized Controlled Study
Lactoferrin is an iron-binding glycoprotein existing in mammalian milk. It has immunomodulatory, antioxidant, and anti-inf...
Tapinarof Cream 1%: Pediatric First Approval
Tapinarof Cream 1%: Pediatric First Approval
The aryl hydrocarbon receptor (AhR) has an integral role in maintaining skin homeostasis. Tapinarof cream 1% (VTAMA®)...
Risk Factors for Nephrotoxicity Among Neonates Receiving Vancomycin: A Systematic Review and Meta-analysis
Risk Factors for Nephrotoxicity Among Neonates Receiving Vancomycin: A Systematic Review and Meta-analysis
Nephrotoxicity may increase the risk of neonatal mortality. Early identification of risk factors for nephrotoxicity is ess...
Prescription Trends for Primary Headache in Children and Adolescents in China During 2019–2023: A Retrospective Study
Prescription Trends for Primary Headache in Children and Adolescents in China During 2019–2023: A Retrospective Study
Globally, primary headache disorders, including migraine, tension type headache and cluster headache, are a leading cause ...
Current and Emerging Therapies for Prevention and Treatment of Bronchopulmonary Dysplasia in Preterm Infants
Current and Emerging Therapies for Prevention and Treatment of Bronchopulmonary Dysplasia in Preterm Infants
Although advances in the care of extremely preterm born infants have yielded improvements in survival and reductions in im...
Efficacy and Safety of Wound Catheter Infusion with Ropivacaine After Abdominal Surgery in Children Aged < 1 Year: A Randomized Controlled Trial
Efficacy and Safety of Wound Catheter Infusion with Ropivacaine After Abdominal Surgery in Children Aged < 1 Year: A Randomized Controlled Trial
Wound catheter infusion (WCI) with local anesthetics provides effective postoperative analgesia in adults, without adverse...
Clinical Study to Evaluate the Possible Efficacy and Safety of -Arginine in Children with Sickle Cell Disease and Increased Tricuspid Regurgitant Jet Velocity: a Randomized Controlled Trial
Clinical Study to Evaluate the Possible Efficacy and Safety of -Arginine in Children with Sickle Cell Disease and Increased Tricuspid Regurgitant Jet Velocity: a Randomized Controlled Trial
Pulmonary hypertension (PH) is a common chronic complication of sickle cell disease (SCD), and patients at risk for PH can...
A Systematic Review of Anti-TNF and Anti-IL-6 Treatments for Pediatric Takayasu Arteritis: Addressing a Therapeutic Dilemma
A Systematic Review of Anti-TNF and Anti-IL-6 Treatments for Pediatric Takayasu Arteritis: Addressing a Therapeutic Dilemma
Takayasu arteritis (TAK) is a rare large-vessel vasculitis primarily affecting young female patients, with pediatric cases...
Association of Serum Levels of Ustekinumab, Vedolizumab, and Faecal Calprotectin in Paediatric Patients with Inflammatory Bowel Diseases: A Prospective Observational Study
Association of Serum Levels of Ustekinumab, Vedolizumab, and Faecal Calprotectin in Paediatric Patients with Inflammatory Bowel Diseases: A Prospective Observational Study
Ustekinumab (USTE) and vedolizumab (VEDO) are increasingly used in paediatric patients with inflammatory bowel diseases (p...
Physiologically Based Pharmacokinetic Modeling-Based Evaluation of Current Carbamazepine and Valproic Acid Dosing Guidelines for Pediatric Epilepsy Treatment
Physiologically Based Pharmacokinetic Modeling-Based Evaluation of Current Carbamazepine and Valproic Acid Dosing Guidelines for Pediatric Epilepsy Treatment
Carbamazepine and valproic acid (VPA) are long-standing treatments for epilepsy in children. Interestingly, they display u...
Effective Sirolimus Use in Prenatal and Postnatal Management of Symptomatic Extensive Congenital Capillary-Lymphatic-Venous Malformations (CLVMs): A Report of Two Cases
Effective Sirolimus Use in Prenatal and Postnatal Management of Symptomatic Extensive Congenital Capillary-Lymphatic-Venous Malformations (CLVMs): A Report of Two Cases
Congenital capillary-lymphatic-venous malformations (CLVMs) often result in life-threatening complications, which may begi...
Levetiracetam Versus Fosphenytoin Infusions as Second-Line Treatment for Pediatric Status Epilepticus: A Multicenter Study Examining Effectiveness, Tolerability, and Ease of Use
Levetiracetam Versus Fosphenytoin Infusions as Second-Line Treatment for Pediatric Status Epilepticus: A Multicenter Study Examining Effectiveness, Tolerability, and Ease of Use
Status epilepticus is a life-threatening neurological emergency that requires rapid and effective treatment to prevent lon...
Targeted Treatments for Myasthenia Gravis in Children and Adolescents
Targeted Treatments for Myasthenia Gravis in Children and Adolescents
Myasthenia gravis (MG) is an antibody-mediated disorder of the neuromuscular junction affecting children and adults. MG is...
Recent Developments in the Treatment of Pediatric Distal Renal Tubular Acidosis
Recent Developments in the Treatment of Pediatric Distal Renal Tubular Acidosis
Distal renal tubular acidosis (dRTA) is characterized by a primary defect in proton secretion by α-intercalated cells...
Adverse Event Profile of First-line Drugs for Treating Patent Ductus Arteriosus in Neonates: A Disproportionality Analysis Study of USFDA Adverse Event Reporting System
Adverse Event Profile of First-line Drugs for Treating Patent Ductus Arteriosus in Neonates: A Disproportionality Analysis Study of USFDA Adverse Event Reporting System
Acetaminophen, ibuprofen, and indomethacin are widely used as first-line drugs for patent ductus arteriosus (PDA) closure ...
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