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Medics for Rare Disease: advocating for rare disease training
Rare cardiovascular diseases affect 5% of the world’s population. Rare disease training for clinicians is essential ...
Fibrosis-targeted, immunosuppressive dendritic cells mitigate cardiac adverse remodelling
Engineered immunosuppressive and fibrosis-targeted dendritic cells protect against pathological cardiac remodelling in ani...
Stenting for post-thrombotic syndrome
In the C-TRACT trial involving patients with post-thrombotic syndrome, the addition of endovascular treatment to standard ...
Local calcium dynamics and signalling in cardiomyocytes
Local calcium dynamics and signalling in cardiomyocytes
Calcium (Ca²⁺) signalling is essential for cardiomyocyte function, regulating excitation–contraction coup...
Base editing and silencing of PCSK9 shows clinical promise in humans
Base editing and silencing of PCSK9 shows clinical promise in humans
Base editing therapies to silence PCSK9 have entered clinical trials, and early results show promise for a durable ‘...
Digital screening and decision-support tools in equitable preventive cardiology
Nguyen and Vinh discuss the insights from the Apple Heart Study on digital screening for atrial fibrillation and highlight...
Home-based care improves blood pressure control
A home-based model of hypertension care can lower blood pressure in patients with hypertension compared with standard care...
Role of Helicobacter pylori screening after myocardial infarction
Role of Helicobacter pylori screening after myocardial infarction
Routine screening for Helicobacter pylori infection during hospitalization for myocardial infarction does not reduce the r...
Baxdrostat beneficial in uncontrolled or resistant hypertension
In patients with uncontrolled or resistant hypertension, the addition of the aldosterone synthase inhibitor baxdrostat to ...
Benefit of digitoxin therapy for HFrEF
Benefit of digitoxin therapy for HFrEF
In the DIGIT-HF trial, treatment with digitoxin in addition to guideline-directed medical therapy reduced the risk of hosp...
Cardiac myosin inhibitors for the treatment of obstructive and non-obstructive HCM
Cardiac myosin inhibitors for the treatment of obstructive and non-obstructive HCM
Two late-breaking clinical trials presented at the ESC Congress 2025 have explored the efficacy of cardiac myosin inhibito...
The prevention of adult cardiovascular disease must begin in childhood: evidence and imperative
The prevention of adult cardiovascular disease must begin in childhood: evidence and imperative
Growing evidence from the past seven decades indicates that atherosclerosis begins in youth and progresses in response to ...
Rethinking the mentoring paradigm to include mentor, sponsor and advocate
In the dynamic landscape of academic medicine, there is an increased interest in refining the traditional mentoring paradi...
Arrhythmia-induced cardiomyopathy: focus on atrial fibrillation
Arrhythmia-induced cardiomyopathy: focus on atrial fibrillation
Arrhythmias and heart failure (HF) are common causes of morbidity and premature death worldwide, and patients who present ...
Interventions for adult congenital heart disease
Interventions for adult congenital heart disease
Advances in imaging diagnostics, surgical techniques and transcatheter interventions for paediatric patients with severe c...
Traction force microscopy of cardiomyocytes
Traction force microscopy of cardiomyocytes
In this Tools of the Trade article, Lyall discusses the use of traction force microscopy to assess the contractile functio...
AI-driven evolution of precision population cardiovascular health in cities
New research shows how the social determinants of cardiovascular health vary locally within cities. Artificial intelligenc...
The relationship between cannabis and cardiovascular disease: clearing the haze
The relationship between cannabis and cardiovascular disease: clearing the haze
Cannabis has been consumed for centuries, but global regulatory changes over the past three decades have increased the ava...
Colchicine in acute coronary syndromes: the present and the possible future
Colchicine in acute coronary syndromes: the present and the possible future
Inflammation is a new therapeutic target for the prevention of cardiovascular disease. Colchicine is a potential cheap opt...
Obesity alters cholesterol homeostasis in regulatory T cells of visceral adipose tissue
Obesity alters cholesterol homeostasis in regulatory T cells of visceral adipose tissue
A new study shows how obesity can disrupt a cholesterol metabolism in a particular subset of metabolically protective regu...
The molecular structure of LDL has finally been elucidated
The molecular structure of LDL has finally been elucidated
Two studies published in Nature report the structure of apolipoprotein B100 on LDL using high-resolution, artificial intel...
Anthracycline-induced cardiomyopathy: risk prediction, prevention and treatment
Anthracycline-induced cardiomyopathy: risk prediction, prevention and treatment
Anthracyclines are the cornerstone of treatment for many malignancies. However, anthracycline cardiotoxicity is a consider...
Clonal expansion of CD8+ T cells in aged mice linked to pro-atherogenic phenotype
In aged mice, but not young mice, with atherosclerosis, depletion of CD8+ T cells significantly reduces atherosclerotic le...
Levothyroxine supplementation does not improve heart transplantation from brain-dead donors
The use of intravenous levothyroxine does not increase the likelihood of hearts being transplanted from haemodynamically u...
Mosaic loss of chromosome Y and cardiovascular disease
Mosaic loss of chromosome Y and cardiovascular disease
Mosaic loss of chromosome Y (mLOY) refers to the condition in male individuals in which a detectable fraction of cells los...
Anticoagulation in patients with atrial high-rate episodes
Anticoagulation in patients with atrial high-rate episodes
The risk of stroke in patients with atrial high-rate episodes (AHREs) depends on age, comorbidities and AHRE burden. Two r...
Not a spectator sport: improving participation of Black patients in cardiovascular clinical trials
Representation of Black patients in cardiovascular clinical trials remains dismally low, reflective of systemic and struct...
Author Correction: Coronary microvascular obstruction and dysfunction in patients with acute myocardial infarction
Department of Cardiology, Maria Cecilia Hospital, GVM Care & Research, Cotignola, ItalyMattia GalliDepartment of Cardi...
Base editing therapy corrects long QT syndrome in mice
Gene therapy involving adenine base editing can correct a pathogenic variant in the Scn5a gene and alleviate arrhythmia ph...
The case for eliminating racial and ethnic cardiovascular disparities in the USA
Racial and ethnic disparities in cardiovascular health in the USA result in a persistent mortality gap between white and B...
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