Therapeutic Potential of Centhaquine Citrate, a Selective Alpha-2B Adrenoceptor Agonist, in the Management of Circulatory Shock

Graham CA, Parke TR. Critical care in the emergency department: shock and circulatory support. Emerg Med J. 2005;22(1):17–21.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Krüger W, Ludman AJ. Shock. In: Core knowledge in critical care medicine. Berlin, Heidelberg: Springer Berlin Heidelberg; 2014. p. 159–271.

Chapter  Google Scholar 

Kroetz FW, Leon DF, Leonard JJ. The diagnosis of acute circulatory failure: shock and syncope. Prog Cardiovasc Dis. 1967;10(3):262–82.

Article  CAS  PubMed  Google Scholar 

Vincent JL, De Backer D. Circulatory shock. N Engl J Med. 2013;369(18):1726–34.

Article  CAS  PubMed  Google Scholar 

Hamm LL, Nakhoul N, Hering-Smith KS. Acid-base homeostasis. Clin J Am Soc Nephrol. 2015;10(12):2232–42.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Jentzer JC, Vallabhajosyula S, Khanna AK, Chawla LS, Busse LW, Kashani KB. Management of refractory vasodilatory shock. Chest. 2018;154(2):416–26.

Article  PubMed  Google Scholar 

Archer M, Dogra N, Dovey Z, Ganta T, Jang HS, Khusid JA, Lantz A, Mihalopoulos M, Stockert JA, Zahalka A, et al. Role of alpha- and beta-adrenergic signaling in phenotypic targeting: significance in benign and malignant urologic disease. Cell Commun Signal. 2021;19(1):78.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Geevarghese M 3rd, Patel K, Gulati A, Ranjan AK. Role of adrenergic receptors in shock. Front Physiol. 2023;14:1094591.

Article  PubMed  PubMed Central  Google Scholar 

Trendelenburg AU, Sutej I, Wahl CA, Molderings GJ, Rump LC, Starke K. A re-investigation of questionable subclassifications of presynaptic alpha2-autoreceptors: rat vena cava, rat atria, human kidney and guinea-pig urethra. Naunyn Schmiedebergs Arch Pharmacol. 1997;356(6):721–37.

Article  CAS  PubMed  Google Scholar 

Altman JD, Trendelenburg AU, MacMillan L, Bernstein D, Limbird L, Starke K, Kobilka BK, Hein L. Abnormal regulation of the sympathetic nervous system in alpha2A-adrenergic receptor knockout mice. Mol Pharmacol. 1999;56(1):154–61.

Article  CAS  PubMed  Google Scholar 

Hein L, Altman JD, Kobilka BK. Two functionally distinct alpha2-adrenergic receptors regulate sympathetic neurotransmission. Nature. 1999;402(6758):181–4.

Article  CAS  PubMed  Google Scholar 

Bucheler MM, Hadamek K, Hein L. Two alpha(2)-adrenergic receptor subtypes, alpha(2A) and alpha(2C), inhibit transmitter release in the brain of gene-targeted mice. Neuroscience. 2002;109(4):819–26.

Article  CAS  PubMed  Google Scholar 

Giovannitti JA Jr, Thoms SM, Crawford JJ. Alpha-2 adrenergic receptor agonists: a review of current clinical applications. Anesth Prog. 2015;62(1):31–9.

Article  PubMed  PubMed Central  Google Scholar 

Philipp M, Brede M, Hein L. Physiological significance of alpha(2)-adrenergic receptor subtype diversity: one receptor is not enough. Am J Physiol Regul Integr Comp Physiol. 2002;283(2):R287–95.

Article  CAS  PubMed  Google Scholar 

Schwinn DA, Roehrborn CG. Alpha1-adrenoceptor subtypes and lower urinary tract symptoms. Int J Urol. 2008;15(3):193–9.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Rudner XL, Berkowitz DE, Booth JV, Funk BL, Cozart KL, D’Amico EB, El-Moalem H, Page SO, Richardson CD, Winters B, et al. Subtype specific regulation of human vascular alpha(1)-adrenergic receptors by vessel bed and age. Circulation. 1999;100(23):2336–43.

Article  CAS  PubMed  Google Scholar 

Hering L, Rahman M, Potthoff SA, Rump LC, Stegbauer J. Role of alpha2-adrenoceptors in hypertension: focus on renal sympathetic neurotransmitter release, inflammation, and sodium homeostasis. Front Physiol. 2020;11:566871.

Article  PubMed  PubMed Central  Google Scholar 

Perez-Rivera AA, Hlavacova A, Rosario-Colon LA, Fink GD, Galligan JJ. Differential contributions of alpha-1 and alpha-2 adrenoceptors to vasoconstriction in mesenteric arteries and veins of normal and hypertensive mice. Vascul Pharmacol. 2007;46(5):373–82.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chotani MA, Mitra S, Su BY, Flavahan S, Eid AH, Clark KR, Montague CR, Paris H, Handy DE, Flavahan NA. Regulation of alpha(2)-adrenoceptors in human vascular smooth muscle cells. Am J Physiol Heart Circ Physiol. 2004;286(1):H59–67.

Article  CAS  PubMed  Google Scholar 

Muszkat M, Sofowora GG, Wood AJ, Stein CM. Alpha2-adrenergic receptor-induced vascular constriction in blacks and whites. Hypertension. 2004;43(1):31–5.

Article  CAS  PubMed  Google Scholar 

Blaxall HS, Hass NA, Bylund DB. Expression of alpha 2-adrenergic receptor genes in rat tissues. Receptor. 1994;4(3):191–9.

CAS  PubMed  Google Scholar 

Nicholas AP, Pieribone VA, Elde R, Hokfelt T. Initial observations on the localization of mRNA for alpha and beta adrenergic receptors in brain and peripheral tissues of rat using in situ hybridization. Mol Cell Neurosci. 1991;2(4):344–50.

Article  CAS  PubMed  Google Scholar 

Saunders C, Limbird LE. Localization and trafficking of alpha2-adrenergic receptor subtypes in cells and tissues. Pharmacol Ther. 1999;84(2):193–205.

Article  CAS  PubMed  Google Scholar 

Davis RA, Fechner GA, Sykes M, Garavelas A, Pass DM, Carroll AR, Addepalli R, Avery VM, Hooper JN, Quinn RJ. (-)-Dibromophakellin: an alpha2B adrenoceptor agonist isolated from the Australian marine sponge, Acanthella costata. Bioorg Med Chem. 2009;17(6):2497–500.

Article  CAS  PubMed  Google Scholar 

Manolopoulos PP, Boutsikos I, Boutsikos P, Iacovidou N, Ekmektzoglou K. Current use and advances in vasopressors and inotropes support in shock. J Emerg Crit Care Med. 2020;4:1–13.

Fage N, Asfar P, Radermacher P, Demiselle J. Norepinephrine and vasopressin in hemorrhagic shock: a focus on renal hemodynamics. Int J Mol Sci. 2023;24(4): 1–13.

Garcia B, Legrand M. Adjunctive vasopressors in distributive shock: how soon is early? Crit Care. 2023;27(1):210.

Article  PubMed  PubMed Central  Google Scholar 

Pannu AK. Circulatory shock in adults in emergency department. Turk J Emerg Med. 2023;23(3):139–48.

Article  PubMed  PubMed Central  Google Scholar 

Foulon P, De Backer D. The hemodynamic effects of norepinephrine: far more than an increase in blood pressure! Ann Transl Med. 2018;6(Suppl 1):S25.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Gulati A, Choudhuri R, Gupta A, Singh S, Ali SKN, Sidhu GK, Haque PD, Rahate P, Bothra AR, Singh GP, et al. A Multicentric, randomized, controlled phase III study of Centhaquine (Lyfaquin((R))) as a resuscitative agent in hypovolemic shock patients. Drugs. 2021;81(9):1079–100.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Leenen FH, Chan YK, Smith DL, Reeves RA. Epinephrine and left ventricular function in humans: effects of beta-1 vs nonselective beta-blockade. Clin Pharmacol Ther. 1988;43(5):519–28.

Article  CAS  PubMed  Google Scholar 

Holmes JC, Fowler NO. Direct cardiac effects of dopamine. Circ Res. 1962;10:68–72.

Article  CAS  PubMed 

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