Mitophagy for cardioprotection

Abeliovich H, Zarei M, Rigbolt KT, Youle RJ, Dengjel J (2013) Involvement of mitochondrial dynamics in the segregation of mitochondrial matrix proteins during stationary phase mitophagy. Nat Commun 4:2789. https://doi.org/10.1038/ncomms3789

Article  CAS  PubMed  Google Scholar 

Acin-Perez R, Lechuga-Vieco AV, Del Mar MM, Nieto-Arellano R, Torroja C, Sánchez-Cabo F, Jiménez C, González-Guerra A, Carrascoso I, Benincá C, Quiros PM, López-Otín C, Castellano JM, Ruíz-Cabello J, Jiménez-Borreguero LJ, Enríquez JA (2018) Ablation of the stress protease OMA1 protects against heart failure in mice. Sci Transl Med. 10:eaan4935. https://doi.org/10.1126/scitranslmed.aan4935

Article  CAS  PubMed  Google Scholar 

Ahn J, Kim J (2013) Nutritional status and cardiac autophagy. Diabetes Metab J 37:30–35. https://doi.org/10.4093/dmj.2013.37.1.30

Article  PubMed  PubMed Central  Google Scholar 

Ambivero CT, Cilenti L, Main S, Zervos AS (2014) Mulan E3 ubiquitin ligase interacts with multiple E2 conjugating enzymes and participates in mitophagy by recruiting GABARAP. Cell Signal 26:2921–2929. https://doi.org/10.1016/j.cellsig.2014.09.004

Article  CAS  PubMed  Google Scholar 

Anand R, Wai T, Baker MJ, Kladt N, Schauss AC, Rugarli E, Langer T (2014) The i-AAA protease YME1L and OMA1 cleave OPA1 to balance mitochondrial fusion and fission. J Cell Biol 204:919–929. https://doi.org/10.1083/jcb.201308006

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ashrafi G, Schwarz TL (2013) The pathways of mitophagy for quality control and clearance of mitochondria. Cell Death Differ 20:31–42. https://doi.org/10.1038/cdd.2012.81

Article  CAS  PubMed  Google Scholar 

Bassiouni W, Valencia R, Mahmud Z, Seubert JM, Schulz R (2023) Matrix metalloproteinase-2 proteolyzes mitofusin-2 and impairs mitochondrial function during myocardial ischemia-reperfusion injury. Basic Res Cardiol 118:29. https://doi.org/10.1007/s00395-023-00999-y

Article  CAS  PubMed  Google Scholar 

Battistutta R, Lolli G (2011) Structural and functional determinants of protein kinase CK2α: facts and open questions. Mol Cell Biochem 356:67–73. https://doi.org/10.1007/s11010-011-0939-6

Article  CAS  PubMed  Google Scholar 

Bhujabal Z, Birgisdottir ÅB, Sjøttem E, Brenne HB, Øvervatn A, Habisov S, Kirkin V, Lamark T, Johansen T (2017) FKBP8 recruits LC3A to mediate Parkin-independent mitophagy. EMBO Rep 18:947–961. https://doi.org/10.15252/embr.201643147

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bravo-San Pedro JM, Kroemer G, Galluzzi L (2017) Autophagy and mitophagy in cardiovascular disease. Circ Res 120:1812–1824. https://doi.org/10.1161/CIRCRESAHA.117.311082

Article  CAS  PubMed  Google Scholar 

Cai X, Zou P, Hong L, Chen Y, Zhan Y, Liu Y, Shao L (2023) RNA methylation reading protein YTHDF2 relieves myocardial ischemia–reperfusion injury by downregulating BNIP3 via m(6)A modification. Hum Cell. https://doi.org/10.1007/s13577-023-00956-w

Article  PubMed  PubMed Central  Google Scholar 

Cao Y, Zheng J, Wan H, Sun Y, Fu S, Liu S, He B, Cai G, Cao Y, Huang H, Li Q, Ma Y, Chen S, Wang F, Jiang H (2023) A mitochondrial SCF-FBXL4 ubiquitin E3 ligase complex degrades BNIP3 and NIX to restrain mitophagy and prevent mitochondrial disease. EMBO J 42:e113033. https://doi.org/10.15252/embj.2022113033

Article  CAS  PubMed  Google Scholar 

Catanzaro MP, Weiner A, Kaminaris A, Li C, Cai F, Zhao F, Kobayashi S, Kobayashi T, Huang Y, Sesaki H, Liang Q (2019) Doxorubicin-induced cardiomyocyte death is mediated by unchecked mitochondrial fission and mitophagy. FASEB J 33:11096–11108. https://doi.org/10.1096/fj.201802663R

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chakrabarti R, Ji W-K, Stan RV, de Juan SJ, Ryan TA, Higgs HN (2018) INF2-mediated actin polymerization at the ER stimulates mitochondrial calcium uptake, inner membrane constriction, and division. J Cell Biol 217:251–268. https://doi.org/10.1083/jcb.201709111

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chen G, Han Z, Feng D, Chen Y, Chen L, Wu H, Huang L, Zhou C, Cai X, Fu C, Duan L, Wang X, Liu L, Liu X, Shen Y, Zhu Y, Chen Q (2014) A regulatory signaling loop comprising the PGAM5 phosphatase and CK2 controls receptor-mediated mitophagy. Mol Cell 54:362–377. https://doi.org/10.1016/j.molcel.2014.02.034

Article  CAS  PubMed  Google Scholar 

Chen H, Detmer SA, Ewald AJ, Griffin EE, Fraser SE, Chan DC (2003) Mitofusins Mfn1 and Mfn2 coordinately regulate mitochondrial fusion and are essential for embryonic development. J Cell Biol 160:189–200. https://doi.org/10.1083/jcb.200211046

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chen W, Ma M, Song Y, Hua Y, Jia H, Liu J, Wang Y (2023) Exercise attenuates myocardial ischemia-reperfusion injury by regulating endoplasmic reticulum stress and mitophagy through M(2) acetylcholine receptor. Antioxid Redox Signal. https://doi.org/10.1089/ars.2022.0168

Article  PubMed  Google Scholar 

Chen Z, Liu L, Cheng Q, Li Y, Wu H, Zhang W, Wang Y, Sehgal SA, Siraj S, Wang X, Wang J, Zhu Y, Chen Q (2017) Mitochondrial E3 ligase MARCH5 regulates FUNDC1 to fine-tune hypoxic mitophagy. EMBO Rep 18:495–509. https://doi.org/10.15252/embr.201643309

Article  CAS  PubMed  PubMed Central  Google Scholar 

Cho B, Cho HM, Jo Y, Kim HD, Song M, Moon C, Kim H, Kim K, Sesaki H, Rhyu IJ, Kim H, Sun W (2017) Constriction of the mitochondrial inner compartment is a priming event for mitochondrial division. Nat Commun 8:15754. https://doi.org/10.1038/ncomms15754

Article  PubMed  PubMed Central  Google Scholar 

Chouchani ET, Pell VR, Gaude E, Aksentijević D, Sundier SY, Robb EL, Logan A, Nadtochiy SM, Ord ENJ, Smith AC, Eyassu F, Shirley R, Hu C-H, Dare AJ, James AM, Rogatti S, Hartley RC, Eaton S, Costa ASH, Brookes PS, Davidson SM, Duchen MR, Saeb-Parsy K, Shattock MJ, Robinson AJ, Work LM, Frezza C, Krieg T, Murphy MP (2014) Ischaemic accumulation of succinate controls reperfusion injury through mitochondrial ROS. Nature 515:431–435. https://doi.org/10.1038/nature13909

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chu CT, Ji J, Dagda RK, Jiang JF, Tyurina YY, Kapralov AA, Tyurin VA, Yanamala N, Shrivastava IH, Mohammadyani D, Wang KZQ, Zhu J, Klein-Seetharaman J, Balasubramanian K, Amoscato AA, Borisenko G, Huang Z, Gusdon AM, Cheikhi A, Steer EK, Wang R, Baty C, Watkins S, Bahar I, Bayir H, Kagan VE (2013) Cardiolipin externalization to the outer mitochondrial membrane acts as an elimination signal for mitophagy in neuronal cells. Nat Cell Biol 15:1197–1205. https://doi.org/10.1038/ncb2837

Article  CAS  PubMed  PubMed Central  Google Scholar 

Cianfanelli V, De Zio D, Di Bartolomeo S, Nazio F, Strappazzon F, Cecconi F (2015) Ambra1 at a glance. J Cell Sci 128:2003–2008. https://doi.org/10.1242/jcs.168153

Article  CAS  PubMed  Google Scholar 

Civiletto G, Varanita T, Cerutti R, Gorletta T, Barbaro S, Marchet S, Lamperti C, Viscomi C, Scorrano L, Zeviani M (2015) Opa1 overexpression ameliorates the phenotype of two mitochondrial disease mouse models. Cell Metab 21:845–854. https://doi.org/10.1016/j.cmet.2015.04.016

Article  CAS  PubMed  PubMed Central  Google Scholar 

Cornelissen T, Haddad D, Wauters F, Van Humbeeck C, Mandemakers W, Koentjoro B, Sue C, Gevaert K, De Strooper B, Verstreken P, Vandenberghe W (2014) The deubiquitinase USP15 antagonizes Parkin-mediated mitochondrial ubiquitination and mitophagy. Hum Mol Genet 23:5227–5242. https://doi.org/10.1093/hmg/ddu244

Article  CAS  PubMed  Google Scholar 

Coronado M, Fajardo G, Nguyen K, Zhao M, Kooiker K, Jung G, Hu DQ, Reddy S, Sandoval E, Stotland A, Gottlieb RA, Bernstein D (2018) Physiological mitochondrial fragmentation is a normal cardiac adaptation to increased energy demand. Circ Res 122:282–295. https://doi.org/10.1161/CIRCRESAHA.117.310725

Article  CAS  PubMed  Google Scholar 

D’Souza K, Nzirorera C, Kienesberger PC (2016) Lipid metabolism and signaling in cardiac lipotoxicity. Biochim Biophys Acta 1861:1513–1524. https://doi.org/10.1016/j.bbalip.2016.02.016

Article  CAS  PubMed  Google Scholar 

Dagar N, Kale A, Steiger S, Anders H-J, Gaikwad AB (2022) Receptor-mediated mitophagy: an emerging therapeutic target in acute kidney injury. Mitochondrion 66:82–91. https://doi.org/10.1016/j.mito.2022.08.004

Article  CAS  PubMed  Google Scholar 

Delettre C, Lenaers G, Griffoin JM, Gigarel N, Lorenzo C, Belenguer P, Pelloquin L, Grosgeorge J, Turc-Carel C, Perret E, Astarie-Dequeker C, Lasquellec L, Arnaud B, Ducommun B, Kaplan J, Hamel CP (2000) Nuclear gene OPA1, encoding a mitochondrial dynamin-related protein, is mutated in dominant optic atrophy. Nat Genet 26:207–210. https://doi.org/10.1038/79936

Article  CAS  PubMed  Google Scholar 

Dhingra A, Jayas R, Afshar P, Guberman M, Maddaford G, Gerstein J, Lieberman B, Nepon H, Margulets V, Dhingra R, Kirshenbaum LA (2017) Ellagic acid antagonizes Bnip3-mediated mitochondrial injury and necrotic cell death of cardiac myocytes. Free Radic Biol Med 112:411–422. https://doi.org/10.1016/j.freeradbiomed.2017.08.010

Article  CAS  PubMed  Google Scholar 

Di Rita A, Peschiaroli A, Acunzo DP, Strobbe D, Hu Z, Gruber J, Nygaard M, Lambrughi M, Melino G, Papaleo E, Dengjel J, El Alaoui S, Campanella M, Dötsch V, Rogov VV, Strappazzon F, Cecconi F (2018) HUWE1 E3 ligase promotes PINK1/PARKIN-independent mitophagy by regulating AMBRA1 activation via IKKα. Nat Commun 9:3755. https://doi.org/10.1038/s41467-018-05722-3

Comments (0)

No login
gif