Saueressig T, Pedder H, Owen PJ, Belavy DL (2024) Contextual effects: how to, and how not to, quantify them. BMC Med Res Methodol 24. https://doi.org/10.1186/s12874-024-02152-2
Spiro H (1997) Placebo: conversation at the disciplinary borders. Harvard University Press, Cambridge
Meissner K, Kohls N, Colloca L (2011) Introduction to placebo effects in medicine: mechanisms and clinical implications. Philos Trans R Soc Lond B Biol Sci 366:1783–1789. https://doi.org/10.1098/RSTB.2010.0414
Article PubMed PubMed Central Google Scholar
Kienle GS, Kiene H (1997) The powerful placebo effect: fact or fiction? J Clin Epidemiol 50. https://doi.org/10.1016/S0895-4356(97)00203-5
Colloca L (2018) Preface: The fascinating mechanisms and ımplications of the placebo effect. Int Rev Neurobiol 138. https://doi.org/10.1016/S0074-7742(18)30027-8
Hafliðadóttir SH, Juhl CB, Nielsen SM, Henriksen M, Harris IA, Bliddal H et al (2021) Placebo response and effect in randomized clinical trials: meta-research with focus on contextual effects. Trials 22. https://doi.org/10.1186/s13063-021-05454-8
Colloca L (2018) Responses to the sham treatment vs expectancy effects. Pain 159. https://doi.org/10.1097/j.pain.0000000000001266
Cook CE, Bailliard A, Bent JA, Bialosky JE, Carlino E, Colloca L et al (2023) An international consensus definition for contextual factors: findings from a nominal group technique. Front Psychol 14. https://doi.org/10.3389/fpsyg.2023.1178560
Testa M, Rossettini G (2016) Enhance placebo, avoid nocebo: how contextual factors affect physiotherapy outcomes. Man Ther 24. https://doi.org/10.1016/j.math.2016.04.006
Planès S, Villier C, Mallaret M (2016) The nocebo effect of drugs. Pharmacol Res Perspect 4. https://doi.org/10.1002/prp2.208
Mitsikostas DD, Chalarakis NG, Mantonakis LI, Delicha EM, Sfikakis PP (2012) Nocebo in fibromyalgia: meta-analysis of placebo-controlled clinical trials and implications for practice. Eur J Neurol 19. https://doi.org/10.1111/j.1468-1331.2011.03528.x
Mitsikostas DD, Mantonakis L, Chalarakis N (2014) Nocebo in clinical trials for depression: a meta-analysis. Psychiatry Res 215. https://doi.org/10.1016/j.psychres.2013.10.019
Enck P, Benedetti F, Schedlowski M (2008) New ınsights into the placebo and nocebo responses. Neuron 59. https://doi.org/10.1016/j.neuron.2008.06.030
Petrie KJ, Rief W (2019) Psychobiological mechanisms of placebo and nocebo effects: pathways to ımprove treatments and reduce side effects. Annu Rev Psychol 70. https://doi.org/10.1146/annurev-psych-010418-102907
Wager TD, Atlas LY (2015) The neuroscience of placebo effects: connecting context, learning and health. Nat Rev Neurosci 16. https://doi.org/10.1038/nrn3976
Colagiuri B, Schenk LA, Kessler MD, Dorsey SG, Colloca L (2015) The placebo effect: from concepts to genes. Neuroscience 307:171–190. https://doi.org/10.1016/J.NEUROSCIENCE.2015.08.017
Article CAS PubMed Google Scholar
Jensen JS, Bielefeldt AØ, Hróbjartsson A (2017) Active placebo control groups of pharmacological interventions were rarely used but merited serious consideration: a methodological overview. J Clin Epidemiol 87. https://doi.org/10.1016/j.jclinepi.2017.03.001
Weimer K, Enck P (2014) Traditional and ınnovative experimental and clinical trial designs and their advantages and pitfalls. In: Benedetti FEPFESM (ed) Handbook of Experimental Pharmacology: Placebo, Springer, vol 225, p 237–73
Shapiro A, Shapiro E (2000) The powerful placebo. Baltimore: Johns Hopkins University Press. https://doi.org/10.1353/book.3471
Moncrieff J, Wessely S, Hardy R (2004) Active placebos versus antidepressants for depression. Cochrane Database Syst Rev 2017. https://doi.org/10.1002/14651858.CD003012.pub2
Bannuru RR, McAlindon TE, Sullivan MC, Wong JB, Kent DM, Schmid CH (2015) Effectiveness and implications of alternative placebo treatments: a systematic review and network meta-analysis of osteoarthritis trials. Ann Intern Med 163. https://doi.org/10.7326/M15-0623
Hróbjartsson A, Gøtzsche PC (2010) Placebo interventions for all clinical conditions. Cochrane Database Syst Rev 2010. https://doi.org/10.1002/14651858.CD003974.pub3
Kaptchuk TJ (2020) Placebo effects in acupuncture. Med Acupunct 32. https://doi.org/10.1089/acu.2020.1483
XY Xuan, XZ Yi, Liu CZ, YS Yan (2023) Placebo effect of acupuncture in clinical study. World J Acupunct – Moxibustion 33. https://doi.org/10.1016/j.wjam.2023.10.003
Charlesworth JEG, Petkovic G, Kelley JM, Hunter M, Onakpoya I, Roberts N et al (2017) Effects of placebos without deception compared with no treatment: a systematic review and meta-analysis. J Evid Based Med 10. https://doi.org/10.1111/jebm.12251
Spille L, Fendel JC, Seuling PD, Göritz AS, Schmidt S (2023) Open-label placebos—a systematic review and meta-analysis of experimental studies with non-clinical samples. Sci Rep 13. https://doi.org/10.1038/s41598-023-30362-z
Walach H (2011) Placebo controls: historical, methodological and general aspects. Philos Trans Royal Soc B: Biol Sci 366. https://doi.org/10.1098/rstb.2010.0401
Beecher HK (1955) The powerful placebo. J Am Med Assoc 159:1602–1606. https://doi.org/10.1001/JAMA.1955.02960340022006
Article CAS PubMed Google Scholar
Hróbjartsson A, Gøtzsche PC (2004) Is the placebo powerless? Update of a systematic review with 52 new randomized trials comparing placebo with no treatment. J Intern Med 256. https://doi.org/10.1111/j.1365-2796.2004.01355.x
Benedetti F (2013) Placebo and the new physiology of the doctor-patient relationship. Physiol Rev 93. https://doi.org/10.1152/physrev.00043.2012
Kirsch I (2019) Placebo effect in the treatment of depression and anxiety. Front Psychiatry 10. https://doi.org/10.3389/fpsyt.2019.00407
Hall KT, Lembo AJ, Kirsch I, Ziogas DC, Douaiher J, Jensen KB et al (2012) Catechol-O-methyltransferase val158met polymorphism predicts placebo effect in ırritable bowel syndrome. PLoS ONE 7:e48135. https://doi.org/10.1371/JOURNAL.PONE.0048135
Article CAS PubMed PubMed Central Google Scholar
Wechsler ME, Kelley JM, Boyd IOE, Dutile S, Marigowda G, Kirsch I, et al (2011) Active albuterol or placebo, sham acupuncture, or no ıntervention in asthma. N Engl J Med 365. https://doi.org/10.1056/nejmoa1103319.
Jacobson AF, Umberger WA, Palmieri PA, Alexander TS, Myerscough RP, Draucker CB et al (2016) Guided ımagery for total knee replacement: a randomized, placebo-controlled pilot study. J Altern Complement Med 22:563–575. https://doi.org/10.1089/ACM.2016.0038
Article PubMed PubMed Central Google Scholar
Blythe JS, Thomaidou MA, Peerdeman KJ, Van Laarhoven AIM, Van Schothorst MME, Veldhuijzen DS et al (2023) Placebo effects on cutaneous pain and itch: a systematic review and meta-analysis of experimental results and methodology. Pain 164. https://doi.org/10.1097/j.pain.0000000000002820
Kirsch I (2018) The clinical significance of drug-placebo differences. Epidemiol Psychiatr Sci 27. https://doi.org/10.1017/S2045796017000725
Margo CE (1999) The placebo effect. Surv Ophthalmol 44:31–44. https://doi.org/10.1016/S0039-6257(99)00060-0
Article CAS PubMed Google Scholar
Zis P, Mitsikostas DD (2015) Nocebo in Alzheimer’s disease; meta-analysis of placebo-controlled clinical trials. J Neurol Sci 355. https://doi.org/10.1016/j.jns.2015.05.029
Carlino E, Piedimonte A, Benedetti F (2016) Nature of the placebo and nocebo effect in relation to functional neurologic disorders. Handb Clin Neurol 139. https://doi.org/10.1016/B978-0-12-801772-2.00048-5
Charron J, Rainville P, Marchand S (2006) Direct comparison of placebo effects on clinical and experimental pain. Clin J Pain 22. https://doi.org/10.1097/01.ajp.0000161526.25374.e5
Carlino E, Vase L (2018) Can knowledge of placebo and nocebo mechanisms help ımprove randomized clinical trials? Int Rev Neurobiol 138. https://doi.org/10.1016/bs.irn.2018.01.012.
Piedimonte A, Benedetti F, Carlino E (2015) Placebo-induced decrease in fatigue: evidence for a central action on the preparatory phase of movement. Eur J Neurosci 41. https://doi.org/10.1111/ejn.12806
Fiorio M (2018) Modulation of the motor system by placebo and nocebo effects. Int Rev Neurobiol 139. https://doi.org/10.1016/bs.irn.2018.07.012
Carlino E, Guerra G, Piedimonte A (2016) Placebo effects: from pain to motor performance. Neurosci Lett 632. https://doi.org/10.1016/j.neulet.2016.08.046
Beedie C, Benedetti F, Barbiani D, Camerone E, Lindheimer J, Roelands B (2020) Incorporating methods and findings from neuroscience to better understand placebo and nocebo effects in sport. Eur J Sport Sci 20. https://doi.org/10.1080/17461391.2019.1675765
Brietzke C, Cesario JCS, Hettinga FJ, Pires FO (2022) The reward for placebos: mechanisms underpinning placebo-induced effects on motor performance. Eur J Appl Physiol 122. https://doi.org/10.1007/s00421-022-05029-8
Cai L, He L (2019) Placebo effects and the molecular biological components involved. Gen Psychiatr 32. https://doi.org/10.1136/gpsych-2019-100089
Colloca L, Mocci E, Wang Y, Massalee R, Chen S, White J et al (2024) Transcriptomic profiles associated with experimental placebo effects in chronic pain. Clin Pharmacol Ther 116:380–389. https://doi.org/10.1002/cpt.3286
Article CAS PubMed Google Scholar
Lasagna L, Laties VG, Dohan JL (1958) Further studies on the pharmacology of placebo administration. J Clin Invest 37. https://doi.org/10.1172/JCI103635
Benedetti F, Frisaldi E, Shaibani A (2022) Thirty years of neuroscientific ınvestigation of placebo and nocebo: the ınteresting, the good, and the bad. Annu Rev Pharmacol Toxicol 62. https://doi.org/10.1146/annurev-pharmtox-052120-104536
Prossin A, Koch A, Campbell P, Laumet G, Stohler CS, Dantzer R et al (2022) Effects of placebo administration on immune mechanisms and relationships with central endogenous opioid neurotransmission. Mol Psychiatry 27. https://doi.org/10.1038/s41380-021-01365-x
Evers AWM, Colloca L, Blease C, Annoni M, Atlas LY, Benedetti F et al (2018) Implications of placebo and nocebo effects for clinical practice: expert consensus. Psychother Psychosom 87. https://doi.org/10.1159/000490354
Colloca L (2019) The placebo effect in pain therapies. Https://Org/101146/Annurev-Pharmtox-010818-021542 59:191–211. https://doi.org/10.1146/ANNUREV-PHARMTOX-010818-021542
Skyt I, Lunde SJ, Baastrup C, Svensson P, Jensen TS, Vase L (2020) Neurotransmitter systems involved in placebo and nocebo effects in healthy participants and patients with chronic pain: a systematic review. Pain 161. https://doi.org/10.1097/j.pain.0000000000001682
Meissner K, Binge U, Colloca L, Wager TD, Watson A, Flaten MA (2011) The placebo effect: advances from different methodological approaches. J Neurosci 31:16117–16124. https://doi.org/10.1523/JNEUROSCI.4099-11.2011
Article CAS PubMed PubMed Central Google Scholar
Rossettini G, Campaci F, Bialosky J, Huysmans E, Vase L, Carlino E (2023) The biology of placebo and nocebo effects on experimental and chronic pain: state of the art. J Clin Med 12. https://doi.org/10.3390/jcm12124113
Zunhammer M, Spisák T, Wager TD, Bingel U, Atlas L, Benedetti F et al (2021) Meta-analysis of neural systems underlying placebo analgesia from individual participant fMRI data. Nat Commun 12. https://doi.org/10.1038/s41467-021-21179-3
Chen C, Niehaus JK, Dinc F, Huang KL, Barnette AL, Tassou A et al (2024) Neural circuit basis of placebo pain relief. Nature 632:1092–1100. https://doi.org/10.1038/s41586-024-07816-z
Article CAS PubMed PubMed Central Google Scholar
Villa-Sánchez B, Emadi Andani M, Cesari P, Fiorio M (2021) The effect of motor and cognitive placebos on the serial reaction time task. Eur J Neurosci 53. https://doi.org/10.1111/ejn.15148
Carlino E, Piedimonte A, Frisaldi E (2014) The effects of placebos and nocebos on physical performance. Handb Exp Pharmacol 225. https://doi.org/10.1007/978-3-662-44519-8_9
Geuter S, Koban L, Wager TD (2017) The cognitive neuroscience of placebo effects: concepts, predictions, and physiology. Annu Rev Neurosci 40. https://doi.org/10.1146/annurev-neuro-072116-031132
Guo JY, Wang JY, Luo F (2010) Dissection of placebo analgesia in mice: the conditions for activation of opioid and non-opioid systems. J Psychopharmacol 24. https://doi.org/10.1177/0269881109104848
Guo JY, Yuan XY, Sui F, Zhang WC, Wang JY, Luo F, et al (2011) Placebo analgesia affects the behavioral despair tests and hormonal secretions in mice. Psychopharmacology (Berl) 217. https://doi.org/10.1007/s00213-011-2259-7
Lee IS, Lee B, Park HJ, Olausson H, Enck P, Chae Y (2015) A new animal model of placebo analgesia: ınvolvement of the dopaminergic system in reward learning. Sci Rep 5. https://doi.org/10.1038/srep17140
Jensen KB, Kaptchuk TJ, Chen X, Kirsch I, Ingvar M, Gollub RL et al (2015) A neural mechanism for nonconscious activation of conditioned placebo and nocebo responses. Cerebral Cortex 25. https://doi.org/10.1093/cercor/bhu275
Schaefer M, Kühnel A, Schweitzer F, Enge S, Gärtner M (2023) Neural underpinnings of open-label placebo effects in emotional distress. Neuropsychopharmacol 48. https://doi.org/10.1038/s41386-022-01501-3
Petrovic P, Dietrich T, Fransson P, Andersson J, Carlsson K, Ingvar M (2005) Placebo in emotional processing - ınduced expectations of anxiety relief activate a generalized modulatory network. Neuron 46. https://doi.org/10.1016/j.neuron.2005.05.023
Kirsch I (1999) Hypnosis and placebos: response expectancy as a mediator of suggestion effects. Anales de Psicologia 15(1):99–110
Brown WA (2013) Expectation, the placebo effect and the response to treatment. R I Med J 2015:98
Reicherts P, Gerdes ABM, Pauli P, Wieser MJ (2016) Psychological placebo and nocebo effects on pain rely on expectation and previous experience. J Pain 17. https://doi.org/10.1016/j.jpain.2015.10.010
Kirsch I (2018) Response expectancy and the placebo effect. Int Rev Neurobiol 138. https://doi.org/10.1016/bs.irn.2018.01.003
Faasse K, Cundy T, Gamble G, Petrie KJ (2013) The effect of an apparent change to a branded or generic medication on drug effectiveness and side effects. Psychosom Med 75. https://doi.org/10.1097/PSY.0b013e3182738826
Bąbel P (2019) Classical conditioning as a distinct mechanism of placebo effects. Front Psychiatry 10. https://doi.org/10.3389/fpsyt.2019.00449
Hyland ME (2011) Motivation and placebos: do different mechanisms occur in different contexts? Philos Trans R Soc Lond B Biol Sci 366:1828–1837. https://doi.org/10.1098/RSTB.2010.0391
Article PubMed PubMed Central Google Scholar
Geers AL, Faasse K, Guevarra DA, Clemens KS, Helfer SG, Colagiuri B (2021) Affect and emotions in placebo and nocebo effects: what do we know so far? Soc Personal Psychol Compass 15. https://doi.org/10.1111/spc3.12575
Kaptchuk TJ (2011) Placebo studies and ritual theory: a comparative analysis of Navajo, acupuncture and biomedical healing. Philos Trans Royal Soc B: Biol Sci 366. https://doi.org/10.1098/rstb.2010.0385
Vrijsen JN, Fischer VS, Müller BW, Scherbaum N, Becker ES, Rinck M et al (2018) Cognitive bias modification as an add-on treatment in clinical depression: results from a placebo-controlled, single-blinded randomized control trial. J Affect Disord 238. https://doi.org/10.1016/j.jad.2018.06.025
Whalley B, Hyland ME, Kirsch I (2008) Consistency of the placebo effect. J Psychosom Res 64. https://doi.org/10.1016/j.jpsychores.2007.11.007
Kirchhof J, Petrakova L, Brinkhoff A, Benson S, Schmidt J, Unteroberdörster M et al (2018) Learned immunosuppressive placebo responses in renal transplant patients. Proc Natl Acad Sci U S A 115. https://doi.org/10.1073/pnas.1720548115
Meeuwis SH, Van Middendorp H, Pacheco-Lopez G, Ninaber MK, Lavrijsen APM, Van Der Wee N et al (2019) Antipruritic placebo effects by conditioning H1-antihistamine. Psychosom Med 81.
Comments (0)