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Impact of obesity on the outcomes and cost of robotic surgery for Stage IA endometrial cancer: a regional perspective from Japan
Impact of obesity on the outcomes and cost of robotic surgery for Stage IA endometrial cancer: a regional perspective from Japan
The incidence of endometrial cancer in Japan has more than doubled over the past 2 decades because of increasing obesity r...
Efficacy and safety of cancer vaccine therapy in malignant melanoma: a systematic review
Efficacy and safety of cancer vaccine therapy in malignant melanoma: a systematic review
Malignant melanoma is a cancer that develops from melanocytes in the skin and mucous membranes. Surgery, and chemotherapy,...
Clinical usefulness of nutritional and immunological indices to distinguish gallbladder carcinoma from benign disease
Clinical usefulness of nutritional and immunological indices to distinguish gallbladder carcinoma from benign disease
It is challenging to accurately and preoperatively diagnose gallbladder carcinoma (GBC) because patients are often asympto...
The curse of blood–brain barrier and blood–tumor barrier in malignant brain tumor treatment
The curse of blood–brain barrier and blood–tumor barrier in malignant brain tumor treatment
The blood–brain barrier (BBB) is crucial for brain homeostasis but is a major obstacle in delivering anticancer drug...
Outcomes of capecitabine plus temozolomide combination therapy in patients with advanced or metastatic pancreatic neuroendocrine tumors: a retrospective observational single-center study
Outcomes of capecitabine plus temozolomide combination therapy in patients with advanced or metastatic pancreatic neuroendocrine tumors: a retrospective observational single-center study
Treatment strategies for patients with unresectable or recurrent pancreatic neuroendocrine tumors (pNETs) have been invest...
Impact of lymph-node dissection during radical cystectomy for non-muscle-invasive bladder cancer: Japanese multicenter retrospective study
Impact of lymph-node dissection during radical cystectomy for non-muscle-invasive bladder cancer: Japanese multicenter retrospective study
There is no definitive consensus on the necessity and impact of lymph-node dissection during radical cystectomy for non-mu...
How to report and discuss subgroup analyses in clinical practice guidelines? Evaluation procedure of the clinical and statistical relevancy
How to report and discuss subgroup analyses in clinical practice guidelines? Evaluation procedure of the clinical and statistical relevancy
The results of subgroup analyses of clinical trials are important reference information when considering the generalizabil...
Impact of body mass index on D-dimer diagnostic utility for deep vein thrombosis in patients with cancer: a single-center retrospective analysis
Impact of body mass index on D-dimer diagnostic utility for deep vein thrombosis in patients with cancer: a single-center retrospective analysis
Deep vein thrombosis (DVT) is a common complication in cancer patients associated with significant morbidity and mortality...
A randomized, double-blind, placebo-controlled phase III study evaluating the preventive effect of diclofenac cream on capecitabine-related hand-foot syndrome: study protocol of J-SUPPORT2401/JORTC-SUP06 (J-DIRECT)
A randomized, double-blind, placebo-controlled phase III study evaluating the preventive effect of diclofenac cream on capecitabine-related hand-foot syndrome: study protocol of J-SUPPORT2401/JORTC-SUP06 (J-DIRECT)
Clinical evidence on preventive therapy for capecitabine-induced hand-foot syndrome (HFS) is limited, and moisturizing and...
Stereotactic body radiotherapy for oligometastatic disease: current evidence and future perspectives
Stereotactic body radiotherapy for oligometastatic disease: current evidence and future perspectives
Oligometastatic disease (OMD) represents an intermediate state between locoregionally advanced and widespread polymetastat...
HSP90 and the cancer transcriptome: a comprehensive review of inhibitors and mechanistic insights
HSP90 and the cancer transcriptome: a comprehensive review of inhibitors and mechanistic insights
This review summarizes the structure, function, expression, and inhibitors of HSP90, the chaperone, in cancers. It systema...
Distant parenchymal recurrence during long-term use of TTFields treatment for glioblastoma
Distant parenchymal recurrence during long-term use of TTFields treatment for glioblastoma
Tumor treating fields (TTFields) treatment has been an important option for the treatment of glioblastoma. The introductio...
Phase 1 study evaluating safety and pharmacokinetics of tusamitamab ravtansine monotherapy in Japanese patients with advanced malignant solid tumors
Phase 1 study evaluating safety and pharmacokinetics of tusamitamab ravtansine monotherapy in Japanese patients with advanced malignant solid tumors
Tusamitamab ravtansine (SAR408701) is an immunoconjugate that binds carcinoembryonic antigen-related cell adhesion molecul...
Efficacy and safety of epcoritamab in Japanese patients with relapsed or refractory diffuse large B-cell lymphoma: 3-year follow-up from the EPCORE NHL-3 trial
Efficacy and safety of epcoritamab in Japanese patients with relapsed or refractory diffuse large B-cell lymphoma: 3-year follow-up from the EPCORE NHL-3 trial
Primary results from the EPCORE NHL-3 trial (NCT04542824) showed deep, durable responses in Japanese patients with relapse...
Phase-Ib dose-finding and pharmacokinetic trial of metformin combined with nivolumab for refractory/recurrent solid tumors
Phase-Ib dose-finding and pharmacokinetic trial of metformin combined with nivolumab for refractory/recurrent solid tumors
Our previous findings showed that the addition of metformin to nivolumab resulted in remarkable tumor regression and incre...
The prognostic factors and treatment patterns of the first recurrence of retroperitoneal liposarcoma
The prognostic factors and treatment patterns of the first recurrence of retroperitoneal liposarcoma
This study aimed to identify prognostic factors and treatment patterns at the first recurrence of retroperitoneal liposarc...
Collaborative frontiers in pediatric neuro-oncology: establishing an international tumor board for enhanced care and global impact
Collaborative frontiers in pediatric neuro-oncology: establishing an international tumor board for enhanced care and global impact
Central nervous system tumors are the leading cause of cancer-related mortality in children, with significant disparities ...
Clinical significance of antinuclear antibody as prognostic marker for first-line pembrolizumab in advanced non-small cell lung cancer
Clinical significance of antinuclear antibody as prognostic marker for first-line pembrolizumab in advanced non-small cell lung cancer
The relationship between antinuclear antibody (ANA) and the efficacy of programmed death-1 (PD-1) blockade remains controv...
FOXM1 transcriptional regulation of RacGAP1 activates the PI3K/AKT signaling pathway to promote the proliferation, migration, and invasion of cervical cancer cells
FOXM1 transcriptional regulation of RacGAP1 activates the PI3K/AKT signaling pathway to promote the proliferation, migration, and invasion of cervical cancer cells
Cervical cancer (CC) is the most common gynecological tumor disease in women, which occurs at the junction of cervical squ...
Clinical outcomes of sentinel node navigation surgery in patients with preoperatively estimated stage IA endometrial cancer and evaluation of validity for continuing sentinel node navigation surgery based on dispersion of recurrence probability
Clinical outcomes of sentinel node navigation surgery in patients with preoperatively estimated stage IA endometrial cancer and evaluation of validity for continuing sentinel node navigation surgery based on dispersion of recurrence probability
To evaluate the feasibility of the use and continuation of sentinel lymph node navigation surgery (SNNS) as an alternative...
Glomerular filtration rate measurement during platinum treatment for urothelial carcinoma: optimal methods for clinical practice
Glomerular filtration rate measurement during platinum treatment for urothelial carcinoma: optimal methods for clinical practice
We assessed the accuracy of four estimated glomerular filtration rate (eGFR) methods: MDRD, Cockcroft–Gault, CKD-EPI...
Concordance of ALK fusion gene-rearrangement between immunohistochemistry and next-generation sequencing
Concordance of ALK fusion gene-rearrangement between immunohistochemistry and next-generation sequencing
Although various companion diagnostic tests of ALK fusion gene-rearrangement are approved, few reports have assessed the c...
Impact of prostate position-based image-guidance in intensity-modulated radiation therapy for localized prostate cancer
Impact of prostate position-based image-guidance in intensity-modulated radiation therapy for localized prostate cancer
The long-term clinical impact of prostate position-based image-guided radiotherapy (IGRT) for localized prostate cancer re...
Analgesic efficacy and safety of percutaneous thermal ablation plus cementoplasty for painful bone metastases: a systematic review and meta-analysis
Analgesic efficacy and safety of percutaneous thermal ablation plus cementoplasty for painful bone metastases: a systematic review and meta-analysis
To conduct a systematic review and meta-analysis of publications to evaluate the analgesic efficacy and safety of percutan...
Predictors for early recurrence beyond up-to-7 or distant metastasis after hepatocellular carcinoma resection: proposal for borderline resectable HCC
Predictors for early recurrence beyond up-to-7 or distant metastasis after hepatocellular carcinoma resection: proposal for borderline resectable HCC
The recurrence rate after curative resection for hepatocellular carcinoma (HCC) reaches over 70% after 5 years an...
Phase II study of S-1 plus docetaxel as first-line treatment for older patients with advanced gastric cancer (OGSG 0902)
Phase II study of S-1 plus docetaxel as first-line treatment for older patients with advanced gastric cancer (OGSG 0902)
Although there is insufficient evidence for the treatment of older patients with advanced gastric cancer, fluorouracil com...
Effects of postoperative oral elemental nutritional supplement on skeletal muscle loss after gastrectomy for gastric cancer
Effects of postoperative oral elemental nutritional supplement on skeletal muscle loss after gastrectomy for gastric cancer
We previously showed that daily nutritional intervention with an oral elemental diet (ED) at 300 kcal/day for 6&#...
Risk factors of secondary cancer in laryngeal, oropharyngeal, or hypopharyngeal cancer after definitive therapy
Risk factors of secondary cancer in laryngeal, oropharyngeal, or hypopharyngeal cancer after definitive therapy
Our previous research showed that a high rate of secondary carcinogenesis is observed during follow-up after transoral sur...
Pegfilgrastim for the management of neutropenia during neoadjuvant chemotherapy with docetaxel, cisplatin, and 5-fluorouracil in esophageal cancer patients
Pegfilgrastim for the management of neutropenia during neoadjuvant chemotherapy with docetaxel, cisplatin, and 5-fluorouracil in esophageal cancer patients
Neoadjuvant docetaxel, cisplatin, and 5-fluorouracil (DCF) therapy is a new standard for locally advanced esophageal squam...
Impact of COVID-19 on gynecological cancer incidence: a large cohort study in Japan
Impact of COVID-19 on gynecological cancer incidence: a large cohort study in Japan
The influence of the coronavirus disease 2019 (COVID-19) pandemic on the number of newly diagnosed gynecological cancers h...
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