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Formulation and Characterization of Niosomal Suspension of Aloenin for the Treatment of Myocardial Toxicity in Isoproterenol-Induced Rats Via Alteration HO-1/Nrf2/TLR4/ Caspase-3 Signaling Pathways
Formulation and Characterization of Niosomal Suspension of Aloenin for the Treatment of Myocardial Toxicity in Isoproterenol-Induced Rats Via Alteration HO-1/Nrf2/TLR4/ Caspase-3 Signaling Pathways
The current investigation aimed to assess the preventive effect of niosomal aloenin suspension on isoproterenol (ISO)-indu...
Efficient Delivery of Atomoxetine Hydrochloride into Skin Using Biphasic Dissolving Microneedles
Efficient Delivery of Atomoxetine Hydrochloride into Skin Using Biphasic Dissolving Microneedles
Based on formulation optimization and pharmacokinetic (PK) assessment, an atomoxetine biphasic dissolving microneedle (DMN...
Development and Evaluation of Sea Buckthorn Oil-Loaded SNEDDS for Hormonal and Lipid Regulation in PCOS
Development and Evaluation of Sea Buckthorn Oil-Loaded SNEDDS for Hormonal and Lipid Regulation in PCOS
Polycystic Ovary Syndrome (PCOS) is a multifactorial endocrine disorder characterized by hormonal imbalance, ovarian cyst ...
Development and Validation of RP-HPLC Method for Simultaneous Estimation of Fisetin and Xanthohumol in Nanosuspension Drug Delivery System and Immediate Release Tablet Formulation
Development and Validation of RP-HPLC Method for Simultaneous Estimation of Fisetin and Xanthohumol in Nanosuspension Drug Delivery System and Immediate Release Tablet Formulation
The study aimed to develop and validate a simple, rapid, and robust reverse-phase (HPLC/UFLC) method for the simultaneous ...
Design and Molecular Insight into Plasticized HPMC Ocular Films for Sustained Acetazolamide Delivery in Glaucoma Management
Design and Molecular Insight into Plasticized HPMC Ocular Films for Sustained Acetazolamide Delivery in Glaucoma Management
Acetazolamide, a carbonic anhydrase inhibitor, reduces intraocular pressure and helps in the management of glaucoma. The p...
pH Responsive Polymeric Blend for Enhanced Solubility, Controlled Release, and Therapeutic Optimization of Rosuvastatin
pH Responsive Polymeric Blend for Enhanced Solubility, Controlled Release, and Therapeutic Optimization of Rosuvastatin
This study developed a novel pH-responsive polyelectrolyte complex hydrogel system for oral delivery of rosuvastatin, a wi...
A Combined Hydrophilic and Lipophilic Strategy for Systemic Delivery of Vitamin D3 Via the Skin: A Potential Alternative to Conventional Vitamin Supplementation Dosage Forms
A Combined Hydrophilic and Lipophilic Strategy for Systemic Delivery of Vitamin D3 Via the Skin: A Potential Alternative to Conventional Vitamin Supplementation Dosage Forms
Vitamin D3 deficiency is widespread globally, primarily due to low bioavailability from poor oral solubility and the scarc...
Development and Optimization of PEGylated Darolutamide-Loaded Liposomes for Treatment of Prostate Cancer: in Vitro and in-vivo Characterization
Development and Optimization of PEGylated Darolutamide-Loaded Liposomes for Treatment of Prostate Cancer: in Vitro and in-vivo Characterization
The present study aimed to develop a darolutamide (DRM) loaded PEGylated DRM liposomes (DRML) to improve pharmacokinetics ...
Antidiabetic Activity of L. Root Fractions in Streptozotocin-Induced Diabetic Rats and Activity-Guided Phytochemical Correlation
Antidiabetic Activity of L. Root Fractions in Streptozotocin-Induced Diabetic Rats and Activity-Guided Phytochemical Correlation
Several Asparagus species are traditionally used in the management of diabetes mellitus; however, the antidiabetic potenti...
Exploring the Wound Healing Efficacy of : Phytochemical Analysis, Network Pharmacology, Molecular Docking, and Molecular Dynamics Simulations
Exploring the Wound Healing Efficacy of : Phytochemical Analysis, Network Pharmacology, Molecular Docking, and Molecular Dynamics Simulations
Kyllinga nemoralis (K. nemoralis) has traditionally been employed for its therapeutic properties, particularly in wound he...
Comparative Analysis of Chitosan from Diverse Indian Fishery Wastes: Characterization and in Vitro Physicochemical and Biological Assessment for Pharmaceutical Uses
Comparative Analysis of Chitosan from Diverse Indian Fishery Wastes: Characterization and in Vitro Physicochemical and Biological Assessment for Pharmaceutical Uses
Efficient management of fishery waste is vital for sustainability and pollution control, particularly in India, the world&...
Next-Generation Mupirocin Hydrogel Dressings for Superior Antimicrobial Action
Next-Generation Mupirocin Hydrogel Dressings for Superior Antimicrobial Action
The study aimed to develop and optimize mupirocin-loaded hydrogel films for topical delivery, targeting improved swelling,...
Exploring Hybrid Nanoparticles for Crizotinib Delivery in Lung Cancer Treatment; Design, Optimization, In-vitro and Cell Line Evaluation
Exploring Hybrid Nanoparticles for Crizotinib Delivery in Lung Cancer Treatment; Design, Optimization, In-vitro and Cell Line Evaluation
The present study outlines the preparation of lipid polymer hybrid nano-system, designed to deliver Crizotinib (CRZ), aimi...
Calcium Butyrate-Integrated Bioadhesive Hydrogel: a Promising Therapeutic Platform for Inflammation Control and Wound Regeneration
Calcium Butyrate-Integrated Bioadhesive Hydrogel: a Promising Therapeutic Platform for Inflammation Control and Wound Regeneration
Butyric acid (a short-chain fatty acid) has anti-inflammatory and wound-healing potential but its direct use is limited by...
Investigation of the Efficacy of A pH-Responsive Ocular in Situ Gel of Posaconazole: In Vitro and Ex Vivo Insights
Investigation of the Efficacy of A pH-Responsive Ocular in Situ Gel of Posaconazole: In Vitro and Ex Vivo Insights
Posaconazole is widely utilized as a salvage therapy, for the treatment of ocular mucormycosis in the patients who are int...
Identification of Natural Product-Based Inhibitors for DENV NS2B/NS3 Protease and RNA-Dependent RNA Polymerase Through Molecular Modelling and Simulation
Identification of Natural Product-Based Inhibitors for DENV NS2B/NS3 Protease and RNA-Dependent RNA Polymerase Through Molecular Modelling and Simulation
Dengue virus (DENV), which belongs to the Flaviviridae family, remains a global health challenge due to its high morbidity...
Efficacy and Safety Evaluation of Ambroxol Hydrochloride in Older Patients with Pneumonia Complicated with Heart Failure
Efficacy and Safety Evaluation of Ambroxol Hydrochloride in Older Patients with Pneumonia Complicated with Heart Failure
Pneumonia poses a significant risk for triggering heart failure (HF), with a notably higher incidence among older patients...
Formulation Optimization and Evaluation of Metformin Hydrochloride Orally Disintegrating Tablets Using Spray Drying and D-Optimal Design of Experiments
Formulation Optimization and Evaluation of Metformin Hydrochloride Orally Disintegrating Tablets Using Spray Drying and D-Optimal Design of Experiments
Metformin hydrochloride (Met.HCl) is widely used for the management of type 2 diabetes mellitus (T2DM); however, conventio...
Advanced Strategic Nanocarriers Containing Posaconazole as an Antifungal Drug for the Treatment of Fungal infection, Targeting topical, Ocular, Vaginal, and Systemic Delivery
Advanced Strategic Nanocarriers Containing Posaconazole as an Antifungal Drug for the Treatment of Fungal infection, Targeting topical, Ocular, Vaginal, and Systemic Delivery
Fungal infections continue to represent a significant global health challenge, contributing to considerable morbidity and ...
Curcumin-loaded Niosomes Prepared by Microfluidic Mixing; Characterization and Cytotoxicity Evaluation
Curcumin-loaded Niosomes Prepared by Microfluidic Mixing; Characterization and Cytotoxicity Evaluation
Curcumin is a commonly used natural chemical compound that has several reported therapeutic applications. Derived from Cur...
A Novel Prednisolone-Loaded Layer-by-Layer Nanoparticles (LBL-NPs) for Rheumatoid Arthritis: Optimization and Therapeutic Evaluation
A Novel Prednisolone-Loaded Layer-by-Layer Nanoparticles (LBL-NPs) for Rheumatoid Arthritis: Optimization and Therapeutic Evaluation
Rheumatoid arthritis (RA) is a chronic autoimmune disease associated with bone erosion, inflammatory joint disease, and lo...
Formulation, In Vitro Characterization and Anti-Tuberculosis Investigation of Isoniazid NANOCAPSULES.
Formulation, In Vitro Characterization and Anti-Tuberculosis Investigation of Isoniazid NANOCAPSULES.
Tuberculosis (TB) is a major cause of mortality worldwide. The most commonly used first-line anti-TB drugs in the treatmen...
Development and Pharmacokinetic Evaluation of Binary Carrier-Based Solid Dispersion of Desidustat, a New Drug for Chronic Kidney Disease-Associated Anemia
Development and Pharmacokinetic Evaluation of Binary Carrier-Based Solid Dispersion of Desidustat, a New Drug for Chronic Kidney Disease-Associated Anemia
Desidustat is a new oral hypoxia-inducible factor prolyl hydroxylase inhibitor indicated for the management of chronic kid...
Phytochemical Composition and Bioactivities of (Briq.) Leaf Extracts: Antimicrobial and Antibiofilm Properties
Phytochemical Composition and Bioactivities of (Briq.) Leaf Extracts: Antimicrobial and Antibiofilm Properties
Many plants have been reported to exhibit both antimicrobial and anti-biofilm activities potentially serving as natural al...
Development of Bimatoprost-Loaded Nano Spanlastic In-Situ Gel for Ophthalmic Drug Delivery: A Box-Behnken Optimization Approach with In Vitro and Ex Vivo Characterization
Development of Bimatoprost-Loaded Nano Spanlastic In-Situ Gel for Ophthalmic Drug Delivery: A Box-Behnken Optimization Approach with In Vitro and Ex Vivo Characterization
The present study aimed to develop and optimize a Bimatoprost-loaded spanlastic in-situ gel to enhance precorneal retentio...
Protection of Mucous Membranes Against the Use of Biocides
Protection of Mucous Membranes Against the Use of Biocides
Biocides, in touch with the mucosa or skin, are capable of penetrating the mucosa or skin and causing possible local lesio...
Development and Evaluation of Benzydamine Hydrochloride-Loaded Pastilles for Local Delivery in the Oral Cavity
Development and Evaluation of Benzydamine Hydrochloride-Loaded Pastilles for Local Delivery in the Oral Cavity
Benzydamine hydrochloride (BZD) is a nonsteroidal anti-inflammatory drug commonly used for the relief of acute sore throat...
Formulation of Mixed Micelles of Various Model Drug Ionic Complexes in an Optimized Micellar Base Composed of Surfactants and Cosolvent Mixture: In Vitro Analysis of Drug Delivery Efficiency
Formulation of Mixed Micelles of Various Model Drug Ionic Complexes in an Optimized Micellar Base Composed of Surfactants and Cosolvent Mixture: In Vitro Analysis of Drug Delivery Efficiency
In this study, micellar complexes of various model drugs were developed and investigated for drug delivery efficiency. Pon...
An Integrated Computational and Experimental Framework for Investigating Flavonoid-driven Bioenhancement of Curcumin
An Integrated Computational and Experimental Framework for Investigating Flavonoid-driven Bioenhancement of Curcumin
Enhancing oral bioavailability remains a key focus in modern medicine. Among various bioenhancers, flavonoid polyphenols s...
Promising Alginate-Gelatin Scaffolds Containing 5-Fluorouracil and Reinforced with Zinc-Modified Hydroxyapatite: Cell Attachment and One-Year Stability Study
Promising Alginate-Gelatin Scaffolds Containing 5-Fluorouracil and Reinforced with Zinc-Modified Hydroxyapatite: Cell Attachment and One-Year Stability Study
The current study evaluated the cell attachment capability and long-term stability of 5-fluorouracil (5-FU) loaded alginat...
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