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New recommendations for reversal of high-dose methotrexate cytotoxicity with folinic acid
New recommendations for reversal of high-dose methotrexate cytotoxicity with folinic acid
Folinic acid (FA) rescue protocols to counter the adverse effects of high-dose methotrexate (HDMTX) vary widely, and the r...
Alternative routes of drug administration: exposure of imatinib using different formulations
Alternative routes of drug administration: exposure of imatinib using different formulations
To explore the possibility of treating patients with alternative imatinib formulations. Two patients were treated with dif...
Population pharmacokinetic analysis of bevacizumab in Japanese cancer patients with proteinuria: a prospective cohort study
Population pharmacokinetic analysis of bevacizumab in Japanese cancer patients with proteinuria: a prospective cohort study
Bevacizumab (BV) is an effective therapeutic antibody utilized in various cancers. Serum BV concentration can be a factor ...
Effect of repeated bolus and continuous doxorubicin administration on bone and soft tissue concentrations– a randomized study evaluated in a tumour-free porcine model
Effect of repeated bolus and continuous doxorubicin administration on bone and soft tissue concentrations– a randomized study evaluated in a tumour-free porcine model
The aim of this study was to evaluate plasma and bone- and soft-tissue concentrations of doxorubicin following two adminis...
An exposure–safety analysis to support the dosage of the novel AKT inhibitor capivasertib
An exposure–safety analysis to support the dosage of the novel AKT inhibitor capivasertib
This study aimed to evaluate capivasertib exposure–response relationships for clinical safety events to support dosa...
Influence of interleukin-6 on the pharmacokinetics and pharmacodynamics of osimertinib in patients with non-small cell lung cancer
Influence of interleukin-6 on the pharmacokinetics and pharmacodynamics of osimertinib in patients with non-small cell lung cancer
The inflammatory cytokine interleukin (IL)-6 reduces the activity of drug metabolic enzymes and promotes tumor progression...
The evaluation of the impact of variants on thiopurine metabolism in Japanese children with acute lymphoblastic leukemia
The evaluation of the impact of variants on thiopurine metabolism in Japanese children with acute lymphoblastic leukemia
This study aimed to evaluate the impact of Nudix hydrolase 15 (NUDT15) variants on thiopurine metabolites, DNA-incorporate...
Napabucasin targets resistant triple negative breast cancer through suppressing STAT3 and mitochondrial function
Napabucasin targets resistant triple negative breast cancer through suppressing STAT3 and mitochondrial function
Chemoresistance in triple negative breast cancer (TNBC) poses a significant challenge in effective treatment, necessitatin...
Evolution of computational techniques against various KRAS mutants in search for therapeutic drugs: a review article
Evolution of computational techniques against various KRAS mutants in search for therapeutic drugs: a review article
KRAS was (Kirsten rat sarcoma viral oncogene homolog) revealed as an important target in current therapeutic cancer resear...
Neurofilament light chain as a marker for neuronal damage: integrating in vitro studies and clinical findings in patients with oxaliplatin-induced neuropathy
Neurofilament light chain as a marker for neuronal damage: integrating in vitro studies and clinical findings in patients with oxaliplatin-induced neuropathy
Oxaliplatin-induced peripheral neuropathy (OIPN) is a chronic, debilitating late effect following oxaliplatin treatment. N...
Pharmacokinetics, metabolism, and excretion of [C]-valemetostat in healthy male participants, and in vitro plasma protein binding
Pharmacokinetics, metabolism, and excretion of [C]-valemetostat in healthy male participants, and in vitro plasma protein binding
Valemetostat tosylate (valemetostat) is an oral, selective, dual inhibitor of enhancer of zeste homolog (EZH)2 and EZH1. T...
Potential role of endothelial dysfunction in hypertension and proteinuria in patients with hepatocellular carcinoma receiving atezolizumab plus bevacizumab: a pilot prospective observational study
Potential role of endothelial dysfunction in hypertension and proteinuria in patients with hepatocellular carcinoma receiving atezolizumab plus bevacizumab: a pilot prospective observational study
Bevacizumab, a monoclonal antibody targeting vascular endothelial growth factor (VEGF), is the first-line treatment for pa...
Pharmacokinetic profile of novel reduced-dose Danziten (nilotinib tablets) versus Tasigna (nilotinib capsules): in vivo bioequivalence and population pharmacokinetic analysis
Pharmacokinetic profile of novel reduced-dose Danziten (nilotinib tablets) versus Tasigna (nilotinib capsules): in vivo bioequivalence and population pharmacokinetic analysis
To evaluate single dose pharmacokinetics (PK) of novel reduced-dose film coated Danziten™ (nilotinib tablet...
Pharmacokinetics, mass balance, and metabolism of [C]FCN-437c, a selective and potent CDK4/6 inhibitor in humans
Pharmacokinetics, mass balance, and metabolism of [C]FCN-437c, a selective and potent CDK4/6 inhibitor in humans
This study investigated the pharmacokinetics, mass balance, and metabolism of [14C]FCN-437c, a selective and potent CDK4/6...
Phase 1 studies of the indenoisoquinolines LMP776 and LMP744 in patients with solid tumors and lymphomas
Phase 1 studies of the indenoisoquinolines LMP776 and LMP744 in patients with solid tumors and lymphomas
Indenoisoquinolines are a class of topoisomerase I (TOP1) inhibitors designed to overcome clinical limitations of camptoth...
Effect of Metformin on vascular endothelial injury in patients with non-small cell lung cancer treated with chemotherapy combined with bevacizumab
Effect of Metformin on vascular endothelial injury in patients with non-small cell lung cancer treated with chemotherapy combined with bevacizumab
This paper aimed to unravel the effect of metformin on vascular endothelial injury in patients with non-small cell lung ca...
From predictive biomarker to therapeutic target: the dual role of SLFN11 in chemotherapy sensitivity
From predictive biomarker to therapeutic target: the dual role of SLFN11 in chemotherapy sensitivity
SLFN11, a DNA/RNA helicase implicated in replication stress response, has recently emerged as a pivotal determinant of che...
Novel desensitization protocol utilizing conventional formulations to mitigate Temozolomide-Related skin hypersensitivity
Novel desensitization protocol utilizing conventional formulations to mitigate Temozolomide-Related skin hypersensitivity
Temozolomide (TMZ) is an oral alkylating agent used in the first-line treatment regimen for glioblastoma (GBM) and other h...
Ruthenium–dihydroartemisinin complex: a promising new compound for colon cancer prevention via G1 cell cycle arrest, apoptotic induction, and adaptive immune regulation
Ruthenium–dihydroartemisinin complex: a promising new compound for colon cancer prevention via G1 cell cycle arrest, apoptotic induction, and adaptive immune regulation
Artemisinin (ART) and its derivatives are important antimalaria agents and have received increased attention due to their ...
Phase I study of the anti-TIGIT antibody tiragolumab in combination with atezolizumab in Japanese patients with advanced or metastatic solid tumors
Phase I study of the anti-TIGIT antibody tiragolumab in combination with atezolizumab in Japanese patients with advanced or metastatic solid tumors
Tiragolumab is a monoclonal antibody that binds to the inhibitory immune checkpoint TIGIT (T-cell immunoreceptor with Ig a...
Evaluation of ABT-751, a novel anti-mitotic agent able to overcome multi-drug resistance, in melanoma cells
Evaluation of ABT-751, a novel anti-mitotic agent able to overcome multi-drug resistance, in melanoma cells
Drug efflux transporter associated multi-drug resistance (MDR) is a potential limitation in the use of taxane chemotherapi...
Correction to: Up-regulation of autophagy is a mechanism of resistance to chemotherapy and can be inhibited by pantoprazole to increase drug sensitivity
Correction to: Up-regulation of autophagy is a mechanism of resistance to chemotherapy and can be inhibited by pantoprazole to increase drug sensitivity
Department of Medical Biophysics, University Health Network, University of Toronto, Toronto, ON, CanadaQian Tan, M. Wang, ...
Midostaurin drug interaction profile: a comprehensive assessment of CYP3A, CYP2B6, and CYP2C8 drug substrates, and oral contraceptives in healthy participants
Midostaurin drug interaction profile: a comprehensive assessment of CYP3A, CYP2B6, and CYP2C8 drug substrates, and oral contraceptives in healthy participants
Midostaurin, approved for treating FLT-3-mutated acute myeloid leukemia and advanced systemic mastocytosis, is metabolized...
Expression of molecular markers and synergistic anticancer effects of chemotherapy with antimicrobial peptides on glioblastoma cells
Expression of molecular markers and synergistic anticancer effects of chemotherapy with antimicrobial peptides on glioblastoma cells
Glioblastoma multiforme (GBM) is the most aggressive and fatal malignant primary brain tumor. The enhancement of the survi...
The landscape of very important pharmacogenes variants and potential clinical relevance in the Chinese Jingpo population: a comparative study with worldwide populations
The landscape of very important pharmacogenes variants and potential clinical relevance in the Chinese Jingpo population: a comparative study with worldwide populations
Pharmacogenomics is a facet of personalized medicine that explores how genetic variants affect drug metabolism and adverse...
Doxorubicin concentrations in bone tumour-relevant tissues after bolus and continuous infusion: a randomized porcine microdialysis study
Doxorubicin concentrations in bone tumour-relevant tissues after bolus and continuous infusion: a randomized porcine microdialysis study
Doxorubicin is a widely used chemotherapeutic drug that can be administered intravenously as both a bolus infusion and a c...
Enhanced anticancer synergy of LOM612 in combination with selinexor: FOXO1 nuclear translocation-mediated inhibition of Wnt/β-catenin signaling pathway in breast cancer
Enhanced anticancer synergy of LOM612 in combination with selinexor: FOXO1 nuclear translocation-mediated inhibition of Wnt/β-catenin signaling pathway in breast cancer
The intricate relationship between Forkhead box O1 (FOXO1), a well-established tumor suppressor, and breast cancer (BC) re...
Prognostic value of RRM1 and its effect on chemoresistance in pancreatic cancer
Prognostic value of RRM1 and its effect on chemoresistance in pancreatic cancer
Pancreatic cancer (PC) remains a lethal disease, and gemcitabine resistance is prevalent. However, the biomarkers suggesti...
Quantitative assessment of skin disorders induced by panitumumab: a prospective observational study
Quantitative assessment of skin disorders induced by panitumumab: a prospective observational study
Acneiform rash is frequently observed in patients undergoing cancer treatment with anti-epidermal growth factor receptor (...
Pharmacokinetics and immunogenicity of eftozanermin alfa in subjects with previously-treated solid tumors or hematologic malignancies: results from a phase 1 first-in-human study
Pharmacokinetics and immunogenicity of eftozanermin alfa in subjects with previously-treated solid tumors or hematologic malignancies: results from a phase 1 first-in-human study
Eftozanermin alfa is a second-generation tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) receptor agonist ...
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