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Diagnostic approaches to cancer of unknown primary—the pathologist’s perspective
Diagnostic approaches to cancer of unknown primary—the pathologist’s perspective
Cancer of unknown primary (CUP), a rare metastatic malignancy for which a primary site cannot be establi...
Lung cancer screening: current knowledge, opportunities, and challenges
Lung cancer screening: current knowledge, opportunities, and challenges
Lung cancer is the leading cause of cancer-related death worldwide, mainly due to its frequent diagnosis at advanced stage...
Circulating tumor DNA in colorectal cancer: from prognostic insight to emerging clinical standard
Circulating tumor DNA in colorectal cancer: from prognostic insight to emerging clinical standard
Liquid biopsy using circulating tumor DNA (ctDNA) has become one of the most promising approaches in precision oncology, o...
Assessing frailty-related risk in older patients in hematology and oncology
Assessing frailty-related risk in older patients in hematology and oncology
The increasing prevalence of cancer among older adults underscores the need for individualized therapy approaches. Chronol...
Current surgical standards in the management of the axilla
Current surgical standards in the management of the axilla
Axillary surgery in breast cancer has undergone a profound transformation in recent decades. While axillary lymph...
Individualizing treatment sequence in metastatic luminal breast cancer
Individualizing treatment sequence in metastatic luminal breast cancer
Metastatic luminal breast cancer remains an incurable disease; however, survival outcomes have improved substantially in r...
Molecular profiling and targeted therapies in biliary tract cancer—a short review
Molecular profiling and targeted therapies in biliary tract cancer—a short review
Biliary tract cancers (BTCs), including intrahepatic cholangiocarcinoma (iCCA), extrahepatic cholangiocarcinoma (eCCA), an...
Advancements in precision therapy and liquid biopsy for pediatric central nervous system tumors
Advancements in precision therapy and liquid biopsy for pediatric central nervous system tumors
Tumors of the central nervous system (CNS) are the most common pediatric tumor type and the leading cause of cancer-relate...
Retrospective study comparing perioperative chemotherapy versus postoperative chemoradiation in resectable gastric cancer
Retrospective study comparing perioperative chemotherapy versus postoperative chemoradiation in resectable gastric cancer
Postoperative chemoradiotherapy (POCRT) and perioperative chemotherapy (PECT) have been established as the preferred treat...
Systemic treatment in metastatic penile cancer: current landscape, challenges, and future directions
Systemic treatment in metastatic penile cancer: current landscape, challenges, and future directions
To evaluate current systemic treatment strategies for metastatic penile squamous cell carcinoma (PSCC), identify limitatio...
Zolbetuximab and the novel biomarker claudin 18.2 in the treatment of gastroesophageal adenocarcinoma
Zolbetuximab and the novel biomarker claudin 18.2 in the treatment of gastroesophageal adenocarcinoma
Systemic chemotherapy remains the standard treatment for advanced gastroesophageal cancer, typically combining a ...
Unraveling (K)RAS in pancreatic ductal adenocarcinoma
Unraveling (K)RAS in pancreatic ductal adenocarcinoma
Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal malignancy with a poor 5‑year survival ...
Rare case of human epidermal growth factor receptor 2-positive gastric remnant cancer after bariatric surgery—case report
Rare case of human epidermal growth factor receptor 2-positive gastric remnant cancer after bariatric surgery—case report
Parallel to the increasing number of patients with obesity and metabolic syndrome, the number of bariatric procedures is r...
Evolving treatment paradigms after CDK4/6 inhibitors in advanced breast cancer
Evolving treatment paradigms after CDK4/6 inhibitors in advanced breast cancer
Cyclin-dependent kinase 4/6 inhibitors (CDK4/6i) have transformed the treatment of hormone-receptor-positive, human epider...
CRLF2 expression associated with poor outcome in Philadelphia-negative acute lymphoblastic leukemia
CRLF2 expression associated with poor outcome in Philadelphia-negative acute lymphoblastic leukemia
Adult Philadelphia (Ph)-negative B‑acute lymphoblastic leukemia (Ph-ALL) patients often exhibit elevated levels of C...
Biomarkers and treatment updates in renal cell carcinoma
Biomarkers and treatment updates in renal cell carcinoma
At this year’s ASCO Annual Meeting, researchers presented detailed findings concerning biomarkers and rare subtypes ...
ASCO highlights: neoadjuvant immunotherapy in mismatch repair deficient colorectal cancer
ASCO highlights: neoadjuvant immunotherapy in mismatch repair deficient colorectal cancer
Despite recent advances in therapy, certain subtypes of colorectal cancer, such as those that are microsatellite instabili...
ASCO 2023: highlights in breast cancer
ASCO 2023: highlights in breast cancer
The 2023 annual meeting of the American Society of Clinical Oncology (ASCO) was again held in June 2023 in Chicag...
Cancer of unknown primary—state of the art
Cancer of unknown primary—state of the art
The Cancer of Unknown Primary (CUP) syndrome does not represent a single clinical entity but comprises a diverse group of ...
Emerging treatment strategies in chronic B-cell malignancies—News from ICML 2023
Emerging treatment strategies in chronic B-cell malignancies—News from ICML 2023
Implementation of targeted drugs in the treatment landscape of indolent B‑cell malignancies has facilitated long-ter...
Supportive management
Supportive management
The introduction of checkpoint inhibitor therapy and advances in targeted therapy...
Prostate cancer special—part 1
Prostate cancer special—part 1
Conflict of interest S.F. Shariat declares the following competing interes...
HER2 in focus—gastric cancer
HER2 in focus—gastric cancer
Conflict of interest A. Ilhan-Mutlu: Participation in advisory boards orga...
ASCO 2023—partnering with patients: the cornerstone of cancer care and research
ASCO 2023—partnering with patients: the cornerstone of cancer care and research
For the 2023 annual meeting of the American Society of Clinical Oncology (ASC...
WNT3 and LEF1 as markers for diagnosis and survival prediction in chronic lymphocytic leukemia patients
WNT3 and LEF1 as markers for diagnosis and survival prediction in chronic lymphocytic leukemia patients
The Wnt pathway is aberrantly activated in chronic lymphocytic leukemia (CLL) and contributes to the antiapoptotic and mit...
A CONGRESS DIGEST ON RADIOLABELED THERANOSTICS FOR SOLID TUMORS. Report from the 36th Annual Congress of the European Association of Nuclear Medicine (EANM), September 9th – 13th, 2023, Vienna
A CONGRESS DIGEST ON RADIOLABELED THERANOSTICS FOR SOLID TUMORS. Report from the 36th Annual Congress of the European Association of Nuclear Medicine (EANM), September 9th – 13th, 2023, Vienna
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A GLOBAL CONGRESS DIGEST ON LUNG CANCER. Report from the International Association for the Study of Lung Cancer (IASLC) 2023 World Conference on Lung Cancer, September 9th-12th , hybrid congress
A GLOBAL CONGRESS DIGEST ON LUNG CANCER. Report from the International Association for the Study of Lung Cancer (IASLC) 2023 World Conference on Lung Cancer, September 9th-12th , hybrid congress
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Decitabine combined with low-dose cytarabine, aclarubicin and rhG-CSF regimen may be a potential alternative for relapsed/refractory acute myeloid leukemia: A single-center study
Decitabine combined with low-dose cytarabine, aclarubicin and rhG-CSF regimen may be a potential alternative for relapsed/refractory acute myeloid leukemia: A single-center study
To analyze the effectiveness of decitabine combined with low-dose Ara‑C, aclarubicin, and rhG-CSF (DCAG) as a&nb...
Genetic testing and management of prostate cancer patients with pathogenic germline variants
Genetic testing and management of prostate cancer patients with pathogenic germline variants
Prostate cancer (PCa) is an androgen-receptor signaling-dependent disease with a subset of patients harboring pat...
Management of malignant hypercalcemia in cancer patients—a short review
Management of malignant hypercalcemia in cancer patients—a short review
Hypercalcemia of malignancy (HCM) can be the first symptom leading to diagnosis and initiation of treatment in cancer pati...
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