Ringer, S. A further contribution regarding the influence of the different constituents of the blood on the contraction of the heart. J. Physiol. 4, 29–42 (1883).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Heilbrunn, L. V. & Wiercinski, F. J. The action of various cations on muscle protoplasm. J. Cell Comp. Physiol. 29, 15–32 (1947).

Article  CAS  PubMed  Google Scholar 

Inesi, G., Ebashi, S. & Watanabe, S. Preparation of vesicular relaxing factor from bovine heart tissue. Am. J. Physiol. 207, 1339–1344 (1964).

Article  CAS  PubMed  Google Scholar 

Inesi, G. Mechanism of calcium transport. Annu. Rev. Physiol. 47, 573–601 (1985).

Article  CAS  PubMed  Google Scholar 

Reuter, H. & Beeler, G. W. Jr Calcium current and activation of contraction in ventricular myocardial fibers. Science 163, 399–401 (1969).

Article  CAS  PubMed  Google Scholar 

Rougier, O., Vassort, G., Garnier, D., Gargouil, Y. M. & Coraboeuf, E. Existence and role of a slow inward current during the frog atrial action potential. Pflugers Arch. 308, 91–110 (1969).

Article  CAS  PubMed  Google Scholar 

Fabiato, A. & Fabiato, F. Contractions induced by a calcium-triggered release of calcium from the sarcoplasmic reticulum of single skinned cardiac cells. J. Physiol. 249, 469–495 (1975).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Pessah, I. N., Waterhouse, A. L. & Casida, J. E. The calcium-ryanodine receptor complex of skeletal and cardiac muscle. Biochem. Biophys. Res. Commun. 128, 449–456 (1985).

Article  CAS  PubMed  Google Scholar 

Lederer, W. J., Niggli, E. & Hadley, R. W. Sodium-calcium exchange in excitable cells: fuzzy space. Science 248, 283 (1990).

Article  CAS  PubMed  Google Scholar 

Stern, M. D. Theory of excitation-contraction coupling in cardiac muscle. Biophys. J. 63, 497–517 (1992).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Cheng, H., Lederer, W. J. & Cannell, M. B. Calcium sparks: elementary events underlying excitation-contraction coupling in heart muscle. Science 262, 740–744 (1993).

Article  CAS  PubMed  Google Scholar 

Eisner, D. A., Caldwell, J. L., Kistamas, K. & Trafford, A. W. Calcium and excitation-contraction coupling in the heart. Circ. Res. 121, 181–195 (2017).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bers, D. M. Cardiac excitation-contraction coupling. Nature 415, 198–205 (2002).

Article  CAS  PubMed  Google Scholar 

Eisner, D., Neher, E., Taschenberger, H. & Smith, G. Physiology of intracellular calcium buffering. Physiol. Rev. 103, 2767–2845 (2023).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Horgmo, J. ae, Ger, K. & Tveito, A. Electrodiffusion dynamics in the cardiomyocyte dyad at nano-scale resolution using the Poisson–Nernst–Planck (PNP) equations. PLoS Comput. Biol. 21, e1013149 (2025).

Article  Google Scholar 

Colman, M. A. et al. Multi-scale computational modeling of spatial calcium handling from nanodomain to whole-heart: overview and perspectives. Front. Physiol. 13, 836622 (2022).

Article  PubMed  PubMed Central  Google Scholar 

Sommer, J. R. & Waugh, R. A. Ultrastructure of heart muscle. Env. Health Perspect. 26, 159–167 (1978).

Article  CAS  Google Scholar 

Amsellem, J., Delorme, R., Souchier, C. & Ojeda, C. Transverse-axial tubular system in guinea pig ventricular cardiomyocyte: 3D reconstruction, quantification and its possible role in K+ accumulation-depletion phenomenon in single cells. Biol. Cell 85, 43–54 (1995).

CAS  PubMed  Google Scholar 

Girardier, L. & Pollet, M. Demonstration of the continuity between the interstitial space and the lumen of the intracellular canals in the rat myocardium [French]. Helv. Physiol. Pharmacol. Acta 22, C72–C73 (1964).

CAS  PubMed  Google Scholar 

Lu, F. & Pu, W. T. The architecture and function of cardiac dyads. Biophys. Rev. 12, 1007–1017 (2020).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bers, D. M. Calcium cycling and signaling in cardiac myocytes. Annu. Rev. Physiol. 70, 23–49 (2008).

Article  CAS  PubMed  Google Scholar 

Dibb, K. M., Louch, W. E. & Trafford, A. W. Cardiac transverse tubules in physiology and heart failure. Annu. Rev. Physiol. 84, 229–255 (2022).

Article  CAS  PubMed  Google Scholar 

Kohl, P., Greiner, J. & Rog-Zielinska, E. A. Electron microscopy of cardiac 3D nanodynamics: form, function, future. Nat. Rev. Cardiol. 19, 607–619 (2022).

Article  PubMed  Google Scholar 

Rog-Zielinska, E. A. et al. Nano-scale morphology of cardiomyocyte T-tubule/sarcoplasmic reticulum junctions revealed by ultra-rapid high-pressure freezing and electron tomography. J. Mol. Cell Cardiol. 153, 86–92 (2021).

Article  CAS  PubMed  Google Scholar 

Wang, S. Q., Song, L. S., Lakatta, E. G. & Cheng, H. Ca2+ signalling between single L-type Ca2+ channels and ryanodine receptors in heart cells. Nature 410, 592–596 (2001).

Article  CAS  PubMed  Google Scholar 

Hong, T. et al. Cardiac BIN1 folds T-tubule membrane, controlling ion flux and limiting arrhythmia. Nat. Med. 20, 624–632 (2014).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Guo, Q. J. et al. Early stage morphogenesis of transverse tubules in rat cardiomyocytes: the role of pBIN1. Circ. Res. 137, 435–448 (2025).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Takeshima, H., Komazaki, S., Nishi, M., Iino, M. & Kangawa, K. Junctophilins: a novel family of junctional membrane complex proteins. Mol. Cell 6, 11–22 (2000).

CAS  PubMed  Google Scholar 

Lehnart, S. E. & Wehrens, X. H. T. The role of junctophilin proteins in cellular function. Physiol. Rev. 102, 1211–1261 (2022).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Landstrom, A. P. et al. Reduction in junctophilin 2 expression in cardiac nodal tissue results in intracellular calcium-driven increase in nodal cell automaticity. Circ. Arrhythm. Electrophysiol. 16, e010858 (2023).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yin, L. H. et al. Impaired binding to junctophilin-2 and nanostructural alteration in CPVT mutation. Circ. Res. 129, E35–E52 (2021).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chu, S. H. et al. Sex differences in expression of calcium-handling proteins and β-adrenergic receptors in rat heart ventricle. Life Sci. 76, 2735–2749 (2005)