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Rusting away with age
Rusting away with age
In a recent study published in Nature, Zhuang et al. outline how ageing affects stemness and tumorigenic potential of tumo...
Decoding the functional impact of the cancer genome through protein–protein interactions
Decoding the functional impact of the cancer genome through protein–protein interactions
Acquisition of genomic mutations enables cancer cells to gain fitness advantages under selective pressure and, ultimately,...
Metabolic interplays between the tumour and the host shape the tumour macroenvironment
Metabolic interplays between the tumour and the host shape the tumour macroenvironment
Metabolic reprogramming of cancer cells and the tumour microenvironment are pivotal characteristics of cancers, and studyi...
Tumour hypoxia in driving genomic instability and tumour evolution
Tumour hypoxia in driving genomic instability and tumour evolution
Intratumour hypoxia is a feature of all heterogenous solid tumours. Increased levels or subregions of tumour hypoxia are a...
Cross-priming in cancer immunology and immunotherapy
Cross-priming in cancer immunology and immunotherapy
Cytotoxic T cell immune responses against cancer crucially depend on the ability of a subtype of professional antigen-pres...
Allies in the epidermis
Allies in the epidermis
Immunosuppression disrupts normal skin homeostasis, raising the risk of cancer development. Now, Son et al. find that comm...
Small speckles, big impact
Small speckles, big impact
In this study, Alexander et al. find that HIF2α regulates speckle–DNA associations to fine-tune the expression ...
Maximizing the dual benefit of pet dogs in cancer trials
Maximizing the dual benefit of pet dogs in cancer trials
Pet dogs with cancer have catalysed the translation of preclinical discoveries to first-in-human trials, highlighting the ...
Pressing defence
Pressing defence
In this study, Bansaccal et al. analyse why, at some skin locations, oncogene-expressing cells rarely progress to cancer a...
How chemokines organize the tumour microenvironment
How chemokines organize the tumour microenvironment
For our immune system to contain or eliminate malignant solid tumours, both myeloid and lymphoid haematopoietic cells must...
Targeting cancer cell dormancy
The field of tumour dormancy, originally defined as a clinical phenomenon of late recurrence after a long, apparently dise...
Fcγ receptors and immunomodulatory antibodies in cancer
Fcγ receptors and immunomodulatory antibodies in cancer
The discovery of both cytotoxic T lymphocyte-associated antigen 4 (CTLA4) and programmed cell death protein 1 (PD1) as neg...
Removing barriers to address sex differences in anticancer drug toxicity
Removing barriers to address sex differences in anticancer drug toxicity
Despite the compelling evidence for greater toxicity in female patients, sex-specific anticancer treatment strategies are ...
Lighting up cancer initiation with mutant p53 reporters
In this Tools of the Trade article, Xiwen Tang describes the development of in vivo reporters detecting mutant p53 at the ...
The dynamic role of platelets in cancer progression and their therapeutic implications
The dynamic role of platelets in cancer progression and their therapeutic implications
Systemic antiplatelet treatment represents a promising option to improve the therapeutic outcomes and therapeutic efficacy...
UXS1: a sweet spot for cell death
UXS1: a sweet spot for cell death
Enzymes that produce metabolites specifically required by cancer cells have become attractive targets for therapy. Recentl...
Eph receptors and ephrins in cancer progression
Eph receptors and ephrins in cancer progression
Evidence implicating Eph receptor tyrosine kinases and their ephrin ligands (that together make up the ‘Eph...
Understanding and addressing race disparities in childhood cancer outcomes
Vulnerable populations remain disproportionately at risk for inferior childhood cancer outcomes. Here, I outline the scope...
Translating tumour immunity control
In this Journal Club, Hajj discusses a study demonstrating that oncogene activation modulates immune control through both ...
The microbiome as a determinant of racial and ethnic cancer disparities
The microbiome as a determinant of racial and ethnic cancer disparities
 People from minority racial and ethnic groups continue to experience disproportionate cancer incidences and canc...
How protons pave the way to aggressive cancers
How protons pave the way to aggressive cancers
Cancers undergo sequential changes to proton (H+) concentration and sensing that are consequences of the disease and facil...
Metabolic pathway analysis using stable isotopes in patients with cancer
Metabolic pathway analysis using stable isotopes in patients with cancer
Metabolic reprogramming is central to malignant transformation and cancer cell growth. How tumours use nutrients and the r...
Deubiquitinases in cancer
Deubiquitinases in cancer
Ubiquitination is an essential regulator of most, if not all, signalling pathways, and defects in cellular signalling are ...
Inflammatory neutrophils
Inflammatory neutrophils
Maas et al. identify an inflammatory, immunosuppressive phenotype in neutrophils that accumulates in brain malignancies, a...
Targeting the tumour’s little helpers
Targeting the tumour’s little helpers
Wang et al. show that antibiotic targeting of anaerobic intratumoral bacteria exposes a unique repertoire of microbial neo...
Breast milk for breast cancer detection
Breast milk for breast cancer detection
Pregnancy-associated breast cancers are typically diagnosed at more advanced stages than other breast cancers. Recently, S...
Advances in translational research of the rare cancer type adrenocortical carcinoma
Advances in translational research of the rare cancer type adrenocortical carcinoma
Adrenocortical carcinoma is a rare malignancy with an annual worldwide incidence of 1–2 cases per 1 million and a 5-...
wildDISCO: HD whole-body imaging
In this Tools of the Trade article, Hongcheng Mai describes the development of wildDISCO, an approach for whole-body immun...
Transfer RNAs as dynamic and critical regulators of cancer progression
Transfer RNAs as dynamic and critical regulators of cancer progression
Transfer RNAs (tRNAs) have been historically viewed as non-dynamic adaptors that decode the genetic code into proteins. Re...
Stem-like exhausted and memory CD8+ T cells in cancer
Stem-like exhausted and memory CD8+ T cells in cancer
T cells can acquire a broad spectrum of differentiation states following activation. At the extreme ends of this continuum...
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