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Prognostic impact of lymphadenectomy in patients with advanced ovarian clear cell carcinoma: an ancillary analysis of the JGOG3017-A4 study
Prognostic impact of lymphadenectomy in patients with advanced ovarian clear cell carcinoma: an ancillary analysis of the JGOG3017-A4 study
Systematic pelvic and aortic lymphadenectomy in stage IIB–IVB patients with epithelial ovarian cancer, undergoing co...
The changes of CD47 and PD-L1 (SP142) before and after neoadjuvant therapy help predict prognosis of patients with stage IIIA-N2 non-small cell lung cancer
The changes of CD47 and PD-L1 (SP142) before and after neoadjuvant therapy help predict prognosis of patients with stage IIIA-N2 non-small cell lung cancer
Non-small cell lung cancer (NSCLC) represents over 80% of lung cancer cases. Neoadjuvant therapy (NAT) improves overall su...
Comparison of first-line immuno-oncology combinations with molecular targeted therapy in patients with advanced renal cell carcinoma undergoing hemodialysis: a real-world multicenter retrospective study
Comparison of first-line immuno-oncology combinations with molecular targeted therapy in patients with advanced renal cell carcinoma undergoing hemodialysis: a real-world multicenter retrospective study
Patients with advanced renal cell carcinoma (RCC) undergoing hemodialysis are often excluded from clinical trials. We aime...
Supporting parents with cancer: a profile of patients using childcare services in a cancer center
Supporting parents with cancer: a profile of patients using childcare services in a cancer center
In Japan, approximately 1 million individuals are newly diagnosed with cancer each year, and 56,000 patients have children...
Prognostic outcomes of immediate complete lymph node dissection versus observation in patients with acral melanoma of the sole with sentinel node metastasis: a retrospective, multicenter study
Prognostic outcomes of immediate complete lymph node dissection versus observation in patients with acral melanoma of the sole with sentinel node metastasis: a retrospective, multicenter study
The clinical utility of immediate complete lymph node dissection (CLND) following positive sentinel node (SN) remains cont...
Sustained antiemetic efficacy of fosnetupitant versus aprepitant in carboplatin-based chemotherapy: a retrospective observational study
Sustained antiemetic efficacy of fosnetupitant versus aprepitant in carboplatin-based chemotherapy: a retrospective observational study
Carboplatin (CBDCA) is highly emetogenic when administered at an area under the curve (AUC) ≥ 4, requiri...
Clinical profiles and predictors of symptomatic skeletal events in patients with metastatic castration-resistant prostate cancer receiving denosumab
Clinical profiles and predictors of symptomatic skeletal events in patients with metastatic castration-resistant prostate cancer receiving denosumab
Denosumab, a bone-modifying agent, reduces the incidence of skeletal-related events (SREs), but its optimal use in real-wo...
Intraperitoneal nivolumab for malignant ascites in patients with advanced gastrointestinal or pancreaticobiliary tract cancer
Intraperitoneal nivolumab for malignant ascites in patients with advanced gastrointestinal or pancreaticobiliary tract cancer
Malignant ascites occur in 10–15% of patients with gastrointestinal tract cancers. The abundance of immune cells in ...
Advances in endometrial cancer screening: a comprehensive review of current methods and emerging technologies
Advances in endometrial cancer screening: a comprehensive review of current methods and emerging technologies
Endometrial cancer represents a major global health concern, with rising incidence particularly in developed countries des...
Microflora: a promising potential in the diagnosis and treatment of non-small cell lung cancer
Microflora: a promising potential in the diagnosis and treatment of non-small cell lung cancer
The incidence and mortality of non-small cell lung cancer (NSCLC) remain high in China. Recently, several studies have sho...
Real-world experience of circulating tumor DNA testing in resectable colorectal cancer: a Japanese single-institution observational study
Real-world experience of circulating tumor DNA testing in resectable colorectal cancer: a Japanese single-institution observational study
Assessment of molecular residual disease (MRD) using circulating tumor DNA (ctDNA) is a powerful prognostic tool for detec...
Prognostic and clinicopathological implications of mismatch-repair deficiency and promoter methylation status in endometrial carcinoma
Prognostic and clinicopathological implications of mismatch-repair deficiency and promoter methylation status in endometrial carcinoma
The prevalence of MSI-H and MLH1 promoter hypermethylation (MLH1-PHM) as well as Lynch syndrome in Japanese patients with ...
Radiotherapy with or without chemotherapy for T2N0 hypopharyngeal cancer: an analysis of the head and neck cancer registry of Japan
Radiotherapy with or without chemotherapy for T2N0 hypopharyngeal cancer: an analysis of the head and neck cancer registry of Japan
This retrospective study compared the outcomes of radiotherapy (RT) and chemoradiotherapy (CRT) in patients with T2N0 hypo...
Impact of baseline regular magnesium oxide administration on chemotherapy-induced constipation during cisplatin-containing treatment
Impact of baseline regular magnesium oxide administration on chemotherapy-induced constipation during cisplatin-containing treatment
Chemotherapy-induced constipation frequently occurs with cisplatin-containing treatments, partly because of concomitant ne...
Long-term progression-free survivors (“super responders”) to olaparib maintenance in recurrent ovarian cancer: a multicenter real-world study (KCOG-G2101s)
Long-term progression-free survivors (“super responders”) to olaparib maintenance in recurrent ovarian cancer: a multicenter real-world study (KCOG-G2101s)
PARP inhibitors have been shown to improve progression-free survival in patients with recurrent ovarian cancer. However, t...
The impact of neutropenia severity in the setting of recent chemotherapy on mortality in sepsis
The impact of neutropenia severity in the setting of recent chemotherapy on mortality in sepsis
Sepsis and septic shock are major causes of non-relapse mortality in cancer patients, with chemotherapy-induced neutropeni...
Cancer epidemiology in rare and hereditary colorectal diseases 2) anal canal cancer (cancer statistics)
Cancer epidemiology in rare and hereditary colorectal diseases 2) anal canal cancer (cancer statistics)
Anal canal carcinoma (ACC) is reported to be a rare cancer worldwide. In Japan, while the incidence rate is similarly low ...
Longitudinal assessment of health-related quality of life, sleep quality, and gustation in patients with advanced urothelial carcinoma receiving late-line enfortumab vedotin monotherapy
Longitudinal assessment of health-related quality of life, sleep quality, and gustation in patients with advanced urothelial carcinoma receiving late-line enfortumab vedotin monotherapy
To describe real-world data on health-related quality of life (HRQoL) in patients with locally advanced or metastatic urot...
Impact of obesity on the outcomes and cost of robotic surgery for Stage IA endometrial cancer: a regional perspective from Japan
Impact of obesity on the outcomes and cost of robotic surgery for Stage IA endometrial cancer: a regional perspective from Japan
The incidence of endometrial cancer in Japan has more than doubled over the past 2 decades because of increasing obesity r...
Efficacy and safety of cancer vaccine therapy in malignant melanoma: a systematic review
Efficacy and safety of cancer vaccine therapy in malignant melanoma: a systematic review
Malignant melanoma is a cancer that develops from melanocytes in the skin and mucous membranes. Surgery, and chemotherapy,...
Clinical usefulness of nutritional and immunological indices to distinguish gallbladder carcinoma from benign disease
Clinical usefulness of nutritional and immunological indices to distinguish gallbladder carcinoma from benign disease
It is challenging to accurately and preoperatively diagnose gallbladder carcinoma (GBC) because patients are often asympto...
The curse of blood–brain barrier and blood–tumor barrier in malignant brain tumor treatment
The curse of blood–brain barrier and blood–tumor barrier in malignant brain tumor treatment
The blood–brain barrier (BBB) is crucial for brain homeostasis but is a major obstacle in delivering anticancer drug...
Outcomes of capecitabine plus temozolomide combination therapy in patients with advanced or metastatic pancreatic neuroendocrine tumors: a retrospective observational single-center study
Outcomes of capecitabine plus temozolomide combination therapy in patients with advanced or metastatic pancreatic neuroendocrine tumors: a retrospective observational single-center study
Treatment strategies for patients with unresectable or recurrent pancreatic neuroendocrine tumors (pNETs) have been invest...
Impact of lymph-node dissection during radical cystectomy for non-muscle-invasive bladder cancer: Japanese multicenter retrospective study
Impact of lymph-node dissection during radical cystectomy for non-muscle-invasive bladder cancer: Japanese multicenter retrospective study
There is no definitive consensus on the necessity and impact of lymph-node dissection during radical cystectomy for non-mu...
How to report and discuss subgroup analyses in clinical practice guidelines? Evaluation procedure of the clinical and statistical relevancy
How to report and discuss subgroup analyses in clinical practice guidelines? Evaluation procedure of the clinical and statistical relevancy
The results of subgroup analyses of clinical trials are important reference information when considering the generalizabil...
Impact of body mass index on D-dimer diagnostic utility for deep vein thrombosis in patients with cancer: a single-center retrospective analysis
Impact of body mass index on D-dimer diagnostic utility for deep vein thrombosis in patients with cancer: a single-center retrospective analysis
Deep vein thrombosis (DVT) is a common complication in cancer patients associated with significant morbidity and mortality...
A randomized, double-blind, placebo-controlled phase III study evaluating the preventive effect of diclofenac cream on capecitabine-related hand-foot syndrome: study protocol of J-SUPPORT2401/JORTC-SUP06 (J-DIRECT)
A randomized, double-blind, placebo-controlled phase III study evaluating the preventive effect of diclofenac cream on capecitabine-related hand-foot syndrome: study protocol of J-SUPPORT2401/JORTC-SUP06 (J-DIRECT)
Clinical evidence on preventive therapy for capecitabine-induced hand-foot syndrome (HFS) is limited, and moisturizing and...
Stereotactic body radiotherapy for oligometastatic disease: current evidence and future perspectives
Stereotactic body radiotherapy for oligometastatic disease: current evidence and future perspectives
Oligometastatic disease (OMD) represents an intermediate state between locoregionally advanced and widespread polymetastat...
HSP90 and the cancer transcriptome: a comprehensive review of inhibitors and mechanistic insights
HSP90 and the cancer transcriptome: a comprehensive review of inhibitors and mechanistic insights
This review summarizes the structure, function, expression, and inhibitors of HSP90, the chaperone, in cancers. It systema...
Distant parenchymal recurrence during long-term use of TTFields treatment for glioblastoma
Distant parenchymal recurrence during long-term use of TTFields treatment for glioblastoma
Tumor treating fields (TTFields) treatment has been an important option for the treatment of glioblastoma. The introductio...
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