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Empagliflozin Supplementation in Cardioplegic Solution Improves Donor Heart Preservation by Maintaining Mitochondrial Homeostasis
Empagliflozin Supplementation in Cardioplegic Solution Improves Donor Heart Preservation by Maintaining Mitochondrial Homeostasis
Prolonged cold ischemia and subsequent reperfusion are major causes of primary graft dysfunction in heart transplantation....
Machine Learning–Based Identification of Exosome-Associated Diagnostic Biomarkers in Acute Myocardial Infarction and in Silico Drug Prioritization
Machine Learning–Based Identification of Exosome-Associated Diagnostic Biomarkers in Acute Myocardial Infarction and in Silico Drug Prioritization
Acute myocardial infarction (AMI) is a major global health burden, with current diagnostic biomarkers often limited by del...
Modulating CGRP Signaling: A Promising Therapeutic Avenue for Attenuating Cardiac Dysfunction in Heart Failure
Modulating CGRP Signaling: A Promising Therapeutic Avenue for Attenuating Cardiac Dysfunction in Heart Failure
Heart failure (HF) is a progressive clinical syndrome characterized by structural and functional cardiac impairment, leadi...
Targeting Vascular Calcification: Novel Insights into Molecular Pathways and Clinical Interventions
Targeting Vascular Calcification: Novel Insights into Molecular Pathways and Clinical Interventions
Vascular calcification (VC), a pathological hallmark of advanced atherosclerosis, exerts a profound impact on arterial sti...
High Mobility Group Protein B1 Mediates the Role of the Neutrophil Extracellular Traps in the Progression of Acute Myocardial Infarction
High Mobility Group Protein B1 Mediates the Role of the Neutrophil Extracellular Traps in the Progression of Acute Myocardial Infarction
Neutrophil extracellular traps (NETs) play a crucial role in the pathogenesis of acute myocardial infarction (AMI), but th...
The Statin Floor Effect: a Mechanistic Framework for Residual Cardiovascular Risk
The Statin Floor Effect: a Mechanistic Framework for Residual Cardiovascular Risk
Despite substantial statin-induced low-density lipoprotein cholesterol (LDL-C) lowering, residual cardiovascular risk rema...
Heart Failure with Preserved Ejection Fraction as a Risk Factor for Atrial Fibrillation Recurrence after Ablation
Heart Failure with Preserved Ejection Fraction as a Risk Factor for Atrial Fibrillation Recurrence after Ablation
Atrial fibrillation (AF) recurrence after radiofrequency ablation is closely associated with patient prognosis, while the ...
Potentially Clinically Significant Drug-Drug Interactions in Older Adults with Atrial Fibrillation and Multimorbidity: Prevalence, Correlates, and Association with Adverse Clinical Outcomes in a Swedish National Register-Based Study
Potentially Clinically Significant Drug-Drug Interactions in Older Adults with Atrial Fibrillation and Multimorbidity: Prevalence, Correlates, and Association with Adverse Clinical Outcomes in a Swedish National Register-Based Study
Current research on potentially clinically significant drug-drug interactions (DDIs) in individuals with atrial fibrillati...
Mitochondria at the Heart of Ischemia-Reperfusion (I/R) Injury: the HOXB5-Sirt5 Axis
Mitochondria at the Heart of Ischemia-Reperfusion (I/R) Injury: the HOXB5-Sirt5 Axis
Ischemic cardiomyopathy (ICM) arises from restricted myocardial blood flow, leading to ischemia/reperfusion (I/R) injury, ...
Protective Effects of Jiawei Baihu Tang in Kawasaki Disease: Omics Analysis and Mechanistic Exploration
Protective Effects of Jiawei Baihu Tang in Kawasaki Disease: Omics Analysis and Mechanistic Exploration
Kawasaki disease (KD) is classified as a “WenBing” syndrome in traditional Chinese medicine (TCM), characteriz...
Macrophage Migration Inhibitory Factor: the Next Adjunct to Reperfusion Therapy in Acute Myocardial Infarction?
Macrophage Migration Inhibitory Factor: the Next Adjunct to Reperfusion Therapy in Acute Myocardial Infarction?
Calandra T, Roger T. Macrophage migration inhibitory factor: a regulator of innate immunity. Nat Rev Immunol. 2003;3(10):7...
Vagus Nerve Stimulation by Focused Ultrasound Attenuates Acute Myocardial Ischemia/Reperfusion Injury Predominantly Through Cholinergic Anti-inflammatory Pathway
Vagus Nerve Stimulation by Focused Ultrasound Attenuates Acute Myocardial Ischemia/Reperfusion Injury Predominantly Through Cholinergic Anti-inflammatory Pathway
This study investigates the cardioprotective effects of focused ultrasound stimulation (FUS) as a novel, noninvasive inter...
Sotagliflozin: Two Birds with One Stone?
Sotagliflozin: Two Birds with One Stone?
Sodium-glucose cotransporter 2 inhibitors (SGLT2i), initially developed as antidiabetic agents, have become a cornerstone ...
Coronary Artery Bypass Grafting With or Without Concomitant Surgical Ventricular Reconstruction in Ischemic Cardiomyopathy Patients
Coronary Artery Bypass Grafting With or Without Concomitant Surgical Ventricular Reconstruction in Ischemic Cardiomyopathy Patients
The present study aims to compare the long-term outcomes of surgical ventricular reconstruction (SVR) combined with corona...
Macrophage CBX4 Potentiates Atherosclerosis by its SUMO E3 Ligase Activity
Macrophage CBX4 Potentiates Atherosclerosis by its SUMO E3 Ligase Activity
Atherosclerosis (AS) is the leading cause of cardiovascular disease and mortality worldwide. Despite extensive research, t...
Effects of Angiotensin-Converting Enzyme Inhibitors/Angiotensin II Receptor Blockers on Prognosis in Acute Coronary Syndrome Patients with Preserved Ejection Fraction Undergoing Regular Dialysis
Effects of Angiotensin-Converting Enzyme Inhibitors/Angiotensin II Receptor Blockers on Prognosis in Acute Coronary Syndrome Patients with Preserved Ejection Fraction Undergoing Regular Dialysis
The utilization of angiotensin-converting enzyme inhibitor (ACEI) or angiotensin II receptor blocker (ARB) following myoca...
Pericardial Administration of Extracellular Vesicles Derived from Bone Marrow Stem Cells Improved Doxorubicin-induced Heart Failure with Mid Range Ejection Fraction (HFmrEF) in Rats
Pericardial Administration of Extracellular Vesicles Derived from Bone Marrow Stem Cells Improved Doxorubicin-induced Heart Failure with Mid Range Ejection Fraction (HFmrEF) in Rats
This study investigates the therapeutic effects of extracellular vesicles (EVs) derived from bone marrow mesenchymal stem ...
Impact of Percutaneous Coronary Interventions on Coronary Microvascular System: Coronary Stenting Versus Drug-Coated Balloon Angioplasty
Impact of Percutaneous Coronary Interventions on Coronary Microvascular System: Coronary Stenting Versus Drug-Coated Balloon Angioplasty
Authors and AffiliationsDepartment of Cardiology, School of Medicine, Trakya University, Edirne, 22030, TurkeyUğur Özkan, ...
Clinical Implication of Quantitative Flow Ratio to Predict Clinical Outcomes in De Novo Coronary Lesions After Drug-Coated Balloon Angioplasty
Clinical Implication of Quantitative Flow Ratio to Predict Clinical Outcomes in De Novo Coronary Lesions After Drug-Coated Balloon Angioplasty
The association between the intra-procedure quantitative flow ratio (QFR) and clinical outcomes after drug-coated balloon ...
Direct Oral Anticoagulants in Valvular Diseases and Prosthetic Valves: Why Not?
Direct Oral Anticoagulants in Valvular Diseases and Prosthetic Valves: Why Not?
Valvular heart disease (VHD) and atrial fibrillation (AF) often coexist and lead to a prothrombotic state that necessitate...
Factor XIa Inhibitors Versus Direct Oral Anticoagulants for Atrial Fibrillation: A Systematic Review and Meta-analysis of Randomized Controlled Trials
Factor XIa Inhibitors Versus Direct Oral Anticoagulants for Atrial Fibrillation: A Systematic Review and Meta-analysis of Randomized Controlled Trials
Direct oral anticoagulants (DOACs) are the standard treatment for reducing thromboembolic risk in patients with atrial fib...
Correction to: Non-Invasive Local Acoustic Therapy Ameliorates Diabetic Heart Fibrosis by Suppressing ACE-Mediated Oxidative Stress and Inflammation in Cardiac Fibroblasts
Correction to: Non-Invasive Local Acoustic Therapy Ameliorates Diabetic Heart Fibrosis by Suppressing ACE-Mediated Oxidative Stress and Inflammation in Cardiac Fibroblasts
Department of Cardiology, The First Affiliated Hospital of Nanjing Medical University, 300 Guangzhou Road, Nanjing, 210029...
Dapagliflozin for Atrial Fibrillation
Dapagliflozin for Atrial Fibrillation
Sodium glucose cotransporter-2 (SGLT2) inhibitors, originally developed for the treat...
Differential Proteomic Profiles of Coronary Serum Exosomes in Acute Myocardial Infarction Patients with or Without Diabetes Mellitus: ANGPTL6 Accelerates Regeneration of Endothelial Cells Treated with Rapamycin via MAPK Pathways
Differential Proteomic Profiles of Coronary Serum Exosomes in Acute Myocardial Infarction Patients with or Without Diabetes Mellitus: ANGPTL6 Accelerates Regeneration of Endothelial Cells Treated with Rapamycin via MAPK Pathways
Delayed re-endothelialization after coronary drug-eluting stent implantation is associated with an increased incidence of ...
The SGLT2i Dapagliflozin Reduces RV Mass Independent of Changes in RV Pressure Induced by Pulmonary Artery Banding
The SGLT2i Dapagliflozin Reduces RV Mass Independent of Changes in RV Pressure Induced by Pulmonary Artery Banding
Sodium glucose linked transporter 2 (SGLT2) inhibition not only reduces morbidity and mortality in patients with diagnosed...
Acute Kidney Injury in Different Anticoagulation Strategies: A Large-Scale Pharmacoepidemiologic Study Using Real-World Data
Acute Kidney Injury in Different Anticoagulation Strategies: A Large-Scale Pharmacoepidemiologic Study Using Real-World Data
Acute kidney injury (AKI) following anticoagulant application has received growing attention as a significant emerging com...
Safety and Effectiveness of Antidysrhythmic Drugs for Pharmacologic Cardioversion of Recent-Onset Atrial Fibrillation: a Systematic Review and Bayesian Network Meta-analysis
Safety and Effectiveness of Antidysrhythmic Drugs for Pharmacologic Cardioversion of Recent-Onset Atrial Fibrillation: a Systematic Review and Bayesian Network Meta-analysis
The available evidence to determine which antidysrhythmic drug is superior for pharmacologic cardioversion of recent-onset...
A Practical Approach to the Management of Residual Cardiovascular Risk: United Arab Emirates Expert Consensus Panel on the Evidence for Icosapent Ethyl and Omega-3 Fatty Acids
A Practical Approach to the Management of Residual Cardiovascular Risk: United Arab Emirates Expert Consensus Panel on the Evidence for Icosapent Ethyl and Omega-3 Fatty Acids
Patients with hyperlipidemia treated with statins remain at a residual cardiovascular (CV) risk. Omega-3 polyunsaturated f...
Isoimperatorin Inhibits Angiogenesis by Suppressing VEGFR2 Signaling Pathway
Isoimperatorin Inhibits Angiogenesis by Suppressing VEGFR2 Signaling Pathway
Angiogenesis involves in many pathological processes, including tumor metastasis, diabetic retinopathy, and rheumatoid art...
An Integrated Network Pharmacology and RNA-seq Approach for Exploring the Protective Effect of Andrographolide in Doxorubicin-Induced Cardiotoxicity
An Integrated Network Pharmacology and RNA-seq Approach for Exploring the Protective Effect of Andrographolide in Doxorubicin-Induced Cardiotoxicity
Doxorubicin (Dox) is clinically limited due to its dose-dependent cardiotoxicity. Andrographolide (Andro) has been confirm...
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