Perrino C, Naga Prasad SV, Mao L, Noma T, Yan Z, Kim HS, et al. Intermittent pressure overload triggers hypertrophy-independent cardiac dysfunction and vascular rarefaction. J Clin Invest. 2006;116:1547–60.
Article CAS PubMed PubMed Central Google Scholar
Bertero E, Maack C. Metabolic remodeling in heart failure. Nat Rev Cardiol. 2018;15:457–70.
Article CAS PubMed Google Scholar
Wang Y, Wang C, Ma J. Role of cardiac endothelial cells-derived microRNAs in cardiac remodeling. Discov Med. 2019;28:95–105.
Gao J, Xu W, Wang J, Wang K, Li P. The role and molecular mechanism of non-coding RNAs in pathological cardiac remodeling. Int J Mol Sci. 2017;18:608.
Article PubMed PubMed Central Google Scholar
Jha S, Thasma Loganathbabu VK, Kumaran K, Krishnasamy G, Aruljothi KN. Long non-coding RNAs (lncRNAs) in heart failure: a comprehensive review. Noncoding RNA. 2023;10:3.
PubMed PubMed Central Google Scholar
Shen S, Jiang H, Bei Y, Xiao J, Li X. Long non-coding RNAs in cardiac remodeling. Cell Physiol Biochem. 2017;41:1830–7.
Herzel L, Ottoz DSM, Alpert T, Neugebauer KM. Splicing and transcription touch base: co-transcriptional spliceosome assembly and function. Nat Rev Mol Cell Biol. 2017;18:637–50.
Article CAS PubMed PubMed Central Google Scholar
Tian B, Manley JL. Alternative polyadenylation of mRNA precursors. Nat Rev Mol Cell Biol. 2017;18:18–30.
Article CAS PubMed Google Scholar
Mayr C. What are 3’UTRs doing? Cold Spring Harb Perspect Biol. 2019;11:a034728.
Article CAS PubMed PubMed Central Google Scholar
Hughes TA. Regulation of gene expression by alternative untranslated regions. Trends Genet. 2006;22:119–22.
Article CAS PubMed Google Scholar
Elkon R, Ugalde AP, Agami R. Alternative cleavage and polyadenylation: extent, regulation and function. Nat Rev Genet. 2013;14:496–506.
Article CAS PubMed Google Scholar
Mercer TR, Wilhelm D, Dinger ME, Soldà G, Korbie DJ, Glazov EA, et al. Expression of distinct RNAs from 3’ untranslated regions. Nucleic Acids Res. 2011;39:2393–403.
Article CAS PubMed Google Scholar
Malka Y, Steiman-Shimony A, Rosenthal E, Argaman L, Cohen-Daniel L, Arbib E, et al. Post-transcriptional 3’-UTR cleavage of mRNA transcripts generates thousands of stable uncapped autonomous RNA fragments. Nat Commun. 2017;8:2029.
Article PubMed PubMed Central Google Scholar
Cook SA, Bezzina CR, Hubner N, van der Velden J, Elkon R, Agami R, et al. Genome-wide polyadenylation maps reveal dynamic mRNA 3’-end formation in the failing human heart. Circ Res. 2016;118:433–8.
Cao J, Kuyumcu-Martinez MN. Alternative polyadenylation regulation in cardiac development and cardiovascular disease. Cardiovasc Res. 2023;119:1324–35.
Article CAS PubMed PubMed Central Google Scholar
Dong B, Xue R, Li J, Ling S, Xing W, Liu Z, et al. Ckip-1 3′UTR alleviates prolonged sleep deprivation- induced cardiac dysfunction by activating CaMKK2/AMPK/cTNI pathway. Mol Biomed. 2024;5:23.
Article CAS PubMed PubMed Central Google Scholar
Wu QJ, Zhang TN, Chen HH, Yu XF, Lv JL, Liu YY, et al. The sirtuin family in health and disease. Signal Transduct Target Ther. 2022;7:402.
Article CAS PubMed PubMed Central Google Scholar
Matsushima S, Sadoshima J. The role of sirtuins in cardiac disease. Am J Physiol Heart Circ Physiol. 2015;309:H1375–89.
Article CAS PubMed PubMed Central Google Scholar
Wang Y, Zhao R, Wu C, Liang X, He L, Wang L, et al. Activation of the sirtuin silent information regulator 1 pathway inhibits pathological myocardial remodeling. Front Pharmacol. 2023;14:1111320.
Xiang Q, Kang L, Wang J, Liao Z, Song Y, Zhao K, et al. CircRNA-CIDN mitigated compression loading-induced damage in human nucleus pulposus cells via miR-34a-5p/SIRT1 axis. EBioMedicine. 2020;53:102679.
Wang W, Wang L, Yang M, Wu C, Lan R, Wang W, et al. Circ-SIRT1 inhibits cardiac hypertrophy via activating SIRT1 to promote autophagy. Cell Death Dis. 2021;12:1069.
Article PubMed PubMed Central Google Scholar
Lou Z, Zhu J, Li X, Li X, Du K, Wang B, et al. LncRNA Sirt1-AS upregulates Sirt1 to attenuate aging related deep venous thrombosis. Aging. 2021;13:6918–35.
Article CAS PubMed PubMed Central Google Scholar
Yang Z, Lin SD, Zhan F, Liu Y, Zhan YW. LncRNA GAS5 alleviates rheumatoid arthritis through regulating miR-222-3p/Sirt1 signalling axis. Autoimmunity. 2021;54:13–22.
Article CAS PubMed Google Scholar
Barangi S, Hayes AW, Karimi G. The role of lncRNAs/miRNAs/Sirt1 axis in myocardial and cerebral injury. Cell Cycle. 2023;22:1062–73.
Article CAS PubMed PubMed Central Google Scholar
Yang KC, Yamada KA, Patel AY, Topkara VK, George I, Cheema FH, et al. Deep RNA sequencing reveals dynamic regulation of myocardial noncoding RNAs in failing human heart and remodeling with mechanical circulatory support. Circulation. 2014;129:1009–21.
Article CAS PubMed PubMed Central Google Scholar
Tang CM, Liu FZ, Zhu JN, Fu YH, Lin QX, Deng CY, et al. Myocyte-specific enhancer factor 2C: a novel target gene of miR-214-3p in suppressing angiotensin II-induced cardiomyocyte hypertrophy. Sci Rep. 2016;6:36146.
Article CAS PubMed PubMed Central Google Scholar
Liang JN, Zou X, Fang XH, Xu JD, Xiao Z, Zhu JN, et al. The Smad3-miR-29b/miR29c axis mediates the protective effect of macrophage migration inhibitory factor against cardiac fibrosis. Biochim Biophys Acta Mol Basis Dis. 2019;1865:2441–50.
Article CAS PubMed Google Scholar
Wu HY, Zhou CM, Gao Y, Wen YH, Hu YT, Zhao HL, et al. circSP199a, a circularized RNA sponge targeting miR-199a-5p and -3p, mitigates mouse cardiac hypertrophy and fibrosis. Acta Pharmacol Sin. 2026;47:86–102.
Article CAS PubMed Google Scholar
Lewis-Israeli YR, Wasserman AH, Gabalski MA, Volmert BD, Ming Y, Ball KA, et al. Self-assembling human heart organoids for the modeling of cardiac development and congenital heart disease. Nat Commun. 2021;12:5142.
Article CAS PubMed PubMed Central Google Scholar
Huang S, Zou X, Zhu JN, Fu YH, Lin QX, Liang YY, et al. Attenuation of microRNA16 derepresses the cyclins D1, D2 and E1 to provoke cardiomyocyte hypertrophy. J Cell Mol Med. 2015;19:608–19.
Article CAS PubMed PubMed Central Google Scholar
Kocabas A, Duarte T, Kumar S, Hynes MA. Widespread differential expression of coding region and 3′UTR sequences in neurons and other tissues. Neuron. 2015;88:1149–56.
Article CAS PubMed Google Scholar
Zhu JN, Fu YH, Hu ZQ, Li WY, Tang CM, Fei HW, et al. Activation of miR-34a-5p/Sirt1/p66shc pathway contributes to doxorubicin-induced cardiotoxicity. Sci Rep. 2017;7:11879.
Article PubMed PubMed Central Google Scholar
Steri M, Idda ML, Whalen MB, Orrù V. Genetic variants in mRNA untranslated regions. Wiley Interdiscip Rev RNA. 2018;9:e1474.
Comments (0)