Johnson E, Albakri JS, Allemailem KS, et al. Mitochondrial dysfunction and calcium homeostasis in heart failure: exploring the interplay between oxidative stress and cardiac remodeling for future therapeutic innovations. Curr Probl Cardiol. 2025;50(3):102968. https://doi.org/10.1016/j.cpcardiol.2024.102968.
Pellicori P, Kaur K, Clark AL. Fluid management in patients with chronic heart failure. Card Fail Rev. 2015;1(2):90–5. https://doi.org/10.15420/cfr.2015.1.2.90.
Article PubMed PubMed Central Google Scholar
Shahim B, Kapelios CJ, Savarese G, Lund LH. Global public health burden of heart failure: an updated review. Card Fail Rev. 2023;9:e11. https://doi.org/10.15420/cfr.2023.05.
Article PubMed PubMed Central Google Scholar
Lippi G, Sanchis-Gomar F. Global epidemiology and future trends of heart failure. AME Med J. 2020;5:28. https://doi.org/10.21037/amj.2020.03.03.
Varghese TP, Tazneem B. Unraveling the complex pathophysiology of heart failure: insights into the role of renin-angiotensin-aldosterone system (RAAS) and sympathetic nervous system (SNS). Curr Probl Cardiol. 2024;49(4):102411. https://doi.org/10.1016/j.cpcardiol.2024.102411.
Hartupee J, Mann DL. Neurohormonal activation in heart failure with reduced ejection fraction. Nat Rev Cardiol. 2017;14(1):30–8. https://doi.org/10.1038/nrcardio.2016.163.
Article CAS PubMed Google Scholar
Manolis AA, Manolis TA, Manolis AS. Neurohumoral activation in heart failure. Int J Mol Sci. 2023;24(20):15472. https://doi.org/10.3390/ijms242015472.
Article CAS PubMed PubMed Central Google Scholar
Russell FA, King R, Smillie SJ, et al. Calcitonin gene-related peptide: physiology and pathophysiology. Physiol Rev. 2014;94(4):1099–142. https://doi.org/10.1152/physrev.00034.2013.
Article CAS PubMed PubMed Central Google Scholar
Kee Z, Kodji X, Brain SD. The role of calcitonin gene-related peptide (CGRP) in neurogenic vasodilation and its cardioprotective effects. Front Physiol. 2018;9:1249. https://doi.org/10.3389/fphys.2018.01249.
Article PubMed PubMed Central Google Scholar
Argunhan F, Brain SD. The vascular-dependent and -independent actions of calcitonin gene-related peptide in cardiovascular disease. Front Physiol. 2022;13:833645. https://doi.org/10.3389/fphys.2022.833645.
Article PubMed PubMed Central Google Scholar
Favoni V, Giani L, Al-Hassany L, et al. CGRP and migraine from a cardiovascular point of view: what do we expect from blocking CGRP? J Headache Pain. 2019;20(1):27. https://doi.org/10.1186/s10194-019-0979-y.
Article PubMed PubMed Central Google Scholar
Saboowala H. Calcitonin gene-related peptide (CGRP): insights into its physiological functions and pathological implications. Dr Hakim Saboowala Rep 2024.
Eller MT, Schwarzová K, Gufler L, et al. CGRP-targeted migraine therapies in patients with vascular risk factors or stroke: a review. Neurology. 2025;105(2):e213852. . https://doi.org/10.1212/WNL.0000000000213852
Article PubMed PubMed Central Google Scholar
Rees TA, Hendrikse ER, Hay DL, Walker CS, Beyond CGRP. The calcitonin peptide family as targets for migraine and pain. Br J Pharmacol. 2022;179(3):381–99. https://doi.org/10.1111/bph.15605.
Article CAS PubMed Google Scholar
Wimalawansa SJ. Calcitonin gene-related peptide and its receptors: molecular genetics, physiology, pathophysiology, and therapeutic potentials. Endocr Rev. 1996;17(5):533–85. https://doi.org/10.1210/edrv-17-5-533.
Article CAS PubMed Google Scholar
Bovenberg RA, Moen TC, Jansz HS, Baas PD. In vitro splicing analysis of mini-gene constructs of the alternatively processed human calcitonin/CGRP-I pre-mRNA. Biochim Biophys Acta Gene Struct Expr. 1989;1008(2):223–33. https://doi.org/10.1016/0167-4781(80)90013-5.
Makowska K, Gonkowski S. The influence of inflammation and nerve damage on the neurochemical characterization of calcitonin gene-related peptide–like immunoreactive (CGRP-LI) neurons in the enteric nervous system of the Porcine descending colon. Int J Mol Sci. 2018;19(2):548. https://doi.org/10.1016/j.tips.2010.06.006.
Article CAS PubMed PubMed Central Google Scholar
Kumar A, Potts JD, DiPette DJ. Protective role of α-calcitonin gene-related peptide in cardiovascular diseases. Front Physiol. 2019;10:821. https://doi.org/10.3389/fphys.2019.00821.
Article PubMed PubMed Central Google Scholar
Durham PL. Calcitonin gene-related peptide (CGRP) and migraine. Headache. 2006;46(Suppl 1):S3–8. https://doi.org/10.1111/j.1526-4610.2006.00483.x.
Article PubMed PubMed Central Google Scholar
Aksoydan B, Durdagi S. Molecular simulations reveal the impact of RAMP1 on ligand binding and dynamics of CGRPR heterodimer. BioRxiv. 2021 May 10. https://doi.org/10.1101/2021.05.10.443383.
Pal K, Melcher K, Xu HE. Structure and mechanism for recognition of peptide hormones by class B G-protein-coupled receptors. Acta Pharmacol Sin. 2012;33(3):300–11. https://doi.org/10.1038/aps.2011.170.
Article CAS PubMed PubMed Central Google Scholar
Shao L, Chen Y, Zhang S, et al. Modulating effects of ramps on signaling profiles of the glucagon receptor family. Acta Pharm Sin B. 2022;12(2):637–50. https://doi.org/10.1016/j.apsb.2021.07.028.
Article CAS PubMed Google Scholar
Farrell SR, Howlett SE. The age-related decrease in catecholamine sensitivity is mediated by beta(1)-adrenergic receptors linked to a decrease in adenylate cyclase activity in ventricular myocytes from male Fischer 344 rats. Mech Ageing Dev. 2008;129(12):735–44. https://doi.org/10.1016/j.mad.2008.09.017.
Article CAS PubMed Google Scholar
Mahmood A, Ahmed K, Zhang Y. β-adrenergic receptor desensitization/down-regulation in heart failure: A friend or foe? Front Cardiovasc Med. 2022;9:925692. https://doi.org/10.3389/fcvm.2022.925692.
Article CAS PubMed PubMed Central Google Scholar
Colombe AS, Pidoux G. Cardiac cAMP-PKA signaling compartmentalization in myocardial infarction. Cells. 2021;10(4):922. https://doi.org/10.3390/cells10040922.
Article CAS PubMed PubMed Central Google Scholar
Eftekhari S, Edvinsson L. Possible sites of action of the new calcitonin gene-related peptide receptor antagonists. Ther Adv Neurol Disord. 2010;3(6):369–78. https://doi.org/10.1177/1756285610388343.
Article CAS PubMed PubMed Central Google Scholar
Brain SD, Tippins JR, Morris HR, et al. Potent vasodilator activity of calcitonin gene-related peptide in human skin. J Invest Dermatol. 1986;87(4):533–6. https://doi.org/10.1111/1523-1747.ep12455620.
Article CAS PubMed Google Scholar
White RE, Kryman JP, El-Mowafy AM, et al. cAMP-dependent vasodilators cross-activate the cGMP-dependent protein kinase to stimulate BK < sub > Ca channel activity in coronary artery smooth muscle cells. Circ Res. 2000;86(8):897–905. https://doi.org/10.1161/01.RES.86.8.897.
Article CAS PubMed Google Scholar
Tellİ G, Tel BC, GÜmÜŞel B. The cardiopulmonary effects of the calcitonin gene-related peptide family. Turk J Pharm Sci. 2020;17(3):349. https://doi.org/10.4274/tjps.galenos.2019.47123.
Article PubMed PubMed Central Google Scholar
Franco-Cereceda A, Liska J. Potential of calcitonin gene-related peptide in coronary heart disease. Pharmacology. 2000;60(1):1–8.
Comments (0)