Bentley S, Feldman N, Boehm L, Zavala M, Dilos B, McIndoe M, et al. Stroke code from EMS to thrombectomy: an interdisciplinary in situ simulation for prompt management of acute ischemic stroke. MedEdPORTAL. 2021;23(17):11177. https://doi.org/10.15766/mep_2374-8265.11177.

Article  Google Scholar 

Zhao W, Ma P, Zhang P, Yue X. Mechanical Thrombectomy for acute ischemic stroke in octogenarians: a systematic review and meta-analysis. Front Neurol. 2020;24(10):1355. https://doi.org/10.3389/fneur.2019.01355.

Article  Google Scholar 

Truelsen T, Piechowski-Jóźwiak B, Bonita R, Mathers C, Bogousslavsky J, Boysen G. Stroke incidence and prevalence in Europe: a review of available data. Eur J Neurol. 2006;13(6):581–98. https://doi.org/10.1111/j.1468-1331.2006.01138.x.

Article  PubMed  CAS  Google Scholar 

Palnum KD, Petersen P, Sørensen HT, Ingeman A, Mainz J, Bartels P, et al. Older patients with acute stroke in Denmark: quality of care and short-term mortality A nationwide follow-up study. Age Ageing. 2008;37(1):90–5. https://doi.org/10.1093/ageing/afm134.

Article  PubMed  Google Scholar 

Debbağ S, Üstün GG. Anesthesia for the elderly: Effects of aging on perioperative and postoperative care. In: Vargel İ, Özgür FF, editors. Beauty, aging, and anti aging. Academic Press; 2023. p. 429–38. https://doi.org/10.1016/B978-0-323-98804-9.00030-X.

Chapter  Google Scholar 

Olotu C. Anesthesia for the elderly: a narrative review. Minerva Anestesiol. 2021;87(10):1128–38. https://doi.org/10.23736/S0375-9393.21.15388-X.

Article  PubMed  Google Scholar 

Singam NSV, Fine C, Fleg JL. Cardiac changes associated with vascular aging. Clin Cardiol. 2020;43(2):92–8. https://doi.org/10.1002/clc.23313.

Article  PubMed  Google Scholar 

Fajemiroye JO, da Cunha LC, Saavedra-Rodríguez R, et al. Aging-induced biological changes and cardiovascular diseases. Biomed Res Int. 2018;10(2018):7156435. https://doi.org/10.1155/2018/7156435.

Article  CAS  Google Scholar 

O’Callaghan S, Kenny RA. Neurocardiovascular instability and cognition. Yale J Biol Med. 2016;89(1):59–71.

PubMed  PubMed Central  Google Scholar 

Rooke GA. Cardiovascular aging and anesthetic implications. J Cardiothorac Vasc Anesth. 2003;17(4):512–23. https://doi.org/10.1016/s1053-0770(03)00161-7.

Article  PubMed  Google Scholar 

Bettelli G. Preoperative evaluation in geriatric surgery: comorbidity, functional status and pharmacological history. Minerva Anestesiol. 2011;77(6):637–46 (PMID: 21617627).

PubMed  CAS  Google Scholar 

Janssens JP, Pache JC, Nicod LP. Physiological changes in respiratory function associated with ageing. Eur Respir J. 1999;13(1):197–205. https://doi.org/10.1034/j.1399-3003.1999.13a36.x.

Article  PubMed  CAS  Google Scholar 

Skloot GS. The effects of aging on lung structure and function. Clin Geriatr Med. 2017;33(4):447–57. https://doi.org/10.1016/j.cger.2017.06.001.

Article  PubMed  Google Scholar 

Swedko PJ, Clark HD, Paramsothy K, Akbari A. Serum creatinine is an inadequate screening test for renal failure in elderly patients. Arch Intern Med. 2003;163(3):356–60. https://doi.org/10.1001/archinte.163.3.356.

Article  PubMed  CAS  Google Scholar 

Alvis BD, Hughes CG. Physiology considerations in geriatric patients. Anesthesiol Clin. 2015;33(3):447–56. https://doi.org/10.1016/j.anclin.2015.05.003.

Article  PubMed  PubMed Central  Google Scholar 

Ahrens E, Wachtendorf LJ, Hill KP, Schaefer MS. Considerations for anesthesia in older adults with cannabis use. Drugs Aging. 2024;41(12):933–43. https://doi.org/10.1007/s40266-024-01161-6.

Article  PubMed  Google Scholar 

Denic A, Glassock RJ, Rule AD. Structural and functional changes with the aging kidney. Adv Chronic Kidney Dis. 2016;23(1):19–28. https://doi.org/10.1053/j.ackd.2015.08.004.

Article  PubMed  PubMed Central  Google Scholar 

Luca E, Schipa C, Cambise C, Sollazzi L, Aceto P. Implication of age-related changes on anesthesia management. Saudi J Anaesth. 2023;17(4):474–81. https://doi.org/10.4103/sja.sja_579_23.

Article  PubMed  PubMed Central  Google Scholar 

Mangoni AA, Jackson SH. Age-related changes in pharmacokinetics and pharmacodynamics: basic principles and practical applications. Br J Clin Pharmacol. 2004;57(1):6–14. https://doi.org/10.1046/j.1365-2125.2003.02007.x.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Akhtar S. Pharmacological considerations in the elderly. Curr Opin Anaesthesiol. 2018;31(1):11–8. https://doi.org/10.1097/ACO.0000000000000544.

Article  PubMed  Google Scholar 

Yang R, Wolfson M, Lewis MC. Unique aspects of the elderly surgical population: an anesthesiologist’s perspective. Geriatr Orthop Surg Rehabil. 2011;2(2):56–64. https://doi.org/10.1177/2151458510394606.

Article  PubMed  PubMed Central  Google Scholar 

Mandal PK, Saharan S, Penna O, Fodale V. Anesthesia issues in central nervous system disorders. Curr Aging Sci. 2016;9(2):116–43. https://doi.org/10.2174/1874609809666151124233206.

Article  PubMed  CAS  Google Scholar 

Kurauti MA, Soares GM, Marmentini C, Bronczek GA, Branco RCS, Boschero AC. Insulin and aging. Vitam Horm. 2021;115:185–219. https://doi.org/10.1016/bs.vh.2020.12.010.

Article  PubMed  CAS  Google Scholar 

Charmandari E, Tsigos C, Chrousos G. Endocrinology of the stress response. Annu Rev Physiol. 2005;67:259–84. https://doi.org/10.1146/annurev.physiol.67.040403.120816.

Article  PubMed  CAS  Google Scholar 

Frontera WR. Physiologic changes of the musculoskeletal system with aging: a brief review. Phys Med Rehabil Clin N Am. 2017;28(4):705–11. https://doi.org/10.1016/j.pmr.2017.06.004.

Article  PubMed  Google Scholar 

Mahender A, Chavan SS, Saroa R, Chauhan M. Recent advances in geriatric anaesthesia. Indian J Anaesth. 2023;67(1):152–8. https://doi.org/10.4103/ija.ija_1029_22.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Akhtar S, Ramani R. Geriatric pharmacology. Anesthesiol Clin. 2015;33(3):457–69. https://doi.org/10.1016/j.anclin.2015.05.004.

Article  PubMed  Google Scholar 

Ngcobo NN. Influence of ageing on the pharmacodynamics and pharmacokinetics of chronically administered medicines in geriatric patients: a review. Clin Pharmacokinet. 2025;64(3):335–67. https://doi.org/10.1007/s40262-024-01466-0. Erratum in: Clin Pharmacokinet. 2025;64(3):463. https://doi.org/10.1007/s40262-025-01494-4.

Thürmann PA. Pharmacodynamics and pharmacokinetics in older adults. Curr Opin Anaesthesiol. 2020;33(1):109–13. https://doi.org/10.1097/ACO.0000000000000814.

Article  PubMed  Google Scholar 

Schonberger RB, Dai F, Michel G, Vaughn MT, Burg MM, Mathis M, et al. Association of propofol induction dose and severe pre-incision hypotension among surgical patients over age 65. J Clin Anesth. 2022;80:110846. https://doi.org/10.1016/j.jclinane.2022.110846.

Article  PubMed  PubMed Central  Google Scholar 

Aceto P, Perilli V, Lai C, Sacco T, Modesti C, Luca E, et al. Minimum alveolar concentration threshold of sevoflurane for postoperative dream recall. Minerva Anestesiol. 2015;81(11):1201–9 (Epub 2014 Dec 23 PMID: 25532493).

PubMed  CAS  Google Scholar 

Zhang GB, Li HY, Yu WJ, Ying YZ, Zheng D, Zhang XK, et al. Occurrence and risk factors for post-stroke delirium: a systematic review and meta-analysis. Asian J Psychiatr. 2024;99:104132. https://doi.org/10.1016/j.ajp.2024.104132.