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Salmonella-based therapeutic strategies: improving tumor microenvironment and bringing new hope for cancer immunotherapy
Salmonella-based therapeutic strategies: improving tumor microenvironment and bringing new hope for cancer immunotherapy
Immunotherapy has revolutionized cancer treatment, yet its effectiveness is limited by immunosuppressive tumor microenviro...
LncRNAs in modulating cancer cell resistance to paclitaxel (PTX) therapy
LncRNAs in modulating cancer cell resistance to paclitaxel (PTX) therapy
Paclitaxel (PTX) is widely used for treating several cancers, including breast, ovarian, lung, esophageal, gastric, pancre...
Sorcin: mechanisms of action in cancer hallmarks, drug resistance and opportunities in therapeutics
Sorcin: mechanisms of action in cancer hallmarks, drug resistance and opportunities in therapeutics
Soluble resistant related calcium binding protein (Sorcin) plays an important role in tumor progression, angiogenesis, met...
Advancing miRNA cancer research through artificial intelligence: from biomarker discovery to therapeutic targeting
Advancing miRNA cancer research through artificial intelligence: from biomarker discovery to therapeutic targeting
MicroRNAs (miRNAs), a class of small non-coding RNAs, play a vital role in regulating gene expression at the post-transcri...
Phase I study of neoadjuvant chemoradiotherapy with S-1 for clinically resectable type 4 or large type 3 gastric cancer in elderly patients aged 75 years and older (OGSG1303)
Phase I study of neoadjuvant chemoradiotherapy with S-1 for clinically resectable type 4 or large type 3 gastric cancer in elderly patients aged 75 years and older (OGSG1303)
Purpose The prognosis for type 4 and large type 3 gastric cancer (GC) is extremely poor, especially in elderly patients (&...
Cytotoxic effects of bee venom-loaded ZIF-8 nanoparticles on thyroid cancer cells: a promising strategy for targeted therapy
Cytotoxic effects of bee venom-loaded ZIF-8 nanoparticles on thyroid cancer cells: a promising strategy for targeted therapy
Thyroid cancer continues to be a notable health issue, requiring the creation of novel treatment methods to enhance patien...
LHX3 promotes EMT in hepatoma cell through β-catenin/TCF4 pathway
LHX3 promotes EMT in hepatoma cell through β-catenin/TCF4 pathway
Hepatocellular carcinoma (HCC) is a highly malignant cancer and&...
Baicalein, a natural flavonoid in gastrointestinal cancers treatment: recent trends and future perspectives
Baicalein, a natural flavonoid in gastrointestinal cancers treatment: recent trends and future perspectives
Gastrointestinal cancer is a malignant condition of the gastrointestinal tract (GI) which affect multi-organs of digestive...
Nanobodies as innovative immune checkpoint modulators: advancing cancer immunotherapy
Nanobodies as innovative immune checkpoint modulators: advancing cancer immunotherapy
The immune system relies on a delicate balance between attacking harmful pathogens and preserving the body’s own tis...
Unraveling non-coding RNAs in breast cancer: mechanistic insights and therapeutic potential
Unraveling non-coding RNAs in breast cancer: mechanistic insights and therapeutic potential
Breast cancer remains a leading global health challenge requiring innovative, therapeutic strategies to improve patient ou...
Investigation of potential anti-metastatic effect of metformin and caffeic acid combination therapy in breast cancer cell line in in-vitro culture model
Investigation of potential anti-metastatic effect of metformin and caffeic acid combination therapy in breast cancer cell line in in-vitro culture model
The invasion and metastasis of cancer cells transform localized cancers into systemic and life-threatening diseases, posin...
Study of the effect of zinc oxide, selenium, and silver nanoparticles on the expression level of oxidative stress-associated genes in ovarian cancer
Study of the effect of zinc oxide, selenium, and silver nanoparticles on the expression level of oxidative stress-associated genes in ovarian cancer
Reactive oxygen species (ROS) generated by oxidative stress have emerged as critical factors in the pathophysiology of mal...
Novel phloretin-based combinations targeting glucose metabolism in hepatocellular carcinoma through GLUT2/PEPCK axis of action: in silico molecular modelling and in vivo studies
Novel phloretin-based combinations targeting glucose metabolism in hepatocellular carcinoma through GLUT2/PEPCK axis of action: in silico molecular modelling and in vivo studies
Hepatocellular carcinoma (HCC) is commonly associated with disturbances in glucose metabolism and enhanced glycolysis. How...
The evaluation of the anti-cancer effects of Anoectochilus roxburghii on hematological cancers in vitro
The evaluation of the anti-cancer effects of Anoectochilus roxburghii on hematological cancers in vitro
The cause of hematological cancers is the uncontrolled proliferation of hematopoietic and lymphoid tissues, and chemothera...
In vitro evaluation of p-coumaric acid and naringin combination in human epidermoid carcinoma cell line (A431)
In vitro evaluation of p-coumaric acid and naringin combination in human epidermoid carcinoma cell line (A431)
Cancer is considered most detrimental due to high mortality worldwide. Among them, skin cancers play a major part by affec...
The roles of P-selectin in cancer cachexia
The roles of P-selectin in cancer cachexia
P-selectin, a cell adhesion molecule of the selectin family, is expressed on the surface of activated endothelial cells (E...
TGF-β in correlation with tumor progression, immunosuppression and targeted therapy in colorectal cancer
TGF-β in correlation with tumor progression, immunosuppression and targeted therapy in colorectal cancer
Colorectal cancer (CRC) is a complex malignancy responsible for the second-highest cancer deaths worldwide. TGF-β mai...
Musashi-2 (MSI2) promotes neuroblastoma tumorigenesis through targeting MYC-mediated glucose-6-phosphate dehydrogenase (G6PD) transcriptional activation
Musashi-2 (MSI2) promotes neuroblastoma tumorigenesis through targeting MYC-mediated glucose-6-phosphate dehydrogenase (G6PD) transcriptional activation
Neuroblastoma (NB) is the deadliest pediatric solid tumor due to its rapid proliferation. Aberrant expression of MYCN is d...
Combretastatin A-4 suppresses the invasive and metastatic behavior of glioma cells and induces apoptosis in them: in-vitro study
Combretastatin A-4 suppresses the invasive and metastatic behavior of glioma cells and induces apoptosis in them: in-vitro study
The most common primary brain malignancy, glioblastoma multiforme, is tremendously resistant to conventional&...
Whole-exome sequencing reveals mutational profiles of anorectal and gynecological melanoma
Whole-exome sequencing reveals mutational profiles of anorectal and gynecological melanoma
Mucosal melanoma is a rare and highly malignant type of melanoma. Among the sites that mucosal melanoma arises, anorectal ...
Identification of novel inhibitors from Urtica spp against TNBC targeting JAK2 receptor for breast cancer therapy
Identification of novel inhibitors from Urtica spp against TNBC targeting JAK2 receptor for breast cancer therapy
Breast cancer is the most prevalent form of cancer in women globally, and TNBC (triple-negative breast cancer) is its aggr...
Are medical oncologists ready for the artificial intelligence revolution? Evaluation of the opinions, knowledge, and experiences of medical oncologists about artificial intelligence technologies
Are medical oncologists ready for the artificial intelligence revolution? Evaluation of the opinions, knowledge, and experiences of medical oncologists about artificial intelligence technologies
The use of artificial intelligence technologies (AIT) in medicine is increasing worldwide. In this study, it was aimed to ...
HDAC11 mediates the ubiquitin-dependent degradation of p53 and inhibits the anti-leukemia effect of PD0166285
HDAC11 mediates the ubiquitin-dependent degradation of p53 and inhibits the anti-leukemia effect of PD0166285
Cytarabine-resistant acute myeloid leukemia (AML) is a common phenomenon, necessitating the search for new chemotherapeuti...
Novel biomolecules in targeted cancer therapy: a new approach towards precision medicine
Novel biomolecules in targeted cancer therapy: a new approach towards precision medicine
Cancer is a major threat to human life around the globe, and the discovery of novel biomolecules continue to be an urgent&...
Himalayan flora: targeting various molecular pathways in lung cancer
Himalayan flora: targeting various molecular pathways in lung cancer
The fatal amplification of lung cancer across the globe and the limitations of current treatment strategies emphasize the ...
Lysates from the probiotic bacterium Streptococcus thermophilus enhances the survival of T cells and triggers programmed cell death in neuroblastoma cells
Lysates from the probiotic bacterium Streptococcus thermophilus enhances the survival of T cells and triggers programmed cell death in neuroblastoma cells
Neuroblastoma is the most common brain solid tumor in infancy. Despite the availability of numerous approaches like immuno...
Identification by molecular dynamic simulation and in vitro validation of SISB-A1, N-[1-(4-bromophenyl)-3-methyl-1H-pyrazol-5-yl]-2-[(2-oxo-4-phenyl-2H-chromen-7-yl) oxy], as an inhibitor of the AblT315I mutant kinase to combat imatinib resistance in chronic myeloid leukemia
Identification by molecular dynamic simulation and in vitro validation of SISB-A1, N-[1-(4-bromophenyl)-3-methyl-1H-pyrazol-5-yl]-2-[(2-oxo-4-phenyl-2H-chromen-7-yl) oxy], as an inhibitor of the AblT315I mutant kinase to combat imatinib resistance in chronic myeloid leukemia
The discovery of imatinib, a specific inhibitor of Abl kinase, revolutionized the therapeutic approach to chronic myeloid ...
Synergistic induction of apoptosis in liver cancer cells: exploring the combined potential of doxorubicin and XL-888
Synergistic induction of apoptosis in liver cancer cells: exploring the combined potential of doxorubicin and XL-888
Combination therapy has been frequently preferred in treating various types of cancer in recent years. Targeted cancer the...
Decoding dysregulated angiogenesis in HTLV-1 asymptomatic carriers compared to healthy individuals
Decoding dysregulated angiogenesis in HTLV-1 asymptomatic carriers compared to healthy individuals
Human T-cell lymphotropic virus type 1 (HTLV-1) is the first identified human retrovirus responsible for two significant d...
Diosmetin induces apoptosis and protective autophagy in human gastric cancer HGC-27 cells via the PI3K/Akt/FoxO1 and MAPK/JNK pathways
Diosmetin induces apoptosis and protective autophagy in human gastric cancer HGC-27 cells via the PI3K/Akt/FoxO1 and MAPK/JNK pathways
Gastric cancer represents a significant global health concern, necessitating the exploration of novel therapeutic options....
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