SCI Abstract

search
+
Effect of ventricular fibrillation on infarct size after myocardial infarction: a translational study
Effect of ventricular fibrillation on infarct size after myocardial infarction: a translational study
Ventricular fibrillation (VF)-induced cardiac arrest frequently complicates ST-segment elevation myocardial infarction (ST...
The cardio-oncologic burden of breast cancer: molecular mechanisms and importance of preclinical models
The cardio-oncologic burden of breast cancer: molecular mechanisms and importance of preclinical models
Breast cancer, the most prevalent cancer affecting women worldwide, poses a significant cardio-oncological burden. Despite...
Inter-organ communication: pathways and targets to cardioprotection and neuro-protection. A report from the 12th Hatter Cardiovascular Institute workshop
Inter-organ communication: pathways and targets to cardioprotection and neuro-protection. A report from the 12th Hatter Cardiovascular Institute workshop
A long-standing aim in the setting of various pathologies including acute myocardial infarction, chronic kidney disease (C...
High-resolution DNA methylation changes reveal biomarkers of heart failure with preserved ejection fraction versus reduced ejection fraction
High-resolution DNA methylation changes reveal biomarkers of heart failure with preserved ejection fraction versus reduced ejection fraction
Novel biomarkers are needed to better identify—and distinguish—heart failure with preserved ejection fraction ...
Intravenous and oral administration of the synthetic RNA drug, TY1, reverses heart failure with preserved ejection fraction in mice
Intravenous and oral administration of the synthetic RNA drug, TY1, reverses heart failure with preserved ejection fraction in mice
TY1, a synthetic non-coding RNA (ncRNA) bioinspired by small Y RNAs abundant in extracellular vesicles (EVs), decreases cG...
Evolocumab attenuates myocardial ischemia/reperfusion injury by blocking PCSK9/LIAS-mediated cuproptosis of cardiomyocytes
Evolocumab attenuates myocardial ischemia/reperfusion injury by blocking PCSK9/LIAS-mediated cuproptosis of cardiomyocytes
Myocardial ischemia‒reperfusion (I/R) injury is the crucial cause of poor prognosis after revascularization in patie...
Associations between female sex hormones, estrous cycle, ischemic preconditioning and myocardial infarct size after ischemia–reperfusion injury
Associations between female sex hormones, estrous cycle, ischemic preconditioning and myocardial infarct size after ischemia–reperfusion injury
Studies on sex differences in myocardial infarction (MI) typically focus on males versus females, the exploration of hormo...
Assessing customized multivalent chemokine-binding peptide treatment in a murine model of coxsackievirus B3 myocarditis
Assessing customized multivalent chemokine-binding peptide treatment in a murine model of coxsackievirus B3 myocarditis
Myocarditis, an inflammatory disease of the heart muscle, is often triggered by viral infections. This inflammation, which...
IMproving Preclinical Assessment of Cardioprotective Therapies (IMPACT): a small animal acute myocardial infarction randomized-controlled multicenter study on the effect of ischemic preconditioning
IMproving Preclinical Assessment of Cardioprotective Therapies (IMPACT): a small animal acute myocardial infarction randomized-controlled multicenter study on the effect of ischemic preconditioning
Although many cardioprotective interventions have been shown to limit infarct size (IS), in preclinical animal studies of ...
Necrosis-like cell death modes in heart failure: the influence of aetiology and the effects of RIP3 inhibition
Necrosis-like cell death modes in heart failure: the influence of aetiology and the effects of RIP3 inhibition
Since cell dying in heart failure (HF) may vary based on the aetiology, we examined the main forms of regulated necrosis, ...
Exendin-4 improves cerebral ischemia by relaxing microvessels, rapidly increasing cerebral blood flow after reperfusion
Exendin-4 improves cerebral ischemia by relaxing microvessels, rapidly increasing cerebral blood flow after reperfusion
Intravenous thrombolysis remains the cornerstone for restoring cerebral reperfusion post-stroke. Despite recombinant tissu...
Critical analysis of descriptive microRNA data in the translational research on cardioprotection and cardiac repair: lost in the complexity of bioinformatics
Critical analysis of descriptive microRNA data in the translational research on cardioprotection and cardiac repair: lost in the complexity of bioinformatics
The unsuccessful translation of cardiac regeneration and cardioprotection from animal experiments to clinical applications...
The ketone body 3-hydroxybutyrate increases cardiac output and cardiac contractility in a porcine model of cardiogenic shock: a randomized, blinded, crossover trial
The ketone body 3-hydroxybutyrate increases cardiac output and cardiac contractility in a porcine model of cardiogenic shock: a randomized, blinded, crossover trial
Cardiogenic shock (CS) is characterized by reduced cardiac output (CO), reduced end-organ perfusion, and high mortality. M...
Impact of chronic hyperglycaemia on the coronary microcirculation – benefits of targeting IL-36 and diet reversal
Impact of chronic hyperglycaemia on the coronary microcirculation – benefits of targeting IL-36 and diet reversal
Following myocardial infarction (MI), patients with type 2 diabetes mellitus (T2DM) have poorer prognosis which may be lin...
Tyrosine phosphorylation of Kir6.2 subunit negatively regulates cardiac K channel activity
Tyrosine phosphorylation of Kir6.2 subunit negatively regulates cardiac K channel activity
The plasma membrane ATP-sensitive potassium (KATP) channel in cardiac myocytes plays a critical role in protecting the hea...
A new model of heart failure with preserved ejection fraction induced by metabolic syndrome in Ossabaw miniature swine
A new model of heart failure with preserved ejection fraction induced by metabolic syndrome in Ossabaw miniature swine
A major obstacle to progress in heart failure with preserved ejection fraction (HFpEF) is the paucity of clinically releva...
Reinstating respiratory heart rate variability improves hemodynamic responses during exercise in heart failure with reduced ejection fraction
Reinstating respiratory heart rate variability improves hemodynamic responses during exercise in heart failure with reduced ejection fraction
Individuals with heart failure have significantly reduced exercise capacity, a critical life-limiting symptom for those li...
Musashi-2 causes cardiac hypertrophy and heart failure by inducing mitochondrial dysfunction through destabilizing Cluh and Smyd1 mRNA
Musashi-2 causes cardiac hypertrophy and heart failure by inducing mitochondrial dysfunction through destabilizing Cluh and Smyd1 mRNA
Regulation of RNA stability and translation by RNA-binding proteins (RBPs) is a crucial process altering gene expression. ...
Activation of the integrated stress response rewires cardiac metabolism in Barth syndrome
Activation of the integrated stress response rewires cardiac metabolism in Barth syndrome
Barth Syndrome (BTHS) is an inherited cardiomyopathy caused by defects in the mitochondrial transacylase TAFAZZIN (Taz), r...
The role of glycolytic metabolic pathways in cardiovascular disease and potential therapeutic approaches
The role of glycolytic metabolic pathways in cardiovascular disease and potential therapeutic approaches
Cardiovascular disease (CVD) is a major threat to human health, accounting for 46% of non-communicable disease deaths. Gly...
Targeting mitochondrial shape: at the heart of cardioprotection
Targeting mitochondrial shape: at the heart of cardioprotection
There remains an unmet need to identify novel therapeutic strategies capable of protecting the myocardium against the detr...
Splenic monocytes mediate inflammatory response and exacerbate myocardial ischemia/reperfusion injury in a mitochondrial cell-free DNA-TLR9-NLRP3-dependent fashion
Splenic monocytes mediate inflammatory response and exacerbate myocardial ischemia/reperfusion injury in a mitochondrial cell-free DNA-TLR9-NLRP3-dependent fashion
The spleen contributes importantly to myocardial ischemia/reperfusion (MI/R) injury. Nucleotide-binding oligomerization do...
Succinate dehydrogenase is essential for epigenetic and metabolic homeostasis in hearts
Succinate dehydrogenase is essential for epigenetic and metabolic homeostasis in hearts
A hallmark of heart failure is a metabolic switch away from fatty acids β-oxidation (FAO) to glycolysis. Here, we sho...
Recent advances on the role of monoamine oxidases in cardiac pathophysiology
Recent advances on the role of monoamine oxidases in cardiac pathophysiology
Numerous physiological and pathological roles have been attributed to the formation of mitochondrial reactive oxygen speci...
Outcomes of hypothalamic oxytocin neuron-driven cardioprotection after acute myocardial infarction
Outcomes of hypothalamic oxytocin neuron-driven cardioprotection after acute myocardial infarction
Altered autonomic balance is a hallmark of numerous cardiovascular diseases, including myocardial infarction (MI). Althoug...
Mitophagy for cardioprotection
Mitophagy for cardioprotection
Mitochondrial function is maintained by several strictly coordinated mechanisms, collectively termed mitochondrial quality...
Novel GSDMD inhibitor GI-Y1 protects heart against pyroptosis and ischemia/reperfusion injury by blocking pyroptotic pore formation
Novel GSDMD inhibitor GI-Y1 protects heart against pyroptosis and ischemia/reperfusion injury by blocking pyroptotic pore formation
Activation of gasdermin D (GSDMD) and its concomitant cardiomyocyte pyroptosis are critically involved in multiple cardiac...
Giant mitochondria in cardiomyocytes: cellular architecture in health and disease
Giant mitochondria in cardiomyocytes: cellular architecture in health and disease
Giant mitochondria are frequently observed in different disease models within the brain, kidney, and liver. In cardiac mus...
The roles of intracellular proteolysis in cardiac ischemia–reperfusion injury
The roles of intracellular proteolysis in cardiac ischemia–reperfusion injury
Ischemic heart disease remains a leading cause of human mortality worldwide. One form of ischemic heart disease is ischemi...
Ketone body 3-hydroxybutyrate elevates cardiac output through peripheral vasorelaxation and enhanced cardiac contractility
Ketone body 3-hydroxybutyrate elevates cardiac output through peripheral vasorelaxation and enhanced cardiac contractility
The ketone body 3-hydroxybutyrate (3-OHB) increases cardiac output and myocardial perfusion without affecting blood pressu...
Load More
format_indent_increase