PI3K Inhibitors as Potential Therapeutic Agents for the Treatment of COPD with Associated Atherosclerosis

Rabe KF, Hurst JR, Suissa S. Cardiovascular disease and COPD: dangerous liaisons? Eur Respir Rev. 2018;27(149): 180057. https://doi.org/10.1183/16000617.0057-2018.

Article  PubMed  PubMed Central  Google Scholar 

Decramer M, Janssens W. Chronic obstructive pulmonary disease and comorbidities. Lancet Respir Med. 2013;1(1):73–83. https://doi.org/10.1016/S2213-2600(12)70060-7.

Article  PubMed  Google Scholar 

Barnes PJ, Celli BR. Systemic manifestations and comorbidities of COPD. Eur Respir J. 2009;33(5):1165–85. https://doi.org/10.1183/09031936.00128008.

Article  CAS  PubMed  Google Scholar 

Cazzola M, Calzetta L, Rinaldi B, et al. Management of chronic obstructive pulmonary disease in patients with cardiovascular diseases. Drugs. 2017;77(7):721–32. https://doi.org/10.1007/s40265-017-0731-3.

Article  CAS  PubMed  Google Scholar 

Rogliani P, Calzetta L. Cardiovascular disease in COPD. In: Martínez-García MÁ, Pépin J-L, Cazzola M, editors. Cardiovascular complications of respiratory disorders (ERS Monograph). Sheffield, European Respiratory Society, 2020; pp. 47–65. https://doi.org/10.1183/2312508X.10027319.

Miklós Z, Horváth I. The role of oxidative stress and antioxidants in cardiovascular comorbidities in COPD. Antioxidants (Basel). 2023;12(6):1196. https://doi.org/10.3390/antiox12061196.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Schade DS, Helitzer D, Eaton P. Evidence that low density lipoprotein is the primary cause of atherosclerotic cardiovascular disease: a Bradford-Hill approach. WJCD. 2017;07(9):271–84. https://doi.org/10.4236/wjcd.2017.79025.

Article  CAS  Google Scholar 

Hou P, Fang J, Liu Z, et al. Macrophage polarization and metabolism in atherosclerosis. Cell Death Dis. 2023;14(10):691. https://doi.org/10.1038/s41419-023-06206-z.

Article  PubMed  PubMed Central  Google Scholar 

Moore KJ, Tabas I. Macrophages in the pathogenesis of atherosclerosis. Cell. 2011;145(3):341–55. https://doi.org/10.1016/j.cell.2011.04.005.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lara-Guzmán OJ, Gil-Izquierdo Á, Medina S, et al. Oxidized LDL triggers changes in oxidative stress and inflammatory biomarkers in human macrophages. Redox Biol. 2018;15:1–11. https://doi.org/10.1016/j.redox.2017.11.017.

Article  CAS  PubMed  Google Scholar 

Groh LA, Ferreira AV, Helder L, et al. oxLDL-induced trained immunity is dependent on mitochondrial metabolic reprogramming. Immunometabolism. 2021;3(3): e210025. https://doi.org/10.20900/immunometab20210025.

Article  PubMed  PubMed Central  Google Scholar 

Chen C, Khismatullin DB. Oxidized low-density lipoprotein contributes to atherogenesis via co-activation of macrophages and mast cells. PLoS ONE. 2015;10(3): e0123088. https://doi.org/10.1371/journal.pone.0123088.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Baaten CCFMJ, Nagy M, Bergmeier W, Spronk HMH, van der Meijden PEJ. Platelet biology and function: plaque erosion vs. rupture. Eur Heart J. 2024;45(1):18–31. https://doi.org/10.1093/eurheartj/ehad720.

Benjamin EJ, Muntner P, Alonso A, et al. Heart disease and stroke statistics—2019 Update: a from the American Heart Association. Circulation. 2019;139(10):e56–528. https://doi.org/10.1161/CIR.0000000000000659.

Article  PubMed  Google Scholar 

Sá-Sousa A, Rodrigues C, Jácome C, et al. Cardiovascular risk in patients with chronic obstructive pulmonary disease: a systematic review. J Clin Med. 2024;13(17):5173. https://doi.org/10.3390/jcm13175173.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Barr RG, Ahmed FS, Carr JJ, et al. Subclinical atherosclerosis, airflow obstruction and emphysema: the MESA Lung Study. Eur Respir J. 2012;39(4):846–54. https://doi.org/10.1183/09031936.00165410.

Article  CAS  PubMed  Google Scholar 

Chandra D, Gupta A, Strollo PJ Jr, et al. Airflow limitation and endothelial dysfunction. Unrelated and independent predictors of atherosclerosis. Am J Respir Crit Care Med. 2016;194(1):38–47. https://doi.org/10.1164/rccm.201510-2093OC

Engström G, Lampa E, Dekkers K, et al. Pulmonary function and atherosclerosis in the general population: causal associations and clinical implications. Eur J Epidemiol. 2024;39(1):35–49. https://doi.org/10.1007/s10654-023-01088-z.

Article  PubMed  PubMed Central  Google Scholar 

Balla T. Phosphoinositides: tiny lipids with giant impact on cell regulation. Physiol Rev. 2013;93(3):1019–137. https://doi.org/10.1152/physrev.00028.2012.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Koyasu S. The role of PI3K in immune cells. Nat Immunol. 2003;4(4):313–9. https://doi.org/10.1038/ni0403-313.

Article  CAS  PubMed  Google Scholar 

Linton MF, Moslehi JJ, Babaev VR. Akt signaling in macrophage polarization, survival, and atherosclerosis. Int J Mol Sci. 2019;20(11):2703. https://doi.org/10.3390/ijms20112703.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhao Y, Qian Y, Sun Z, et al. Role of PI3K in the progression and regression of atherosclerosis. Front Pharmacol. 2021;12: 632378. https://doi.org/10.3389/fphar.2021.632378.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Gupta V, Khan A, Higham A, et al. The effect of phosphatidylinositol-3 kinase inhibition on matrix metalloproteinase-9 and reactive oxygen species release from chronic obstructive pulmonary disease neutrophils. Int Immunopharmacol. 2016;35:155–62. https://doi.org/10.1016/j.intimp.2016.03.027.

Article  CAS  PubMed  Google Scholar 

Finicelli M, Digilio FA, Galderisi U, Peluso G. The emerging role of macrophages in chronic obstructive pulmonary disease: the potential impact of oxidative stress and extracellular vesicle on macrophage polarization and function. Antioxidants (Basel). 2022;11(3):464. https://doi.org/10.3390/antiox11030464.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Barnes PJ. Inflammatory mechanisms in patients with chronic obstructive pulmonary disease. J Allergy Clin Immunol. 2016;138(1):16–27. https://doi.org/10.1016/j.jaci.2016.05.011.

Article  CAS  PubMed  Google Scholar 

Murray PJ, Allen JE, Biswas SK, et al. Macrophage activation and polarization: nomenclature and experimental guidelines. Immunity. 2014;41(1):14–20. https://doi.org/10.1016/j.immuni.2014.06.008.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kim GD, Lim EY, Shin HS. Macrophage polarization and functions in pathogenesis of chronic obstructive pulmonary disease. Int J Mol Sci. 2024;25(11):5631. https://doi.org/10.3390/ijms25115631.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Durrant TN, Hers I. PI3K inhibitors in thrombosis and cardiovascular disease. Clin Transl Med. 2020;9(1):8. https://doi.org/10.1186/s40169-020-0261-6.

Article  PubMed  PubMed Central  Google Scholar 

Nunes-Santos CJ, Uzel G, Rosenzweig SD. PI3K pathway defects leading to immunodeficiency and immune dysregulation. J Allergy Clin Immunol. 2019;143(5):1676–87. https://doi.org/10.1016/j.jaci.2019.03.017.

Article  CAS  PubMed  Google Scholar 

Cazzola M, Calzetta L, Rogliani P, Matera MG. Emerging anti-inflammatory COPD treatments: potential cardiovascular impacts. Int J Chron Obstruct Pulmon Dis. 2024;19:2481–95. https://doi.org/10.2147/COPD.S498255.

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