Chang JT. Pathophysiology of inflammatory bowel diseases. N Engl J Med. 2020;383:2652–64.
Article PubMed CAS Google Scholar
Kaplan GG, Windsor JW. The four epidemiological stages in the global evolution of inflammatory bowel disease. Nat Rev Gastroenterol Hepatol. 2021;18:56–66.
Kaplan GG. The global burden of IBD: from 2015 to 2025. Nat Rev Gastroenterol Hepatol. 2015;12:720–7.
Mayberry J. The history of 5-ASA compounds and their use in ulcerative colitis-trailblazing discoveries in gastroenterology. J Gastrointestin Liver Dis. 2013;22:375–7.
Chan HC, Ng SC. Emerging biologics in inflammatory bowel disease. J Gastroenterol. 2017;52:141–50.
Article PubMed CAS Google Scholar
Ho GT, Cartwright JA, Thompson EJ, Bain CC, Rossi AG. Resolution of inflammation and gut repair in IBD: translational steps towards complete mucosal healing. Inflamm Bowel Dis. 2020;26:1131–43.
Article PubMed PubMed Central Google Scholar
Colombel JF, Panaccione R, Bossuyt P, Lukas M, Baert F, Vaňásek T, et al. Effect of tight control management on Crohn’s disease (CALM): a multicentre, randomised, controlled phase 3 trial. Lancet. 2017;390:2779–89.
Amiot A, Peyrin-Biroulet L. Current, new and future biological agents on the horizon for the treatment of inflammatory bowel diseases. Therap Adv Gastroenterol. 2015;8:66–82.
Article PubMed PubMed Central Google Scholar
Li J, Liu Z, Hu P, Wen Z, Cao Q, Zou X, et al. Indicators of suboptimal response to anti-tumor necrosis factor therapy in patients from China with inflammatory bowel disease: results from the EXPLORE study. BMC Gastroenterol. 2022;22:44.
Article PubMed PubMed Central CAS Google Scholar
Panigrahy D, Gilligan MM, Serhan CN, Kashfi K. Resolution of inflammation: An organizing principle in biology and medicine. Pharmacol Ther. 2021;227:107879.
Article PubMed CAS Google Scholar
Serhan CN. Pro-resolving lipid mediators are leads for resolution physiology. Nature. 2014;510:92–101.
Article PubMed PubMed Central CAS Google Scholar
Perretti M, Leroy X, Bland EJ, Montero-Melendez T. Resolution pharmacology: opportunities for therapeutic innovation in inflammation. Trends Pharmacol Sci. 2015;36:737–55.
Article PubMed CAS Google Scholar
Perretti M, Godson C. Formyl peptide receptor type 2 agonists to kick-start resolution pharmacology. Br J Pharmacol. 2020;177:4595–600.
Article PubMed PubMed Central CAS Google Scholar
Doyle R, Godson C, editors. Chapter 5 - Endogenous antiinflammatory and proresolving lipid mediators in renal disease. United States: Academic Press; 2022. p 55–67.
Zhang H, Lu Y, Sun G, Teng F, Luo N, Jiang J, et al. The common promoter polymorphism rs11666254 downregulates FPR2/ALX expression and increases risk of sepsis in patients with severe trauma. Crit Care. 2017;21:171.
Article PubMed PubMed Central Google Scholar
Rogler G. Resolution of inflammation in inflammatory bowel disease. Lancet Gastroenterol Hepatol. 2017;2:521–30.
Brennan EP, Cacace A, Godson C. Specialized pro-resolving mediators in renal fibrosis. Mol Aspects Med. 2017;58:102–13.
Article PubMed CAS Google Scholar
Crocetti L, Vergelli C, Guerrini G, Giovannoni MP, Kirpotina LN, Khlebnikov AI, et al. Pyridinone derivatives as interesting formyl peptide receptor (FPR) agonists for the treatment of rheumatoid arthritis. Molecules. 2021;26:6583.
Qin CX, May LT, Li R, Cao N, Rosli S, Deo M, et al. Small-molecule-biased formyl peptide receptor agonist compound 17b protects against myocardial ischaemia-reperfusion injury in mice. Nat Commun. 2017;8:14232.
Article PubMed PubMed Central CAS Google Scholar
Possebon L, Costa SS, Souza HR, Azevedo LR, Sant’Ana M, Iyomasa-Pilon MM, et al. Mimetic peptide AC2-26 of annexin A1 as a potential therapeutic agent to treat COPD. Int Immunopharmacol. 2018;63:270–81.
Article PubMed CAS Google Scholar
Stama ML, Ślusarczyk J, Lacivita E, Kirpotina LN, Schepetkin IA, Chamera K, et al. Novel ureidopropanamide based N-formyl peptide receptor 2 (FPR2) agonists with potential application for central nervous system disorders characterized by neuroinflammation. Eur J Med Chem. 2017;141:703–20.
Article PubMed PubMed Central CAS Google Scholar
Kim SD, Kwon S, Lee SK, Kook M, Lee HY, Song KD, et al. The immune-stimulating peptide WKYMVm has therapeutic effects against ulcerative colitis. Exp Mol Med. 2013;45:e40.
Article PubMed PubMed Central Google Scholar
Maciuszek M, Cacace A, Brennan E, Godson C, Chapman TM. Recent advances in the design and development of formyl peptide receptor 2 (FPR2/ALX) agonists as pro-resolving agents with diverse therapeutic potential. Eur J Med Chem. 2021;213:113167.
Article PubMed CAS Google Scholar
Yang WS, Wang JL, Wu W, Wang GF, Yan J, Liu Q, et al. Formyl peptide receptor 2 as a potential therapeutic target for inflammatory bowel disease. Acta Pharmacol Sin. 2023;44:19–31.
Article PubMed CAS Google Scholar
Duan J, Shen DD, Zhou XE, Bi P, Liu QF, Tan YX, et al. Cryo-EM structure of an activated VIP1 receptor-G protein complex revealed by a NanoBiT tethering strategy. Nat Commun. 2020;11:4121.
Article PubMed PubMed Central CAS Google Scholar
Liang YL, Zhao P, Draper-Joyce C, Baltos JA, Glukhova A, Truong TT, et al. Dominant negative G proteins enhance formation and purification of agonist-GPCR-G protein complexes for structure determination. ACS Pharmacol Transl Sci. 2018;1:12–20.
Article PubMed PubMed Central CAS Google Scholar
Zhuang Y, Liu H, Edward Zhou X, Kumar Verma R, de Waal PW, Jang W, et al. Structure of formylpeptide receptor 2-G(i) complex reveals insights into ligand recognition and signaling. Nat Commun. 2020;11:885.
Article PubMed PubMed Central CAS Google Scholar
Zhu Y, Lin X, Zong X, Han S, Wang M, Su Y, et al. Structural basis of FPR2 in recognition of Aβ42 and neuroprotection by humanin. Nat Commun. 2022;13:1775.
Friesner RA, Banks JL, Murphy RB, Halgren TA, Klicic JJ, Mainz DT, et al. Glide: a new approach for rapid, accurate docking and scoring. 1. Method and assessment of docking accuracy. J Med Chem. 2004;47:1739–49.
Article PubMed CAS Google Scholar
Nanamori M, Cheng X, Mei J, Sang H, Xuan Y, Zhou C, et al. A novel nonpeptide ligand for formyl peptide receptor-like 1. Mol Pharmacol. 2004;66:1213–22.
Article PubMed CAS Google Scholar
Zhou C, Zhang S, Nanamori M, Zhang Y, Liu Q, Li N, et al. Pharmacological characterization of a novel nonpeptide antagonist for formyl peptide receptor-like 1. Mol Pharmacol. 2007;72:976–83.
Article PubMed CAS Google Scholar
Wirtz S, Popp V, Kindermann M, Gerlach K, Weigmann B, Fichtner-Feigl S, et al. Chemically induced mouse models of acute and chronic intestinal inflammation. Nat Protoc. 2017;12:1295–309.
Article PubMed CAS Google Scholar
Moynihan KD, Opel CF, Szeto GL, Tzeng A, Zhu EF, Engreitz JM, et al. Eradication of large established tumors in mice by combination immunotherapy that engages innate and adaptive immune responses. Nat Med. 2016;22:1402–10.
Comments (0)