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Constructing a co-culture model of cancer-associated fibroblasts and ovarian cancer organoids and studying mechanisms of drug resistance
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FMR1 KH0-KH1 domains coordinate m6A binding and phase separation in Fragile X syndrome
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Secreted phosphoprotein 1 promotes the activation of keloid fibroblasts via the CD44/TGF-β1/Smad pathway
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Vinculin and c-Cbl-associated protein (CAP) suppress Meflin expression to regulate stiffness-dependent osteogenic differentiation of mesenchymal stem cells
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Cathepsin S mediates the disruption of airway epithelial Pannexin 1 via an Akt-dependent pathway in an LPS-induced murine model of acute lung injury
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Timosaponin AIII alleviates type 2 diabetes-induced cardiomyopathy by targeting galectin-3 (LGALS3)
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The NF-κB/LY6E axis promotes oral squamous cell carcinoma stemness by responding to interaction with macrophages
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USP7-mediated NUF2 deubiquitination accelerates ovarian cancer progression through regulating SLC7A11 expression
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Comparative analysis of 3D culture methodologies in prostate cancer cells
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K542 acetylation promotes YTHDF2 binding to m6A-modified mRNAs and fosters colorectal cancer progression
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Immunomodulatory, anti-synoviocyte, and anti-osteoclastic abilities of embryonic stem cell-derived mesenchymal stem cells in rheumatoid arthritis
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The phosphorylation of moesin impairs the integrity of vascular basement membrane in pathological angiogenesis
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“TFEB–HNRNPA2B1”: A positive feedback loop facilitating metastasis in hepatocellular carcinoma cells
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Comprehensive network pharmacology and experimental study to investigate the effects and mechanisms of Lophatherum gracile Brongn. for glioma treatment
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Hsa_circ_0001640 inactivation of the PI3K/AKT signaling pathway by targeting the MiR-942-5p/PTEN axis to inhibit the progression of non-small cell lung cancer
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Non-canonical role of Yorkie in the development of Malpighian tubules of Drosophila melanogaster
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In vitro dynamics of oyster hemocytes in plasma-based primary cultures
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PKR inhibition reduces high glucose and H2O2-induced injury in rat renal epithelial cells by suppressing the sonic hedgehog pathway
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Aging and Lung Cancer: the Role of Macrophages
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The Effect of TSPO Transmembrane Transport-Mediated Paeonol Mitochondrial Antioxidant on Dexamethasone-Induced Mitochondrial Abnormalities, Oxidative Stress Damage, and Apoptosis in SV40-MES-13 Cells
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Upregulation of serine metabolism enzyme PSAT1 predicts poor prognosis and promotes proliferation, metastasis and drug resistance of clear cell renal cell carcinoma
Upregulation of serine metabolism enzyme PSAT1 predicts poor prognosis and promotes proliferation, metastasis and drug resistance of clear cell renal cell carcinoma
Most early-stage ccRCC is easy to be ignored since it has no clinical symptoms, and most patients are detected through phy...
The loss of antioxidant activities impairs intestinal epithelium homeostasis by altering lipid metabolism
The loss of antioxidant activities impairs intestinal epithelium homeostasis by altering lipid metabolism
Accumulation of cellular damage, inflammation and loss of regenerative capacity are major challenges that tissues have to ...
Tumor-derived exosomal hyaluronidase 1 induced M2 macrophage polarization and promoted esophageal cancer progression
Tumor-derived exosomal hyaluronidase 1 induced M2 macrophage polarization and promoted esophageal cancer progression
Esophageal cancer (EC) ranks eighth among the most common cancers in the world. There are two main histological subtypes o...
The KDM5 inhibitor PBIT reduces proliferation of castration-resistant prostate cancer cells via cell cycle arrest and the induction of senescence
The KDM5 inhibitor PBIT reduces proliferation of castration-resistant prostate cancer cells via cell cycle arrest and the induction of senescence
The compound 2–4(4-methylphenyl)-1,2-benzisothiazol-3(2H)-one (PBIT) is an inhibitor of the KDM5 family of lysine-specific...
METTL3 promotes trophoblast ferroptosis in preeclampsia by stabilizing the ACSL4 m6A modification
METTL3 promotes trophoblast ferroptosis in preeclampsia by stabilizing the ACSL4 m6A modification
Preeclampsia is defined as the early event of hypertensive pregnancy with systolic blood pressure ≥140 mmHg and diastolic ...
Single-cell tracking as a tool for studying EMT-phenotypes
Single-cell tracking as a tool for studying EMT-phenotypes
KeywordsEpithelial-mesenchymal transitionSingle-cell trackingCell migrationViabilityMorphologyInheritanceData availability...
Targeting inhibitor of apoptosis proteins (IAPs) enhances susceptibility of oral squamous carcinoma cells to cisplatin
Targeting inhibitor of apoptosis proteins (IAPs) enhances susceptibility of oral squamous carcinoma cells to cisplatin
Oral Squamous Cell Carcinoma (OSCC) is currently the 6th most common type of cancer worldwide. It is generally aggressive ...
Exosomes derived from human umbilical cord mesenchymal stem cells pretreated by monosialoteterahexosyl ganglioside alleviate intracerebral hemorrhage by down-regulating autophagy
Exosomes derived from human umbilical cord mesenchymal stem cells pretreated by monosialoteterahexosyl ganglioside alleviate intracerebral hemorrhage by down-regulating autophagy
Intracerebral hemorrhage (ICH) can lead to the loss of neuronal cells through the response to the hematoma and the release...
Anti-proliferation and apoptosis induced via the mTOR/PGC-1α signaling pathway in trophoblast cells of miscarriage
Anti-proliferation and apoptosis induced via the mTOR/PGC-1α signaling pathway in trophoblast cells of miscarriage
Miscarriage, also termed spontaneous abortion, is one of the most frequent complications during gestation, and approximate...
Rab25 is involved in hypospadias via the β1 integrin/EGFR pathway
Rab25 is involved in hypospadias via the β1 integrin/EGFR pathway
Hypospadias is a congenital external genital malformation in which the urethral folds are incompletely fused, resulting in...
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