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CENPF (+) cancer cells promote malignant progression of early-stage TP53 mutant lung adenocarcinoma
CENPF (+) cancer cells promote malignant progression of early-stage TP53 mutant lung adenocarcinoma
The prevention and precise treatment of early-stage lung adenocarcinoma (LUAD) characterized by small nodules (stage IA) r...
Tumor cell-derived ISG15 promotes fibroblast recruitment in oral squamous cell carcinoma via CD11a-dependent glycolytic reprogramming
Tumor cell-derived ISG15 promotes fibroblast recruitment in oral squamous cell carcinoma via CD11a-dependent glycolytic reprogramming
Cancer-associated fibroblast (CAF) recruitment and activation within the tumor microenvironment (TME) are increasingly ack...
FLT3 inhibition upregulates OCT4/NANOG to promote maintenance and TKI resistance of FLT3-ITD+ acute myeloid leukemia
FLT3 inhibition upregulates OCT4/NANOG to promote maintenance and TKI resistance of FLT3-ITD+ acute myeloid leukemia
Up to 30% of acute myeloid leukemia (AML) patients face unfavorable outcomes due to the FMS-like receptor tyrosine kinase-...
A HOTAIR-associated super-enhancer orchestrates glioblastoma malignancy via MEST
A HOTAIR-associated super-enhancer orchestrates glioblastoma malignancy via MEST
Glioblastoma (GBM) is one of the most malignant primary brain tumors, and factors governing its progression are not fully ...
Myeloma mesenchymal stem cells’ bioenergetics afford a novel selective therapeutic target
Myeloma mesenchymal stem cells’ bioenergetics afford a novel selective therapeutic target
Bone-marrow mesenchymal stem cells (BM-MSCs) rely on glycolysis, yet their trafficked mitochondria benefit recipient cells...
Chasing non-existent “microRNAs” in cancer
Chasing non-existent “microRNAs” in cancer
MicroRNAs (miRNAs) are important regulators of gene expression whose dysregulation is widely linked to tumourigenesis, tum...
O-GlcNAcylation of FBP1 promotes pancreatic cancer progression by facilitating its Lys48-linked polyubiquitination in hypoxic environments
O-GlcNAcylation of FBP1 promotes pancreatic cancer progression by facilitating its Lys48-linked polyubiquitination in hypoxic environments
Fructose-1,6-bisphosphatase 1 (FBP1), a rate-limiting enzyme in gluconeogenesis, is important for cancer progression. The ...
EPHA5 promotes cell proliferation and inhibits apoptosis in Follicular Thyroid Cancer via the STAT3 signaling pathway
EPHA5 promotes cell proliferation and inhibits apoptosis in Follicular Thyroid Cancer via the STAT3 signaling pathway
Follicular thyroid carcinoma (FTC) is a common endocrine malignancy characterized by a higher propensity for invasion and ...
Programmed cell death 11 modulates but not entirely relies on p53-HDM2 loop to facilitate G2/M transition in colorectal cancer cells
Programmed cell death 11 modulates but not entirely relies on p53-HDM2 loop to facilitate G2/M transition in colorectal cancer cells
We previously described a nucleolar protein RSL1D1 but distributed throughout the nucleus in HCT116 colorectal cancer (CRC...
Identifying a locus in super-enhancer and its resident NFE2L1/MAFG as transcriptional factors that drive PD-L1 expression and immune evasion
Identifying a locus in super-enhancer and its resident NFE2L1/MAFG as transcriptional factors that drive PD-L1 expression and immune evasion
Although the transcriptional regulation of the programmed death ligand 1 (PD-L1) promoter has been extensively studied, th...
NF-κB signaling activation and roles in thyroid cancers: implication of MAP3K14/NIK
NF-κB signaling activation and roles in thyroid cancers: implication of MAP3K14/NIK
Among follicular-derived thyroid cancers (TC), those with aggressive behavior and resistance to current treatments display...
Molecular mechanisms in colitis-associated colorectal cancer
Molecular mechanisms in colitis-associated colorectal cancer
Sustained chronic inflammation of the large intestine leads to tissue damage and repair, which is associated with an incre...
Decreased B4GALT1 promotes hepatocellular carcinoma cell invasiveness by regulating the laminin-integrin pathway
Decreased B4GALT1 promotes hepatocellular carcinoma cell invasiveness by regulating the laminin-integrin pathway
Beta1,4-galactosyltransferases (B4GALTs) play a crucial role in several diseases, including cancer. B4GALT1 is highly expr...
Fibroblasts in metastatic lymph nodes confer cisplatin resistance to ESCC tumor cells via PI16
Fibroblasts in metastatic lymph nodes confer cisplatin resistance to ESCC tumor cells via PI16
Although many studies have compared tumor fibroblasts (T-Fbs) and nontumor fibroblasts (N-Fbs), less is understood about t...
Combined in vitro/in vivo genome-wide CRISPR screens in triple negative breast cancer identify cancer stemness regulators in paclitaxel resistance
Combined in vitro/in vivo genome-wide CRISPR screens in triple negative breast cancer identify cancer stemness regulators in paclitaxel resistance
Triple negative breast cancer (TNBC) is defined as lacking the expressions of estrogen receptor (ER), progesterone recepto...
Correction: PBK phosphorylates MSL1 to elicit epigenetic modulation of CD276 in nasopharyngeal carcinoma
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, whi...
Coordinate transcriptional regulation of ErbB2/3 by C-terminal binding protein 2 signals sensitivity to ErbB2 inhibition in pancreatic adenocarcinoma
Coordinate transcriptional regulation of ErbB2/3 by C-terminal binding protein 2 signals sensitivity to ErbB2 inhibition in pancreatic adenocarcinoma
There is a critical need to identify new therapeutic vulnerabilities in pancreatic ductal adenocarcinoma (PDAC). Transcrip...
Kinesin family member 18B activates mTORC1 signaling via actin gamma 1 to promote the recurrence of human hepatocellular carcinoma
Kinesin family member 18B activates mTORC1 signaling via actin gamma 1 to promote the recurrence of human hepatocellular carcinoma
The mechanistic target of rapamycin complex 1 (mTORC1) signaling pathway is frequently reported to be hyperactivated in he...
WDR4 promotes the progression and lymphatic metastasis of bladder cancer via transcriptional down-regulation of ARRB2
WDR4 promotes the progression and lymphatic metastasis of bladder cancer via transcriptional down-regulation of ARRB2
Lymph node (LN) metastasis is one of the key prognostic factors in bladder cancer, but its underlying mechanisms remain un...
AIFM2 promotes hepatocellular carcinoma metastasis by enhancing mitochondrial biogenesis through activation of SIRT1/PGC-1α signaling
AIFM2 promotes hepatocellular carcinoma metastasis by enhancing mitochondrial biogenesis through activation of SIRT1/PGC-1α signaling
AIFM2 is a crucial NADH oxidase involved in the regulation of cytosolic NAD+. However, the role of AIFM2 in the progressio...
Discovery of neddylation E2s inhibitors with therapeutic activity
Discovery of neddylation E2s inhibitors with therapeutic activity
Neddylation is the writing of monomers or polymers of neural precursor cells expressed developmentally down-regulated 8 (N...
Biological differences underlying sex and gender disparities in bladder cancer: current synopsis and future directions
Biological differences underlying sex and gender disparities in bladder cancer: current synopsis and future directions
Sex and gender disparities in bladder cancer have long been a subject of interest to the cancer research community, wherei...
Correction: Non-enzymatic heparanase enhances gastric tumor proliferation via TFEB-dependent autophagy
Correction: Non-enzymatic heparanase enhances gastric tumor proliferation via TFEB-dependent autophagy
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, whi...
Glucocorticoid receptor-induced non-muscle caldesmon regulates metastasis in castration-resistant prostate cancer
Glucocorticoid receptor-induced non-muscle caldesmon regulates metastasis in castration-resistant prostate cancer
Lethal prostate cancer (PCa) is characterized by the presence of metastases and development of resistance to therapies. Me...
SLC26A3/NHERF2-IκB/NFκB/p65 feedback loop suppresses tumorigenesis and metastasis in colorectal cancer
SLC26A3/NHERF2-IκB/NFκB/p65 feedback loop suppresses tumorigenesis and metastasis in colorectal cancer
Colorectal cancer (CRC) is a formidable disease due to the intricate mechanisms that drive its proliferation and metastasi...
Loss of Pkd1 limits susceptibility to colitis and colorectal cancer
Loss of Pkd1 limits susceptibility to colitis and colorectal cancer
Colorectal cancer (CRC) is one of the most common cancers, with an annual incidence of ~135,000 in the US, associated with...
Retraction Note: Acetyl-CoA synthetase 3 promotes bladder cancer cell growth under metabolic stress
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, whi...
Correction: Targeting IL-3Rα on tumor-derived endothelial cells blunts metastatic spread of triple-negative breast cancer via extracellular vesicle reprogramming
Correction: Targeting IL-3Rα on tumor-derived endothelial cells blunts metastatic spread of triple-negative breast cancer via extracellular vesicle reprogramming
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, whi...
Deep learning identifies a T-cell exhaustion-dependent transcriptional signature for predicting clinical outcomes and response to immune checkpoint blockade
Deep learning identifies a T-cell exhaustion-dependent transcriptional signature for predicting clinical outcomes and response to immune checkpoint blockade
Immune checkpoint blockade (ICB) therapies have brought unprecedented advances in cancer treatment, but responses are limi...
The tumor suppressor CREBBP and the oncogene MYCN cooperate to induce malignant brain tumors in mice
The tumor suppressor CREBBP and the oncogene MYCN cooperate to induce malignant brain tumors in mice
The tumor suppressor and chromatin modifier cAMP response element-binding protein binding protein (CREBBP) and v-myc avian...
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