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Tranexamic acid administered intraarticularly to the knee is safer for the articular cartilage and anterior cruciate ligament compared to intravenous administration: Histological analysis of an experimental rat model
Tranexamic acid administered intraarticularly to the knee is safer for the articular cartilage and anterior cruciate ligament compared to intravenous administration: Histological analysis of an experimental rat model
In this study, the effects of tranexamic acid (TXA) on the knee’s articular cartilage, anterior cruciate ligament (A...
Dexpanthenol protects against nicotine-induced kidney injury by reducing oxidative stress and apoptosis through activation of the AKT/Nrf2/HO-1 pathway
Dexpanthenol protects against nicotine-induced kidney injury by reducing oxidative stress and apoptosis through activation of the AKT/Nrf2/HO-1 pathway
Dexpanthenol (DEX), a subtype of vitamin B5, plays an important role in anabolic reactions, cellular energy and regenerati...
Ex vivo treatment with poly (I:C) alleviates the exhausted phenotype of tumor-infiltrating TCD8+ cells of gastric cancer patients
Ex vivo treatment with poly (I:C) alleviates the exhausted phenotype of tumor-infiltrating TCD8+ cells of gastric cancer patients
Gastric cancer is associated with the phenotypic and functional exhaustion of TCD8+ cells. On the other hand, Toll-like re...
Effect of diminazene on cardiac hypertrophy through mitophagy in rat models with hyperthyroidism induced by levothyroxine
Effect of diminazene on cardiac hypertrophy through mitophagy in rat models with hyperthyroidism induced by levothyroxine
Hyperthyroidism is associated with the alteration in molecular pathways involved in the regulation of mitochondrial mass a...
Retraction Note: Ameliorative effect of two structurally divergent hydrazide derivatives against DSS-induced colitis by targeting Nrf2 and NF-κB signaling in mice
Retraction Note: Ameliorative effect of two structurally divergent hydrazide derivatives against DSS-induced colitis by targeting Nrf2 and NF-κB signaling in mice
Pharmacological Sciences Research Laboratory, Department of Pharmacy, Faculty of Biological Sciences, Quaid-I-Azam Univers...
Exploring the influence of the microbiome on the pharmacology of anti-asthmatic drugs
Exploring the influence of the microbiome on the pharmacology of anti-asthmatic drugs
The microbiome is increasingly implicated in playing a role in physiology and pharmacology; in this review, we investigate...
Dexamethasone improves thymoma-associated myasthenia gravis via the AKT-mTOR pathway
Dexamethasone improves thymoma-associated myasthenia gravis via the AKT-mTOR pathway
Clinically, thymoma patients are often complicated with myasthenia gravis (MG). Dexamethasone, a glucocorticoid with anti-...
Phytochemical studies of white mulberry fruits (Morus alba L.)
Phytochemical studies of white mulberry fruits (Morus alba L.)
Medicinal preparations made from plant materials have been widely used for many years due to their high pharmacological ef...
Can acetate via FFA receptors contribute to the diabetogenic effect of statins?
Can acetate via FFA receptors contribute to the diabetogenic effect of statins?
Despite the proven effects of statins in preventing cardiovascular disease, their diabetogenic effect has caused concern. ...
Gentiopicroside inhibits retinoblastoma cell proliferation, invasion, and tumorigenesis in nude mice by suppressing the PI3K/AKT pathway
Gentiopicroside inhibits retinoblastoma cell proliferation, invasion, and tumorigenesis in nude mice by suppressing the PI3K/AKT pathway
Retinoblastoma is a prevalent pediatric intraocular tumor. The suppressive effect of gentiopicroside (GPS) has been report...
Protective effects of topiramate on acetic acid-induced colitis in rats through the inhibition of oxidative stress
Protective effects of topiramate on acetic acid-induced colitis in rats through the inhibition of oxidative stress
Ulcerative colitis is an intestinal inflammatory condition characterized by a rise in inflammatory mediator production and...
Study on the mechanism of puerarin against osteoarthritis from ferroptosis based on network pharmacology and bioinformatics
Study on the mechanism of puerarin against osteoarthritis from ferroptosis based on network pharmacology and bioinformatics
Network pharmacology and bioinformatics were used to study puerarin’s molecular mechanism in treating osteoarthritis...
Assessment of antibacterial drug utilization patterns and antibiogram in infectious diseases: a prospective cross-sectional study
Assessment of antibacterial drug utilization patterns and antibiogram in infectious diseases: a prospective cross-sectional study
Antibacterial drugs are successful in combating most types of infections. Irrational use and higher consumption of these d...
Effects of evodiamine on ROS/TXNIP/NLRP3 pathway against gouty arthritis
Effects of evodiamine on ROS/TXNIP/NLRP3 pathway against gouty arthritis
Evodiamine (EVO) was tested on acute gouty arthritis rats to investigate its anti-inflammatory effect. Seventy-two male Sp...
Cardioprotective effect of naringin against the ischemia/reperfusion injury of aged rats
Cardioprotective effect of naringin against the ischemia/reperfusion injury of aged rats
Aging is known as a main risk factor in the development of cardiovascular diseases. Naringin (NRG) is a flavonoid compound...
Quercetin, a key active ingredient of Jianpi Zishen Xiehuo Formula, suppresses M1 macrophage polarization and platelet phagocytosis by inhibiting STAT3 activation based on network pharmacology
Quercetin, a key active ingredient of Jianpi Zishen Xiehuo Formula, suppresses M1 macrophage polarization and platelet phagocytosis by inhibiting STAT3 activation based on network pharmacology
Primary immune thrombocytopenia (ITP) is an autoimmune hemorrhagic disease, and abnormal M1 macrophage polarization partic...
Exploring the potential of Moringa oleifera Lam in skin disorders and cosmetics: nutritional analysis, phytochemistry, geographical distribution, ethnomedicinal uses, dermatological studies and cosmetic formulations
Exploring the potential of Moringa oleifera Lam in skin disorders and cosmetics: nutritional analysis, phytochemistry, geographical distribution, ethnomedicinal uses, dermatological studies and cosmetic formulations
Moringa oleifera Lam. is a pan-tropical plant well known to the ancient world for its extensive therapeutic benefits in th...
Role of Nrf2/HO-1, PPAR-γ, and cytoglobin signals in the pathogenesis of methotrexate-induced testicular intoxication in rats and the protective effect of diacerein
Role of Nrf2/HO-1, PPAR-γ, and cytoglobin signals in the pathogenesis of methotrexate-induced testicular intoxication in rats and the protective effect of diacerein
Methotrexate (MTX) is an inhibitor of folic acid reductase used in managing a variety of malignancies. Testicular injury b...
Review of the potential pharmacological role of erucic acid: a monounsaturated omega-9 fatty acid
Review of the potential pharmacological role of erucic acid: a monounsaturated omega-9 fatty acid
This comprehensive review aims to provide an overview of the pharmacological properties of erucic acid (EA) and highlight ...
Antibiofilm activity of mesoporous silica nanoparticles against the biofilm associated infections
Antibiofilm activity of mesoporous silica nanoparticles against the biofilm associated infections
In pharmaceutical industries, various chemical carriers are present which are used for drug delivery to the correct target...
Dose-dependent renoprotective effect of vanillic acid on methotrexate-induced nephrotoxicity via its anti-apoptosis, antioxidant, and anti-inflammatory properties
Dose-dependent renoprotective effect of vanillic acid on methotrexate-induced nephrotoxicity via its anti-apoptosis, antioxidant, and anti-inflammatory properties
Methotrexate-induced nephrotoxicity is a medical emergency which is associated with a variety of side effects. Vanillic ac...
Tramadol suppresses growth of orthotopic liver tumors via promoting M1 macrophage polarization in the tumor microenvironment
Tramadol suppresses growth of orthotopic liver tumors via promoting M1 macrophage polarization in the tumor microenvironment
Tumor-associated macrophages (TAMs) are major infiltrating immune cells in liver cancer. They are polarized to anti-tumor ...
Dihydromyricetin alleviates inflammatory bowel disease associated intestinal fibrosis by inducing autophagy through the PI3K/AKT/mTOR signaling pathway
Dihydromyricetin alleviates inflammatory bowel disease associated intestinal fibrosis by inducing autophagy through the PI3K/AKT/mTOR signaling pathway
Intestinal fibrosis is a common complication of inflammatory bowel disease and is characterized by tissue stiffening and l...
Bezafibrate reduces the damage, activation and mechanical properties of lung fibroblast cells induced by hydrogen peroxide
Bezafibrate reduces the damage, activation and mechanical properties of lung fibroblast cells induced by hydrogen peroxide
In pulmonary fibrosis, the proliferation of fibroblasts and their differentiation into myofibroblasts is often caused by t...
Parthenolide as a potential analgesic in the treatment of paclitaxel-induced neuropathic pain: the rat modeling
Parthenolide as a potential analgesic in the treatment of paclitaxel-induced neuropathic pain: the rat modeling
In this study, we determined the therapeutic effect of parthenolide (PTL), the active component of Tanacetum parthenium, o...
Bisdemethoxycurcumin suppresses the progression of atherosclerosis and VSMC-derived foam cell formation by promoting lipophagy
Bisdemethoxycurcumin suppresses the progression of atherosclerosis and VSMC-derived foam cell formation by promoting lipophagy
Vascular smooth muscle cells (VSMCs) are one of the sources of foam cells in atherosclerosis. However, the mechanism of VS...
Ergometrine stimulates histamine H2 receptors in the isolated human atrium
Ergometrine stimulates histamine H2 receptors in the isolated human atrium
Ergometrine (6aR,9R)-N-((S)-1-hydroxypropan-2-yl)-7-methyl-4,6,6a,7,8,9-hexa-hydro-indolo-[4,3-fg]chinolin-9-carboxamide o...
RNA sequencing reveals the mechanism of FTO in inhibiting inflammation and excessive proliferation of lipopolysaccharide-induced human glomerular mesangial cells
RNA sequencing reveals the mechanism of FTO in inhibiting inflammation and excessive proliferation of lipopolysaccharide-induced human glomerular mesangial cells
Chronic glomerulonephritis (CGN) is a leading cause of end-stage renal disease in China; thus, there is an urgent need for...
The anti-tumoral role of Hesperidin and Aprepitant on prostate cancer cells through redox modifications
The anti-tumoral role of Hesperidin and Aprepitant on prostate cancer cells through redox modifications
Prostate cancer is the second prevalent cancer in men. While the anti-cancer effect of Hesperidin and (Aprepitant) AP on p...
Retraction Note: Piceatannol protects against cisplatin nephrotoxicity via activation of Nrf2/HO-1 pathway and hindering NF-κB inflammatory cascade
Retraction Note: Piceatannol protects against cisplatin nephrotoxicity via activation of Nrf2/HO-1 pathway and hindering NF-κB inflammatory cascade
Cite this articleWahdan, S.A., Azab, S.S., Elsherbiny, D.A. et al. Retraction Note: Piceatannol protects against cisplatin...
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