SCI Abstract

search
+
Detection of genome-wide methylation changes in bladder cancer by long-read sequencing of urinary DNA
Detection of genome-wide methylation changes in bladder cancer by long-read sequencing of urinary DNA
Non-invasive urine tests for bladder cancer (BC) could reduce dependence on flexible cystoscopy for diagnosis and surveill...
Deciphering the methylation landscape of long noncoding RNAs in hepatocellular carcinoma: a focus on LINC00942
Deciphering the methylation landscape of long noncoding RNAs in hepatocellular carcinoma: a focus on LINC00942
Conduct a comprehensive genome-wide methylomic analysis of long noncoding RNA (lncRNA) genes in hepatocellular carcinoma (...
DNA methylation of food sensitization in a French-Canadian population
DNA methylation of food sensitization in a French-Canadian population
Food allergy (FA) is a great public health concern with an increased prevalence in the last decades. The underlying develo...
Landscape analysis of m5C modification regulators unveils DNMT1-mediated dysregulated pyrimidine metabolism in hepatocellular carcinoma
Landscape analysis of m5C modification regulators unveils DNMT1-mediated dysregulated pyrimidine metabolism in hepatocellular carcinoma
The 5-methylcytosine (m5C) post-transcriptional modification has been linked with the development and progression of a var...
Regulation of cisplatin resistance in lung cancer by epigenetic mechanisms
Regulation of cisplatin resistance in lung cancer by epigenetic mechanisms
Lung cancer remains one of the most prevalent and lethal malignancies worldwide, responsible for nearly 1.8 milli...
Clinical promise and applications of epigenetic biomarkers
Clinical promise and applications of epigenetic biomarkers
Berdasco M, Esteller M. Clinical epigenetics: seizing opportunities for translation. Nat Rev Genet. 2019;20(2):109–27.Arti...
Altered chromatin landscape and 3D interactions associated with primary constitutional MLH1 epimutations
Altered chromatin landscape and 3D interactions associated with primary constitutional MLH1 epimutations
Lynch syndrome (LS), characterised by an increased risk for cancer, is mainly caused by germline pathogenic variants affec...
Unraveling the causal impact of smoking and its DNA methylation signatures on cardiovascular disease: Mendelian randomization and colocalization analysis
Unraveling the causal impact of smoking and its DNA methylation signatures on cardiovascular disease: Mendelian randomization and colocalization analysis
To explore the mechanisms linking smoking to cardiovascular diseases (CVDs) from an epigenetic perspective. Mendelian Rand...
Impaired ARID1A expression attenuated the immune response in gastric cancer via histone acetylation
Impaired ARID1A expression attenuated the immune response in gastric cancer via histone acetylation
The primary objective of this study was to examine whether ARID1A mutations confer a fitness advantage to gastric cancer f...
A meta-analysis of epigenome-wide association studies of ultra-processed food consumption with DNA methylation in European children
A meta-analysis of epigenome-wide association studies of ultra-processed food consumption with DNA methylation in European children
There is limited knowledge on how diet affects the epigenome of children. Ultra-processed food (UPF) consumption is emergi...
Epigenetics of the far northern Yakutian population
Epigenetics of the far northern Yakutian population
Yakuts are one of the indigenous populations of the subarctic and arctic territories of Siberia characterized by a contine...
DNA methylation profiles reveal sex-specific associations between gestational exposure to ambient air pollution and placenta cell-type composition in the PRISM cohort study
DNA methylation profiles reveal sex-specific associations between gestational exposure to ambient air pollution and placenta cell-type composition in the PRISM cohort study
Gestational exposure to ambient air pollution has been associated with adverse health outcomes for mothers and newborns. T...
Epigenetic age acceleration in surviving versus deceased COVID-19 patients with acute respiratory distress syndrome following hospitalization
Epigenetic age acceleration in surviving versus deceased COVID-19 patients with acute respiratory distress syndrome following hospitalization
Aging has been reported as a major risk factor for severe symptoms and higher mortality rates in COVID-19 patients. Molecu...
Long-term decitabine/retinoic acid maintenance treatment in an elderly sAML patient with high-risk genetics
Long-term decitabine/retinoic acid maintenance treatment in an elderly sAML patient with high-risk genetics
Elderly patients with AML ineligible for induction have a dismal prognosis; hence disease stabilization is a primary treat...
EZH2 K63-polyubiquitination affecting migration in extranodal natural killer/T-cell lymphoma
EZH2 K63-polyubiquitination affecting migration in extranodal natural killer/T-cell lymphoma
Overexpressed EZH2 is oncogenically involved in the pathogenesis of different cancerous contexts including extranodal natu...
Targeting oncogenic TERT promoter variants by allele-specific epigenome editing
Targeting oncogenic TERT promoter variants by allele-specific epigenome editing
Activation of dominant oncogenes by small or structural genomic alterations is a common driver mechanism in many cancers. ...
A 2-decade bibliometric analysis of epigenetics of cardiovascular disease: from past to present
A 2-decade bibliometric analysis of epigenetics of cardiovascular disease: from past to present
Cardiovascular disease (CVD) remains a major health killer worldwide, and the role of epigenetic regulation in CVD has bee...
Retraction Note: Dissecting the role of novel EZH2 inhibitors in primary glioblastoma cell cultures: effects on proliferation, epithelialmesenchymal transition, migration, and on the pro-inflammatory phenotype
Retraction Note: Dissecting the role of novel EZH2 inhibitors in primary glioblastoma cell cultures: effects on proliferation, epithelialmesenchymal transition, migration, and on the pro-inflammatory phenotype
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, whi...
Upregulation of RSPO3 via targeted promoter DNA demethylation inhibits the progression of cholangiocarcinoma
Upregulation of RSPO3 via targeted promoter DNA demethylation inhibits the progression of cholangiocarcinoma
Cholangiocarcinoma (CCA) refers to a collection of malignant tumors that develop from the biliary epithelium. Extensive cl...
Tazemetostat decreases β-catenin and CD13 protein expression in HEPG-2 and Hepatitis B virus-transfected HEPG-2 with decreased cell viability
Tazemetostat decreases β-catenin and CD13 protein expression in HEPG-2 and Hepatitis B virus-transfected HEPG-2 with decreased cell viability
Hepatocellular carcinoma (HCC) is one of the global health concerns. Hepatitis B virus (HBV) is one of the major causes of...
DNA methylation sites in early adulthood characterised by pubertal timing and development: a twin study
DNA methylation sites in early adulthood characterised by pubertal timing and development: a twin study
Puberty is a highly heritable and variable trait, with environmental factors having a role in its eventual timing and deve...
Histone deacetylase 3 deletion in alveolar type 2 epithelial cells prevents bleomycin-induced pulmonary fibrosis
Histone deacetylase 3 deletion in alveolar type 2 epithelial cells prevents bleomycin-induced pulmonary fibrosis
Epithelial mesenchymal transformation (EMT) in alveolar type 2 epithelial cells (AT2) is closely associated with pulmonary...
Predictive value of DNA methylation patterns in AML patients treated with an azacytidine containing induction regimen
Predictive value of DNA methylation patterns in AML patients treated with an azacytidine containing induction regimen
Acute myeloid leukemia (AML) is a heterogeneous disease with a poor prognosis. Dysregulation of the epigenetic machinery i...
Metabolomic biomarkers of habitual B vitamin intakes unveil novel differentially methylated positions in the human epigenome
Metabolomic biomarkers of habitual B vitamin intakes unveil novel differentially methylated positions in the human epigenome
B vitamins such as folate (B9), B6, and B12 are key in one carbon metabolism, which generates methyl donors for DNA methyl...
N6-methyladenosine methylation in kidney injury
N6-methyladenosine methylation in kidney injury
Multiple mechanisms are involved in kidney damage, among which the role of epigenetic modifications in the occurrence and ...
Unlocking the secrets: the power of methylation-based cfDNA detection of tissue damage in organ systems
Unlocking the secrets: the power of methylation-based cfDNA detection of tissue damage in organ systems
Detecting organ and tissue damage is essential for early diagnosis, treatment decisions, and monitoring disease progressio...
Pharmacological EZH2 inhibition combined with retinoic acid treatment promotes differentiation and apoptosis in rhabdomyosarcoma cells
Pharmacological EZH2 inhibition combined with retinoic acid treatment promotes differentiation and apoptosis in rhabdomyosarcoma cells
Rhabdomyosarcomas (RMS) are predominantly paediatric sarcomas thought to originate from muscle precursor cells due to impa...
Further refinement of the differentially methylated distant lung-specific FOXF1 enhancer in a neonate with alveolar capillary dysplasia
Further refinement of the differentially methylated distant lung-specific FOXF1 enhancer in a neonate with alveolar capillary dysplasia
Heterozygous SNVs or CNV deletions involving the FOXF1 gene, or its distant enhancer, are causative for 80–...
Maternal adverse childhood experiences (ACEs) and DNA methylation of newborns in cord blood
Maternal adverse childhood experiences (ACEs) and DNA methylation of newborns in cord blood
Adverse childhood experiences (ACEs) increase the risk of poor health outcomes later in life. Psychosocial stressors may a...
KDM4C-mediated senescence defense is a targetable vulnerability in gastric cancer harboring TP53 mutations
KDM4C-mediated senescence defense is a targetable vulnerability in gastric cancer harboring TP53 mutations
Gastric cancer patients harboring a TP53 mutation exhibit a more aggressive and chemoresistant phenotype. Unfortunately, e...
Load More
format_indent_increase