pH Responsive Polymeric Blend for Enhanced Solubility, Controlled Release, and Therapeutic Optimization of Rosuvastatin

Şahin B, İlgün G. Risk factors of deaths related to cardiovascular diseases in world health organization (WHO) member countries. Health Soc Care Community. 2022;30(1):73–80.

Article  PubMed  Google Scholar 

Zhao D. Epidemiological features of cardiovascular disease in Asia. JACC: Asia. 2021;1(1):1–13.

PubMed  PubMed Central  Google Scholar 

Watts GF, et al. Hypercholesterolemia and cardiovascular disease: focus on high cardiovascular risk patients. Atherosclerosis Supplements. 2020;42:e30–4.

Article  PubMed  Google Scholar 

Ferrara F, Vitiello A. The advantages of drug treatment with statins in patients with SARS-CoV-2 infection. Wien Klin Wochenschr. 2021;133(17):958–65.

Article  CAS  PubMed  PubMed Central  Google Scholar 

González R, et al. Design, development, and characterization of amorphous rosuvastatin calcium tablets. PLoS One. 2022;17(3):e0265263.

Article  PubMed  PubMed Central  Google Scholar 

Wei CR et al. Comparison of the efficacy of Atorvastatin with Rosuvastatin in preventing cardiovascular events among patients with cardiovascular disease: a meta-analysis. Cureus, 2023. 15(12).

Barrios V, Escobar C. Fixed-dose combination of rosuvastatin and ezetimibe: treating hypercholesteremia according to cardiovascular risk. Expert Rev Clin Pharmacol. 2021;14(7):793–806.

Article  CAS  PubMed  Google Scholar 

Najafi M, et al. Production of Rosuvastatin calcium nanoparticles using gas antisolvent technique: experimental and optimization. Periodica Polytech Chem Eng. 2021;65(4):442–53.

Article  CAS  Google Scholar 

Rahul K et al. Characterization and pharmacokinetic analysis of rosuvastatin calcium-2-hydroxypropyl-β-cyclodextrin inclusion complexes for enhanced oral bioavailability. Next Research, 2025: p. 100528.

Zhang J, et al. Dose study of Rosuvastatin calcium in the treatment of coronary heart disease and hyperlipidemia. Am J Translational Res. 2023;15(5):3403.

CAS  Google Scholar 

Ryu H, et al. Pharmacokinetic interactions between the Fixed-Dose combination of Ezetimibe/Rosuvastatin 10/20 Mg and the Fixed-Dose combination of Telmisartan/Amlodipine 80/5 Mg in healthy subjects. Development and Therapy: Drug Design; 2024. pp. 2641–52.

Google Scholar 

Jang J-H, Jeong S-H. Current status of development of oral formulations combining Omega-3 fatty acids and Statin ingredients and prospects for new formulations. J Pharm Innov. 2025;20(2):1–15.

Article  Google Scholar 

Strilchuk L, et al. An overview of rosuvastatin/ezetimibe association for the treatment of hypercholesterolemia and mixed dyslipidemia. Expert Opin Pharmacother. 2020;21(5):531–9.

Article  CAS  PubMed  Google Scholar 

Ye B, Xiang R, Luo F. Hydrogel-based drug delivery systems for diabetes bone defects. Chem Eng J. 2024. https://doi.org/10.1016/j.cej.2024.154436.

Article  Google Scholar 

Matricardi P, et al. Interpenetrating polymer networks polysaccharide hydrogels for drug delivery and tissue engineering. Adv Drug Deliv Rev. 2013;65(9):1172–87.

Article  CAS  PubMed  Google Scholar 

Thang NH, Chien TB, Cuong DX. Polymer-based hydrogels applied in drug delivery: an overview. Gels. 2023;9(7):523.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ding H, et al. Preparation and application of pH-responsive drug delivery systems. J Controlled Release. 2022;348:206–38.

Article  CAS  Google Scholar 

Liu B, Chen K. Advances in hydrogel-based drug delivery systems. Gels. 2024;10(4):262.

Article  PubMed  PubMed Central  Google Scholar 

Singh J, Nayak P. pH-responsive polymers for drug delivery: trends and opportunities. J Polym Sci. 2023;61(22):2828–50.

Article  CAS  Google Scholar 

Aranaz I, et al. Chitosan: an overview of its properties and applications. Polymers. 2021;13(19):3256.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hong F, et al. Chitosan-based hydrogels: from Preparation to applications, a review. Food Chemistry: X. 2024;21:101095.

CAS  PubMed  Google Scholar 

Saleem A, et al. Highly responsive chitosan-co-poly (MAA) nanomatrices through cross-linking polymerization for solubility improvement. Gels. 2022;8(3):196.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Sworn G. Xanthan gum. In: Handbook of hydrocolloids. Elsevier; 2021. p. 833–53.

Chapter  Google Scholar 

Furtado IF, et al. Xanthan gum: applications, challenges, and advantages of this asset of biotechnological origin. Biotechnol Res Innov J. 2022;6(1):0–0.

Google Scholar 

Mehrabi A, et al. Evaluation of inherent properties of the carboxymethyl cellulose (CMC) for potential application in tissue engineering focusing on bone regeneration. Polym Adv Technol. 2024;35(1):e6258.

Article  CAS  Google Scholar 

Mohammed M, et al. Comprehensive insights on mechanical attributes of natural-synthetic fibres in polymer composites. J Mater Res Technol. 2023;25:4960–88.

Article  CAS  Google Scholar 

Malik NS, et al. Chitosan/Xanthan gum based hydrogels as potential carrier for an antiviral drug: Fabrication, Characterization, and safety evaluation. Front Chem. 2020;8:50.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Khan S, et al. β-Cyclodextrin-based (IA-co-AMPS) semi-IPNs as smart biomaterials for oral delivery of hydrophilic drugs: synthesis, characterization, in-Vitro and in-Vivo evaluation. J Drug Deliv Sci Technol. 2020. https://doi.org/10.1016/j.jddst.2020.101970.

Article  Google Scholar 

Namazi NI, et al. Nanoparticles of thiolated xanthan gum for the oral delivery of miconazole nitrate: in vitro and in vivo evaluation. Pharmaceutics. 2024. https://doi.org/10.3390/pharmaceutics16020225.

Article  PubMed  PubMed Central  Google Scholar 

Badshah SF, et al. Structural and in-vitro characterization of highly swellable β-cyclodextrin polymeric nanogels fabricated by free radical polymerization for solubility enhancement of Rosuvastatin. Part Sci Technol. 2023;41(8):1131–45.

Article  CAS  Google Scholar 

Sarfraz RM, et al. Development and evaluation of Rosuvastatin calcium based microparticles for solubility enhancement: an in vitro study. Adv Polym Technol. 2017;36(4):433–41.

Article  CAS  Google Scholar 

Patel J, Maiti S, Moorthy NHN. Repaglinide-laden hydrogel particles of Xanthan gum derivatives for the management of diabetes. Carbohydr Polym. 2022;287:119354.

Article  CAS  PubMed  Google Scholar 

Asad MI, et al. Development and in vitro/in vivo evaluation of pH-sensitive polymeric nanoparticles loaded hydrogel for the management of psoriasis. Nanomaterials. 2021;11(12):3433.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Richbourg N, et al. Precise control of synthetic hydrogel network structure via linear, independent synthesis-swelling relationships. Sci Adv. 2021;7(7):eabe3245.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Khan MUA, et al. Antibacterial and hemocompatible pH-responsive hydrogel for skin wound healing application: in vitro drug release. Polymers. 2021;13(21):3703.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Weng J, Tong HH, Chow SF. Vitro release study of the polymeric drug nanoparticles: development and validation of a novel method. Pharmaceutics. 2020;12(8):732.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Magalhães S, Goodfellow BJ, Nunes A. FTIR spectroscopy in biomedical research: how to get the most out of its potential. Appl Spectrosc Rev. 2021;56(8–10):869–907.

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