Associations between female sex hormones, estrous cycle, ischemic preconditioning and myocardial infarct size after ischemia–reperfusion injury

Al-Awar A, Almasi N, Szabo R, Takacs I, Murlasits Z, Szucs G, Torok S, Posa A, Varga C, Kupai K (2018) Novel potentials of the DPP-4 Inhibitor Sitagliptin against Ischemia-Reperfusion (I/R) injury in rat ex-vivo heart model. Int J Mol Sci. https://doi.org/10.3390/ijms19103226

Article  PubMed  PubMed Central  Google Scholar 

Almeida SA, Claudio ER, Mengal V, Oliveira SG, Merlo E, Podratz PL, Gouvea SA, Graceli JB, de Abreu GR (2014) Exercise training reduces cardiac dysfunction and remodeling in ovariectomized rats submitted to myocardial infarction. PLoS ONE 9:e115970. https://doi.org/10.1371/journal.pone.0115970

Article  CAS  PubMed  PubMed Central  Google Scholar 

Botker HE, Hausenloy D, Andreadou I, Antonucci S, Boengler K, Davidson SM, Deshwal S, Devaux Y, Di Lisa F, Di Sante M, Efentakis P, Femmino S, Garcia-Dorado D, Giricz Z, Ibanez B, Iliodromitis E, Kaludercic N, Kleinbongard P, Neuhauser M, Ovize M, Pagliaro P, Rahbek-Schmidt M, Ruiz-Meana M, Schluter KD, Schulz R, Skyschally A, Wilder C, Yellon DM, Ferdinandy P, Heusch G (2018) Practical guidelines for rigor and reproducibility in preclinical and clinical studies on cardioprotection. Basic Res Cardiol 113:39. https://doi.org/10.1007/s00395-018-0696-8

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bugiardini R, Manfrini O, Cenko E (2019) Female sex as a biological variable: a review on younger patients with acute coronary syndrome. Trends Cardiovasc Med 29:50–55. https://doi.org/10.1016/j.tcm.2018.06.002

Article  PubMed  Google Scholar 

Canali E, Masci P, Bogaert J, Bucciarelli Ducci C, Francone M, McAlindon E, Carbone I, Lombardi M, Desmet W, Janssens S, Agati L (2012) Impact of gender differences on myocardial salvage and post-ischaemic left ventricular remodelling after primary coronary angioplasty: new insights from cardiovascular magnetic resonance. Eur Heart J Cardiovasc Imaging 13:948–953. https://doi.org/10.1093/ehjci/jes087

Article  PubMed  Google Scholar 

Cardiff RD, Miller CH, Munn RJ (2014) Manual hematoxylin and eosin staining of mouse tissue sections. Cold Spring Harb Protoc 2014:655–658. https://doi.org/10.1101/pdb.prot073411

Article  PubMed  Google Scholar 

Ciocci Pardo A, Scuri S, Gonzalez Arbelaez LF, Caldiz C, Fantinelli J, Mosca SM (2018) Survival kinase-dependent pathways contribute to gender difference in the response to myocardial ischemia-reperfusion and ischemic post-conditioning. Cardiovasc Pathol 33:19–26. https://doi.org/10.1016/j.carpath.2017.12.003

Article  CAS  PubMed  Google Scholar 

Das B, Sarkar C (2006) Similarities between ischemic preconditioning and 17beta-estradiol mediated cardiomyocyte KATP channel activation leading to cardioprotective and antiarrhythmic effects during ischemia/reperfusion in the intact rabbit heart. J Cardiovasc Pharmacol 47:277–286. https://doi.org/10.1097/01.fjc.0000202563.54043.d6

Article  CAS  PubMed  Google Scholar 

Dworatzek E, Mahmoodzadeh S (2017) Targeted basic research to highlight the role of estrogen and estrogen receptors in the cardiovascular system. Pharmacol Res 119:27–35. https://doi.org/10.1016/j.phrs.2017.01.019

Article  CAS  PubMed  Google Scholar 

Elmahdy A, Shekka Espinosa A, Kakaei Y, Pylova T, Jha A, Zulfaj E, Krasnikova M, Al-Awar A, Sheybani Z, Sevastianova V, Berger E, Nejat A, Molander L, Andersson EA, Omerovic E, Hussain S, Redfors B (2024) Ischemic preconditioning affects phosphosites and accentuates myocardial stunning while reducing infarction size in rats. Front Cardiovasc Med 11:1376367. https://doi.org/10.3389/fcvm.2024.1376367

Article  CAS  PubMed  PubMed Central  Google Scholar 

Espinosa AS, Hussain S, Al-Awar A, Jha S, Elmahdy A, Kalani M, Kakei Y, Zulfaj E, Aune E, Poller A, Bobbio E, Thoirleifsson S, Zeijlon R, Gudmundursson T, Wernbom M, Lindahl B, Polte CL, Omerovic E, Hammarsten O, Redfors B (2023) Differences between cardiac troponin I vs. T according to the duration of myocardial ischaemia. Eur Heart J Acute Cardiovasc Care 12:355–363. https://doi.org/10.1093/ehjacc/zuad017

Article  PubMed  Google Scholar 

Ferdinandy P, Hausenloy DJ, Heusch G, Baxter GF, Schulz R (2014) Interaction of risk factors, comorbidities, and comedications with ischemia/reperfusion injury and cardioprotection by preconditioning, postconditioning, and remote conditioning. Pharmacol Rev 66:1142–1174. https://doi.org/10.1124/pr.113.008300

Article  CAS  PubMed  Google Scholar 

Frasier CR, Brown DA, Sloan RC, Hayes B, Stewart LM, Patel HD, Lust RM, Rosenbaum MD (2013) Stage of the estrous cycle does not influence myocardial ischemia-reperfusion injury in rats (Rattus norvegicus). Comp Med 63:416–421

CAS  PubMed  PubMed Central  Google Scholar 

Goldman JM, Murr AS, Cooper RL (2007) The rodent estrous cycle: characterization of vaginal cytology and its utility in toxicological studies. Birth Defects Res B Dev Reprod Toxicol 80:84–97. https://doi.org/10.1002/bdrb.20106

Article  CAS  PubMed  Google Scholar 

Helms J, De Jong A, Einav S (2021) Yentl syndrome and the ICU. Intensive Care Med 47:594–597. https://doi.org/10.1007/s00134-021-06420-3

Article  PubMed  Google Scholar 

Heusch G (2024) Myocardial ischemia/reperfusion: translational pathophysiology of ischemic heart disease. Med 5(1):10–31. https://doi.org/10.1016/j.medj.2023.12.007

Article  CAS  PubMed  Google Scholar 

Iorga A, Cunningham CM, Moazeni S, Ruffenach G, Umar S, Eghbali M (2017) The protective role of estrogen and estrogen receptors in cardiovascular disease and the controversial use of estrogen therapy. Biol Sex Differ 8:33. https://doi.org/10.1186/s13293-017-0152-8

Article  CAS  PubMed  PubMed Central  Google Scholar 

Javed A, Ravi PC, Bilal Delvi S, Faraz Hussain I, Acosta GA, Iqbal W, Krishnamaneni V, Alasaadi S, Pradhan S, Vashisht R, Modi S (2023) The relationship between myocardial infarction and estrogen use: a literature review. Cureus 15:e46134. https://doi.org/10.7759/cureus.46134

Article  PubMed  PubMed Central  Google Scholar 

Kleinbongard P, Lieder H, Skyschally A, Heusch G (2023) No sex-related differences in infarct size, no-reflow, and protection by ischaemic pre-conditioning in Gottingen minipigs. Cardiovasc Res 119:561–570. https://doi.org/10.1093/cvr/cvac062

Article  CAS  PubMed  Google Scholar 

Kleinbongard P, Botker HE, Ovize M, Hausenloy DJ, Heusch G (2020) Co-morbidities and co-medications as confounders of cardioprotection-Does it matter in the clinical setting? Br J Pharmacol 177:5252–5269. https://doi.org/10.1111/bph.14839

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kul A, Baltaci AK, Mogulkoc R (2012) Effect of testosterone supplementation on leptin release in rats after castration and/or unilateral surrenalectomy. Endokrynol Pol 63:119–124

CAS  PubMed  Google Scholar 

Lecour S, Andreadou I, Botker HE, Davidson SM, Heusch G, Ruiz-Meana M, Schulz R, Zuurbier CJ, Ferdinandy P, Hausenloy DJ, C.C.A.C. on behalf of the European Union (2021) IMproving Preclinical Assessment of Cardioprotective Therapies (IMPACT) criteria: guidelines of the EU-CARDIOPROTECTION COST Action. Basic Res Cardiol 116:52. https://doi.org/10.1007/s00395-021-00893-5

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lieder HR, Irmert A, Kamler M, Heusch G, Kleinbongard P (2019) Sex is no determinant of cardioprotection by ischemic preconditioning in rats, but ischemic/reperfused tissue mass is for remote ischemic preconditioning. Physiol Rep 7:e14146. https://doi.org/10.14814/phy2.14146

Article  CAS  PubMed  PubMed Central  Google Scholar 

Marcondes FK, Bianchi FJ, Tanno AP (2002) Determination of the estrous cycle phases of rats: some helpful considerations. Braz J Biol 62:609–614. https://doi.org/10.1590/s1519-69842002000400008

Article  CAS  PubMed  Google Scholar 

Mauvais-Jarvis F, Bairey Merz N, Barnes PJ, Brinton RD, Carrero JJ, DeMeo DL, De Vries GJ, Epperson CN, Govindan R, Klein SL, Lonardo A, Maki PM, McCullough LD, Regitz-Zagrosek V, Regensteiner JG, Rubin JB, Sandberg K, Suzuki A (2020) Sex and gender: modifiers of health, disease, and medicine. Lancet 396:565–582. https://doi.org/10.1016/S0140-6736(20)31561-0

Article  PubMed  PubMed Central  Google Scholar 

Mendelsohn ME, Karas RH (1999) The protective effects of estrogen on the cardiovascular system. N Engl J Med 340:1801–1811. https://doi.org/10.1056/NEJM199906103402306

Article  CAS  PubMed 

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