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Immunological outcomes of a bespoke DNA cancer vaccine in glioblastoma
Immunological outcomes of a bespoke DNA cancer vaccine in glioblastoma
We report the results of a phase 1 clinical trial (NCT04015700) evaluating the safety and immunogenicity of GNOS-PV01, a p...
Targeting cysteinyl leukotriene receptor 1 reprograms tumor-promoting myelopoiesis and overcomes immune checkpoint therapy resistance
Targeting cysteinyl leukotriene receptor 1 reprograms tumor-promoting myelopoiesis and overcomes immune checkpoint therapy resistance
‘Emergency’ myelopoiesis usually occurs to facilitate malignancy progression. Immunosuppressive neutrophils, a...
Coupling dead cell recognition to Fcγ receptors augments anticancer immunity
Coupling dead cell recognition to Fcγ receptors augments anticancer immunity
Type 1 conventional dendritic cells (cDC1s) are key antigen-presenting cells (APCs) for cross-priming of CD8+ T cells agai...
Tumor irradiation promotes antigen dressing of dendritic cells to enhance CAR T cell persistence and efficacy in lung metastases
Tumor irradiation promotes antigen dressing of dendritic cells to enhance CAR T cell persistence and efficacy in lung metastases
Metastatic solid tumors remain the principal cause of cancer mortality worldwide. High tumor burden impairs responses to c...
Copper depletion boosts CNS leukemia therapy by inhibiting nucleotide synthesis through impairment of mitochondrial complex IV activity
Copper depletion boosts CNS leukemia therapy by inhibiting nucleotide synthesis through impairment of mitochondrial complex IV activity
The nutrient-sparse cerebrospinal fluid (CSF) poses a major challenge to spreading cancer cells. Despite this challenge, l...
Gemcitabine and nab-paclitaxel with or without the VDR agonist paricalcitol for metastatic pancreatic cancer: a randomized, multiarm, run-in phase trial
Gemcitabine and nab-paclitaxel with or without the VDR agonist paricalcitol for metastatic pancreatic cancer: a randomized, multiarm, run-in phase trial
Vitamin D receptor (VDR) agonists promote quiescence of cancer-associated fibroblasts and improve efficacy of chemotherapy...
Added value of ctDNA testing with primary treatment for metastatic prostate cancer prognosis
Added value of ctDNA testing with primary treatment for metastatic prostate cancer prognosis
Circulating tumor DNA (ctDNA) and serum prostate-specific antigen (PSA) measured when primary combination treatments comme...
Author Correction: The efficacy of chemotherapy is limited by intratumoral senescent cells expressing PD-L2
These authors contributed equally: Selim Chaib, José Alberto López-Domínguez.Institute for Research in Biomedicine, Barcel...
Evolving landscape of nasopharyngeal carcinoma therapy
Evolving landscape of nasopharyngeal carcinoma therapy
Propelled by a growing understanding of nasopharyngeal carcinoma pathogenesis through elucidation of its genomic and immun...
SMAD4 induces opposite effects on metastatic growth from pancreatic tumors depending on the organ of residence
SMAD4 induces opposite effects on metastatic growth from pancreatic tumors depending on the organ of residence
The role of driver gene mutations in sustaining tumor growth at metastatic sites is poorly understood. SMAD4 inactivation ...
Radiopharma pipeline builds ahead of key data
Investment continues as the field awaits phase 3 readouts for next-generation radioligand therapies in 2026.
Aberrant expression of SLAMF6 constitutes a targetable immune escape mechanism in acute myeloid leukemia
Aberrant expression of SLAMF6 constitutes a targetable immune escape mechanism in acute myeloid leukemia
Immunotherapy has shown limited success in acute myeloid leukemia (AML), indicating an incomplete understanding of the und...
Hijacked brain–gut polysynaptic pathway promotes colorectal cancer growth
Hijacked brain–gut polysynaptic pathway promotes colorectal cancer growth
Bidirectional signaling between the brain and peripheral tumors plays a major part in cancer biology but is poorly underst...
Author Correction: Evolving landscape of nasopharyngeal carcinoma therapy
Department of Clinical Oncology, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong SAR, ChinaKar Wei Chi...
Neoadjuvant cabozantinib for locally advanced nonmetastatic clear cell renal cell carcinoma: a phase 2 trial
Neoadjuvant cabozantinib for locally advanced nonmetastatic clear cell renal cell carcinoma: a phase 2 trial
Cabozantinib is an oral multikinase inhibitor approved for treatment in metastatic renal cell carcinoma (RCC). We conducte...
An antibody–toxin conjugate enhances innate immune cell responses in tumors
An antibody–toxin conjugate enhances innate immune cell responses in tumors
Traditional antibody–toxin conjugates (ATCs) are designed to target and destroy cancer cells. We present an ATC that...
Hallmarks of artificial intelligence contributions to precision oncology
Hallmarks of artificial intelligence contributions to precision oncology
The integration of artificial intelligence (AI) into oncology promises to revolutionize cancer care. In this Review, we di...
Neutrophils physically interact with tumor cells to form a signaling niche promoting breast cancer aggressiveness
Neutrophils physically interact with tumor cells to form a signaling niche promoting breast cancer aggressiveness
Tissue remodeling and cell plasticity in the mammary gland are activated by multilineage communications; however, the dyna...
Long-term results with nivolumab and ipilimumab in melanoma
Immune checkpoint inhibitors such as PD-1 inhibitors and antibodies to CTLA-4 provide much better survival rates for patie...
Glioblastoma’s widespread integration into neuronal networks
A few years ago, independent research groups studying brain-cancer biology demonstrated that neurons form synaptic connect...
Neutrophils take their PICk to promote breast cancer
Neutrophils take their PICk to promote breast cancer
Tumor-infiltrating neutrophils can have either pro-tumoral potential or anti-tumoral potential. Physical contact between h...
Targeting both death and paracaspase domains of MALT1 with antisense oligonucleotides overcomes resistance to immune-checkpoint inhibitors
Targeting both death and paracaspase domains of MALT1 with antisense oligonucleotides overcomes resistance to immune-checkpoint inhibitors
Targeting MALT1’s paracaspase activity has been explored for B cell lymphoma and solid tumors. While the role of MAL...
First, novel and paradigm-shifting
First, novel and paradigm-shifting
In delineating scientific findings, authors should avoid assertions of primacy and novelty, in favor of measured descripti...
A deep dive into transmissible cancer evolution in bivalve mollusks
A deep dive into transmissible cancer evolution in bivalve mollusks
Transmissible cancer affects marine bivalve mollusks worldwide, but how genetic mechanisms influence cancer evolution and ...
Myeloma evades T cell-engaging therapies
Myeloma evades T cell-engaging therapies
Chimeric antigen receptor T cells and T cell-redirecting bispecific antibody therapies are changing the landscape of myelo...
Endothelium directs fat remodeling in cachexia
Endothelium directs fat remodeling in cachexia
Certain cancers disrupt metabolism, leading to the wasting syndrome known as cachexia. How tumor-induced mediators of cach...
Cytokine-armed dendritic cell progenitors for antigen-agnostic cancer immunotherapy
Cytokine-armed dendritic cell progenitors for antigen-agnostic cancer immunotherapy
Dendritic cells (DCs) are antigen-presenting myeloid cells that regulate T cell activation, trafficking and function...
Turning a failing PhD around
Turning a failing PhD around
Charles Swanton obtained a PhD from the Imperial Cancer Research Fund Laboratories (now the Francis Crick Institute) in 19...
Targeting network circuitry in glioma
Targeting network circuitry in glioma
The nervous system regulates cancer progression, and the importance of neuron–glioma communication in tumor growth i...
The never-abating excitement for targeted therapies
In combining technical innovation with foundational research, targeted therapies remain at the forefront of oncology drug ...
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