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Quad Shot Like Radiotherapy with Concurrent Chemotherapy for Advanced Head and Neck Cancer
Background: Improvement in quality of life and palliation of symptoms forms the primary end point in patients unfit for de...
Venetoclax Drives Significant Shifts in BIM and BCL-2 but not MCL-1 Gene Expression in a Mouse Model of Acute Lymphoblastic Leukemia
Background: T and B acute lymphoblastic leukemia (T, B-ALL) has seen improved survival rates with intensified chemotherapy...
Investigating the Protective Effects of Atorvastatin against Radiotherapy-Induced Gastrointestinal Toxicity in Abdominal and Pelvic Cancers: A Randomized, Double-Blind, Placebo-Controlled Trial
Background: Radiotherapy (RT) for pelvic cancers often causes gastrointestinal toxicity. While statins show promise in red...
Primary Hodgkin's Lymphoma of Thyroid Simulating Subacute Thyroiditis: A Case Report
Primary thyroid lymphoma is rare, with the majority of cases being non-Hodgkin and occurs in patients with autoimmune thyr...
Pelvic Nodal Irradiation in MIBC Bladder Cancer
Background: Bladder cancer preservation treatment achieved 5/10-year overall survival rates comparable to those of radical...
Prognostic Significance of LncRNA PANDAR Expression Levels in Patients with Hepatocellular Carcinoma
Background: Long non-coding RNAs (LncRNAs) have been implicated in various biological processes and tumorigenesis. PANDAR ...
Long-term Breast Tumor Control with Brachytherapy and External Beam Radiotherapy: A Case Report
While surgical resection of the primary tumour and regional nodes is part of the standard algorithm for the treatment of e...
Hairy Cell Leukemia Variant Masquerading as Acute Leukemia: A Rare Case Report
The key purpose of this report is to present an uncommon case of hairy cell leukemia variant (HCLv). HCLv is found to be a...
Polypoid Ganglioneuroma in a Patient with Colonic Polyposis: A Case Report
Ganglioneuromas are benign tumors of the autonomic nervous system. They are rarely found in the colonic mucosa, where symp...
Intervention of Primary Focus of Type 1 Neurofibromatosis Presenting with Melena and Gastric Hemorrhage of Unknown Origin and Nursing Care: A Case Report
There are four types of neurofibromatosis, with types 1 and 2 being the most prevalent among them. The disease incidence i...
Updates on Peritoneal Surface Malignancy Cytoreductive Surgery and Hyperthermic Intraoperative Peritoneal Chemotherapy Morbidity and Mortality Outcomes from the Shiraz Surgical Oncology Group
Background: Cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) are well-known in the treatm...
Investigating the Role of Escherichia coli Infection in the Pathogenesis of Bladder Cancer: A Comparative Genomics Interaction
Background: Bladder cancer (BC) is the 10th most common cancer worldwide. Microorganisms, including bacteria, may contribu...
Comparison Anticancer Effects of Platinum Ribavirin with Platinum Azidothymidine via Telomerase, Bcl-2, miRNA-21 and miRNA-122 Biomarkers Genes Expression on HepG2 Cancer Cell Lines
Background: Anticancer medication assessment is performed by numerous approaches including biomarkers gene expression. Thi...
Oridonin Enhances Radiotherapy Efficacy by Inducing Late-Stage Cell Death and G2/M Arrest in U87MG Glioma Cells
Background: Glioblastoma multiforme is a deadly brain tumor with limited treatment options. The aim of this study was to i...
Gefitinib Combination with Radiotherapy in Patients with Local Advanced Non-Small Cell Lung Cancer
Background: Epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors is a crucial agent in EGFR-mutated advanced...
A Dosimetric Study of Accidental Internal Mammary Lymph Node Irradiation during Locoregional Breast Irradiation
Background: One remaining grey zone in locoregional breast irradiation is whether to irradiate internal mammary lymph node...
Evaluation of the Prognostic Role of Leptin and Cyclin D1 Expression in Colorectal Cancer
Background: Colorectal cancer (CRC) is one of the most malignancies worldwide. This study aimed to determine the role of l...
Comparison of Interleukin-18 Serum Levels in Patients with Breast Cancer and Idiopathic Granulomatous Mastitis
Background: Breast cancer (BC), as a global challenge, is one of the most prevalent malignant diseases among women. Idiopa...
Urothelial Carcinoma Stage and Grade Association with the Expression Levels of Eukaryotic Initiation Factor 4E and 4E Binding Protein 1
Background: Bladder cancer (BCa) accounts for the fourth most common cancer among men. Eukaryote translation initiation fa...
Flaxseed Extract Can Modulates Apoptotic Genes to Promote Cell Death in Breast Cancer Cells
Background: Breast cancer is a multifactorial malignancy with uncertain treatment outcomes that make its challenging treat...
Evaluation of Potential miR-221, miR-93, miR-21, and miR-24 as Molecular Markers for Laryngeal Squamous Cell Carcinoma
Background: Laryngeal cancer, the most prevalent head and neck malignancy, represents 2.4% of all tumors and is the 11th m...
Feature Selection Algorithms Combined with Experimental Validation Reveal COL10A1 and TMPRSS4 Genes as Potential Diagnostic Biomarkers in Pancreatic Ductal Adenocarcinoma
Background: Pancreatic adenocarcinoma (PAAD) is often diagnosed at a late stage, preventing curative surgery. Early detect...
Prevalence and Clinicopathologic Features of HER2 Overexpression in Endocervical Adenocarcinoma
Background: Endocervical adenocarcinoma (ENCA) has poor prognosis and is increasing in developing countries. Human epiderm...
Nettle (Urtica Dioica L.) Modulates Angiogenesis by Targeting the PI3K/AKT/eNOS Pathway in Prostate Cancer
Background: Medicinal plants, predominantly those rich in polyphenolic mixtures, have been recommended to have chemopreven...
The Safety and Efficacy of Cold Atmospheric Plasma as a Novel Therapy: An in vivo Study
Background: Cold atmospheric plasma (CAP) may reduce bacteria and aid wound healing through reactive oxygen species. Recen...
N-Nornuciferine Promotes Human Non-Small Cell Lung Cancer A549 Cells Apoptosis via miR-361-3p/TRAF2/JNK Axis
Background: N-Nornuciferine (N-NF) is an aporphine alkaloid in lotus leaf with a good resource for obtaining the biologica...
The Effect of Proton Pump Inhibitors on Metastatic Breast Cancer in Patients Treated with CDK4/6i
Background: This study aimed to assess the effect of proton pump inhibitors (PPIs) on hormone receptor-positive (HR+) and ...
Efficacy of Combined Bevacizumab and Angiotensin-Converting Enzyme Inhibitors or Angiotensin II type 1 Receptor Blockers in Metastatic Colorectal Cancer Patients
Background: Bevacizumab, used in the treatment of metastatic colorectal cancer (mCRC), has an angiogenesis inhibitory effe...
Stromal Cell-Derived Factor1 Genetic Variation at Locus 801 in Patients with Endometrial Cancer
Background: The gene's 3′ untranslated region of stromal cell-derived factor1 (SDF-1/ CXC chemokine ligand 12 (CXCL12...
Ozonated Aloe Vera Oil Accelerates Radiation Dermatitis Healing in Sprague Dawley Rats
Background: Radiation dermatitis is the most common side-effect of radiation therapy. The current daily therapy uses topic...
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