Ananth CV, Brandt JS, Keyes KM, Graham HL, Kostis JB, Kostis WJ. Epidemiology and trends in stroke mortality in the USA, 1975–2019. Int J Epidemiol. 2023;52:858–66.

Article  PubMed  Google Scholar 

Campbell BCV, De Silva DA, Macleod MR, Coutts SB, Schwamm LH, Davis SM, et al. Ischaemic stroke. Nat Rev Dis Prim. 2019;5:70.

Article  PubMed  Google Scholar 

Sochocka M, Diniz BS, Leszek J. Inflammatory response in the CNS: friend or foe?. Mol Neurobiol. 2017;54:8071–89.

Article  CAS  PubMed  Google Scholar 

Shi K, Tian DC, Li ZG, Ducruet AF, Lawton MT, Shi FD. Global brain inflammation in stroke. Lancet Neurol. 2019;18:1058–66.

Article  PubMed  Google Scholar 

Russo MV, McGavern DB. Immune surveillance of the CNS following infection and injury. Trends Immunol. 2015;36:637–50.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bernhardt J, Hayward KS, Kwakkel G, Ward NS, Wolf SL, Borschmann K, et al. Agreed definitions and a shared vision for new standards in stroke recovery research: the stroke recovery and rehabilitation roundtable taskforce. Neurorehabilit Neural Repair. 2017;31:793–9.

Article  Google Scholar 

Chen GY, Nunez G. Sterile inflammation: sensing and reacting to damage. Nat Rev Immunol. 2010;10:826–37.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Qiu YM, Zhang CL, Chen AQ, Wang HL, Zhou YF, Li YN, et al. Immune cells in the BBB disruption after acute ischemic stroke: targets for immune therapy?. Front Immunol. 2021;12:678744.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Pan Z, Ma G, Kong L, Du G. Hypoxia-inducible factor-1: regulatory mechanisms and drug development in stroke. Pharmacol Res. 2021;170:105742.

Article  CAS  PubMed  Google Scholar 

Mastropietro A, Rizzo G, Fontana L, Figini M, Bernardini B, Straffi L, et al. Microstructural characterization of corticospinal tract in subacute and chronic stroke patients with distal lesions by means of advanced diffusion MRI. Neuroradiology. 2019;61:1033–45.

Article  PubMed  PubMed Central  Google Scholar 

Xie W, Huang T, Guo Y, Zhang Y, Chen W, Li Y, et al. Neutrophil-derived cathelicidin promotes cerebral angiogenesis after ischemic stroke. J Cereb Blood Flow Metab. 2023;43:1503–18.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ng MSF, Tan L, Wang Q, Mackay CR, Ng LG. Neutrophils in cancer-unresolved questions. Sci China Life Sci. 2021;64:1829–41.

Article  CAS  PubMed  Google Scholar 

Doring Y, Soehnlein O, Weber C. Neutrophil extracellular traps in atherosclerosis and atherothrombosis. Circ Res. 2017;120:736–43.

Article  PubMed  Google Scholar 

Liew PX, Kubes P. The neutrophil’s role during health and disease. Physiol Rev. 2019;99:1223–48.

Article  CAS  PubMed  Google Scholar 

Mantovani A, Cassatella MA, Costantini C, Jaillon S. Neutrophils in the activation and regulation of innate and adaptive immunity. Nat Rev Immunol. 2011;11:519–31.

Article  CAS  PubMed  Google Scholar 

Ma Y, Yang S, He Q, Zhang D, Chang J. The role of immune cells in post-stroke angiogenesis and neuronal remodeling: the known and the unknown. Front Immunol. 2021;12:784098.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hottz ED, Azevedo-Quintanilha IG, Palhinha L, Teixeira L, Barreto EA, Pão CRR, et al. Platelet activation and platelet-monocyte aggregate formation trigger tissue factor expression in patients with severe COVID-19. Blood. 2020;136:1330–41.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Benakis C, Garcia-Bonilla L, Iadecola C, Anrather J. The role of microglia and myeloid immune cells in acute cerebral ischemia. Front Cell Neurosci. 2014;8:461.

PubMed  Google Scholar 

Dhanesha N, Jain M, Tripathi AK, Doddapattar P, Chorawala M, Bathla G, et al. Targeting myeloid-specific integrin alpha9beta1 improves short- and long-term stroke outcomes in murine models with preexisting comorbidities by limiting thrombosis and inflammation. Circ Res. 2020;126:1779–94.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ehlers R, Ustinov V, Chen Z, Zhang X, Rao R, Luscinskas FW, et al. Targeting platelet-leukocyte interactions: identification of the integrin Mac-1 binding site for the platelet counter receptor glycoprotein Ibalpha. J Exp Med. 2003;198:1077–88.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chen C, Chu SF, Liu DD, Zhang Z, Kong LL, Zhou X, et al. Chemokines play complex roles in cerebral ischemia. Neurochem Int. 2018;112:146–58.

Article  CAS  PubMed  Google Scholar 

Kong LL, Wang ZY, Hu JF, Yuan YH, Han N, Li H, et al. Inhibition of chemokine-like factor 1 protects against focal cerebral ischemia through the promotion of energy metabolism and anti-apoptotic effect. Neurochem Int. 2014;76:91–8.

Article  CAS  PubMed  Google Scholar 

Kong LL, Wang ZY, Han N, Zhuang XM, Wang ZZ, Li H, et al. Neutralization of chemokine-like factor 1, a novel C-C chemokine, protects against focal cerebral ischemia by inhibiting neutrophil infiltration via MAPK pathways in rats. J Neuroinflamm. 2014;11:112.

Article  Google Scholar 

Weisenburger-Lile D, Dong Y, Yger M, Weisenburger G, Polara GF, Chaigneau T, et al. Harmful neutrophil subsets in patients with ischemic stroke: association with disease severity. Neurol Neuroimmunol Neuroinflamm. 2019;6:e571.

Article  PubMed  PubMed Central  Google Scholar 

Ouk T, Potey C, Maestrini I, Petrault M, Mendyk AM, Leys D, et al. Neutrophils in tPA-induced hemorrhagic transformations: main culprit, accomplice or innocent bystander?. Pharmacol Ther. 2019;194:73–83.

Article  CAS  PubMed  Google Scholar 

Stowe AM, Adair-Kirk TL, Gonzales ER, Perez RS, Shah AR, Park TS, et al. Neutrophil elastase and neurovascular injury following focal stroke and reperfusion. Neurobiol Dis. 2009;35:82–90.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhao Z, Pan Z, Zhang S, Ma G, Zhang W, Song J, et al. Neutrophil extracellular traps: A novel target for the treatment of stroke. Pharmacol Ther. 2023;241:108328.

Article  CAS  PubMed  Google Scholar 

Folco EJ, Mawson TL, Vromman A, Bernardes-Souza B, Franck G, Persson O, et al. Neutrophil extracellular traps induce endothelial cell activation and tissue factor production through interleukin-1alpha and cathepsin G. Arterioscler Thromb Vasc Biol. 2018;38:1901–12.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Vaibhav K, Braun M, Alverson K, Khodadadi H, Kutiyanawalla A, Ward A, et al. Neutrophil extracellular traps exacerbate neurological deficits after traumatic brain injury. Sci Adv. 2020;6:eaax8847.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Li C, Xing Y, Zhang Y, Hua Y, Hu J, Bai Y. Neutrophil extracellular traps exacerbate ischemic brain damage. Mol Neurobiol. 2022;59:643–56.

Article  CAS  PubMed  Google Scholar 

Planas AM. Role of immune cells migrating to the ischemic brain. Stroke. 2018;49:2261–7.

Article