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KRAS mutation promotes immune escape of lung adenocarcinoma via ZNF24/SLC7A5/PD-L1 axis
KRAS mutation promotes immune escape of lung adenocarcinoma via ZNF24/SLC7A5/PD-L1 axis
The imbalance of immune checkpoint molecules leads to immune escape of tumor cells. It has been established that KRAS muta...
Prognostic value of risk factors in cervical squamous cell carcinoma based on tumour infiltration depth
Prognostic value of risk factors in cervical squamous cell carcinoma based on tumour infiltration depth
To evaluate whether the prognostic significance of distinct risk factors differs according to tumour infiltration depth in...
Overall survival following radical surgery and postoperative chemotherapy in colorectal cancer patients aged ≥ 70 years: a population-based retrospective cohort study
Overall survival following radical surgery and postoperative chemotherapy in colorectal cancer patients aged ≥ 70 years: a population-based retrospective cohort study
Colorectal cancer (CRC) predominantly affects the elderly, with a growing demand for evidence-based treatment strategies i...
CARBOMETASPINE: protocol for a multicenter, prospective, randomized controlled trial of carbonfiber spinal fixation in metastatic disease
CARBOMETASPINE: protocol for a multicenter, prospective, randomized controlled trial of carbonfiber spinal fixation in metastatic disease
Spinal metastases frequently cause neurological compromise and mechanical instability. Titanium fixation limits postoperat...
A phase II trial of hepatic ablation of metastases to modulate and enhance immunotherapy response in non-small cell lung cancer (HAMMER-NSCLC)
A phase II trial of hepatic ablation of metastases to modulate and enhance immunotherapy response in non-small cell lung cancer (HAMMER-NSCLC)
Anti-programmed cell death protein 1/programmed death-ligand 1 (anti-PD-[L]1) immunotherapy promotes systemic anti-tumor i...
TGF-β signaling orchestrates cancer-associated fibroblasts in the tumor microenvironment of human hepatocellular carcinoma: unveiling insights and clinical significance
TGF-β signaling orchestrates cancer-associated fibroblasts in the tumor microenvironment of human hepatocellular carcinoma: unveiling insights and clinical significance
Liver cancer, specifically hepatocellular carcinoma (HCC), stands out as one of the most formidable solid tumors, characte...
Resolution of oncogene-induced senescence markers in HPV-infected cervical cancer tissue
Resolution of oncogene-induced senescence markers in HPV-infected cervical cancer tissue
Oncogene-Induced Senescence (OIS) is a form of senescence that occurs as a consequence of oncogenic overstimulation and po...
A new prognostic model for predicting overall survival and progression-free survival in unresectable hepatocellular carcinoma treated with the FOLFOX-HAIC regimen based on patient clinical characteristics and blood biomarkers
A new prognostic model for predicting overall survival and progression-free survival in unresectable hepatocellular carcinoma treated with the FOLFOX-HAIC regimen based on patient clinical characteristics and blood biomarkers
We developed a prognostic model to evaluate the overall survival (OS) and progression-free survival (PFS) of patients with...
Gross recurrent laryngeal nerve invasion by extranodal extension in thyroid carcinoma
Gross recurrent laryngeal nerve invasion by extranodal extension in thyroid carcinoma
Lymphatic metastasis commonly occurs in patients with papillary thyroid carcinoma and medullary thyroid carcinoma. The cli...
3D synergistic tumor-liver analysis further improves the efficacy prediction in hepatocellular carcinoma: a multi-center study
3D synergistic tumor-liver analysis further improves the efficacy prediction in hepatocellular carcinoma: a multi-center study
Besides tumorous information, synergistic liver parenchyma assessments may provide additional insights into the prognosis ...
Nomogram incorporating Epstein-Barr virus DNA and a novel immune-nutritional marker for survival prediction in nasopharyngeal carcinoma
Nomogram incorporating Epstein-Barr virus DNA and a novel immune-nutritional marker for survival prediction in nasopharyngeal carcinoma
Since Immune response, nutritional status and Epstein–Barr Virus (EBV) DNA status have been confirmed to be relevant...
CD147 promotes breast cancer migration and invasion by inducing epithelial-mesenchymal transition via the MAPK/ERK signaling pathway
CD147 promotes breast cancer migration and invasion by inducing epithelial-mesenchymal transition via the MAPK/ERK signaling pathway
CD147, a transmembrane glycoprotein, has been implicated in various cancer-related processes but its role in breast cancer...
Impact of perioperative decreased serum albumin level on anastomotic leakage in esophageal squamous cell carcinoma patients treated with neoadjuvant chemotherapy followed by minimally invasive esophagectomy
Impact of perioperative decreased serum albumin level on anastomotic leakage in esophageal squamous cell carcinoma patients treated with neoadjuvant chemotherapy followed by minimally invasive esophagectomy
Anastomotic leakage (AL) is a severe complication following esophagectomy with high mortality. Perioperative decreased ser...
Multidimensional analysis to elucidate the possible mechanism of bone metastasis in breast cancer
Multidimensional analysis to elucidate the possible mechanism of bone metastasis in breast cancer
Breast cancer (BC) patients tend to suffer from distant metastasis, especially bone metastasis. All the analysis based on ...
Immediate histologic correlation in patients with different HPV genotypes and ages: a single center analysis in China
Immediate histologic correlation in patients with different HPV genotypes and ages: a single center analysis in China
Human papillomavirus (HPV) has been confirmed as a major causative factor for malignant transformation of cervical epithel...
Dynamic profiling of immune microenvironment during anti-PD-1 immunotherapy for head and neck squamous cell carcinoma: the IPRICE study
Dynamic profiling of immune microenvironment during anti-PD-1 immunotherapy for head and neck squamous cell carcinoma: the IPRICE study
Immune checkpoint inhibitors of programmed cell death protein 1 (PD-1) represent a significant breakthrough in treating he...
Phase I dose escalation study and pilot efficacy analysis of LXI-15029, a novel mTOR dual inhibitor, in Chinese subjects with advanced malignant solid tumors
Phase I dose escalation study and pilot efficacy analysis of LXI-15029, a novel mTOR dual inhibitor, in Chinese subjects with advanced malignant solid tumors
The mammalian target of rapamycin (mTOR) kinase, a central component of the PI3K/AKT/mTOR pathway, plays a critical role i...
A population-based analysis of hematological malignancies from a French-West-Indies cancer registry’s data (2009–2018)
A population-based analysis of hematological malignancies from a French-West-Indies cancer registry’s data (2009–2018)
A worldwide increased incidence of HM has been marked in recent decades. Therefore, to update epidemiological characterist...
Cancer-associated fibroblasts induce sorafenib resistance of hepatocellular carcinoma cells through CXCL12/FOLR1
Cancer-associated fibroblasts induce sorafenib resistance of hepatocellular carcinoma cells through CXCL12/FOLR1
Due to the high drug resistance of hepatocellular carcinoma (HCC), sorafenib has limited efficacy in the treatment of adva...
Significance of circulating tumor cells detection in tumor diagnosis and monitoring
Significance of circulating tumor cells detection in tumor diagnosis and monitoring
To detect circulating tumor cells (CTCs) in the peripheral blood of patients with tumor, and to analyze the significance o...
A novel patient-derived immortalised cell line of myxofibrosarcoma: a tool for preclinical drugs testing and the generation of near-patient models
A novel patient-derived immortalised cell line of myxofibrosarcoma: a tool for preclinical drugs testing and the generation of near-patient models
Myxofibrosarcoma is a rare malignant soft tissue sarcoma characterised by multiple local recurrence and can become of high...
A practical prognostic peripheral blood-based risk model for the evaluation of the likelihood of a response and survival of metastatic cancer patients treated with immune checkpoint inhibitors
A practical prognostic peripheral blood-based risk model for the evaluation of the likelihood of a response and survival of metastatic cancer patients treated with immune checkpoint inhibitors
Less than half of unselected metastatic cancer patients benefit from the immune checkpoint inhibitor (ICI) therapy. System...
Refining gastric cancer staging: examining the interplay between number and anatomical location of metastatic lymph nodes - a retrospective multi-institutional study
Refining gastric cancer staging: examining the interplay between number and anatomical location of metastatic lymph nodes - a retrospective multi-institutional study
The current gastric cancer staging system relies on the number of metastatic lymph nodes (MLNs) for nodal stage determinat...
Prognostic implications of alpha-fetoprotein and C-reactive protein elevation in hepatocellular carcinoma following resection (PACE): a large cohort study of 2770 patients
Prognostic implications of alpha-fetoprotein and C-reactive protein elevation in hepatocellular carcinoma following resection (PACE): a large cohort study of 2770 patients
Routine clinical staging for hepatocellular carcinoma (HCC) incorporates liver function, general health, and tumor morphol...
Patient and physician perspectives on treatments for low-risk prostate cancer: a qualitative study
Patient and physician perspectives on treatments for low-risk prostate cancer: a qualitative study
Patients diagnosed with low-risk prostate cancer (PCa) are confronted with a difficult decision regarding whether to under...
A multicenter noninferior randomized controlled study of sentinel lymph node biopsy alone versus sentinel lymph node biopsy plus lymphadenectomy for patients with stage I endometrial cancer, INSEC trial concept
A multicenter noninferior randomized controlled study of sentinel lymph node biopsy alone versus sentinel lymph node biopsy plus lymphadenectomy for patients with stage I endometrial cancer, INSEC trial concept
Up to the present time, there has remained a lack of strong evidence as to whether sentinel lymph node biopsy can replace ...
Proteome-wide analysis reveals potential therapeutic targets for Colorectal cancer: a two-sample mendelian randomization study
Proteome-wide analysis reveals potential therapeutic targets for Colorectal cancer: a two-sample mendelian randomization study
Colorectal cancer (CRC) is a leading cause of cancer-related mortality, highlighting an unmet clinical need for more effec...
Can we use a simple blood test to reduce unnecessary adverse effects from radiotherapy by timely identification of radiotherapy-resistant rectal cancers? MeD-Seq rectal study protocol
Can we use a simple blood test to reduce unnecessary adverse effects from radiotherapy by timely identification of radiotherapy-resistant rectal cancers? MeD-Seq rectal study protocol
Chemoradiation therapy (CRT) followed by surgery is currently the standard of care to treat patients with locally advanced...
Hepatocellular carcinoma immune prognosis score predicts the clinical outcomes of hepatocellular carcinoma patients receiving immune checkpoint inhibitors
Hepatocellular carcinoma immune prognosis score predicts the clinical outcomes of hepatocellular carcinoma patients receiving immune checkpoint inhibitors
The predictive biomarkers of immune checkpoint inhibitors (ICIs) in hepatocellular carcinoma (HCC) still need to be furthe...
Construction of a prognostic risk score model based on the ARHGAP family to predict the survival of osteosarcoma
Construction of a prognostic risk score model based on the ARHGAP family to predict the survival of osteosarcoma
Osteosarcoma (OS) is the most common primary malignancy of bone tumors. More and more ARHGAP family genes have been confir...
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