Aberrant neuronal excitation promotes neuroinflammation in the primary motor cortex of ischemic stroke mice

Collaborators GBDN. Global, regional, and national burden of neurological disorders, 1990-2016: a systematic analysis for the Global Burden of Disease Study 2016. Lancet Neurol. 2019;18:459–80.

Article  Google Scholar 

Badhiwala JH, Nassiri F, Alhazzani W, Selim MH, Farrokhyar F, Spears J, et al. Endovascular thrombectomy for acute ischemic stroke: a meta-analysis. JAMA. 2015;314:1832–43.

Article  CAS  PubMed  Google Scholar 

Goyal M, Menon BK, van Zwam WH, Dippel DW, Mitchell PJ, Demchuk AM, et al. Endovascular thrombectomy after large-vessel ischaemic stroke: a meta-analysis of individual patient data from five randomised trials. Lancet. 2016;387:1723–31.

Article  PubMed  Google Scholar 

Marko M, Miksova D, Ebner J, Lang M, Serles W, Sommer P, et al. Temporal trends of functional outcome in patients with acute ischemic stroke treated with intravenous thrombolysis. Stroke. 2022;53:3329–37.

Article  CAS  PubMed  Google Scholar 

Tsao CW, Aday AW, Almarzooq ZI, Alonso A, Beaton AZ, Bittencourt MS, et al. Heart disease and stroke statistics-2022 update: a report from the American Heart Association. Circulation. 2022;145:e153–e639.

Article  PubMed  Google Scholar 

Liao LY, Zhu Y, Peng QY, Gao Q, Liu L, Wang QH, et al. Intermittent theta-burst stimulation for stroke: primary motor cortex versus cerebellar stimulation: a randomized sham-controlled trial. Stroke. 2024;55:156–65.

CAS  PubMed  Google Scholar 

Luoma JI, Kelley BG, Mermelstein PG. Progesterone inhibition of voltage-gated calcium channels is a potential neuroprotective mechanism against excitotoxicity. Steroids. 2011;76:845–55.

CAS  PubMed  PubMed Central  Google Scholar 

Papazian I, Kyrargyri V, Evangelidou M, Voulgari-Kokota A, Probert L. Mesenchymal stem cell protection of neurons against glutamate excitotoxicity involves reduction of NMDA-triggered calcium responses and surface GluR1, and is partly mediated by TNF. Int J Mol Sci. 2018;19:651.

Article  PubMed  PubMed Central  Google Scholar 

Gelderblom M, Leypoldt F, Steinbach K, Behrens D, Choe CU, Siler DA, et al. Temporal and spatial dynamics of cerebral immune cell accumulation in stroke. Stroke. 2009;40:1849–57.

Article  PubMed  Google Scholar 

Emmrich JV, Ejaz S, Neher JJ, Williamson DJ, Baron JC. Regional distribution of selective neuronal loss and microglial activation across the MCA territory after transient focal ischemia: quantitative versus semiquantitative systematic immunohistochemical assessment. J Cereb Blood Flow Metab. 2015;35:20–7.

Article  PubMed  Google Scholar 

Ma MW, Wang J, Zhang Q, Wang R, Dhandapani KM, Vadlamudi RK, et al. NADPH oxidase in brain injury and neurodegenerative disorders. Mol Neurodegener. 2017;12:7.

Article  PubMed  PubMed Central  Google Scholar 

Zhou M, Wang CM, Yang WL, Wang P. Microglial CD14 activated by iNOS contributes to neuroinflammation in cerebral ischemia. Brain Res. 2013;1506:105–14.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Jiang D, Gong F, Ge X, Lv C, Huang C, Feng S, et al. Neuron-derived exosomes-transmitted miR-124-3p protect traumatically injured spinal cord by suppressing the activation of neurotoxic microglia and astrocytes. J Nanobiotechnology. 2020;18:105.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Peng H, Harvey BT, Richards CI, Nixon K. Neuron-derived extracellular vesicles modulate microglia activation and function. Biol (Basel). 2021;10:948.

CAS  Google Scholar 

Yin Z, Han Z, Hu T, Zhang S, Ge X, Huang S, et al. Neuron-derived exosomes with high miR-21-5p expression promoted polarization of M1 microglia in culture. Brain, Behav, Immun. 2020;83:270–82.

Article  CAS  PubMed  Google Scholar 

Xian X, Cai LL, Li Y, Wang RC, Xu YH, Chen YJ, et al. Neuron secrete exosomes containing miR-9-5p to promote polarization of M1 microglia in depression. J Nanobiotechnology. 2022;20:122.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Guo X, Qiu W, Li B, Qi Y, Wang S, Zhao R, et al. Hypoxia-induced neuronal activity in glioma patients polarizes microglia by potentiating RNA m6A demethylation. Clin Cancer Res. 2024;30:1160–74.

Article  CAS  PubMed  Google Scholar 

Atasoy D, Sternson SM. Chemogenetic tools for causal cellular and neuronal biology. Physiol Rev. 2018;98:391–418.

Article  CAS  PubMed  Google Scholar 

Sternson SM, Roth BL. Chemogenetic tools to interrogate brain functions. Annu Rev Neurosci. 2014;37:387–407.

Article  CAS  PubMed  Google Scholar 

Wang YC, Galeffi F, Wang W, Li X, Lu L, Sheng H, et al. Chemogenetics-mediated acute inhibition of excitatory neuronal activity improves stroke outcome. Exp Neurol. 2020;326:113206.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Cho J, Ryu S, Lee S, Kim J, Park JY, Kwon HS, et al. Clozapine-induced chemogenetic neuromodulation rescues post-stroke deficits after chronic capsular infarct. Transl Stroke Res. 2022;14:499–512.

Article  PubMed  PubMed Central  Google Scholar 

Zhang X, Gong P, Zhao Y, Wan T, Yuan K, Xiong Y, et al. Endothelial caveolin-1 regulates cerebral thrombo-inflammation in acute ischemia/reperfusion injury. EBioMedicine. 2022;84:104275.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Benito E, Barco A. The neuronal activity-driven transcriptome. Mol Neurobiol. 2015;51:1071–88.

Article  CAS  PubMed  Google Scholar 

Tian X, Shen H, Li Z, Wang T, Wang S. Tumor-derived exosomes, myeloid-derived suppressor cells, and tumor microenvironment. J Hematol Oncol 2019;12:84.

Article  PubMed  PubMed Central  Google Scholar 

Wang D, Chen F, Fang B, Zhang Z, Dong Y, Tong X, et al. MiR-128-3p alleviates spinal cord ischemia/reperfusion injury associated neuroinflammation and cellular apoptosis via SP1 suppression in rat. Front Neurosci. 2020;14:609613.

Article  PubMed  PubMed Central  Google Scholar 

Zhang G, Chen L, Liu J, Jin Y, Lin Z, Du S, et al. HIF-1alpha/microRNA-128-3p axis protects hippocampal neurons from apoptosis via the Axin1-mediated Wnt/beta-catenin signaling pathway in Parkinson’s disease models. Aging. 2020;12:4067–81.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bartel DP. MicroRNAs: target recognition and regulatory functions. Cell. 2009;136:215–33.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Sheedy FJ, Palsson-McDermott E, Hennessy EJ, Martin C, O’Leary JJ, Ruan Q, et al. Negative regulation of TLR4 via targeting of the proinflammatory tumor suppressor PDCD4 by the microRNA miR-21. Nat Immunol. 2010;11:141–7.

Article  CAS  PubMed  Google Scholar 

Matsuhashi S, Manirujjaman M, Hamajima H, Ozaki I. Control mechanisms of the tumor suppressor PDCD4: expression and functions. Int J Mol Sci. 2019;20:2304.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Roque C, Pinto N, Vaz Patto M, Baltazar G. Astrocytes contribute to the neuronal recovery promoted by high-frequency repetitive magnetic stimulation in in vitro models of ischemia. J Neurosci Res. 2021;99:1414–32.

Article  CAS  PubMed  Google Scholar 

Gava-Junior G, Ferreira SA, Roque C, Mendes-Oliveira J, Serrenho I, Pinto N, et al. High-frequency repetitive magnetic stimulation rescues ischemia-injured neurons through modulation of glial-derived neurotrophic factor present in the astrocyte’s secretome. J Neurochem. 2023;164:813–28.

Article  CAS 

Comments (0)

No login
gif