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Therapeutic exploration of combined local hyperthermia and anti-CD200 blockade therapy in the EMT6 breast cancer model
Therapeutic exploration of combined local hyperthermia and anti-CD200 blockade therapy in the EMT6 breast cancer model
Breast cancer remains the leading cause of cancer-related deaths among women worldwide. Combinatorial therapies are often ...
ULK1-driven autophagy modulation alters tumor-promoting pathways in triple-negative breast cancer
ULK1-driven autophagy modulation alters tumor-promoting pathways in triple-negative breast cancer
Triple-negative breast cancer (TNBC) is an aggressive subtype with limited targeted therapies and poor prognosis. Unc-51-l...
Exploitation of CREB signaling by HTLV-1 and BLV: A central axis in viral persistence and leukemogenesis
Exploitation of CREB signaling by HTLV-1 and BLV: A central axis in viral persistence and leukemogenesis
Deltaretroviruses, including Human T-cell Leukemia Virus type 1 (HTLV-1) and Bovine Leukemia Virus (BLV), are oncogenic pa...
Piperine-induced AMPK activation and cell cycle arrest: insights from molecular simulations and experimental validation in breast cancer
Piperine-induced AMPK activation and cell cycle arrest: insights from molecular simulations and experimental validation in breast cancer
Breast cancer remains a leading cause of mortality among women, underscoring the need for novel, low-toxicity therapeutic ...
Evaluation of the anticancer effects of ellagic acid and cisplatin in cisplatin-sensitive and -resistant MDA-MB-231 breast cancer cells
Evaluation of the anticancer effects of ellagic acid and cisplatin in cisplatin-sensitive and -resistant MDA-MB-231 breast cancer cells
Ellagic acid (EA) is a natural polyphenol noted for its antiproliferative and pro-apoptotic effects. This study investigat...
A different perspective on the cancer stem cell theory
A different perspective on the cancer stem cell theory
Increased recurrence risk, aggressiveness, metastasis, and poor prognosis of cancer disease are challenges of conventional...
 ethyl acetate extract suppresses HepG2 hepatocellular carcinoma cell proliferation via PCNA downregulation and mitochondria-mediated apoptosis
 ethyl acetate extract suppresses HepG2 hepatocellular carcinoma cell proliferation via PCNA downregulation and mitochondria-mediated apoptosis
Merremia tridentata of the Convolvulaceae family exhibits multiple therapeutic properties and is commonly utilized in ethn...
Research progress and clinical translation challenges in the use of oncolytic bacteria for cancer therapy
Research progress and clinical translation challenges in the use of oncolytic bacteria for cancer therapy
Oncolytic bacteria represent a distinct group of microorganisms capable of selectively infecting and colonizing tumor tiss...
A natural nephroprotective adjuvant for cancer chemotherapy: Rosmarinic acid disrupts IL-17 A-Ferroptosis coupling in Ifosfamide-induced renal injury
A natural nephroprotective adjuvant for cancer chemotherapy: Rosmarinic acid disrupts IL-17 A-Ferroptosis coupling in Ifosfamide-induced renal injury
Rosmarinic acid (RA) is a natural polyphenol with established pleiotropic protective effects. Ifosfamide (IFA) is a potent...
Disrupting the USP1–UAF1 deubiquitinase complex: a master regulator of replication stress and frontier target in cancer therapy
Disrupting the USP1–UAF1 deubiquitinase complex: a master regulator of replication stress and frontier target in cancer therapy
Replication stress is a therapeutic vulnerability in cancer, and the deubiquitinase USP1, in complex with its WD40 cofacto...
Patient-derived spheroid culture: A promising in vitro model for drug screening in retinoblastoma
Patient-derived spheroid culture: A promising in vitro model for drug screening in retinoblastoma
In retinoblastoma (RB), the search for newer therapeutics is a thrust area for better disease management, and there is a l...
Glioma–Immune crosstalk in the tumor microenvironment: mechanistic insights and therapeutic translation
Glioma–Immune crosstalk in the tumor microenvironment: mechanistic insights and therapeutic translation
Tumor progression is governed not only by genetic alterations but also by the dynamic interplay within the tumor microenvi...
A novel matrine derivative exerts antitumor effects against hepatocellular carcinoma by inducing oxidative stress and DNA damage
A novel matrine derivative exerts antitumor effects against hepatocellular carcinoma by inducing oxidative stress and DNA damage
DNA has long been a major target in the development of anticancer drugs. Natural products, as an important source of antit...
Enhanced antitumor activity of atorvastatin and luteolin, with or without doxorubicin, in a solid Ehrlich carcinoma mouse model: modulation of ABC transporters, telomerase, and cancer stem cells
Enhanced antitumor activity of atorvastatin and luteolin, with or without doxorubicin, in a solid Ehrlich carcinoma mouse model: modulation of ABC transporters, telomerase, and cancer stem cells
This study evaluated the antitumor efficacy of atorvastatin (ATO) and luteolin (LUT), administered individually or in comb...
Trigonelline suppresses the tumor progression via STAT2 signalling pathway in non-Small cell lung carcinoma
Trigonelline suppresses the tumor progression via STAT2 signalling pathway in non-Small cell lung carcinoma
Trigonelline, a naturally derived bioactive compound, has gained interest for its potential anticancer properties. This st...
Thymoquinone decreases cell proliferation and immune evasion of breast cancer cells by reducing CD55 and CD114 levels
Thymoquinone decreases cell proliferation and immune evasion of breast cancer cells by reducing CD55 and CD114 levels
Controlling the proliferation and immune evasion of cancer cells can lead to effective strategies for cancer treatment. Th...
Evolutionary conservation and cancer implications of the WNT signaling pathway
Evolutionary conservation and cancer implications of the WNT signaling pathway
One of the essential cellular machinations co-opted by the WNT signaling pathway, including its canonical β-Catenin a...
Signaling pathways as the pivotal regulators of cisplatin resistance in tumor cells through SOX2 upregulation
Signaling pathways as the pivotal regulators of cisplatin resistance in tumor cells through SOX2 upregulation
Chemotherapy is one of the first-line treatment options in cancer patients. Cisplatin (CDDP) is widely used as one of the ...
Circ_0000847 promotes the migration, invasion, and EMT process in colorectal cancer through binding to IGF2BP2 to enhance IGF2 mRNA stability
Circ_0000847 promotes the migration, invasion, and EMT process in colorectal cancer through binding to IGF2BP2 to enhance IGF2 mRNA stability
Colorectal cancer (CRC) stands as one of the most prevalent forms of malignant gastrointestinal tumors. Circular RNAs (cir...
Mechanistic insights into the therapeutic potential of β-elemene on glioma and other central nervous system diseases
Mechanistic insights into the therapeutic potential of β-elemene on glioma and other central nervous system diseases
The central nervous system (CNS) governs critical physiological processes, and its dysregulation drives severe pathologies...
Genistein enhances TLR3-mediated apoptosis and immune signaling in breast cancer cells
Genistein enhances TLR3-mediated apoptosis and immune signaling in breast cancer cells
Breast cancer is one of the most common malignant tumors globally and the second leading cause of cancer-related death in ...
Gold nanoparticles capped with inclusion complex for the delivery of Chrysin in triple-negative breast cancer
Gold nanoparticles capped with inclusion complex for the delivery of Chrysin in triple-negative breast cancer
Chrysin (CHR), a naturally occurring flavonoid with promising anticancer potential, suffers from poor water solubility, li...
Drug repurposing in oncology: a path beyond the bottleneck
Drug repurposing in oncology: a path beyond the bottleneck
Cancer is a major worldwide health burden, with rising incidence and mortality rates highlighting the critical need for mo...
Female and male hormonal-dependent malignancies: the role of long non-coding RNAs
Female and male hormonal-dependent malignancies: the role of long non-coding RNAs
Since their discovery, long non-coding RNAs (lncRNAs) have emerged as critical regulators of diverse biological processes ...
Chrysin mitigates therapy-induced senescence in breast cancer via cGAS–STING pathway inhibition
Chrysin mitigates therapy-induced senescence in breast cancer via cGAS–STING pathway inhibition
Breast cancer continues to be a leading cause of cancer-related deaths among women globally, with cellular senescence havi...
Water-based propolis enhances 5-fluorouracil drug efficiency in gastric and colorectal cancer cells through cell stress response, anti-migratory, and apoptotic effects regardless of p53 status
Water-based propolis enhances 5-fluorouracil drug efficiency in gastric and colorectal cancer cells through cell stress response, anti-migratory, and apoptotic effects regardless of p53 status
Digestive system tumors, including gastric and colorectal cancers, have notable global incidence and mortality rates. Whil...
A novel long non-coding RNA, PICSAR, promotes thyroid cancer progression through the hsa-miR-320A/hsa-miR-485/RAPGEFL1 axis
A novel long non-coding RNA, PICSAR, promotes thyroid cancer progression through the hsa-miR-320A/hsa-miR-485/RAPGEFL1 axis
Among endocrine cancers, thyroid carcinoma (TC) is the most prevalent and ranks sixth in global mortality rates. Aberrant ...
The landscape of cyclin-dependent kinase 4/6 inhibitors in solid malignancies: emphasis on immunotherapy combinatorial strategies
The landscape of cyclin-dependent kinase 4/6 inhibitors in solid malignancies: emphasis on immunotherapy combinatorial strategies
Given the pivotal role of CDK4/6 deregulation in the pathogenesis of various malignancies, CDK4/6 inhibitors have been inc...
Progress in the mechanistic understanding of NETs formation in cancer
Progress in the mechanistic understanding of NETs formation in cancer
Recent studies have revealed that the tumor microenvironment (TME) mediates neutrophil activation through multicomponent c...
The role of phosphatidylcholine metabolism in tumors
The role of phosphatidylcholine metabolism in tumors
Phosphatidylcholine (PC), a core component of eukaryotic cell membranes essential for maintaining membrane integrity, has ...
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