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The pathological landscape of tumor evolution: a paradigm shift from morphology to functional networks
Tumor pathology is undergoing a profound transformation, shifting from pure morphological description toward multidimensio...
Capmatinib targeted therapy in MET-fusion driven radiation induced glioma
IntroductionRadiation-induced gliomas (RIGs) can occur in regions of the central nervous system (CNS) previously irradiate...
Development of an early diagnostic model for gastric cancer combining serum cytokine profiles with conventional tumor markers: a case–control study
BackgroundEarly detection of gastric cancer (GC) remains challenging, and conventional serum tumor markers show limited se...
Ultrasound localization microscopy for evaluation of therapeutic efficacy assessment after transarterial chemoembolization in hepatocellular carcinoma
ObjectivesThe timely and precise evaluation of the efficacy of Transarterial chemoembolization (TACE) in hepatocellular ca...
Genomic profile of an IDH−wild−type glioblastoma diagnosed following TNF−α inhibitor therapy: a molecular case study
TNF α inhibitors such as adalimumab are widely used for autoimmune diseases, yet their long-term impact on tumor developme...
External validation and updating of NTCP models for radiation pneumonitis: QUANTEC, Appelt, and a local simplified model
ObjectiveTo externally evaluate and update the QUANTEC and Appelt NTCP models for radiation pneumonitis (RP) in lung cance...
Lisaftoclax combined with ixazomib and dexamethasone after CAR-T for maintenance therapy in transplant-ineligible relapsed/refractory ultra-high-risk multiple myeloma: two case reports and literature review
Multiple myeloma (MM) is an incurable malignancy. The treatment mainly includes induction therapy, minimal residual diseas...
Hereditary cancer syndromes with gynecological cancer risk: focus on prevention strategies
BackgroundHereditary cancer syndromes, including pathogenic variants in BRCA1/2 and mismatch-repair genes, confer a substa...
AI models based on gadoxetic acid–enhanced MRI to predict treatment response and prognosis after TACE in hepatocellular carcinoma
ObjectivesTo develop and validate radiomics and deep learning models based on the hepatobiliary phase (HBP) of gadoxetic a...
Successful diagnosis and treatment of autoimmune hepatitis leading to liver failure following PD-1 immunotherapy in a patient with nasopharyngeal carcinoma: a case report
BackgroundImmune checkpoint inhibitors (ICIs), particularly programmed cell death protein 1 (PD-1) inhibitors, are widely ...
HBV reactivation in HCC patients following TACE: risk factors, antiviral therapy impact, and survival analysis
BackgroundHepatitis B virus (HBV) reactivation after transcatheter Arterial Chemoembolization (TACE) can lead to severe co...
Cerebral lipiodol embolism after transcatheter arterial chemoembolization for hepatocellular carcinoma: a case report and review of the literature
Cerebral lipiodol embolism (CLE) is a rare and serious complication of transcatheter arterial chemoembolization (TACE). A ...
A KMT2C loss-of-function mutation in a JAK2-negative polycythemia vera–like myeloproliferative neoplasm: a case report
BackgroundPolycythemia vera (PV) is a clonal myeloproliferative neoplasm (MPN) typically defined by JAK2 mutations. JAK2-n...
Quantitative peri-lesional densitometry mapping via thin-slice volume rendering enhances differentiation of pneumonic-type lung cancer and inflammatory pneumonia
ObjectivesPneumonic-type lung cancer (PTLC) poses significant diagnostic challenges owing to its overlapping computed tomo...
Indolent natural killer-cell lymphoproliferative disorder of the gallbladder: a rare case report
BackgroundIndolent natural killer (NK)-cell lymphoproliferative disorder (iNKLPD) is a rare, recently defined neoplasm tha...
The efficacy and safety of four different PD-1 checkpoint inhibitors in advanced non-small cell lung cancer: a real-world retrospective study
BackgroundWhile various PD-1 inhibitors are approved for advanced non-small cell lung cancer (NSCLC), direct comparisons o...
Case Report: A rare case of EBV-positive inflammatory follicular dendritic cell sarcoma occurring in the testes
Follicular dendritic cell sarcoma (FDCS) is an exceedingly rare low-grade malignant tumor originating from follicular dend...
Preoperative nutritional status and sarcopenia are associated with disease-free survival in patients with resected pancreatic neuroendocrine tumors
BackgroundPancreatic neuroendocrine tumors (pNETs) show heterogeneous clinical behavior, and better predictors of postoper...
Penile pseudomyogenic hemangioendothelioma/epithelioid sarcoma-like hemangioendothelioma: a case report and literature review
Pseudomyogenic hemangioendothelioma (PHE) is a rare vascular neoplasm predominantly affecting young adult males, often pre...
Enhanced survival in resectable duodenal adenocarcinoma with adjuvant chemotherapy: evidence from a retrospective study
BackgroundDuodenal adenocarcinoma (DA) is a rare malignancy, and the effectiveness of adjuvant chemotherapy on survival af...
Brigatinib treatment in a patient with advanced NSCLC with XPO1-ALK fusion: a case report
1 IntroductionNSCLC, which is a malignant tumor of epithelial origin, accounts for 85%-88% of all lung cancer cases; NSCLC...
Targeting the kynurenine pathway: another therapeutic opportunity in the metabolic crosstalk between cancer and immune cells
IntroductionDrug resistance in cancer remains a formidable challenge in modern oncology, severely limiting the efficacy of...
Changes in gut microbiota after gastric cancer surgery: a prospective longitudinal study
1 IntroductionGastric cancer (GC) is a global health issue, being the fifth most prevalent cancer and the third leading ca...
Case report: Gastric langerhans cell histiocytosis with BRAF deletion mutation in a child that was misdiagnosed as lymphoma
1 IntroductionLangerhans cell histiocytosis (LCH) is a myeloid neoplasm of mixed cellularity, which is characterized by ac...
Natural killer cell engagers for cancer immunotherapy
1 IntroductionAntibody-mediated cancer immunotherapy is a type of treatment approach that harnesses the power of antibodie...
HLA-DMB correlates with antitumor immunity and an improved prognosis in endometrial carcinoma tumors
1 IntroductionEndometrial cancer is the sixth most common cancer among women, with an overall incidence that has risen by ...
A comparative analysis and survival analysis of open versus minimally invasive radical antegrade modular pancreatosplenectomy for pancreatic cancer: a systematic review and meta-analysis
1 IntroductionPancreatic ductal adenocarcinoma (PDAC) is a significant threat to human health, ranking as the fourth leadi...
Rare skin adverse reactions induced by osimertinib: a case report and literature review
IntroductionLung cancer is the leading cause of cancer-related deaths worldwide, with approximately 85% of cases attribute...
Prognostic role of prognostic nutritional index in patients with bladder cancer: a systematic review and meta-analysis
IntroductionBladder cancer is one of the most common malignant tumors of the urinary system, originating from the urotheli...
Interactions between key genes and pathways in prostate cancer progression and therapy resistance
1 IntroductionProstate cancer is currently the most common malignancy among men in the United States, with an incidence of...
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