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Evolutionary conservation and cancer implications of the WNT signaling pathway
Evolutionary conservation and cancer implications of the WNT signaling pathway
One of the essential cellular machinations co-opted by the WNT signaling pathway, including its canonical β-Catenin a...
Signaling pathways as the pivotal regulators of cisplatin resistance in tumor cells through SOX2 upregulation
Signaling pathways as the pivotal regulators of cisplatin resistance in tumor cells through SOX2 upregulation
Chemotherapy is one of the first-line treatment options in cancer patients. Cisplatin (CDDP) is widely used as one of the ...
Circ_0000847 promotes the migration, invasion, and EMT process in colorectal cancer through binding to IGF2BP2 to enhance IGF2 mRNA stability
Circ_0000847 promotes the migration, invasion, and EMT process in colorectal cancer through binding to IGF2BP2 to enhance IGF2 mRNA stability
Colorectal cancer (CRC) stands as one of the most prevalent forms of malignant gastrointestinal tumors. Circular RNAs (cir...
Mechanistic insights into the therapeutic potential of β-elemene on glioma and other central nervous system diseases
Mechanistic insights into the therapeutic potential of β-elemene on glioma and other central nervous system diseases
The central nervous system (CNS) governs critical physiological processes, and its dysregulation drives severe pathologies...
Genistein enhances TLR3-mediated apoptosis and immune signaling in breast cancer cells
Genistein enhances TLR3-mediated apoptosis and immune signaling in breast cancer cells
Breast cancer is one of the most common malignant tumors globally and the second leading cause of cancer-related death in ...
Gold nanoparticles capped with inclusion complex for the delivery of Chrysin in triple-negative breast cancer
Gold nanoparticles capped with inclusion complex for the delivery of Chrysin in triple-negative breast cancer
Chrysin (CHR), a naturally occurring flavonoid with promising anticancer potential, suffers from poor water solubility, li...
Drug repurposing in oncology: a path beyond the bottleneck
Drug repurposing in oncology: a path beyond the bottleneck
Cancer is a major worldwide health burden, with rising incidence and mortality rates highlighting the critical need for mo...
Female and male hormonal-dependent malignancies: the role of long non-coding RNAs
Female and male hormonal-dependent malignancies: the role of long non-coding RNAs
Since their discovery, long non-coding RNAs (lncRNAs) have emerged as critical regulators of diverse biological processes ...
Chrysin mitigates therapy-induced senescence in breast cancer via cGAS–STING pathway inhibition
Chrysin mitigates therapy-induced senescence in breast cancer via cGAS–STING pathway inhibition
Breast cancer continues to be a leading cause of cancer-related deaths among women globally, with cellular senescence havi...
Water-based propolis enhances 5-fluorouracil drug efficiency in gastric and colorectal cancer cells through cell stress response, anti-migratory, and apoptotic effects regardless of p53 status
Water-based propolis enhances 5-fluorouracil drug efficiency in gastric and colorectal cancer cells through cell stress response, anti-migratory, and apoptotic effects regardless of p53 status
Digestive system tumors, including gastric and colorectal cancers, have notable global incidence and mortality rates. Whil...
A novel long non-coding RNA, PICSAR, promotes thyroid cancer progression through the hsa-miR-320A/hsa-miR-485/RAPGEFL1 axis
A novel long non-coding RNA, PICSAR, promotes thyroid cancer progression through the hsa-miR-320A/hsa-miR-485/RAPGEFL1 axis
Among endocrine cancers, thyroid carcinoma (TC) is the most prevalent and ranks sixth in global mortality rates. Aberrant ...
The landscape of cyclin-dependent kinase 4/6 inhibitors in solid malignancies: emphasis on immunotherapy combinatorial strategies
The landscape of cyclin-dependent kinase 4/6 inhibitors in solid malignancies: emphasis on immunotherapy combinatorial strategies
Given the pivotal role of CDK4/6 deregulation in the pathogenesis of various malignancies, CDK4/6 inhibitors have been inc...
Progress in the mechanistic understanding of NETs formation in cancer
Progress in the mechanistic understanding of NETs formation in cancer
Recent studies have revealed that the tumor microenvironment (TME) mediates neutrophil activation through multicomponent c...
The role of phosphatidylcholine metabolism in tumors
The role of phosphatidylcholine metabolism in tumors
Phosphatidylcholine (PC), a core component of eukaryotic cell membranes essential for maintaining membrane integrity, has ...
Advances in cancer therapy using fluorinated chitosan: a promising nanoplatform for drug delivery
Advances in cancer therapy using fluorinated chitosan: a promising nanoplatform for drug delivery
Chitosan, a naturally derived polysaccharide, has gained considerable attention as a biomaterial for drug delivery due to ...
Salmonella-based therapeutic strategies: improving tumor microenvironment and bringing new hope for cancer immunotherapy
Salmonella-based therapeutic strategies: improving tumor microenvironment and bringing new hope for cancer immunotherapy
Immunotherapy has revolutionized cancer treatment, yet its effectiveness is limited by immunosuppressive tumor microenviro...
LncRNAs in modulating cancer cell resistance to paclitaxel (PTX) therapy
LncRNAs in modulating cancer cell resistance to paclitaxel (PTX) therapy
Paclitaxel (PTX) is widely used for treating several cancers, including breast, ovarian, lung, esophageal, gastric, pancre...
Sorcin: mechanisms of action in cancer hallmarks, drug resistance and opportunities in therapeutics
Sorcin: mechanisms of action in cancer hallmarks, drug resistance and opportunities in therapeutics
Soluble resistant related calcium binding protein (Sorcin) plays an important role in tumor progression, angiogenesis, met...
Advancing miRNA cancer research through artificial intelligence: from biomarker discovery to therapeutic targeting
Advancing miRNA cancer research through artificial intelligence: from biomarker discovery to therapeutic targeting
MicroRNAs (miRNAs), a class of small non-coding RNAs, play a vital role in regulating gene expression at the post-transcri...
Phase I study of neoadjuvant chemoradiotherapy with S-1 for clinically resectable type 4 or large type 3 gastric cancer in elderly patients aged 75 years and older (OGSG1303)
Phase I study of neoadjuvant chemoradiotherapy with S-1 for clinically resectable type 4 or large type 3 gastric cancer in elderly patients aged 75 years and older (OGSG1303)
Purpose The prognosis for type 4 and large type 3 gastric cancer (GC) is extremely poor, especially in elderly patients (&...
Cytotoxic effects of bee venom-loaded ZIF-8 nanoparticles on thyroid cancer cells: a promising strategy for targeted therapy
Cytotoxic effects of bee venom-loaded ZIF-8 nanoparticles on thyroid cancer cells: a promising strategy for targeted therapy
Thyroid cancer continues to be a notable health issue, requiring the creation of novel treatment methods to enhance patien...
LHX3 promotes EMT in hepatoma cell through β-catenin/TCF4 pathway
LHX3 promotes EMT in hepatoma cell through β-catenin/TCF4 pathway
Hepatocellular carcinoma (HCC) is a highly malignant cancer and&...
Baicalein, a natural flavonoid in gastrointestinal cancers treatment: recent trends and future perspectives
Baicalein, a natural flavonoid in gastrointestinal cancers treatment: recent trends and future perspectives
Gastrointestinal cancer is a malignant condition of the gastrointestinal tract (GI) which affect multi-organs of digestive...
Nanobodies as innovative immune checkpoint modulators: advancing cancer immunotherapy
Nanobodies as innovative immune checkpoint modulators: advancing cancer immunotherapy
The immune system relies on a delicate balance between attacking harmful pathogens and preserving the body’s own tis...
Unraveling non-coding RNAs in breast cancer: mechanistic insights and therapeutic potential
Unraveling non-coding RNAs in breast cancer: mechanistic insights and therapeutic potential
Breast cancer remains a leading global health challenge requiring innovative, therapeutic strategies to improve patient ou...
Investigation of potential anti-metastatic effect of metformin and caffeic acid combination therapy in breast cancer cell line in in-vitro culture model
Investigation of potential anti-metastatic effect of metformin and caffeic acid combination therapy in breast cancer cell line in in-vitro culture model
The invasion and metastasis of cancer cells transform localized cancers into systemic and life-threatening diseases, posin...
Study of the effect of zinc oxide, selenium, and silver nanoparticles on the expression level of oxidative stress-associated genes in ovarian cancer
Study of the effect of zinc oxide, selenium, and silver nanoparticles on the expression level of oxidative stress-associated genes in ovarian cancer
Reactive oxygen species (ROS) generated by oxidative stress have emerged as critical factors in the pathophysiology of mal...
Novel phloretin-based combinations targeting glucose metabolism in hepatocellular carcinoma through GLUT2/PEPCK axis of action: in silico molecular modelling and in vivo studies
Novel phloretin-based combinations targeting glucose metabolism in hepatocellular carcinoma through GLUT2/PEPCK axis of action: in silico molecular modelling and in vivo studies
Hepatocellular carcinoma (HCC) is commonly associated with disturbances in glucose metabolism and enhanced glycolysis. How...
The evaluation of the anti-cancer effects of Anoectochilus roxburghii on hematological cancers in vitro
The evaluation of the anti-cancer effects of Anoectochilus roxburghii on hematological cancers in vitro
The cause of hematological cancers is the uncontrolled proliferation of hematopoietic and lymphoid tissues, and chemothera...
In vitro evaluation of p-coumaric acid and naringin combination in human epidermoid carcinoma cell line (A431)
In vitro evaluation of p-coumaric acid and naringin combination in human epidermoid carcinoma cell line (A431)
Cancer is considered most detrimental due to high mortality worldwide. Among them, skin cancers play a major part by affec...
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