Albakova Z, Mangasarova Y, Albakov A et al (2022) HSP70 and HSP90 in cancer: cytosolic, endoplasmic reticulum and mitochondrial chaperones of tumorigenesis. Front Oncol. https://doi.org/10.3389/fonc.2022.829520

Article  PubMed  PubMed Central  Google Scholar 

Ali MMU, Roe SM, Vaughan CK et al (2006) Crystal structure of an Hsp90-nucleotide-p23/Sba1 closed chaperone complex. Nature 440:1013–1017. https://doi.org/10.1038/nature04716

Article  PubMed  PubMed Central  CAS  Google Scholar 

Aligue R, Akhavan-Niak H, Russell P (1994) A role for Hsp90 in cell cycle control: Wee1 tyrosine kinase activity requires interaction with Hsp90. EMBO J 13:6099–6106. https://doi.org/10.1002/j.1460-2075.1994.tb06956.x

Article  PubMed  PubMed Central  CAS  Google Scholar 

Anckar J, Sistonen L (2011) Regulation of HSF1 function in the heat stress response: implications in aging and disease. Annu Rev Biochem 80:1089–1115. https://doi.org/10.1146/annurev-biochem-060809-095203

Article  PubMed  CAS  Google Scholar 

Arlander SJH, Felts SJ, Wagner JM et al (2006) Chaperoning checkpoint kinase 1 (Chk1), an Hsp90 client, with purified chaperones. J Biol Chem 281:2989–2998. https://doi.org/10.1074/jbc.M508687200

Article  PubMed  CAS  Google Scholar 

Bhattacharya K, Weidenauer L, Luengo TM et al (2020) The Hsp70-Hsp90 co-chaperone Hop/Stip1 shifts the proteostatic balance from folding towards degradation. Nat Commun 11:5975. https://doi.org/10.1038/s41467-020-19783-w

Article  PubMed  PubMed Central  CAS  Google Scholar 

Boulton DP, Caino MC (2022) Mitochondrial fission and fusion in tumor progression to metastasis. Front Cell Dev Biol. https://doi.org/10.3389/fcell.2022.849962

Article  PubMed  PubMed Central  Google Scholar 

Broemer M, Krappmann D, Scheidereit C (2004) Requirement of Hsp90 activity for IκB kinase (IKK) biosynthesis and for constitutive and inducible IKK and NF-κB activation. Oncogene 23:5378–5386. https://doi.org/10.1038/sj.onc.1207705

Article  PubMed  CAS  Google Scholar 

Burrows F, Zhang H, Kamal A (2004) Hsp90 activation and cell cycle regulation. Cell Cycle 3:1530–1536. https://doi.org/10.4161/cc.3.12.1277

Article  PubMed  CAS  Google Scholar 

Calderwood SK (2015) Cdc37 as a Co-chaperone to Hsp90. Subcell Biochem 78:103–112. https://doi.org/10.1007/978-3-319-11731-7_5

Article  PubMed  PubMed Central  CAS  Google Scholar 

Carmeliet P (2005) VEGF as a key mediator of angiogenesis in cancer. Oncology 69(Suppl 3):4–10. https://doi.org/10.1159/000088478

Article  PubMed  CAS  Google Scholar 

Carrello A, Allan RK, Morgan SL et al (2004) Interaction of the Hsp90 cochaperone cyclophilin 40 with Hsc70. Cell Stress Chaperones 9:167–181. https://doi.org/10.1379/CSC-26R.1

Article  PubMed  PubMed Central  CAS  Google Scholar 

Chen L, Li J, Farah E et al (2016) Cotargeting HSP90 and its client proteins for treatment of prostate cancer. Mol Cancer Ther 15:2107–2118. https://doi.org/10.1158/1535-7163.MCT-16-0241

Article  PubMed  PubMed Central  CAS  Google Scholar 

Cheng C-F, Fan J, Fedesco M et al (2008) Transforming growth factor α (TGFα)-stimulated secretion of HSP90α: using the receptor LRP-1/CD91 To promote human skin cell migration against a TGFβ-rich environment during wound healing. Mol Cell Biol 28:3344–3358. https://doi.org/10.1128/MCB.01287-07

Article  PubMed  PubMed Central  CAS  Google Scholar 

Citri A, Gan J, Mosesson Y et al (2004) Hsp90 restrains ErbB-2/HER2 signalling by limiting heterodimer formation. EMBO Rep 5:1165–1170. https://doi.org/10.1038/sj.embor.7400300

Article  PubMed  PubMed Central  CAS  Google Scholar 

Cyran AM, Zhitkovich A (2022) Heat shock proteins and HSF1 in cancer. Front Oncol. https://doi.org/10.3389/fonc.2022.860320

Article  PubMed  PubMed Central  Google Scholar 

Dai C, Whitesell L, Rogers AB et al (2007) Heat shock factor 1 is a powerful multifaceted modifier of carcinogenesis. Cell 130:1005–1018. https://doi.org/10.1016/j.cell.2007.07.020

Article  PubMed  PubMed Central  CAS  Google Scholar 

De Nardo D, Masendycz P, Ho S et al (2005) A central role for the Hsp90·Cdc37 molecular chaperone module in interleukin-1 receptor-associated-kinase-dependent signaling by toll-like receptors. J Biol Chem 280:9813–9822. https://doi.org/10.1074/jbc.M409745200

Article  PubMed  CAS  Google Scholar 

Dias S, Shmelkov SV, Lam G et al (2002) VEGF165 promotes survival of leukemic cells by Hsp90-mediated induction of Bcl-2 expression and apoptosis inhibition. Blood 99:2532–2540. https://doi.org/10.1182/blood.V99.7.2532

Article  PubMed  CAS  Google Scholar 

Douglas M, Lim AR, Porter JR et al (2009) The antiproliferative activity of the heat shock protein 90 inhibitor IPI-504 is not dependent on NAD(P)H:quinone oxidoreductase 1 activity in vivo. Mol Cancer Ther 8:3369–3378. https://doi.org/10.1158/1535-7163.MCT-09-0568

Article  PubMed  CAS  Google Scholar 

Eckert K, Saliou J-M, Monlezun L et al (2010) The Pih1-Tah1 cochaperone complex inhibits Hsp90 molecular chaperone ATPase activity. J Biol Chem 285:31304–31312. https://doi.org/10.1074/jbc.M110.138263

Article  PubMed  PubMed Central  CAS  Google Scholar 

Eustace BK, Sakurai T, Stewart JK et al (2004) Functional proteomic screens reveal an essential extracellular role for hsp90 alpha in cancer cell invasiveness. Nat Cell Biol 6:507–514. https://doi.org/10.1038/ncb1131

Article  PubMed  CAS  Google Scholar 

Fan ACY, Young JC (2011) Function of cytosolic chaperones in Tom70-mediated mitochondrial import. Protein Pept Lett 18:122–131. https://doi.org/10.2174/092986611794475020

Article  PubMed  PubMed Central  CAS  Google Scholar 

Fan C-S, Chen C-C, Chen L-L et al (2022) Extracellular HSP90α induces MyD88-IRAK complex-associated IKKα/β-NF-κB/IRF3 and JAK2/TYK2-STAT-3 signaling in macrophages for tumor-promoting M2-polarization. Cells 11:229. https://doi.org/10.3390/cells11020229

Article  PubMed  PubMed Central  CAS  Google Scholar 

Garg G, Khandelwal A, Blagg BSJ (2016) Anticancer inhibitors of Hsp90 function: beyond the usual suspects. Adv Cancer Res 129:51–88. https://doi.org/10.1016/bs.acr.2015.12.001

Article  PubMed  PubMed Central  CAS  Google Scholar 

Guo W, Reigan P, Siegel D et al (2008) Enzymatic reduction and glutathione conjugation of benzoquinone ansamycin heat shock protein 90 inhibitors: relevance for toxicity and mechanism of action. Drug Metab Dispos Biol Fate Chem 36:2050–2057. https://doi.org/10.1124/dmd.108.022004

Article  PubMed  CAS  Google Scholar 

Hanahan D, Folkman J (1996) Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis. Cell 86:353–364. https://doi.org/10.1016/s0092-8674(00)80108-7

Article