Gilbert MR, Dignam JJ, Armstrong TS et al (2014) A randomized trial of bevacizumab for newly diagnosed glioblastoma. N Engl J Med 370(8):699–708. https://doi.org/10.1056/NEJMoa1308573
Article CAS PubMed PubMed Central Google Scholar
Chinot OL, Wick W, Mason W et al (2014) Bevacizumab plus radiotherapy-temozolomide for newly diagnosed glioblastoma. N Engl J Med 370(8):709–722. https://doi.org/10.1056/NEJMoa1308345
Article CAS PubMed Google Scholar
Pardridge WM (2005) The blood–brain barrier: bottleneck in brain drug development. NeuroRx 2(1):3–14. https://doi.org/10.1602/neurorx.2.1.3
Article PubMed PubMed Central Google Scholar
Fidler IJ, Yano S, Zhang RD et al (2002) The seed and soil hypothesis: vascularisation and brain metastases. Lancet Oncol 3(1):53–57. https://doi.org/10.1016/s1470-2045(01)00622-2
Article CAS PubMed Google Scholar
Sweeney MD, Zhao Z, Montagne A et al (2019) Blood–brain barrier: from physiology to disease and back. Physiol Rev 99(1):21–78. https://doi.org/10.1152/physrev.00050.2017
Article CAS PubMed Google Scholar
Harati R, Villegier AS, Banks WA et al (2012) Susceptibility of juvenile and adult blood–brain barrier to endothelin-1: regulation of P-glycoprotein and breast cancer resistance protein expression and transport activity. J Neuroinflammation 9:273. https://doi.org/10.1186/1742-2094-9-273
Article CAS PubMed PubMed Central Google Scholar
Kadry H, Noorani B, Cucullo L (2020) A blood–brain barrier overview on structure, function, impairment, and biomarkers of integrity. Fluids Barriers CNS 17(1):69. https://doi.org/10.1186/s12987-020-00230-3
Article PubMed PubMed Central Google Scholar
Cai Q, Li X, Xiong H et al (2023) Optical blood–brain-tumor barrier modulation expands therapeutic options for glioblastoma treatment. Nat Commun 14(1):4934. https://doi.org/10.1038/s41467-023-40579-1
Article CAS PubMed PubMed Central Google Scholar
Abbott NJ (2013) Blood–brain barrier structure and function and the challenges for CNS drug delivery. J Inherit Metab Dis 36(3):437–449. https://doi.org/10.1007/s10545-013-9608-0
Article CAS PubMed Google Scholar
O’Brown NM, Pfau SJ, Gu C (2018) Bridging barriers: a comparative look at the blood–brain barrier across organisms. Genes Dev 32(7–8):466–478. https://doi.org/10.1101/gad.309823.117
Article CAS PubMed PubMed Central Google Scholar
Wong AD, Ye M, Levy AF et al (2013) The blood–brain barrier: an engineering perspective. Front Neuroeng 6:7. https://doi.org/10.3389/fneng.2013.00007
Article CAS PubMed PubMed Central Google Scholar
Abbott NJ, Patabendige AA, Dolman DE et al (2010) Structure and function of the blood–brain barrier. Neurobiol Dis 37(1):13–25. https://doi.org/10.1016/j.nbd.2009.07.030
Article CAS PubMed Google Scholar
Daneman R, Prat A (2015) The blood–brain barrier. Cold Spring Harb Perspect Biol 7(1):a020412. https://doi.org/10.1101/cshperspect.a020412
Article PubMed PubMed Central Google Scholar
Abbott NJ, Ronnback L, Hansson E (2006) Astrocyte-endothelial interactions at the blood–brain barrier. Nat Rev Neurosci 7(1):41–53. https://doi.org/10.1038/nrn1824
Article CAS PubMed Google Scholar
Zhao Z, Nelson AR, Betsholtz C et al (2015) Establishment and dysfunction of the blood–brain barrier. Cell 163(5):1064–1078. https://doi.org/10.1016/j.cell.2015.10.067
Article CAS PubMed PubMed Central Google Scholar
Lipinski CA (2000) Drug-like properties and the causes of poor solubility and poor permeability. J Pharmacol Toxicol Methods 44(1):235–249. https://doi.org/10.1016/s1056-8719(00)00107-6
Article CAS PubMed Google Scholar
Banks WA (2009) Characteristics of compounds that cross the blood–brain barrier. BMC Neurol 9(1):S3. https://doi.org/10.1186/1471-2377-9-S1-S3
Article CAS PubMed PubMed Central Google Scholar
Pardridge WM (2012) Drug transport across the blood–brain barrier. J Cereb Blood Flow Metab 32(11):1959–1972. https://doi.org/10.1038/jcbfm.2012.126
Article CAS PubMed PubMed Central Google Scholar
Levin VA (1980) Relationship of octanol/water partition coefficient and molecular weight to rat brain capillary permeability. J Med Chem 23(6):682–684. https://doi.org/10.1021/jm00180a022
Article CAS PubMed Google Scholar
van de Waterbeemd H, Camenisch G, Folkers G et al (1998) Estimation of blood–brain barrier crossing of drugs using molecular size and shape, and H-bonding descriptors. J Drug Target 6(2):151–165. https://doi.org/10.3109/10611869808997889
Sarin H (2009) Recent progress toward development of effective systemic chemotherapy for the treatment of malignant brain tumors. J Transl Med 7:77. https://doi.org/10.1186/1479-5876-7-77
Article CAS PubMed PubMed Central Google Scholar
Pardridge WM (1998) CNS drug design based on principles of blood–brain barrier transport. J Neurochem 70(5):1781–1792. https://doi.org/10.1046/j.1471-4159.1998.70051781.x
Article CAS PubMed Google Scholar
Pan L, Aller SG (2018) Allosteric role of substrate occupancy toward the alignment of p-glycoprotein nucleotide binding domains. Sci Rep 8(1):14643. https://doi.org/10.1038/s41598-018-32815-2
Article CAS PubMed PubMed Central Google Scholar
Callaghan R (2015) Providing a molecular mechanism for P-glycoprotein; why would I bother? Biochem Soc Trans 43(5):995–1002. https://doi.org/10.1042/BST20150131
Article CAS PubMed PubMed Central Google Scholar
Saaby L, Brodin B (2017) A critical view on in vitro analysis of P-glycoprotein (P-gp) transport kinetics. J Pharm Sci 106(9):2257–2264. https://doi.org/10.1016/j.xphs.2017.04.022
Article CAS PubMed Google Scholar
Zlokovic BV (2011) Neurovascular pathways to neurodegeneration in Alzheimer’s disease and other disorders. Nat Rev Neurosci 12(12):723–738. https://doi.org/10.1038/nrn3114
Article CAS PubMed PubMed Central Google Scholar
Ohtsuki S, Hirayama M, Ito S et al (2014) Quantitative targeted proteomics for understanding the blood–brain barrier: towards pharmacoproteomics. Exp Rev Proteom 11(3):303–313. https://doi.org/10.1586/14789450.2014.893830
Comments (0)