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0.5ZnO@Cu5.4O nanoparticle for regulates the expression of GSDMB and targeted therapy of tumor
0.5ZnO@Cu5.4O nanoparticle for regulates the expression of GSDMB and targeted therapy of tumor
GSDMB, a key protein in pyroptosis, is closely linked to various diseases. Nanomaterials can target and regulate specific ...
ACK1 condensates promote STAT5 signaling in lung squamous cell carcinoma
ACK1 condensates promote STAT5 signaling in lung squamous cell carcinoma
ACK1, a non-receptor tyrosine kinase, phosphorylates various substrates involved in cancer progression. Its oncogenic acti...
Efficacy and prognostic analysis of venetoclax combined with hypomethylating agents for induction therapy in acute myeloid leukemia: a multi-center real-world study on indication-specific stratification, molecular markers, and hematologic toxicities
Efficacy and prognostic analysis of venetoclax combined with hypomethylating agents for induction therapy in acute myeloid leukemia: a multi-center real-world study on indication-specific stratification, molecular markers, and hematologic toxicities
The combination of venetoclax and hypomethylating agents (VEN + HMAs) has shown significant progress in treati...
Skin melanoma cells produce diverse gelsolin (GSN) isoforms, which play non-redundant roles in cells’ proliferation and motility
Skin melanoma cells produce diverse gelsolin (GSN) isoforms, which play non-redundant roles in cells’ proliferation and motility
Skin melanoma is a malignant tumor that becomes increasingly difficult to treat when diagnosed late. Previously, we demons...
An EcDNA gene-based risk model and functional verification of a key ec-lncRNA AC016394.2 for prostate cancer
An EcDNA gene-based risk model and functional verification of a key ec-lncRNA AC016394.2 for prostate cancer
Prostate cancer(PCa) ranks among the most frequently diagnosed malignancies in men. The progression and heterogeneity of t...
ACADL-YAP axis activity in non-small cell lung cancer carcinogenicity
ACADL-YAP axis activity in non-small cell lung cancer carcinogenicity
The role of Acyl-CoA dehydrogenase long chain (ACADL) in different tumor types had different inhibiting or promoting effec...
Emerging trends in the coexistence of primary lung Cancer and hematologic malignancy: a comprehensive analysis of clinicopathological features and genetic abnormalities
Emerging trends in the coexistence of primary lung Cancer and hematologic malignancy: a comprehensive analysis of clinicopathological features and genetic abnormalities
The incidence of multiple primary cancers (MPC), especially involving primary lung cancer (PLC) and primary hematologic ma...
SLC25A17 inhibits autophagy to promote triple-negative breast cancer tumorigenesis by ROS-mediated JAK2/STAT3 signaling pathway
SLC25A17 inhibits autophagy to promote triple-negative breast cancer tumorigenesis by ROS-mediated JAK2/STAT3 signaling pathway
SLC25A17, a peroxisomal solute carrier, has been implicated in various physiological and pathological processes. However, ...
Genome-wide CRISPR screen identifies ESPL1 limits the response of gastric cancer cells to apatinib
Genome-wide CRISPR screen identifies ESPL1 limits the response of gastric cancer cells to apatinib
Apatinib was the first anti-angiogenic agent approved for treatment of metastatic gastric cancer (GC). However, the emerge...
Leveraging a disulfidptosis‑related lncRNAs signature for predicting the prognosis and immunotherapy of glioma
Leveraging a disulfidptosis‑related lncRNAs signature for predicting the prognosis and immunotherapy of glioma
Gliomas, a prevalent form of primary brain tumors, are linked with a high mortality rate and unfavorable prognoses. Disulf...
The emerging role of glycolysis and immune evasion in gastric cancer
The emerging role of glycolysis and immune evasion in gastric cancer
Gastric cancer (GC) is the fifth most common malignancy and the third leading cause of cancer-related deaths worldwide. Si...
Tumour cells can escape antiproliferative pressure by interferon-β through immunoediting of interferon receptor expression
Tumour cells can escape antiproliferative pressure by interferon-β through immunoediting of interferon receptor expression
Type I interferons (IFNs) play a central role not only in innate immunity against viral infection, but also in the antitum...
Single-cell RNA sequencing in cancer research: discovering novel biomarkers and therapeutic targets for immune checkpoint blockade
Single-cell RNA sequencing in cancer research: discovering novel biomarkers and therapeutic targets for immune checkpoint blockade
Immune checkpoint blockade (ICB) has become a promising strategy in treating advanced cancers, providing significant survi...
Technical comparison of Abbott’s UroVysion® and Biocare’s CytoFISH urine fluorescence in situ hybridization (FISH) assays
Technical comparison of Abbott’s UroVysion® and Biocare’s CytoFISH urine fluorescence in situ hybridization (FISH) assays
This study aims to compare the technical performance of Abbott’s UroVysion and Biocare’s CytoFISH urine cytolo...
The nexus of natural killer cells and melanoma tumor microenvironment: crosstalk, chemotherapeutic potential, and innovative NK cell-based therapeutic strategies
The nexus of natural killer cells and melanoma tumor microenvironment: crosstalk, chemotherapeutic potential, and innovative NK cell-based therapeutic strategies
The metastasis of melanoma cells to regional lymph nodes and distant sites is an important contributor to cancer-related m...
Disclosing a metabolic signature of cisplatin resistance in MDA-MB-231 triple-negative breast cancer cells by NMR metabolomics
Disclosing a metabolic signature of cisplatin resistance in MDA-MB-231 triple-negative breast cancer cells by NMR metabolomics
This work compared the metabolic profile of a parental MDA-MB-231 cisplatin-sensitive triple negative breast cancer (TNBC)...
Single-cell histone chaperones patterns guide intercellular communication of tumor microenvironment that contribute to breast cancer metastases
Single-cell histone chaperones patterns guide intercellular communication of tumor microenvironment that contribute to breast cancer metastases
Histone chaperones (HCs) are crucial for governing genome stability and gene expression in multiple cancers. However, the ...
The function and mechanism of PSMD14 in promoting progression and resistance to anlotinib in osteosarcoma
The function and mechanism of PSMD14 in promoting progression and resistance to anlotinib in osteosarcoma
Osteosarcoma is a rare bone malignancy that frequently affects adolescents and poses formidable obstacles in its advanced ...
Circular RNA circEYA3 promotes the radiation resistance of hepatocellular carcinoma via the IGF2BP2/DTX3L axis
Circular RNA circEYA3 promotes the radiation resistance of hepatocellular carcinoma via the IGF2BP2/DTX3L axis
Hepatocellular carcinoma (HCC) has a high incidence and mortality rate despite various treatment options, including 125I s...
Prognostic significance of Lymphocyte-activation gene 3 (LAG3) in patients with solid tumors: a systematic review, meta-analysis and pan-cancer analysis
Prognostic significance of Lymphocyte-activation gene 3 (LAG3) in patients with solid tumors: a systematic review, meta-analysis and pan-cancer analysis
Lymphocyte-activation gene 3 (LAG3) is a recently discovered immune checkpoint molecule that has been linked to immunosupp...
A pan-cancer analysis indicates long noncoding RNA HAND2-AS1 as a potential prognostic, immunomodulatory and therapeutic biomarker in various cancers including colorectal adenocarcinoma
A pan-cancer analysis indicates long noncoding RNA HAND2-AS1 as a potential prognostic, immunomodulatory and therapeutic biomarker in various cancers including colorectal adenocarcinoma
The HAND2-AS1 (HAND2 Antisense RNA 1) Long noncoding RNA (lncRNA) has emerged as a participant in the initiation of variou...
Identifying prognostic characteristics of m6A-related glycolysis gene and predicting the immune infiltration landscape in bladder cancer
Identifying prognostic characteristics of m6A-related glycolysis gene and predicting the immune infiltration landscape in bladder cancer
Glucose metabolism is associated with the development of cancers, and m6A RNA methylation regulator-related genes play vit...
GNF-7, a novel FLT3 inhibitor, overcomes drug resistance for the treatment of FLT3‑ITD acute myeloid leukemia
GNF-7, a novel FLT3 inhibitor, overcomes drug resistance for the treatment of FLT3‑ITD acute myeloid leukemia
Acute myeloid leukemia (AML) with FMS-like tyrosine kinase 3 internal tandem duplication (FLT3-ITD) mutation accounts for ...
Cancer stem cells and their niche in cancer progression and therapy
Cancer stem cells and their niche in cancer progression and therapy
High recurrence and metastasis rates and poor prognoses are the major challenges of current cancer therapy. Mounting evide...
Glucose transporter 3 (GLUT3) promotes lactylation modifications by regulating lactate dehydrogenase A (LDHA) in gastric cancer
Glucose transporter 3 (GLUT3) promotes lactylation modifications by regulating lactate dehydrogenase A (LDHA) in gastric cancer
Glucose transporter 3 (GLUT3) plays a major role in glycolysis and glucose metabolism in cancer cells. We aimed to investi...
DHRS4-AS1 regulate gastric cancer apoptosis and cell proliferation by destabilizing DHX9 and inhibited the association between DHX9 and ILF3
DHRS4-AS1 regulate gastric cancer apoptosis and cell proliferation by destabilizing DHX9 and inhibited the association between DHX9 and ILF3
Gastric cancer (GC) causes millions of cancer-related deaths due to anti-apoptosis and rapid proliferation. However, the m...
miR-590-5p/Tiam1-mediated glucose metabolism promotes malignant evolution of pancreatic cancer by regulating SLC2A3 stability
miR-590-5p/Tiam1-mediated glucose metabolism promotes malignant evolution of pancreatic cancer by regulating SLC2A3 stability
T lymphoma invasion and metastasis 1 (Tiam1) is a tumor related gene that specifically activates Rho-like GTPases Rac1 and...
Noggin contributes to brain metastatic colonization of lung cancer cells
Noggin contributes to brain metastatic colonization of lung cancer cells
Brain metastasis is a common complication among patients with lung cancer, yet the underlying mechanisms remain unclear. I...
Characterization of cancer-associated fibroblasts (CAFs) and development of a CAF-based risk model for triple-negative breast cancer
Characterization of cancer-associated fibroblasts (CAFs) and development of a CAF-based risk model for triple-negative breast cancer
Triple-negative breast Cancer (TNBC) is a highly malignant cancer with unclear pathogenesis. Within the tumor microenviron...
The effects of ARID1A mutation in gastric cancer and its significance for treatment
The effects of ARID1A mutation in gastric cancer and its significance for treatment
Gastric cancer (GC) has emerged as a significant issue in public health all worldwide as a result of its high mortality ra...
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