Nobiletin and polydatin synergistically alleviate triple-negative breast cancer liver metastasis via suppressing ECM1a-mediated fatty acid biosynthesis

Bray F, Laversanne M, Sung H, Ferlay J, Siegel RL, Soerjomataram I, et al. Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2024;74:229–63.

PubMed  Google Scholar 

Miller KD, Nogueira L, Mariotto AB, Rowland JH, Yabroff KR, Alfano CM, et al. Cancer treatment and survivorship statistics, 2019. CA Cancer J Clin. 2019;69:363–85.

PubMed  Google Scholar 

Gong Y, Liu YR, Ji P, Hu X, Shao ZM. Impact of molecular subtypes on metastatic breast cancer patients: a SEER population-based study. Sci Rep. 2017;7:45411.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Diamond JR, Finlayson CA, Borges VF. Hepatic complications of breast cancer. Lancet Oncol. 2009;10:615–21.

Article  PubMed  Google Scholar 

Ibragimova MK, Tsyganov MM, Kravtsova EA, Tsydenova IA, Litviakov NV. Organ-specificity of breast cancer metastasis. Int J Mol Sci. 2023;24:15625.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Luo X, Cheng C, Tan Z, Li N, Tang M, Yang L, et al. Emerging roles of lipid metabolism in cancer metastasis. Mol Cancer. 2017;16:76.

Article  PubMed  PubMed Central  Google Scholar 

Zipinotti Dos Santos D, de Souza JC, Pimenta TM, da Silva Martins B, Junior RSR, Butzene SMS, et al. The impact of lipid metabolism on breast cancer: a review about its role in tumorigenesis and immune escape. Cell Commun Signal. 2023;21:161.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Jiang W, Xing XL, Zhang C, Yi L, Xu W, Ou J, et al. MET and FASN as prognostic biomarkers of triple negative breast cancer: a systematic evidence landscape of clinical study. Front Oncol. 2021;11:604801.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Jung SH, Lee HC, Hwang HJ, Park HA, Moon YA, Kim BC, et al. Acyl-CoA thioesterase 7 is involved in cell cycle progression via regulation of PKCζ-p53-p21 signaling pathway. Cell Death Dis. 2017;8:e2793.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Sammarco A, Guerra G, Eyme KM, Kennewick K, Qiao Y, El Hokayem J, et al. Targeting SCD triggers lipotoxicity of cancer cells and enhances anti-tumor immunity in breast cancer brain metastasis mouse models. Commun Biol. 2025;8:562.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ackermann T, Shokry E, Deshmukh R, Anand J, Galbraith LCA, Mitchell L, et al. Breast cancer secretes anti-ferroptotic MUFAs and depends on selenoprotein synthesis for metastasis. EMBO Mol Med. 2024;16:2749–74.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Pan J, Fan Z, Wang Z, Dai Q, Xiang Z, Yuan F, et al. CD36 mediates palmitate acid-induced metastasis of gastric cancer via AKT/GSK-3β/β-catenin pathway. J Exp Clin Cancer Res. 2019;38:52.

Article  PubMed  PubMed Central  Google Scholar 

Xiao J, Cao S, Wang J, Li P, Cheng Q, Zhou X, et al. Leptin-mediated suppression of lipoprotein lipase cleavage enhances lipid uptake and facilitates lymph node metastasis in gastric cancer. Cancer Commun. 2024;44:855–78.

Article  Google Scholar 

Shen CJ, Chang KY, Lin BW, Lin WT, Su CM, Tsai JP, et al. Oleic acid-induced NOX4 is dependent on ANGPTL4 expression to promote human colorectal cancer metastasis. Theranostics. 2020;10:7083–99.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Xie X, Chen C, Feng S, Zuo S, Zhao X, Li H. Acyl-CoA thioesterase 7 is transcriptionally activated by krüppel-like factor 13 and promotes the progression of hepatocellular carcinoma. J Hepatocell Carcinoma. 2021;8:1623–41.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wang T, Wang K, Zhu X, Chen N. ARNTL2 upregulation of ACOT7 promotes NSCLC cell proliferation through inhibition of apoptosis and ferroptosis. BMC Mol Cell Biol. 2023;24:14.

Article  PubMed  PubMed Central  Google Scholar 

Gan L, Meng J, Xu M, Liu M, Qi Y, Tan C, et al. Extracellular matrix protein 1 promotes cell metastasis and glucose metabolism by inducing integrin β4/FAK/SOX2/HIF-1α signaling pathway in gastric cancer. Oncogene. 2018;37:744–55.

Article  CAS  PubMed  Google Scholar 

Lal G, Hashimi S, Smith BJ, Lynch CF, Zhang L, Robinson RA, et al. Extracellular matrix 1 (ECM1) expression is a novel prognostic marker for poor long-term survival in breast cancer: a hospital-based cohort study in Iowa. Ann Surg Oncol. 2009;16:2280–7.

Article  PubMed  Google Scholar 

Yu Y, Lyu C, Li X, Yang L, Wang J, Li H, et al. Remodeling of tumor microenvironment by extracellular matrix protein 1a differentially regulates ovarian cancer metastasis. Cancer Lett. 2024;596:217022.

Article  CAS  PubMed  Google Scholar 

Yin H, Wang J, Li H, Yu Y, Wang X, Lu L, et al. Extracellular matrix protein-1 secretory isoform promotes ovarian cancer through increasing alternative mRNA splicing and stemness. Nat Commun. 2021;12:4230.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wang J, Chen Y, Luo Z, Huang Q, Zhang Y, Ning H, et al. Citri Reticulatae Pericarpium-Reynoutria japonica Houtt. herb pair suppresses breast cancer liver metastasis by targeting ECM1-mediated cholesterol biosynthesis pathway. Phytomedicine. 2023;116:154896.

Article  CAS  PubMed  Google Scholar 

Yuan J, Liu Y, Zhang T, Zheng C, Ding X, Zhu C, et al. Traditional Chinese medicine for breast cancer treatment: a bibliometric and visualization analysis. Pharm Biol. 2024;62:499–512.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kim BR, Ha J, Lee S, Park J, Cho S. Anti-cancer effects of ethanol extract of Reynoutria japonica Houtt. radix in human hepatocellular carcinoma cells via inhibition of MAPK and PI3K/Akt signaling pathways. J Ethnopharmacol. 2019;245:112179.

Article  CAS  PubMed  Google Scholar 

Song L, Xiong P, Zhang W, Hu H, Tang S, Jia B, et al. Mechanism of Citri Reticulatae Pericarpium as an anticancer agent from the perspective of flavonoids: a review. Molecules. 2022;27:5622.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Sp N, Kang DY, Joung YH, Park JH, Kim WS, Lee HK, et al. Nobiletin inhibits angiogenesis by regulating Src/FAK/STAT3-mediated signaling through PXN in ER⁺ breast cancer cells. Int J Mol Sci. 2017;18:935.

Article  PubMed  PubMed Central  Google Scholar 

Kim E, Kim YJ, Ji Z, Kang JM, Wirianto M, Paudel KR, et al. ROR activation by nobiletin enhances antitumor efficacy via suppression of IκB/NF-κB signaling in triple-negative breast cancer. Cell Death Dis. 2022;13:374.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhang T, Zhu X, Wu H, Jiang K, Zhao G, Shaukat A, et al. Targeting the ROS/PI3K/AKT/HIF-1α/HK2 axis of breast cancer cells: combined administration of polydatin and 2-Deoxy-d-glucose. J Cell Mol Med. 2019;23:3711–23.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chen S, Tao J, Zhong F, Jiao Y, Xu J, Shen Q, et al. Polydatin down-regulates the phosphorylation level of Creb and induces apoptosis in human breast cancer cell. PLoS One. 2017;12:e0176501.

Article  PubMed  PubMed Central  Google Scholar 

Chou TC. Drug combination studies and their synergy quantification using the Chou-Talalay method. Cancer Res. 2010;70:440–6.

Article  CAS  PubMed  Google Scholar 

Guo Z, Bergeron KF, Mounier C. Oleate promotes triple-negative breast cancer cell migration by enhancing filopodia formation through a PLD/Cdc42-dependent pathway. Int J Mol Sci. 2024;25:34.

Comments (0)

No login
gif