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Alpha-ketoglutarate protects against myocardial infarction via FTO-mediated anti-inflammatory macrophage activation
Alpha-ketoglutarate protects against myocardial infarction via FTO-mediated anti-inflammatory macrophage activation
Ischemic heart disease lacks optimal therapies targeting post-infarction inflammation and remodeling. The role of TCA cycl...
Calcific aortic valve disease augments vesicular microRNA-145-5p to regulate the calcification of valvular interstitial cells via cellular crosstalk
Calcific aortic valve disease augments vesicular microRNA-145-5p to regulate the calcification of valvular interstitial cells via cellular crosstalk
Calcific aortic valve disease (CAVD) is one of the leading causes of cardiovascular death in the elderly population worldw...
Cardiac sodium-glucose co-transporter 1 (SGLT1) contributes to heart failure in a mouse model of diabetic cardiomyopathy
Cardiac sodium-glucose co-transporter 1 (SGLT1) contributes to heart failure in a mouse model of diabetic cardiomyopathy
Diabetes mellitus can lead to a cardiomyopathy independent of other risk factors such as coronary artery disease and hyper...
NLRP3 mediates lipid-driven macrophage proliferation in established atherosclerosis
NLRP3 mediates lipid-driven macrophage proliferation in established atherosclerosis
An increased number of macrophages in the atherosclerotic plaque is associated with plaque instability and plaque progress...
Renal denervation attenuates cardiac dysfunction in HFpEF by inhibiting the ATP-P2X7-NLRP3 inflammasome axis
Renal denervation attenuates cardiac dysfunction in HFpEF by inhibiting the ATP-P2X7-NLRP3 inflammasome axis
Heart failure with preserved ejection fraction (HFpEF) arises from intersecting comorbidities involving inflammation, meta...
Downregulation of TCF19 and ATAD2 causes endothelial cell cycle arrest at the transition from cardiac hypertrophy to heart failure
Downregulation of TCF19 and ATAD2 causes endothelial cell cycle arrest at the transition from cardiac hypertrophy to heart failure
Cardiac hypertrophy is a key mechanism that allows the heart to adapt to increased load, but in the long term is associate...
The CNP analogue vosoritide mediates PDE2-sensitive anti-arrhythmogenic effects in mouse hearts with STZ-induced type 1 diabetes
The CNP analogue vosoritide mediates PDE2-sensitive anti-arrhythmogenic effects in mouse hearts with STZ-induced type 1 diabetes
Diabetes mellitus induces adverse structural, electrophysiological and autonomic remodelling increasing the risk for life-...
Chemokine–receptor-guided B-cell immunity in cardiovascular disease
Chemokine–receptor-guided B-cell immunity in cardiovascular disease
Cardiovascular diseases (CVD) include a wide range of disorders affecting the heart and blood vessels, many of which are a...
The role of NO, HO, and non-NO/HO mechanisms in acetylcholine (ACh)-induced dilation of human arterioles in the absence and presence of coronary artery disease
The role of NO, HO, and non-NO/HO mechanisms in acetylcholine (ACh)-induced dilation of human arterioles in the absence and presence of coronary artery disease
This study defines the mechanisms of vasodilation to acetylcholine (ACh) in arterioles from patients with and without coro...
Single cell and spatial transcriptomic profiling of the type 2 diabetic coronary microcirculation and myocardium
Single cell and spatial transcriptomic profiling of the type 2 diabetic coronary microcirculation and myocardium
Coronary microvascular disease (CMD) is an early complication of type 2 diabetes (T2D) involving adverse endothelial and s...
Mixed lineage kinase 3 contributes to myocardial ischemia/reperfusion injury by regulating neutrophil activation
Mixed lineage kinase 3 contributes to myocardial ischemia/reperfusion injury by regulating neutrophil activation
Mixed lineage kinase 3 (MLK3), a member of the MAP3K family, is known to participate in cellular stress and inflammatory r...
Autophagy modulates the mechanism of flow-mediated dilation upstream of telomerase
Autophagy modulates the mechanism of flow-mediated dilation upstream of telomerase
The non-canonical functions of telomerase reverse transcriptase (TERT), the catalytic subunit of telomerase play a critica...
Impairment of local metabolic coronary control involves perfusion-contraction matching not supply–demand imbalance
Impairment of local metabolic coronary control involves perfusion-contraction matching not supply–demand imbalance
Understanding of local metabolic control of coronary flow remains stifled by debate around data interpretation and anticip...
Mechanical unloading coupled with coronary reperfusion stimulates cardiomyocyte proliferation and prevents unloading-induced fibrosis after myocardial infarction
Mechanical unloading coupled with coronary reperfusion stimulates cardiomyocyte proliferation and prevents unloading-induced fibrosis after myocardial infarction
Percutaneous left ventricular assist devices (LVADs) have become essential tools during coronary reperfusion in high-risk ...
Serum amyloid A in HFpEF and cardiometabolic diseases
Serum amyloid A in HFpEF and cardiometabolic diseases
Heart failure with preserved ejection fraction (HFpEF) accounts for more than half of all heart failure cases, and its pre...
Dysfunctional high-density lipoprotein particles are associated with cardiac alterations in cancer patients and tumor-bearing mice receiving doxorubicin
Dysfunctional high-density lipoprotein particles are associated with cardiac alterations in cancer patients and tumor-bearing mice receiving doxorubicin
Cancer patients receiving doxorubicin (DOX) chemotherapy are at high risk of developing cardiac alterations, but the mecha...
Coronary microvascular dysfunction is a determinant of perfusion–contraction matching during ischemia
Coronary microvascular dysfunction is a determinant of perfusion–contraction matching during ischemia
Canty JM, Giglia J, Kandath D (1990) Effect of tachycardia on regional function and transmural myocardial perfusion during...
NLGN3 contributes to angiogenesis in myocardial infarction via activation of the Gαi1/3-Akt pathway
NLGN3 contributes to angiogenesis in myocardial infarction via activation of the Gαi1/3-Akt pathway
Angiogenesis is an important repair mechanism for myocardial infarction. Neuroligin-3 (NLGN3) can promote angiogenesis by ...
Treadmill exercise activates mechanosensitive Piezo1 to inhibit cardiomyocyte apoptosis and improve cardiac function after myocardial infarction in mice
Treadmill exercise activates mechanosensitive Piezo1 to inhibit cardiomyocyte apoptosis and improve cardiac function after myocardial infarction in mice
The cardioprotective mechanisms through which the heart directly senses exercise remain incompletely defined. In this stud...
Effect of ventricular fibrillation on infarct size after myocardial infarction: a translational study
Effect of ventricular fibrillation on infarct size after myocardial infarction: a translational study
Ventricular fibrillation (VF)-induced cardiac arrest frequently complicates ST-segment elevation myocardial infarction (ST...
The cardio-oncologic burden of breast cancer: molecular mechanisms and importance of preclinical models
The cardio-oncologic burden of breast cancer: molecular mechanisms and importance of preclinical models
Breast cancer, the most prevalent cancer affecting women worldwide, poses a significant cardio-oncological burden. Despite...
Inter-organ communication: pathways and targets to cardioprotection and neuro-protection. A report from the 12th Hatter Cardiovascular Institute workshop
Inter-organ communication: pathways and targets to cardioprotection and neuro-protection. A report from the 12th Hatter Cardiovascular Institute workshop
A long-standing aim in the setting of various pathologies including acute myocardial infarction, chronic kidney disease (C...
High-resolution DNA methylation changes reveal biomarkers of heart failure with preserved ejection fraction versus reduced ejection fraction
High-resolution DNA methylation changes reveal biomarkers of heart failure with preserved ejection fraction versus reduced ejection fraction
Novel biomarkers are needed to better identify—and distinguish—heart failure with preserved ejection fraction ...
Intravenous and oral administration of the synthetic RNA drug, TY1, reverses heart failure with preserved ejection fraction in mice
Intravenous and oral administration of the synthetic RNA drug, TY1, reverses heart failure with preserved ejection fraction in mice
TY1, a synthetic non-coding RNA (ncRNA) bioinspired by small Y RNAs abundant in extracellular vesicles (EVs), decreases cG...
Evolocumab attenuates myocardial ischemia/reperfusion injury by blocking PCSK9/LIAS-mediated cuproptosis of cardiomyocytes
Evolocumab attenuates myocardial ischemia/reperfusion injury by blocking PCSK9/LIAS-mediated cuproptosis of cardiomyocytes
Myocardial ischemia‒reperfusion (I/R) injury is the crucial cause of poor prognosis after revascularization in patie...
Associations between female sex hormones, estrous cycle, ischemic preconditioning and myocardial infarct size after ischemia–reperfusion injury
Associations between female sex hormones, estrous cycle, ischemic preconditioning and myocardial infarct size after ischemia–reperfusion injury
Studies on sex differences in myocardial infarction (MI) typically focus on males versus females, the exploration of hormo...
Assessing customized multivalent chemokine-binding peptide treatment in a murine model of coxsackievirus B3 myocarditis
Assessing customized multivalent chemokine-binding peptide treatment in a murine model of coxsackievirus B3 myocarditis
Myocarditis, an inflammatory disease of the heart muscle, is often triggered by viral infections. This inflammation, which...
IMproving Preclinical Assessment of Cardioprotective Therapies (IMPACT): a small animal acute myocardial infarction randomized-controlled multicenter study on the effect of ischemic preconditioning
IMproving Preclinical Assessment of Cardioprotective Therapies (IMPACT): a small animal acute myocardial infarction randomized-controlled multicenter study on the effect of ischemic preconditioning
Although many cardioprotective interventions have been shown to limit infarct size (IS), in preclinical animal studies of ...
Necrosis-like cell death modes in heart failure: the influence of aetiology and the effects of RIP3 inhibition
Necrosis-like cell death modes in heart failure: the influence of aetiology and the effects of RIP3 inhibition
Since cell dying in heart failure (HF) may vary based on the aetiology, we examined the main forms of regulated necrosis, ...
Exendin-4 improves cerebral ischemia by relaxing microvessels, rapidly increasing cerebral blood flow after reperfusion
Exendin-4 improves cerebral ischemia by relaxing microvessels, rapidly increasing cerebral blood flow after reperfusion
Intravenous thrombolysis remains the cornerstone for restoring cerebral reperfusion post-stroke. Despite recombinant tissu...
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