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Repurposing atorvastatin for uterine leiomyosarcoma: mevalonate pathway inhibition yields preclinical antitumor efficacy
Repurposing atorvastatin for uterine leiomyosarcoma: mevalonate pathway inhibition yields preclinical antitumor efficacy
Uterine leiomyosarcoma (ULMS) is a rare yet aggressive uterine malignancy with high recurrence and poor survival, promptin...
Epigenetic plasticity in cancer drug resistance: mechanistic insights and strategies for therapeutic intervention
Epigenetic plasticity in cancer drug resistance: mechanistic insights and strategies for therapeutic intervention
Therapy resistance remains a central barrier to durable clinical benefit across cancer types, limiting the long-term effic...
S1UTRSP5, a short restructured RNA from SLIT1 3′UTR, mitigates mouse cardiac remodeling via enhancing SlRT1 activity
S1UTRSP5, a short restructured RNA from SLIT1 3′UTR, mitigates mouse cardiac remodeling via enhancing SlRT1 activity
The 3′ untranslated regions (3′UTRs) have been known to regulate mRNA location, stability, and translation. 3&...
METTL3 loss exacerbates colitis via m6A-dependent Slc39a8 regulation and epithelial lineage depletion
METTL3 loss exacerbates colitis via m6A-dependent Slc39a8 regulation and epithelial lineage depletion
The intestinal epithelium maintains host-microbiota homeostasis, while inflammatory conditions, such as inflammatory bowel...
Serum/glucocorticoid-regulated kinase 1 regulates vascular inflammation in atherosclerosis
Serum/glucocorticoid-regulated kinase 1 regulates vascular inflammation in atherosclerosis
Endothelial and macrophage inflammation and sterol transport play an important role in atherogenesis. Serum/glucocorticoid...
Paclitaxel prodrug loaded high-density lipoprotein nanoparticles for chemoimmunotherapy of triple-negative breast cancer
Paclitaxel prodrug loaded high-density lipoprotein nanoparticles for chemoimmunotherapy of triple-negative breast cancer
Insufficient tumor-specific immunogenicity and cytotoxic T lymphocytes infiltration limit the therapeutic efficacy of comb...
Sevoflurane-induced disruption of critical period Arc signaling drives aberrant microglial synaptic pruning and cognitive deficits
Sevoflurane-induced disruption of critical period Arc signaling drives aberrant microglial synaptic pruning and cognitive deficits
Early-life sevoflurane exposure is associated with long-term cognitive deficits. Given that hippocampal development relies...
Amyloid-beta fibrils as active contributors to synaptic dysfunction in Alzheimer’s disease
Amyloid-beta fibrils as active contributors to synaptic dysfunction in Alzheimer’s disease
Alzheimer’s disease (AD) is a neurodegenerative disorder that is characterized by the accumulation of amyloid-beta (...
Targeting the interactions between neutrophils and microglia: a novel strategy for anti-inflammatory treatment of stroke
Targeting the interactions between neutrophils and microglia: a novel strategy for anti-inflammatory treatment of stroke
Stroke is the second leading cause of mortality and the leading cause of adult disability worldwide. Neuroinflammation is ...
Retraction Note: Physcion inhibits the metastatic potential of human colorectal cancer SW620 cells in vitro by suppressing the transcription factor SOX2
Cite this articleHan, Yt., Chen, Xh., Gao, H. et al. Retraction Note: Physcion inhibits the metastatic potential of human ...
Nobiletin and polydatin synergistically alleviate triple-negative breast cancer liver metastasis via suppressing ECM1a-mediated fatty acid biosynthesis
Nobiletin and polydatin synergistically alleviate triple-negative breast cancer liver metastasis via suppressing ECM1a-mediated fatty acid biosynthesis
Breast cancer liver metastasis (BCLM) is characterized by high incidence and poor prognosis, lacking effective therapeutic...
Lung memory B cells ameliorate Alzheimer’s disease-like pathology in 5×FAD mice through the CXCL12-CXCR4 axis
Lung memory B cells ameliorate Alzheimer’s disease-like pathology in 5×FAD mice through the CXCL12-CXCR4 axis
Although most AD-related pathological studies are limited to the brain, increasing evidence has demonstrated the contribut...
Zinc pyrithione functions as a small-molecule STING agonist to exert antitumor immunotherapy effects
Zinc pyrithione functions as a small-molecule STING agonist to exert antitumor immunotherapy effects
The stimulator of interferon genes (STING) is a crucial pattern recognition receptor that activates innate immunity, parti...
Author Correction: The novel sophoridine derivate IMB-HDC induced lessened phosphorylation of STAT5a at 694 and 780 and promoted DNA breakage and cell apoptosis via blocking STAT5a nuclear translocation
Author Correction: The novel sophoridine derivate IMB-HDC induced lessened phosphorylation of STAT5a at 694 and 780 and promoted DNA breakage and cell apoptosis via blocking STAT5a nuclear translocation
Author notesThese authors contributed equally: Wu-li Zhao, Yan XingAuthors and AffiliationsKey Laboratory of Antibiotic Bi...
MMP-9 inhibitor SB-3CT improves neurological outcomes in ischemic stroke mice by modulation of astrocytic lipid metabolism
MMP-9 inhibitor SB-3CT improves neurological outcomes in ischemic stroke mice by modulation of astrocytic lipid metabolism
The acute phase of ischemic stroke is marked by a surge in matrix metalloproteinase-9 (MMP-9) activity. While integral to ...
CYP2A6 suppresses hepatocellular carcinoma via inhibiting SRC/Wnt/β-Catenin pathway
CYP2A6 suppresses hepatocellular carcinoma via inhibiting SRC/Wnt/β-Catenin pathway
Patients with hepatocellular carcinoma (HCC) at advanced stages face limited treatment options, highlighting the urgent ne...
Epigenetic regulation of iron metabolism and ferroptosis in Parkinson’s disease: Identifying novel epigenetic targets
Epigenetic regulation of iron metabolism and ferroptosis in Parkinson’s disease: Identifying novel epigenetic targets
Parkinson’s disease (PD) is a neurodegenerative disease, and emerging evidence has shown that iron deposition, ferro...
An efficient deep learning-based strategy to screen inhibitors for GluN1/GluN3A receptor
An efficient deep learning-based strategy to screen inhibitors for GluN1/GluN3A receptor
The GluN1/GluN3A receptor, a unique excitatory glycine receptor recently identified in the central nervous system, challen...
Oral FPR2/ALX modulators tune myeloid cell activity to ameliorate mucosal inflammation in inflammatory bowel disease
Oral FPR2/ALX modulators tune myeloid cell activity to ameliorate mucosal inflammation in inflammatory bowel disease
Current treatments of inflammatory bowel disease (IBD) largely depend on anti-inflammatory and immunosuppressive strategie...
Aberrant neuronal excitation promotes neuroinflammation in the primary motor cortex of ischemic stroke mice
Aberrant neuronal excitation promotes neuroinflammation in the primary motor cortex of ischemic stroke mice
Current treatments for ischemic stroke aim to achieve rapid reperfusion with intravenous thrombolysis and/or endovascular ...
p-Coumaric acid alleviates neuronal damage in ischemic stroke mice by promoting BACH1 nuclear export and degradation
p-Coumaric acid alleviates neuronal damage in ischemic stroke mice by promoting BACH1 nuclear export and degradation
Oxidative damage induced by glutamate triggers neuronal death in cerebral ischemic/reperfusion injury. BTB and CNC homolog...
Lonicerin promotes wound healing in diabetic rats by enhancing blood vessel regeneration through Sirt1-mediated autophagy
Lonicerin promotes wound healing in diabetic rats by enhancing blood vessel regeneration through Sirt1-mediated autophagy
Among the numerous complications of diabetes mellitus, diabetic wounds seriously affect patients’ quality of life an...
E3 ubiquitin ligase NEDD4L inhibits epithelial-mesenchymal transition by suppressing the β-catenin/HIF-1α positive feedback loop in chronic rhinosinusitis with nasal polyps
E3 ubiquitin ligase NEDD4L inhibits epithelial-mesenchymal transition by suppressing the β-catenin/HIF-1α positive feedback loop in chronic rhinosinusitis with nasal polyps
Chronic rhinosinusitis with nasal polyp (CRSwNP) is a refractory inflammatory disease with epithelial-mesenchymal transiti...
SMAD4 endows TGF-β1-induced highly invasive tumor cells with ferroptosis vulnerability in pancreatic cancer
SMAD4 endows TGF-β1-induced highly invasive tumor cells with ferroptosis vulnerability in pancreatic cancer
Pancreatic ductal adenocarcinoma (PDAC) is an extremely aggressive malignancy prone to recurrence and metastasis. Studies ...
From bench to bedside: current development and emerging trend of KRAS-targeted therapy
From bench to bedside: current development and emerging trend of KRAS-targeted therapy
Kirsten rat sarcoma 2 viral oncogene homolog (KRAS) is the most frequently mutated oncogene in human cancers with mutation...
A novel human single-domain antibody-drug conjugate targeting CEACAM5 exhibits potent in vitro and in vivo antitumor activity
A novel human single-domain antibody-drug conjugate targeting CEACAM5 exhibits potent in vitro and in vivo antitumor activity
Leveraging the specificity of antibody to deliver cytotoxic agent into tumor, antibody-drug conjugates (ADCs) have become ...
Colon-targeted S100A8/A9-specific peptide systems ameliorate colitis and colitis-associated colorectal cancer in mouse models
Colon-targeted S100A8/A9-specific peptide systems ameliorate colitis and colitis-associated colorectal cancer in mouse models
The link between chronic inflammation and cancer development is well acknowledged. Inflammatory bowel disease including ul...
Author Correction: DCZ5248, a novel dual inhibitor of Hsp90 and autophagy, exerts antitumor activity against colon cancer
Author Correction: DCZ5248, a novel dual inhibitor of Hsp90 and autophagy, exerts antitumor activity against colon cancer
Authors and AffiliationsShanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, ChinaXiang-li...
Amuc_1100 pretreatment alleviates acute pancreatitis in a mouse model through regulating gut microbiota and inhibiting inflammatory infiltration
Amuc_1100 pretreatment alleviates acute pancreatitis in a mouse model through regulating gut microbiota and inhibiting inflammatory infiltration
Amuc_1100 is a membrane protein from Akkermansia muciniphila, which has been found to play a role in host immunological ho...
Schisandrin B, a dual positive allosteric modulator of GABAA and glycine receptors, alleviates seizures in multiple mouse models
Schisandrin B, a dual positive allosteric modulator of GABAA and glycine receptors, alleviates seizures in multiple mouse models
Epilepsy is a prevalent and severe neurological disorder and approximately 30% of patients are resistant to existing medic...
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