Investigation of the Efficacy of A pH-Responsive Ocular in Situ Gel of Posaconazole: In Vitro and Ex Vivo Insights

Abdulkader R, Ponnaiah M, Bhatnagar T, Rozario A, Mohan M, Saravanakumar D, Moorthy A, Tyagi A. Baseline findings of a multicentric ambispective cohort study (2021–2022) among hospitalised mucormycosis patients in India. Mycology. 2024;15(1):70–84. https://doi.org/10.1080/21501203.2023.2271928.

Article  PubMed  PubMed Central  Google Scholar 

Bupha-Intr O, Butters C, Reynolds G, Kennedy K, Meyer W, Patil S. Consensus guidelines for the diagnosis and management of invasive fungal disease due to moulds other than Aspergillus in the haematology/oncology setting. Intern Med J. 2021;51(7):177–219. https://doi.org/10.1111/imj.15592.

Article  PubMed  Google Scholar 

Prakash H, Chakrabarti A. Global epidemiology of mucormycosis. J Fungi. 2019;5(1):26. https://doi.org/10.3390/jof5010026.

Article  CAS  Google Scholar 

Pham D, Howard-Jones AR, Sparks R, Stefani M, Sivalingam V, Halliday CL, et al. Epidemiology, modern diagnostics, and the management of Mucorales infections. J Fungi. 2023;9(6):659. https://doi.org/10.3390/jof9060659.

Article  CAS  Google Scholar 

Sipsas NV, Gamaletsou MN, Anastasopoulou A, Kontoyiannis DP. Therapy of mucormycosis. J Fungi. 2018;4(3):90. https://doi.org/10.3390/jof4030090.

Article  CAS  Google Scholar 

Groll AH, Walsh TJ. Posaconazole: clinical pharmacology and potential for management of fungal infections. Expert Rev Anti-Infect Ther. 2005;3(4):467–87. https://doi.org/10.1586/14787210.3.4.467.

Article  PubMed  CAS  Google Scholar 

Kasif M, Gupta R, Singh PP, Bhardwaj P, Goyal R, Bansal KK, et al. Development of biocompatible lipid-polymer hybrid nanoparticles for enhanced oral absorption of posaconazole: a mechanistic in vitro and in silico assessment. J Drug Deliv Sci Technol. 2024;101:106109. https://doi.org/10.1016/j.jddst.2024.106109.

Article  CAS  Google Scholar 

Torres HA, Hachem RY, Chemaly RF, Kontoyiannis DP, Raad II. Posaconazole: a broad-spectrum triazole antifungal. Lancet Infect Dis. 2005;5(12):775–85. https://doi.org/10.1016/S1473-3099(05)70297-8.

Article  PubMed  CAS  Google Scholar 

Kolawole OM, Cook MT. In situ gelling drug delivery systems for topical drug delivery. Eur J Pharm Biopharm. 2023;184:36–49. https://doi.org/10.1016/j.ejpb.2023.01.007.

Article  PubMed  CAS  Google Scholar 

Al-Kinani AA, Zidan G, Elsaid N, Seyfoddin A, Alani AWG, Alany RG. Ophthalmic gels: past, present and future. Adv Drug Deliv Rev. 2018;126:113–26. https://doi.org/10.1016/j.addr.2017.12.017.

Article  PubMed  CAS  Google Scholar 

Nagappan V, Deresinski S. Reviews of anti-infective agents: posaconazole: a broad-spectrum triazole antifungal agent. Clin Infect Dis. 2007;45(12):1610–7. https://doi.org/10.1086/523576.

Article  PubMed  CAS  Google Scholar 

Gopalakrishna PK, Jayaramu RA, Boregowda SS, Eshwar S, Suresh NV, Abu Lila AS. Piperine-loaded in situ gel: formulation, in vitro characterization, and clinical evaluation against periodontitis. Gels. 2023;9(7):577. https://doi.org/10.3390/gels9070577.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Ahmed B, Jaiswal S, Naryal S, Shah RM, Alany RG, Kaur IP. In situ gelling systems for ocular drug delivery. J Control Release. 2024;371:67–84. https://doi.org/10.1016/j.jconrel.2024.05.031.

Article  PubMed  CAS  Google Scholar 

Jumelle C, Gholizadeh S, Annabi N, Dana R. Advances and limitations of drug delivery systems formulated as eye drops. J Control Release. 2020;321:1–22. https://doi.org/10.1016/j.jconrel.2020.01.057.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Gohil DD. Large ring cyclodextrin and cosolvency-based techniques to improve solubility of antifungal drug. Asian J Pharm. 2023;17(3). https://doi.org/10.22377/ajp.v17i03.4987.

Volkova TV, Simonova OR, Perlovich GL. New antifungal compound: impact of cosolvency, micellization and complexation on solubility and permeability processes. Pharmaceutics. 2021;13(11):1865. https://doi.org/10.3390/pharmaceutics13111865.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Osouli M, Abdollahizad E, Alavi S, Mahboubi A, Abbasian Z, Haeri A. Biocompatible phospholipid-based mixed micelles for posaconazole ocular delivery: development, characterization, and in - vitro antifungal activity. J Biomater Appl. 2022;37(6):969–78. https://doi.org/10.1177/08853282221141962.

Article  PubMed  CAS  Google Scholar 

Deshkar S, Madankar S, Shinde A, et al. Posaconazole loaded lipid polymer hybrid nanoparticles: design and development for vaginal drug delivery. J Pharm Innov. 2025;20:4. https://doi.org/10.1007/s12247-024-09898-8.

Article  Google Scholar 

Ahirrao SP, Bhambere DS, Agiwale B, Algat S, Zoman D, Chaudhari V. pH sensitive in-situ gel for ophthalmic delivery of Ofloxacin and dexamethasone sodium phosphate: formulation, development, and evaluation. Mater Today Proc. 2023. https://doi.org/10.1016/j.matpr.2023.07.161.

Article  Google Scholar 

Asif A, Desu P, Alavala R, Rao G, Sreeharsha N, Meravanige G. Development, statistical optimization and characterization of fluvastatin loaded solid lipid nanoparticles: a 32 factorial design approach. Pharmaceutics. 2022;14(3):584. https://doi.org/10.3390/pharmaceutics14030584.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Mishra SK, Kumar R, Patil PR, Gupta R, Mahor A, Bhardwaj P. Preparation and characterization of transdermal therapeutic system containing simvastatin: a statistical study. Indian J Pharm Educ Res. 2022;56:112–20. https://doi.org/10.5530/ijper.56.1.14.

Article  CAS  Google Scholar 

Honmane SM, Chimane SM, Bandgar SA, Patil SS. Development and optimization of capecitabine loaded nanoliposomal system for cancer delivery. Indian J Pharm Educ Res. 2020;54(2):376–84. https://doi.org/10.5530/ijper.54.2.43.

Article  CAS  Google Scholar 

Makwana SB, Patel VA, Parmar SJ. Development and characterization of in-situ gel for ophthalmic formulation containing ciprofloxacin hydrochloride. Results Pharma Sci. 2015;6:1–6. https://doi.org/10.1016/j.rinphs.2015.06.001.

Article  PubMed  PubMed Central  Google Scholar 

Liu Y, Chen X, Chen X, et al. Preparation and in vivo and ex vivo studies of sirolimus nano-in-situ gel ophthalmic formulation. J Nanobiotechnol. 2024;22:417. https://doi.org/10.1186/s12951-024-02668-1.

Article  CAS  Google Scholar 

Dasankoppa F, Kujur S, Ahmed Sholapur HN, Jamakandi V. Design, formulation and evaluation of carboxy methyl tamarind based in situ gelling ophthalmic drug delivery system of dorzolamide hydrochloride. Indian J Health Sci Biomedical Res (KLEU). 2016;9(1):56. https://doi.org/10.4103/2349-5006.183688.

Article  Google Scholar 

Durgun ME, Mesut B, Hacıoğlu M, Güngör S, Özsoy Y. Optimization of the micellar-based in situ gelling systems posaconazole with quality by design (QbD) approach and characterization by. Vitro Stud Pharm. 2022;14(3):526. https://doi.org/10.3390/pharmaceutics14030526.

Article  CAS  Google Scholar 

Vigani B, Rossi S, Sandri G, Bonferoni MC, Caramella CM, Ferrari F. Recent advances in the development of in situ gelling drug delivery systems for non-parenteral administration routes. Pharmaceutics. 2020;12(9):859. https://doi.org/10.3390/pharmaceutics12090859.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Galgatte UC, Kumbhar AB, Chaudhari PD. Development of in situ gel for nasal delivery: design, optimization, in vitro and in vivo evaluation. Drug Deliv. 2013;21(1):62–73. https://doi.org/10.3109/10717544.2013.849778.

Article  PubMed  CAS  Google Scholar 

Nair AB, Shah J, Jacob S, Al-Dhubiab BE, Sreeharsha N, Morsy MA, et al. Experimental design, formulation and in vivo evaluation of a novel topical in situ gel system to treat ocular infections. PLoS One. 2021;16(3):e0248857. https://doi.org/10.1371/journal.pone.0248857.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Gupta NV, Shivakumar HG. Investigation of swelling behavior and mechanical properties of a pH-sensitive superporous hydrogel composite. Iran J Pharm Res. 2012;11(2):481–93.

Comments (0)

No login
gif