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Methods for investigating STAT3 regulation of lysosomal function in mammary epithelial cells
Methods for investigating STAT3 regulation of lysosomal function in mammary epithelial cells
The transcription factor STAT3 is activated by multiple cytokines and other extrinsic factors. It plays a key role in immu...
Rat Models of Hormone Receptor-Positive Breast Cancer
Rat Models of Hormone Receptor-Positive Breast Cancer
Hormone receptor-positive (HR+) breast cancer (BC) is the most common type of breast cancer among women worldwide, account...
Perimenopausal and Menopausal Mammary Glands In A 4-Vinylcyclohexene Diepoxide Mouse Model
Perimenopausal and Menopausal Mammary Glands In A 4-Vinylcyclohexene Diepoxide Mouse Model
As both perimenopausal and menopausal periods are recognized critical windows of susceptibility for breast carcinogenesis,...
Immune Cell Contribution to Mammary Gland Development
Immune Cell Contribution to Mammary Gland Development
Postpartum breast cancer (PPBC) is a unique subset of breast cancer, accounting for nearly half of the women diagnosed dur...
Intramammary Labeling of Epithelial Cell Division
Intramammary Labeling of Epithelial Cell Division
Thymidine analogs such as ethynyl deoxyuridine (EdU) or bromodeoxyuridine (BrdU) can be used to label mitosis of mammary e...
Transcription Impairment of TMEM208 by ZBTB14 Suppresses Breast cancer Radiotherapy Resistance
Transcription Impairment of TMEM208 by ZBTB14 Suppresses Breast cancer Radiotherapy Resistance
Zinc finger and BTB domain-containing protein (ZBTB) proteins have been implicated in different cellular processes, includ...
Defective Mammary Epithelial Outgrowth in Transgenic EKAREV–NLS Mice: Correction via Estrogen Supplementation and Genetic Background Modification
Defective Mammary Epithelial Outgrowth in Transgenic EKAREV–NLS Mice: Correction via Estrogen Supplementation and Genetic Background Modification
Fluorescent biosensors offer a powerful tool for tracking and quantifying protein activity in living systems with high tem...
Recurrent Nipple Duct Obstruction in Two Breastfeeding Patients: A Case Report and Discussion of the Underlying Pathophysiology
Recurrent Nipple Duct Obstruction in Two Breastfeeding Patients: A Case Report and Discussion of the Underlying Pathophysiology
Nipple pain is a common reason for premature breastfeeding cessation. There exists anecdotal evidence that one cause of la...
Mammalian Species-Specific Resistance to Mammary Cancer
Mammalian Species-Specific Resistance to Mammary Cancer
Tumorigenesis in mammals is driven by inherited genetic variants, environmental factors and random errors during normal DN...
Buenos Aires Breast Cancer Symposium (BA-BCS 2024) A Second Successful “Trial” for Bringing Together both World Hemispheres To Debate the Future of Translational Breast Cancer Research
Buenos Aires Breast Cancer Symposium (BA-BCS 2024) A Second Successful “Trial” for Bringing Together both World Hemispheres To Debate the Future of Translational Breast Cancer Research
The second edition of the Buenos Aires Breast Cancer Symposium (BA-BCS), the first held in person, took place from Septemb...
Association of , , and Polymorphisms with Breast Cancer Risk in the KP Population, A Case-Control Study
Association of , , and Polymorphisms with Breast Cancer Risk in the KP Population, A Case-Control Study
Breast cancer is a complex disease characterized by the uncontrolled growth of breast cells. Genetic variants in ESR1, HER...
Disease-Associated Mutations of the STAT5B SH2 Domain Regulate Cytokine-Driven Enhancer Function and Mammary Development
Disease-Associated Mutations of the STAT5B SH2 Domain Regulate Cytokine-Driven Enhancer Function and Mammary Development
Mammary gland development during pregnancy is controlled by lactogenic hormones via the JAK2-STAT5 pathway. Gene deletion ...
Developmental Regulation of circRNAs in Normal and Diseased Mammary Gland: A Focus on circRNA-miRNA Networks
Developmental Regulation of circRNAs in Normal and Diseased Mammary Gland: A Focus on circRNA-miRNA Networks
Circular RNAs (circRNAs) have emerged as critical regulators in various biological processes including diseases. In the ma...
biogrowleR: Enhancing Longitudinal Data Analysis
biogrowleR: Enhancing Longitudinal Data Analysis
Time course measurements are used for many applications in biomedical research, ranging from growth curves to drug efficac...
Intraductal Injection of Adenoviruses to Perform Lineage Tracing in the Mammary Gland
Intraductal Injection of Adenoviruses to Perform Lineage Tracing in the Mammary Gland
Lineage tracing is a fundamental tool in developmental biology and cancer research, providing critical insights into cell ...
Toward Characterizing Lymphatic Vasculature in the Mammary Gland During Normal Development and Tumor-Associated Remodeling
Toward Characterizing Lymphatic Vasculature in the Mammary Gland During Normal Development and Tumor-Associated Remodeling
Lymphatic vasculature has been shown to promote metastatic spread of breast cancer. Lymphatic vasculature, which is made u...
Single-Cell Transcription Mapping of Murine and Human Mammary Organoids Responses to Female Hormones
Single-Cell Transcription Mapping of Murine and Human Mammary Organoids Responses to Female Hormones
During female adolescence and pregnancy, rising levels of hormones result in a cyclic source of signals that control the d...
Fast Ultrasound Scanning is a Rapid, Sensitive, Precise and Cost-Effective Method to Monitor Tumor Grafts in Mice
Fast Ultrasound Scanning is a Rapid, Sensitive, Precise and Cost-Effective Method to Monitor Tumor Grafts in Mice
In preclinical studies, accurate monitoring of tumor dynamics is crucial for understanding cancer biology and evaluating t...
Protocols for Co-Culture Phenotypic Assays with Breast Cancer Cells and THP-1-Derived Macrophages
Protocols for Co-Culture Phenotypic Assays with Breast Cancer Cells and THP-1-Derived Macrophages
Tumor mass comprises not only cancer cells but also heterogeneous populations of immune and stromal cells, along with the ...
Spatial Engineering of Mammary Epithelial Cell Cultures with 3D Bioprinting Reveals Growth Control by Branch Point Proximity
Spatial Engineering of Mammary Epithelial Cell Cultures with 3D Bioprinting Reveals Growth Control by Branch Point Proximity
The three-dimensional (3D) structure of the ductal epithelium and the surrounding extracellular matrix (ECM) are integral ...
Single-cell Analysis Reveals Inter- and Intratumour Heterogeneity in Metastatic Breast Cancer
Single-cell Analysis Reveals Inter- and Intratumour Heterogeneity in Metastatic Breast Cancer
Metastasis is the leading cause of cancer-related deaths of breast cancer patients. Some cancer cells in a tumour go throu...
TGFß1 Stimulates Lymphatic Endothelial Cells to Produce IL7 and IL15, Which Act as Chemotactic Factors for Breast Cancer Cells with Mesenchymal Properties
TGFß1 Stimulates Lymphatic Endothelial Cells to Produce IL7 and IL15, Which Act as Chemotactic Factors for Breast Cancer Cells with Mesenchymal Properties
The lymphatic system is a major gateway for tumor cell dissemination but the mechanisms of how tumor cells gain access to ...
A molecular toolbox to study progesterone receptor signaling
A molecular toolbox to study progesterone receptor signaling
Progesterone receptor (PR) signaling is required for mammary gland development and homeostasis. A major bottleneck in stud...
High-fat diet, but not duration of lactation, increases mammary gland lymphatic vessel function and subsequent growth of inflammatory breast cancer cells
High-fat diet, but not duration of lactation, increases mammary gland lymphatic vessel function and subsequent growth of inflammatory breast cancer cells
Inflammatory breast cancer (IBC) presents as rapid-onset swelling and breast skin changes caused by tumor emboli in the br...
Fourteenth Annual ENBDC Workshop: Methods in Mammary Gland Biology and Breast Cancer
Fourteenth Annual ENBDC Workshop: Methods in Mammary Gland Biology and Breast Cancer
The fourteenth annual workshop of the European Network for Breast Development and Cancer (ENBDC) on Methods in Mammary Gla...
RETRACTED ARTICLE: Pure Primary Squamous Cell Carcinoma of the Breast Arising from the Epithelium of a Complex Mammary Cyst: A Case Report
RETRACTED ARTICLE: Pure Primary Squamous Cell Carcinoma of the Breast Arising from the Epithelium of a Complex Mammary Cyst: A Case Report
The Editor-in-Chief has retracted this article because it was published in error before peer review, and because of concer...
Distinct Requirements for Adaptor Proteins NCK1 and NCK2 in Mammary Gland Development
Distinct Requirements for Adaptor Proteins NCK1 and NCK2 in Mammary Gland Development
The adaptor proteins NCK1 and NCK2 are well-established signalling nodes that regulate diverse biological processes includ...
Non-Linear Lymphatic Anatomy in Breast Cancer Patients Prior to Axillary Lymph Node Dissection: A Risk Factor For Lymphedema Development
Non-Linear Lymphatic Anatomy in Breast Cancer Patients Prior to Axillary Lymph Node Dissection: A Risk Factor For Lymphedema Development
Immediate lymphatic reconstruction (ILR) at the time of axillary lymph node dissection (ALND) has become increasingly util...
Studying Mammary Physiology and Pathology in Domestic Species Benefits Both Humans and Animals
Studying Mammary Physiology and Pathology in Domestic Species Benefits Both Humans and Animals
In 2010 the worldwide population of domesticated ruminants was estimated to be 3.6 bi...
Gestational Breast Cancer – a Review of Outcomes, Pathophysiology, and Model Systems
Gestational Breast Cancer – a Review of Outcomes, Pathophysiology, and Model Systems
The onset of pregnancy marks the start of offspring development, and represents the key physiological event that induces r...
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