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PRMT5 deficiency in myeloid cells reprograms macrophages to enhance antitumor immunity and synergizes with anti-PD-L1 therapy
IntroductionProtein arginine methyltransferase 5 (PRMT5) is a highly conserved enzyme that catalyzes the symmetric di-meth...
Potency-optimized CD28-activating bispecific antibody for the targeted treatment of Nectin-4 positive cancers
WHAT IS ALREADY KNOWN ON THIS TOPICCD28 bispecific antibodies are an emerging class of immunotherapies with the potential ...
Flagellin engineering enhances CAR-T cell function by reshaping tumor microenvironment in solid tumors
BackgroundAdoptive cellular therapy using chimeric antigen receptor (CAR)-T cells has shown remarkable therapeutic outcome...
Conformation-sensitive targeting of CD18 depletes M2-like tumor-associated macrophages resulting in inhibition of solid tumor progression
IntroductionThe tumor microenvironment (TME) plays a pivotal role in the behavior and development of solid tumors.1 Notabl...
Correction: Tissue-specific properties of type 1 dendritic cells in lung cancer: implications for immunotherapy
López L, Amadio R, Piperno GM et al. Tissue-specific properties of type 1 dendritic cells in lung cancer: implications for...
MHC class II-mediated spontaneous rejection of breast carcinomas expressing model neoantigens
WHAT IS ALREADY KNOWN ON THIS TOPICTumors develop and persist despite expressing numerous tumor-specific neoantigens that ...
JAK3A573V and JAK3M511I mutations in peripheral T-cell lymphoma mediating resistance to anti-PD-1 therapy through the STAT3/PD-L1 pathway
IntroductionPeripheral T-cell lymphoma (PTCL) accounts for 25% of non-Hodgkin’s lymphoma (NHL) patients in China and about...
Consensus disease definitions for ophthalmic immune-related adverse events of immune checkpoint inhibitors
Approach to Eye-irAE diagnosis and general guidance statementsEye-irAEs were broadly classified anatomically into ocular s...
CD40L stimulates tumor-infiltrating B-cells and improves ex vivo TIL expansion
BackgroundAmtagvi (lifileucel) melanoma tumor-infiltrating lymphocytes (TIL) was the first adoptive cellular therapy (ACT)...
Bevacizumab, tislelizumab and nab-paclitaxel for previously untreated metastatic triple-negative breast cancer: a phase II trial
IntroductionTriple-negative breast cancer (TNBC) represented a heterogeneous group of cancers, some of which were associat...
Neural crest-associated gene FOXD1 induces an immunosuppressive microenvironment by regulating myeloid-derived suppressor cells in melanoma
WHAT IS ALREADY KNOWN ON THIS TOPICNeural crest-associated genes are critical for tumor initiation and shaping the tumor m...
Correction: ICOS-expressing CAR-T cells mediate durable eradication of triple-negative breast cancer and metastasis
Cao L, Peng H, Chen Y, et al. ICOS-expressing CAR-T cells mediate durable eradication of triple-negative breast cancer and...
Correction: Combination cancer immunotherapy targeting TNFR2 and PD-1/PD-L1 signaling reduces immunosuppressive effects in the microenvironment of pancreatic tumors
Zhang X, Lao M, Xu J, et al. Combination cancer immunotherapy targeting TNFR2 and PD-1/PD-L1 signaling reduces immunosuppr...
Expanding the CAR toolbox with high throughput screening strategies for CAR domain exploration: a comprehensive review
BackgroundTreatment of B-cell leukemia and lymphoma has seen a tremendous improvement in clinical outcomes with the advent...
Tumor-infiltrating lymphocyte immunotherapy comes of age: a journey of development in the Surgery Branch, NCI
Nearly 40 years ago, a milky white infusion bag was carried from a cramped research lab to the bedside of a patient with m...
Prior chemotherapy deteriorates T-cell quality for CAR T-cell therapy in B-cell non-Hodgkins lymphoma
BackgroundChimeric antigen receptor (CAR) T-cell therapy has revolutionized the treatment of relapsed or refractory (r/r) ...
Siglec-15 antibody-GM-CSF chimera suppresses tumor progression via reprogramming tumor-associated macrophages
IntroductionThe discovery of immune checkpoints has revolutionized cancer immunotherapy.1 2 The sialic acid-binding immuno...
Acasunlimab, an Fc-inert PD-L1x4-1BB bispecific antibody, combined with PD-1 blockade potentiates antitumor immunity via complementary immune modulatory effects
WHAT IS ALREADY KNOWN ON THIS TOPICCombining programmed cell death protein-1 (PD-1)/programmed death-ligand 1 (PD-L1) bloc...
Memory-promoting function of miR-379-5p attenuates CD8+ T cell exhaustion by targeting immune checkpoints
BackgroundT cell exhaustion, caused by prolonged exposure to tumor antigens and the overexpression of immune checkpoint pr...
Targeting B7-H3 inhibition-induced activation of fatty acid synthesis boosts anti-B7-H3 immunotherapy in triple-negative breast cancer
BackgroundBreast cancer (BC) remains the most prevalent malignancy among women, accounting for 31% of all female cancers a...
Aldehyde dehydrogenase 2-mediated aldehyde metabolism promotes tumor immune evasion by regulating the NOD/VISTA axis
IntroductionImmune evasion plays a key role in tumor progression, which implies that tumors have potential to establish co...
Differential requirements for CD4+ T cells in the efficacy of the anti-PD-1+LAG-3 and anti-PD-1+CTLA-4 combinations in melanoma flank and brain metastasis models
WHAT IS ALREADY KNOWN ON THIS TOPICWHAT THIS STUDY ADDSOur studies suggest that the antitumor activity of the anti-PD-1+LA...
First-in-human study of SBRT and adenosine pathway blockade to potentiate the benefit of immunochemotherapy in early-stage luminal B breast cancer: results of the safety run-in phase of the Neo-CheckRay trial
WHAT IS ALREADY KNOWN ON THIS TOPICHOW THIS STUDY MIGHT AFFECT RESEARCH, PRACTICE, OR POLICYThe study paves the way for ra...
CXCL10 and Nrf2-upregulated mesenchymal stem cells reinvigorate T lymphocytes for combating glioblastoma
WHAT IS ALREADY KNOWN ON THIS TOPICGlioblastoma (GBM) immunotherapy resistance has been linked primarily to a deficiency i...
iPSC-derived natural killer cells expressing the Fc{gamma}R fusion CD64/16A can be armed with antibodies for multitumor antigen targeting
BackgroundNatural killer (NK) cells are cytotoxic lymphocytes of the innate immune system . These cells express numerous g...
Allogeneic NK cells induce monocyte-to-dendritic cell conversion, control tumor growth, and trigger a pro-inflammatory shift in patient-derived cultures of primary and metastatic colorectal cancer
IntroductionColorectal cancer (CRC) is the third leading cause of cancer worldwide and, despite therapeutic advances, the ...
Caspase-9 inhibition triggers Hsp90-based chemotherapy-mediated tumor intrinsic innate sensing and enhances antitumor immunity
BackgroundAlthough immunotherapy, especially immune checkpoint inhibitors, has shown clinical success, its efficacy is oft...
Tumor cell-intrinsic SETD2 inactivation sensitizes cancer cells to immune checkpoint blockade through the NR2F1-STAT1 pathway
BackgroundImmune checkpoint inhibitors (ICIs) mainly include antibodies that targeting programmed cell death protein-1 (PD...
Deletion of the protein tyrosine phosphatase PTPN22 for adoptive T cell therapy facilitates CTL effector function but promotes T cell exhaustion
BackgroundIn recent decades, the field of cancer immunotherapy has expanded greatly, leading to improved outcomes for many...
Fibrinogen-like protein 2 promotes tumor immune suppression by regulating cholesterol metabolism in myeloid-derived suppressor cells
IntroductionThe tumor microenvironment (TME) is a complex environment consisting of tumor cells, immune cells, secreted fa...
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