S1UTRSP5, a short restructured RNA from SLIT1 3′UTR, mitigates mouse cardiac remodeling via enhancing SlRT1 activity

Perrino C, Naga Prasad SV, Mao L, Noma T, Yan Z, Kim HS, et al. Intermittent pressure overload triggers hypertrophy-independent cardiac dysfunction and vascular rarefaction. J Clin Invest. 2006;116:1547–60.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bertero E, Maack C. Metabolic remodeling in heart failure. Nat Rev Cardiol. 2018;15:457–70.

Article  CAS  PubMed  Google Scholar 

Wang Y, Wang C, Ma J. Role of cardiac endothelial cells-derived microRNAs in cardiac remodeling. Discov Med. 2019;28:95–105.

PubMed  Google Scholar 

Gao J, Xu W, Wang J, Wang K, Li P. The role and molecular mechanism of non-coding RNAs in pathological cardiac remodeling. Int J Mol Sci. 2017;18:608.

Article  PubMed  PubMed Central  Google Scholar 

Jha S, Thasma Loganathbabu VK, Kumaran K, Krishnasamy G, Aruljothi KN. Long non-coding RNAs (lncRNAs) in heart failure: a comprehensive review. Noncoding RNA. 2023;10:3.

PubMed  PubMed Central  Google Scholar 

Shen S, Jiang H, Bei Y, Xiao J, Li X. Long non-coding RNAs in cardiac remodeling. Cell Physiol Biochem. 2017;41:1830–7.

Herzel L, Ottoz DSM, Alpert T, Neugebauer KM. Splicing and transcription touch base: co-transcriptional spliceosome assembly and function. Nat Rev Mol Cell Biol. 2017;18:637–50.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Tian B, Manley JL. Alternative polyadenylation of mRNA precursors. Nat Rev Mol Cell Biol. 2017;18:18–30.

Article  CAS  PubMed  Google Scholar 

Mayr C. What are 3’UTRs doing? Cold Spring Harb Perspect Biol. 2019;11:a034728.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hughes TA. Regulation of gene expression by alternative untranslated regions. Trends Genet. 2006;22:119–22.

Article  CAS  PubMed  Google Scholar 

Elkon R, Ugalde AP, Agami R. Alternative cleavage and polyadenylation: extent, regulation and function. Nat Rev Genet. 2013;14:496–506.

Article  CAS  PubMed  Google Scholar 

Mercer TR, Wilhelm D, Dinger ME, Soldà G, Korbie DJ, Glazov EA, et al. Expression of distinct RNAs from 3’ untranslated regions. Nucleic Acids Res. 2011;39:2393–403.

Article  CAS  PubMed  Google Scholar 

Malka Y, Steiman-Shimony A, Rosenthal E, Argaman L, Cohen-Daniel L, Arbib E, et al. Post-transcriptional 3’-UTR cleavage of mRNA transcripts generates thousands of stable uncapped autonomous RNA fragments. Nat Commun. 2017;8:2029.

Article  PubMed  PubMed Central  Google Scholar 

Cook SA, Bezzina CR, Hubner N, van der Velden J, Elkon R, Agami R, et al. Genome-wide polyadenylation maps reveal dynamic mRNA 3’-end formation in the failing human heart. Circ Res. 2016;118:433–8.

Article  PubMed  Google Scholar 

Cao J, Kuyumcu-Martinez MN. Alternative polyadenylation regulation in cardiac development and cardiovascular disease. Cardiovasc Res. 2023;119:1324–35.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Dong B, Xue R, Li J, Ling S, Xing W, Liu Z, et al. Ckip-1 3′UTR alleviates prolonged sleep deprivation- induced cardiac dysfunction by activating CaMKK2/AMPK/cTNI pathway. Mol Biomed. 2024;5:23.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wu QJ, Zhang TN, Chen HH, Yu XF, Lv JL, Liu YY, et al. The sirtuin family in health and disease. Signal Transduct Target Ther. 2022;7:402.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Matsushima S, Sadoshima J. The role of sirtuins in cardiac disease. Am J Physiol Heart Circ Physiol. 2015;309:H1375–89.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wang Y, Zhao R, Wu C, Liang X, He L, Wang L, et al. Activation of the sirtuin silent information regulator 1 pathway inhibits pathological myocardial remodeling. Front Pharmacol. 2023;14:1111320.

Xiang Q, Kang L, Wang J, Liao Z, Song Y, Zhao K, et al. CircRNA-CIDN mitigated compression loading-induced damage in human nucleus pulposus cells via miR-34a-5p/SIRT1 axis. EBioMedicine. 2020;53:102679.

Wang W, Wang L, Yang M, Wu C, Lan R, Wang W, et al. Circ-SIRT1 inhibits cardiac hypertrophy via activating SIRT1 to promote autophagy. Cell Death Dis. 2021;12:1069.

Article  PubMed  PubMed Central  Google Scholar 

Lou Z, Zhu J, Li X, Li X, Du K, Wang B, et al. LncRNA Sirt1-AS upregulates Sirt1 to attenuate aging related deep venous thrombosis. Aging. 2021;13:6918–35.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yang Z, Lin SD, Zhan F, Liu Y, Zhan YW. LncRNA GAS5 alleviates rheumatoid arthritis through regulating miR-222-3p/Sirt1 signalling axis. Autoimmunity. 2021;54:13–22.

Article  CAS  PubMed  Google Scholar 

Barangi S, Hayes AW, Karimi G. The role of lncRNAs/miRNAs/Sirt1 axis in myocardial and cerebral injury. Cell Cycle. 2023;22:1062–73.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yang KC, Yamada KA, Patel AY, Topkara VK, George I, Cheema FH, et al. Deep RNA sequencing reveals dynamic regulation of myocardial noncoding RNAs in failing human heart and remodeling with mechanical circulatory support. Circulation. 2014;129:1009–21.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Tang CM, Liu FZ, Zhu JN, Fu YH, Lin QX, Deng CY, et al. Myocyte-specific enhancer factor 2C: a novel target gene of miR-214-3p in suppressing angiotensin II-induced cardiomyocyte hypertrophy. Sci Rep. 2016;6:36146.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Liang JN, Zou X, Fang XH, Xu JD, Xiao Z, Zhu JN, et al. The Smad3-miR-29b/miR29c axis mediates the protective effect of macrophage migration inhibitory factor against cardiac fibrosis. Biochim Biophys Acta Mol Basis Dis. 2019;1865:2441–50.

Article  CAS  PubMed  Google Scholar 

Wu HY, Zhou CM, Gao Y, Wen YH, Hu YT, Zhao HL, et al. circSP199a, a circularized RNA sponge targeting miR-199a-5p and -3p, mitigates mouse cardiac hypertrophy and fibrosis. Acta Pharmacol Sin. 2026;47:86–102.

Article  CAS  PubMed  Google Scholar 

Lewis-Israeli YR, Wasserman AH, Gabalski MA, Volmert BD, Ming Y, Ball KA, et al. Self-assembling human heart organoids for the modeling of cardiac development and congenital heart disease. Nat Commun. 2021;12:5142.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Huang S, Zou X, Zhu JN, Fu YH, Lin QX, Liang YY, et al. Attenuation of microRNA16 derepresses the cyclins D1, D2 and E1 to provoke cardiomyocyte hypertrophy. J Cell Mol Med. 2015;19:608–19.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kocabas A, Duarte T, Kumar S, Hynes MA. Widespread differential expression of coding region and 3′UTR sequences in neurons and other tissues. Neuron. 2015;88:1149–56.

Article  CAS  PubMed  Google Scholar 

Zhu JN, Fu YH, Hu ZQ, Li WY, Tang CM, Fei HW, et al. Activation of miR-34a-5p/Sirt1/p66shc pathway contributes to doxorubicin-induced cardiotoxicity. Sci Rep. 2017;7:11879.

Article  PubMed  PubMed Central  Google Scholar 

Steri M, Idda ML, Whalen MB, Orrù V. Genetic variants in mRNA untranslated regions. Wiley Interdiscip Rev RNA. 2018;9:e1474.

Article 

Comments (0)

No login
gif