Development and Evaluation of Benzydamine Hydrochloride-Loaded Pastilles for Local Delivery in the Oral Cavity

Gunnarsson RK, Ebell M, Centor R, Little P, Verheij T, Lindbæk M, Sundvall PD. Best management of patients with an acute sore throat - a critical analysis of current evidence and a consensus of experts from different countries and traditions. Infect Dis. 2023;55(6):384–95. https://doi.org/10.1080/23744235.2023.2191714.

Article  Google Scholar 

Catic T, Kapo B, Pintol Z, Skopljak A, Cengic A, Gojak R, Gazibera B, Zelihic V, Becirovic M, Setic-Avdagic I, Jankovic SM. An instrument for rating quality of life related to sore throat in [atients suffering from acute pharyngitis or tonsillitis. Mater Sociomed. 2018;30(1):43–8. https://doi.org/10.5455/msm.2018.30.43-48.

Article  PubMed  PubMed Central  Google Scholar 

Snow V, Mottur-Pilson C, Cooper RJ, Hoffman JR. Principles of appropriate antibiotic use for acute pharyngitis in adults. Ann Intern Med. 2001;134(6):506–8. https://doi.org/10.7326/0003-4819-134-6-200103200-00018.

Article  CAS  PubMed  Google Scholar 

Kurbanoglu S, Uslu B, Ozkan SA. Carbon-based nanostructures for electrochemical analysis of oral medicines. In: Andronescu E, Grumezescu AM, editors. Nanostructures for oral medicine. Amsterdam: Elsevier; 2017. pp. 885–938.

Google Scholar 

Passali D, Arezzo MF, De Rose A, De Simone G, Forte G, Jablko-Musial M, Mösges R. Benzydamine hydrochloride for the treatment of sore throat and irritative/inflammatory conditions of the oropharynx: a cross-national survey among pharmacists and general practitioners. BMC Prim Care. 2022;23(1):154. https://doi.org/10.1186/s12875-022-01762-3.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Dudzik A, Sozkes S, Michalak E, Olszewska-Czyz I. Efficacy of a zinc lactate mouthwash and tongue scraping in the reduction of intra-oral halitosis: A single-blind, controlled, crossover clinical trial-A pilot study. J Clin Med. 2021;10(23):5532. https://doi.org/10.3390/jcm10235532.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Barkin RL. Topical nonsteroidal anti-inflammatory drugs: the importance of drug, delivery, and therapeutic outcome. Am J Ther. 2015;22(5):388–407. https://doi.org/10.1097/MJT.0b013e3182459abd.

Article  PubMed  Google Scholar 

Ardizzoni A, Boaretto G, Pericolini E, Pinetti D, Capezzone de Joannon A, Durando L, Ragni L, Blasi E. Effects of benzydamine and mouthwashes containing benzydamine on Candida albicans adhesion, biofilm formation, regrowth, and persistence. Clin Oral Investig. 2022;26(4):3613–25. https://doi.org/10.1007/s00784-021-04330-8.

Article  PubMed  PubMed Central  Google Scholar 

Valerio C, Di Loreto G, Salvatori E, Cattaneo A. Comparative evaluation of rapidity of action of benzydamine hydrochloride 0.3% oromucosal spray and benzydamine hydrochloride 3 mg lozenges in patients with acute sore throat: A phase IV randomized trial. Med (Baltim). 2023;102(13):e33367. https://doi.org/10.1097/MD.0000000000033367.

Article  CAS  Google Scholar 

Mastropietro D, Park K, Omidian H. 4.23 Polymers in oral drug delivery. In: Ducheyne P, editor. Comprehensive biomaterials II. Amsterdam: Elsevier; 2017. pp. 430–44.

Google Scholar 

Silva FC, Marto JM, Salgado A, Machado P, Silva AN, Almeida AJ. Nystatin and Lidocaine pastilles for the local treatment of oral mucositis. Pharm Dev Technol. 2017;22(2):266–74. https://doi.org/10.1080/10837450.2016.1221424.

Article  CAS  PubMed  Google Scholar 

Choursiya S, Indurkhya A. Development and evaluation of hard candy lozenges containing roxithromycin for treatment of oral infection. Asian J Pharm Ana. 2020;10(3):150–4. https://doi.org/10.5958/2231-5675.2020.00027.7.

Article  Google Scholar 

Vojvodić Cebin A, Bunić M, Mandura Jarić A, Šeremet D, Komes D. Physicochemical and sensory stability evaluation of gummy candies fortified with mountain Germander extract and prebiotics. Polymers. 2024;17(2):259. https://doi.org/10.3390/polym16020259.

Article  CAS  Google Scholar 

Milenkova S, Pilicheva B, Uzunova Y, Yovcheva T, Marudova M. Casein microgels as benzydamine hydrochloride carriers for prolonged release. Materials. 2022;15(4):1333. https://doi.org/10.3390/ma15041333.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wee MSM, Goh AT, Stieger M, Forde CG. Correlation of instrumental texture properties from textural profile analysis (TPA) with eating behaviours and macronutrient composition for a wide range of solid foods. Food Funct. 2018;9(10):5301–12. https://doi.org/10.1039/c8fo00791h.

Article  CAS  PubMed  Google Scholar 

Datri S, Rao L, Narayana MC, Bhavani D, Bhargavi, Bhavani YP. Meghana. Formulation and evaluation of herbal lozenges using Embelia Ribes. J Drug Alcohol Res. 2023;12:236229. https://doi.org/10.4303/JDAR/236229.

Article  Google Scholar 

Sharma D, Singh R, Garg R. Development and validation of stability indicating UV spectrophotometric method for the Estimation of benzydamine hydrochloride in bulk and in pharmaceutical dosage form: A novel analytical technique for conducting in-vitro quality control tests. Int J Pharm Sci Res. 2018;92;678–86. https://doi.org/10.13040/IJPSR.0975-8232.9(2).678-86.

Association of Southeast Asian Nations (ASEAN). ASEAN Guideline on stability study of drug product (R1). 2018. https://asean.org/wp-content/uploads/2018/01/25PPWG-ANNEX-7-iv-Final-ASEAN-Guideline-on-Stability-Study-Drug-Product-R2.pdf. Accessed 11 Mar 2025.

Chuensun T, Intipunya P. Optimization of gelatin gummy properties influenced by black Garlic vinegar and honey using D-optimal mixture design. Nat Life Sci Commun. 2025;24(1):e2025005. https://doi.org/10.12982/NLSC.2025.005.

Article  Google Scholar 

Kangsanant S, Rakkaew S, Kummara S. The study of gelling agent and sweeteners in jelly gummy from toddy palm sugar. Recent Sci Technol. 2023;15(1):236–47. https://li01.tci-thaijo.org/index.php/rmutsvrj/article/view/250112.

Google Scholar 

Hong HJ, Yang Q, Liu Q, Leong F, Chen XJ. Chemical comparison of monk fruit products processed by different drying methods using high-performance thin-layer chromatography combined with chemometric analysis. Front Nutr. 2022;9:887992. https://doi.org/10.3389/fnut.2022.887992.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Juvonen H, Antikainen O, Lemmens M, Ehlers H, Juppo A. The effect of relative humidity and formulation variables on chewable xylitol-sorbitol tablets. Int J Pharm. 2021;601:120573. https://doi.org/10.1016/j.ijpharm.2021.120573.

Article  CAS  PubMed  Google Scholar 

United States Pharmacopeia. (USP 43–NF 38). <1216 > Tablet friability. Rockville (MD): United States Pharmacopeial Convention; 2020.

Google Scholar 

Osei-Yeboah F, Sun CC. Validation and applications of an expedited tablet friability method. Int J Pharm. 2015;484(1–2). https://doi.org/10.1016/j.ijpharm.2015.02.061. 146– 55.

Samia MO, Fathy IA, Noha MA. Effect of mannitol on physical characters of lyophilized fast-disintegrating tablets. J Adv Pharm Res. 2017;1(4):228–33. https://doi.org/10.21608/aprh.2017.4044.

Article  Google Scholar 

VW-Ingredients. Luo Han Guo (Monk Fruit) Product Description. 2025. https://vw-ingredients.com/product/luo-han-guo Accessed 10 Apr 2025.

May SMW, Ai TG, Markus S, Ciarán GF. Correlation of instrumental texture properties from textural profile analysis (TPA) with eating behaviours and macronutrient composition for a wide range of solid foods. Food Function. 2018;10:1–21. https://doi.org/10.1039/C8FO00791H.

Article  Google Scholar 

Pronina Y, Belozertseva O, Nabiyeva Z, Pirozzi A, Carpentieri S, Ferrari G, Bazylkhanova E, Burlyayeva A. Enhancing nutritional value and health benefits of gluten-free confectionery products: innovative pastilles and marshmallows. Front Nutr. 2024;1321004. https://doi.org/10.3389/fnut.2023.1321004.,12;10.

Ganesh DK, Abhishek RR, Avinash S, Suresh B. Texture profile analysis: a comprehensive insight into food texture evaluation. J Dyn Control. 2024;8(9):30–45. https://doi.org/10.71058/jodac.v8i9003.

Article  Google Scholar 

Grembecka M. Sugar alcohols-their role in the modern world of sweeteners: a review. Eur Food Res Technol. 2015;241:1–14. https://doi.org/10.1007/s00217-015-2437-7.

Article  CAS  Google Scholar 

Mazi TA, Stanhope KL, Erythritol. An in-depth discussion of its potential to be a beneficial dietary component. Nutrients. 2023;15(1):204. https://doi.org/10.3390/nu15010204.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Sievenpiper JL, Purkayastha S, Grotz VL, Mora M, Zhou J, Hennings K, Goody CM, Germana K. Dietary guidance, sensory, health and safety considerations when choosing low and no-calorie sweeteners. Nutrients. 2025;17(5):793. https://doi.org/10.3390/nu17050793.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Mehravaran M, Haeri A, Rabbani S, Mortazavi SA, Torshabi M. Preparation and characterization of benzydamine hydrochloride-loaded lyophilized mucoadhesive wafers for the treatment of oral mucositis. J Drug Deliv Sci Technol. 2022;78:103944. https://doi.org/10.1016/j.jddst.2022.103944.

Article  CAS  Google Scholar 

Treesuppharat W, Rojanapanthu P, Siangsanoh C, Manuspiya H, Ummartyotin S. Synthesis and characterization of bacterial cellulose and gelatin-based hydrogel composites for drug-delivery systems. Biotechnol Rep. 2017;15:84–91. https://doi.org/10.1016/j.btre.2017.07.002.

Article  CAS  Google Scholar 

Fu X, Zhong L, Cao Y, Chen H, Lu F. Quantitative analysis of excipient dominated drug formulations by Raman spectroscopy combined with deep learning. Anal Methods. 2021;13:64–8. https://doi.org/10.1039/D0AY01874K.

Article 

Comments (0)

No login
gif